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1 Interindividual variation in the response by fibrinogen, C-reactive protein and interleukin-6 to yellow fever vaccination
article 2004    
Author: Verschuur, M. · Beek, M.T. van der · Tak, H.S. · Visser, L.G. · Maat, M.P.M. de
Keywords: Biology · Biomedical Research · Acute phase proteins · Interindividual variation · Polymorphisms · C reactive protein · Pasteur merieux · Yellow fever vaccine · Adult · Allele · Clinical article · Controlled study · Drug effect · Female · Fibrinogen blood level · Genetic polymorphism · Genetic variability · Male · Yellow fever flavivirus · C-Reactive Protein · Cardiovascular Diseases · Fibrinogen · Homozygote · Humans · Inflammation · Interleukin-6 · Vaccination · Variation (Genetics) · Yellow Fever Vaccine
[Abstract]

2 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

3 A physiologically-based pharmacokinetic (PB-PK) model for ethylene dibromide : relevance of extrahepatic metabolism
article 2000    
Author: Hissink, A.M. · Wormhoudt, L.W. · Sherratt, P.J. · Hayes, J.D. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Ethylene dibromide · Extrapolation · Glutathione S-transferase · Interindividual variation · PBPK · Risk assessment · 1,2 dibromoethane · cytochrome P450 · glutathione · glutathione transferase · animal experiment · animal model · article · biotransformation · controlled study · male · nonhuman · pharmacokinetics · prediction · rat · risk assessment · toxicity testing · xenobiotic metabolism · Administration, Oral · Animals · Area Under Curve · Biotransformation · Chromatography, Gas · Cytochrome P-450 Enzyme System · Ethylene Dibromide · Glutathione Transferase · Humans · Injections, Intravenous · Liver · Male · Models, Biological · Rats · Rats, Wistar · Risk Assessment
[Abstract]

4 Intestinal beta-carotene absorption and cleavage in men : response of beta-carotene and retinyl esters in the triglyceride-rich lipoprotein fraction after a single oral dose of beta-carotene
article 1995    
Author: Vliet, T. van · Schreurs, W.H.P. · Berg, H. van den
Keywords: Nutrition · β-carotene · chylomicrons · interindividual variation · intraindividual variation · plasma · response · retinyl esters · second meal · single dose · triglycerides · alpha tocopherol · arachidic acid · beta carotene · lipoprotein · retinol · retinol ester · retinol palmitate · retinol stearate · sugar · triacylglycerol · yoghurt · adult · article · blood level · clinical article · clinical trial · controlled clinical trial · controlled study · dietary intake · drug degradation · human · human tissue · intestine absorption · male · oral drug administration · test meal · Administration, Oral · Adult · beta Carotene · Carotenoids · Humans · Intestinal Absorption · Intestines · Lipoproteins · Male · Triglycerides · Vitamin A
[Abstract]

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