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1 The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides
article 2007    
Author: Moen, C.J.A. · Tholens, A.P. · Voshol, P.J. · Haan, W. de · Havekes, L.M. · Gargalovic, P. · Lusis, A.J. · Dyk, K.W. van · Frants, R.R. · Hofker, M.H. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Congenic mice · Lipoprotein clearance · Lipoprotein lipase · Lipoproteins · Triglyceride hydrolysis · Animals · Chylomicrons · Female · Genetic Techniques · Hypertriglyceridemia · Lipase · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Mice · Mice, Congenic · Postprandial Period · Triglycerides
[PDF] [Abstract]

2 Gender-related association between the -93T →Gg/D9N haplotype of the lipoprotein lipase gene and elevated lipid levels in familial combined hyperlipidemia
article 1998    
Author: Hoffer, M.J.V. · Bredie, S.J.H. · Snieder, H. · Reymer, P.W.A. · Demacker, P.N.M. · Havekes, L.M. · Boomsma, D.I. · Stalenhoef, A.F.H. · Frants, R.R. · Kastelein, J.J.P.
Keywords: Health · Familial combined hyperlipidemia · Family study · Genetic predisposition · Lipoprotein lipase · Mutation analysis · Adult · Amino Acid Sequence · DNA Mutational Analysis · Female · Haplotypes · Heterozygote · Humans · Hyperlipidemias · Likelihood Functions · Linkage (Genetics) · Lipids · Lipoprotein Lipase · Male · Middle Aged · Pedigree · Promoter Regions (Genetics) · Sex Characteristics
[Abstract]

3 The binding of human lipoprotein lipase treated VLDL by the human hepatoma cell line HepG2
article 1991    
Author: Mulder, M. · Wit, E.de · Havekes, L.M.
Keywords: Biology · HepG2 cell line · LDLD receptor · Lipoprotein lipase · Remnant receptor · VLDL · VLDL remnant · Binding, Competitive · Carcinoma, Hepatocellular · Human · Lipoprotein Lipase · Lipoproteins, LDL · Lipoproteins, VLDL · Liver Neoplasms · Receptors, LDL · Triglycerides · Tumor Cells, Cultured · Bovinae
[Abstract]

4 Binding of β-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas apoE only modulates binding affinity
article 1999    
Author: Beer, F. de · Hendriks, W.L. · Vark, L.C. van · Kamerling, S.W.A. · Dijk, K.W. van · Hofker, M.H. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Biology · β-VLDL · apoE · Heparan sulfate proteoglycans · Lipoprotein lipase · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Binding, Competitive · Cell Line · Cholesterol, VLDL · Heparan Sulfate Proteoglycans · Iodine Radioisotopes · Lipoprotein Lipase · Macrophages · Mice · Mice, Knockout
[Abstract]

5 Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: Studies using genetically engineered mouse models
article 2009    
Author: Voshol, P.J. · Rensen, P.C.N. · Dijk, K.W. van · Romijn, J.A. · Havekes, L.M.
Keywords: Biology · Biomedical Research · Animal model · Fatty acid · Fatty acid transporter · Lipid metabolism · Lipoprotein lipase · Metabolic syndrome · Obesity · Animalia
[Abstract]

6 Improved cholesterol phenotype analysis by a model relating lipoprotein life cycle processes to particle size
article 2009    
Author: Schalkwijk, D.B. van · Graaf, A.A. de · Ommen, B. van · Bochove, K. van · Rensen, P.C.N. · Havekes, L.M. · Pas, N.C.A. van de · Hoefsloot, H.C.J. · Greef, J. van der · Freidig, A.P.
Keywords: Health · Physiological Sciences · Data analysis · Genetic polymorphism · Hepatic lipase · Kinetics · Lipoprotein lipase · Mathematical modeling · Stable isotope flux data
[PDF] [Abstract]

7 Oxidized VLDL induces less triglyceride accumulation in J774 macrophages than native VLDL due to an impaired extracellular lipolysis
article 2000    
Author: Jong, M.C. · Hendriks, W.L. · Vark, L.C. van · Dahlmans, V.E.H. · Groener, J.E.M. · Havekes, L.M.
Keywords: Biology · Lipid accumulation · Lipolysis · Macrophages · Oxidized VLDL · Animals · Cell Line · Lipolysis · Lipoprotein Lipase · Lipoproteins, VLDL · Macrophages · Mice · Oxidation-Reduction · Triglycerides
[Abstract]

8 Overexpression of Angiopoietin-Like Protein 4 Protects Against Atherosclerosis Development
article 2013    
Author: Georgiadi, A. · Wang, Y. · Stienstra, R. · Tjeerdema, N. · Janssen, A. · Stalenhoef, A. · Vliet, J.A. van der · Roos, A. de · Tamsma, J.T. · Smit, J.W. · Tan, N.S. · Müller, M. · Rensen, P.C. · Kersten, S.
Keywords: Health · Atherosclerosis · Inflammation · Lipoprotein lipase · Lipoproteins · Macrophages · Food and Nutrition · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

9 Role of apoCs in lipoprotein metabolism : Functional differences between ApoC1, ApoC2, and ApoC3
article 1999    
Author: Jong, M.C. · Hofker, M.H. · Havekes, L.M.
Keywords: Biology · Apolipoproteins · Lipoprotein lipase · Lipoproteins, VLDL · Mice, transgenic · Animals · Apolipoprotein C-I · Apolipoprotein C-II · Apolipoprotein C-III · Apolipoproteins C · Humans · Lipoproteins · Mice · Mice, Transgenic · Mutation
[Abstract]

10 Lipolysis of very low density lipoproteins by heparan sulfate proteoglycan-bound lipoprotein lipase
article 1997    
Author: Man, F.H.A.F. de · Beer, F. de · Laarse, A. van der · Smelt, A.H.M. · Havekes, L.M.
Keywords: Animals · Binding, Competitive · Cattle · Fatty Acids · Heparan Sulfate Proteoglycans · Heparin Lyase · Humans · Iodine Radioisotopes · Kinetics · Lipolysis · Lipoprotein Lipase · Lipoproteins, VLDL · Protein Binding · Radioligand Assay · Triglycerides
[PDF] [Abstract]

11 The lipoprotein lipase (Asn291 → Ser) mutation is associated with elevated lipid levels in families with familial combined hyperlipidaemia
article 1996    
Author: Hoffer, M.J.V. · Bredie, S.J.H. · Boomsma, D.I. · Reymer, P.W.A. · Kastelein, J.J.P. · Knijff, P. de · Demacker, P.N.M. · Stalenhoef, A.F.H. · Havekes, L.M. · Frants, R.R.
Keywords: Biology · Cholesterol · Familial combined hyperlipidaemia · Lipoprotein lipase · LPL(Asn291→ Ser) mutation · Triglycerides · cholesterol · high density lipoprotein cholesterol · lipoprotein lipase · low density lipoprotein cholesterol · triacylglycerol · very low density lipoprotein · adult · article · controlled study · coronary artery atherosclerosis · enzyme activity · familial hyperlipemia · gene mutation · genetic predisposition · human · major clinical study · male · pedigree analysis · priority journal · Base Sequence · Cholesterol · Coronary Disease · Female · Gene Frequency · Genetic Predisposition to Disease · Heterozygote · Humans · Hyperlipidemia, Familial Combined · Lipids · Lipoprotein Lipase · Male · Molecular Sequence Data · Netherlands · Pedigree · Point Mutation · Prevalence · Risk Factors · Triglycerides
[Abstract]

12 ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression
article 2005    
Author: Gerritsen, G. · Rensen, P.C.N. · Kypreos, K.E. · Zannis, V.I. · Havekes, L.M. · Dijk, K.W. van
Keywords: Biology · Biomedical Research · Adenovirus-mediated gene transfer · Lipoprotein lipase-mediated triglyceride hydrolysis · Mice · Very low density lipoprotein · Cholesterol · Fatty acid · Intermediate density lipoprotein · Lipoprotein · Triacylglycerol · Lipid · Lipoprotein lipase · Animal experiment · Animal tissue · Cholesterol blood level · Controlled study · Dose response · Emulsion · Female · Gene dosage · Gene overexpression · Hydrolysis · Hyperlipidemia · In vitro study · In vivo study · Injection · Lipoprotein deficiency · Mouse · Nonhuman · Protein blood level · White adipose tissue · Animal · Biosynthesis · Blood · Genetic transfection · Genetics · Metabolism · Mouse mutant · Animals · Apolipoprotein C-III · Apolipoprotein E4 · Apolipoproteins C · Apolipoproteins E · Humans · Hyperlipidemias · Lipids · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Mice · Mice, Knockout · Transfection · Triglycerides
[PDF] [Abstract]

13 Effect of apolipoprotein E variants on lipolysis of very low density lipoproteins by heparan sulphate proteoglycan-bound lipoprotein lipase
article 1998    
Author: Man, F.H.A.F. de · Beer, F. de · Laarse, A. van der · Smelt, A.H.M. · Leuven, J.A.G. · Havekes, L.M.
Keywords: Health · Atherosclerosis · Familial dysbetalipoproteinemia · Metabolism · Triglyceride · VLDL · Adult · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Female · Heparan Sulfate Proteoglycans · Heterozygote · Homozygote · Humans · Hyperlipoproteinemia Type III · Lipolysis · Lipoprotein Lipase · Lipoproteins, VLDL · Male · Middle Aged
[Abstract]

14 In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE
article 1999    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Hof, H.B. van 't · Zee, A. van der · Santamarina-Fojo, S. · Berkel, T.J.C. van · Havekes, L.M. · Hofker, M.H.
Keywords: Health · Adenovirus-mediated gene transfer · Hepatic VLDL triglyceride production · Hypertriglyceridemia · LDL receptor-related protein · VLDL-triglyceride lipolysis · Adenovirus · Adenoviridae · Animals · Apolipoproteins E · Cholesterol · Female · Humans · Immunohistochemistry · Lipolysis · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Receptors, LDL · Transfection · Triglycerides
[PDF] [Abstract]

15 Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice
article 2001    
Author: Jong, M.C. · Rensen, P.C.N. · Dahlmans, V.E.H. · Boom, H. van der · Berkel, T.J.C. van · Havekes, L.M.
Keywords: Animals · Apolipoprotein C-III · Apolipoproteins C · Apolipoproteins E · Chylomicrons · Crosses, Genetic · Female · Gene Deletion · Hydrolysis · Lipoprotein Lipase · Lipoproteins, VLDL · Male · Mice · Mice, Inbred C57BL · Mice, Knockout · Time Factors · Triglycerides
[PDF] [Abstract]

16 An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins
article 1999    
Author: Vlijmen, B.J.M. van · Rohlmann, A. · Page, S.T. · Bensadoun, A. · Bos, I.S.T. · Berkel, T.J.C. van · Havekes, L.M. · Herz, J.
Keywords: Animals · Binding Sites · Cholesterol · Chylomicrons · Detergents · Gene Transfer Techniques · Heymann Nephritis Antigenic Complex · Immunoblotting · LDL-Receptor Related Protein 1 · Lipase · Lipoprotein Lipase · Liver · Membrane Glycoproteins · Mice · Mice, Transgenic · Polyethylene Glycols · Rats · Receptors, Immunologic · Receptors, LDL · Time Factors · Transfection · Triglycerides
[PDF] [Abstract]

17 Uptake by J774 macrophages of very-low-density lipoproteins isolated from apoE-deficient mice is mediated by a distinct receptor and stimulated by lipoprotein lipase
article 1997    
Author: Hendriks, W.L. · Sman van der - Beer, F. de · Vlijmen, B.J.M. van · Vark, L.C. van · Hofker, M.H. · Havekes, L.M.
Keywords: Biology · apoE-deficient mice · foam cells · lipoprotein lipase · macrophages · receptor-mediated uptake · apolipoprotein a1 · apolipoprotein a4 · apolipoprotein b100 · apolipoprotein c · cholesterol ester · lipoprotein receptor · receptor protein · triacylglycerol · very low density lipoprotein · animal cell · animal experiment · animal model · atherosclerotic plaque · cell line · controlled study · foam cell · hyperlipoproteinemia type 3 · intima · lipoprotein metabolism · macrophage · mouse · nonhuman · Animals · Apolipoproteins E · Biological Transport · Cell Line · Lipoprotein Lipase · Lipoproteins, VLDL · Macrophages · Mice · Radioligand Assay · Receptors, Lipoprotein
[Abstract]

18 The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI
article 2008    
Author: Hu, L. · Hoogt, C.C. van der · Espirito Santo, S.M.S. · Out, R. · Kypreos, K.E. · Vlijmen, B.J.M. van · Berkel, T.J.C. van · Romijn, J.A. · Havekes, L.M. · Dijk, K.W. van · Rensen, P.C.N.
Keywords: Biology · Apolipoprotein · Denovirus-mediated gene transfer · Lipoprotein lipase · Low density lipoprotein receptor · Low density lipoprotein receptor-related protein · Transgenic mice · Triglyceride-rich emulsion particles · Very low density lipoprotein receptor · apolipoprotein E · cell surface protein · cholesterol · lipoprotein lipase · low density lipoprotein receptor · low density lipoprotein receptor related protein · proteoglycan · proteoheparan sulfate · scavenger receptor BI · triacylglycerol · very low density lipoprotein · very low density lipoprotein receptor · CD36 antigen · ligand · very low density lipoprotein cholesterol · Adenovirus · animal cell · animal experiment · animal tissue · article · cell isolation · cell surface · controlled study · enzyme activity · in vitro study · in vivo study · internalization · lipid analysis · liver cell · male · mouse · nonhuman · priority journal · protein expression · regulatory mechanism · animal · blood · emulsion · genetics · liver · metabolism · mouse mutant · Animals · Antigens, CD36 · Cholesterol, VLDL · Emulsions · LDL-Receptor Related Proteins · Ligands · Lipoprotein Lipase · Liver · Male · Mice · Mice, Knockout · Proteoglycans · Receptors, LDL · Healthy for Life · Healthy Living
[Abstract]

19 The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis
article 2004    
Author: Goudriaan, J.R. · Espirito Santo, S.M.S. · Voshol, P.J. · Teusink, B. · Dijk, K.W. van · Vlijmen, B.J.M. van · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Adipose tissue · Free fatty acids · Lipoprotein lipase · Postprandial lipid metabolism · Transgenic mice · Very low density lipoprotein-like emulsion · Albumin · Carbon 14 · Chylomicron · Fatty acid · Lipoprotein lipase · Triacylglycerol · Very low density lipoprotein · Very low density lipoprotein receptor · Animal experiment · Animal tissue · Bolus injection · Continuous infusion · Controlled study · Diet restriction · Emulsion · Enzyme activity · Fatty acid transport · Female · Half life time · Lipid blood level · Lipid hydrolysis · Lipid metabolism · Lipolysis · Mouse · Nonhuman · Plasma clearance · Postprandial state · Protein expression · Transgenic mouse · Adipose Tissue · Albumins · Animals · Chylomicrons · Fatty Acids, Nonesterified · Mice · Receptors, LDL · Triglycerides
[PDF] [Abstract]

20 Increased fecal bile acid excretion in transgenic mice with elevated expression of human phospholipid transfer protein
article 2003    
Author: Post, S.M. · Crom, R. de · Haperen, R. van · Tol, A. van · Princen, H.M.G.
Keywords: Biology · Biomedical Research · Bile acid · HDL · Mouse · Phospholipid transfer protein · Reverse cholesterol transport · Animals · Bile Acids and Salts · Biological Transport · Carrier Proteins · Cholesterol · Cholesterol, HDL · Feces · Humans · Lipase · Lipoprotein Lipase · Liver · Male · Membrane Proteins · Mice · Mice, Inbred C57BL · Mice, Transgenic · Phospholipid Transfer Proteins · Sterols
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 40 found. Next | Sort by date