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1 Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding
article 1995    
Author: Ree, J.H. van · Gijbels, M.J.J. · Broek, W.J.A.A. van den · Hofker, M.H. · Havekes, L.M.
Keywords: Biology · Cholesterol deposition · Familial dysbetalipoproteinemia · Gene targeting · Hypercholesterolemia · Lipoprotein metabolism · Mouse model · apolipoprotein e · cholesterol · animal experiment · animal model · article · cholesterol diet · familial hypercholesterolemia · gene targeting · histology · hyperlipoproteinemia type 3 · lipoprotein metabolism · mouse · nonhuman · priority journal · xanthomatosis · Animal · Apolipoproteins E · Cholesterol, Dietary · Human · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Support, Non-U.S. Gov't · Xanthomatosis
[Abstract]

2 Comment on "Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice" by Rebholz S.L. et al. Toxicol. Rep. 2016 (3) 46-54
article 2016    
Author: Princen, H.M.G. · Pouwer, M.G. · Pieterman, E.J.
Keywords: Biology · APOE*3-Leiden.CETP mice · Lipoprotein metabolism · Lipoproteins · Non-HDL-C/HDL-C · Perfluorooctanoate (PFOA) · Plasma cholesterol · Plasma triglycerides · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences

3 Developing computational model-based diagnostics to analyse clinical chemistry data
article 2010    
Author: Schalkwijk, D.B. van · Bochove, K. van · Ommen, B. van · Freidig, A.P. · Someren, E.P. van · Greef, J. van der · Graaf, A.A. de
Keywords: Biology · Biomedical Research · Clinical chemistry · Clinical diagnostics · Computational modelling · Lipoprotein metabolism · Particle profiler · Probabilistic and deterministic modelling · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis
article 2017    
Author: Hoeke, G. · Wang, Y. · Dam, A.D. van · Mol, M. · Gart, E. · Klop, H.G. · Berg, S.M. van den · Pieterman, E.H. · Princen, H.M.G. · Groen, A.K. · Rensen, P.C.N. · Berbée, J.F.P. · Boon, M.R.
Keywords: Biology · Atherosclerosis · Brown adipose tissue · Hypercholesterolemia · Cholesterol metabolism · Lipid and lipoprotein metabolism · 5 [2 [[2 (3 chlorophenyl) 2 hydroxyethyl]amino]propyl] 1,3 benzodioxole 2,2 dicarboxylic acid · Atorvastatin · Cholesterol · Fatty acid · High density lipoprotein cholesterol · Lipoprotein · Proprotein convertase 9 · Triacylglycerol · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Brown adipose tissue · Cholesterol blood level · Controlled study · Drug effect · Drug potentiation · Energy expenditure · Female · Gene expression · Hypercholesterolemia · Lipid composition · Lipid liver level · Lipid metabolism · Lipid oxidation · Lipid transport · Lipoprotein metabolism · Mouse · Nonhuman · Triacylglycerol blood level · Western diet · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Low-density lipoproteins are degraded in HepG2 cells with low efficiency
article 1993    
Author: Lombardi, P. · Mulder, M. · Wit, E. de · Berkel, T.J.C. van · Frants, R.R. · Havekes, L.M.
Keywords: Low density lipoprotein · Low density lipoprotein receptor · Cell density · Cell fractionation · Comparative study · Density gradient centrifugation · Endosome · Hepatoma cell · Human cell · Internalization · Isotope labeling · Lipoprotein metabolism · Protein degradation · Receptor down regulation · Biological Transport · Cell Aggregation · Cell Line · Cells, Cultured · Down-Regulation · Fibroblasts · Human · Iodine Radioisotopes · Kinetics · Lipoproteins, LDL · Liver · Lysosomes · Receptors, LDL · Support, Non-U.S. Gov't
[Abstract]

6 Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice
article 2005    
Author: Verschuren, L. · Kleemann, R. · Offerman, E.H. · Szalai, A.J. · Emeis, S.J. · Princen, H.M.G. · Kooistra, T.
Keywords: Biology · Biomedical Research · Growth factors · Lipids · Lipoprotein metabolism · Pathophysiology · C reactive protein · Cholesterol · Gelatinase B · Macrophage migration inhibition factor · Plasminogen activator inhibitor 1 · Vascular cell adhesion molecule 1 · Animal cell · Animal experiment · animal model · Antiinflammatory activity · Aorta arch · Cholesterol blood level · Cholesterol diet · Controlled study · Dietary intake · Disease activity · Disease course · Disease severity · Inflammation · Lipoprotein metabolism · Low drug dose · Macrophage · Monocyte · Mouse · Nonhuman · Pathophysiology · Protein expression · Smooth muscle fiber · Transgenic mouse · Treatment outcome · Amyloid A protein · Apolipoprotein E3 · Atorvastatin · Animals · Anticholesteremic Agents · Aorta · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Biological Markers · C-Reactive Protein · Cholesterol · Diet · Diet, Atherogenic · Drug Administration Schedule · Female · Heptanoic Acids · Inflammation · Male · Mice · Mice, Transgenic · Pyrroles · Serum Amyloid A Protein
[Abstract]

7 Effect of simultaneous, single oral doses of beta-carotene with lutein or lycopene on the beta-carotene and retinyl ester responses in the triacylglycerol-rich lipoprotein fraction of men
article 1998    
Author: Berg, H. van den · Vliet, T. van
Keywords: Nutrition · β-Carotene · Chylomicrons · Humans · Interactions · Lutein · Lycopene · Retinyl esters · Retinyl palmitate · Triacylglycerol-rich lipoprotein · Vegetables · Beta carotene · Carotenoid · Chylomicron · Lipoprotein · Lycopene · Retinol ester · Retinol palmitate · Triacylglycerol · Xanthophyll · Adult · Antioxidant activity · Area under the curve · Carrot · Cell communication · Data analysis · Food intake · Human · Immunosurveillance · Intestine absorption · Lipoprotein metabolism · Male · Oral drug administration · Quantitative diagnosis · Spinach · Statistical analysis · Test meal · Tomato · Absorption · Adult · beta Carotene · Carotenoids · Humans · Kinetics · Lipoproteins · Lutein · Male · Triglycerides · Vegetables · Vitamin A · Daucus carota · Lycopersicon esculentum · Spinacia oleracea
[Abstract]

8 Mechanism of the slow induction of apolipoprotein A-I synthesis by retinoids in cynomolgus hepatocytes: Involvement of retinoic acid and retinoid X receptors
article 1997    
Author: Kaptein, A. · Neele, D.M. · Twisk, J. · Hendriks, H.F.J. · Kooistra, T. · Princen, H.M.G.
Keywords: Apolipoprotein A-I · Cynomolgus hepatocytes · MRNA · RAP · Receptor-selective ligands · Retinoids · RXR · Transcriptional regulation · apolipoprotein a1 · retinoic acid · retinoid x receptor · animal cell · article · lipogenesis · lipoprotein metabolism · liver cell · liver metabolism · monkey · nonhuman · transcription regulation · Animals · Apolipoprotein A-I · Benzoates · Blotting, Northern · Cells, Cultured · Female · Gene Expression Regulation · Liver · Macaca fascicularis · Male · Receptors, Retinoic Acid · Retinoid X Receptors · Retinoids · RNA, Messenger · Tetrahydronaphthalenes · Time Factors · Trans-Activation (Genetics) · Transcription Factors · Tretinoin
[PDF] [Abstract]

9 Sex steroids and lipoprotein metabolism
article 1994    
Author: Gevers Leuven, J.A.
Keywords: Health · Cardiovascular risk · Cholesterol · Estrogens · Lipoproteins · Progestogens · Sex steroids · chlormadinone acetate · cholesterol · conjugated estrogen · cyproterone acetate · desogestrel · dydrogesterone · gestodene · high density lipoprotein · hydroxytamoxifen · low density lipoprotein · lynestrenol · medrogestone · medroxyprogesterone acetate · mifepristone · norethisterone · noretynodrel · norgestimate · norgestrel · oral contraceptive agent · sex hormone · steroid receptor · very low density lipoprotein · atherogenesis · cardiovascular disease · drug structure · lipid metabolism · lipoprotein metabolism · Animal · Arteriosclerosis · Cardiovascular Diseases · Contraceptives, Oral, Hormonal · Female · Human · Lipoproteins · Male · Risk Factors · Sex Hormones
[Abstract]

10 Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels
article 1994    
Author: Knijff, P. de · Maagdenberg, A.M.J.M. van den · Frants, R.R. · Havekes, L.M.
Keywords: Biology · Apolipoprotein (apo) E · Atherosclerosis · Familial Dysbetalipoproteinemia (FD) · Mutations · Polymorphisms · Type III Hyperlipoproteinemia · Cholesterol · Chylomicron · Low density lipoprotein receptor · Triacylglycerol · Very low density lipoprotein · Alzheimer disease · Atherosclerosis · Cholesterol blood level · Coronary artery disease · Creutzfeldt jakob disease · Gene mutation · Genetic heterogeneity · Genetic linkage · Genetic polymorphism · Ligand binding · Lipoprotein metabolism · Alleles · Amino Acid Sequence · Base Sequence · DNA · Female · Gene Frequency · Human · Hyperlipidemia · Hyperlipoproteinemia Type III · Lipids · Lipoproteins · Male · Molecular Sequence Data · Mutation · Variation (Genetics)
[Abstract]

11 Uptake by J774 macrophages of very-low-density lipoproteins isolated from apoE-deficient mice is mediated by a distinct receptor and stimulated by lipoprotein lipase
article 1997    
Author: Hendriks, W.L. · Sman van der - Beer, F. de · Vlijmen, B.J.M. van · Vark, L.C. van · Hofker, M.H. · Havekes, L.M.
Keywords: Biology · apoE-deficient mice · foam cells · lipoprotein lipase · macrophages · receptor-mediated uptake · apolipoprotein a1 · apolipoprotein a4 · apolipoprotein b100 · apolipoprotein c · cholesterol ester · lipoprotein receptor · receptor protein · triacylglycerol · very low density lipoprotein · animal cell · animal experiment · animal model · atherosclerotic plaque · cell line · controlled study · foam cell · hyperlipoproteinemia type 3 · intima · lipoprotein metabolism · macrophage · mouse · nonhuman · Animals · Apolipoproteins E · Biological Transport · Cell Line · Lipoprotein Lipase · Lipoproteins, VLDL · Macrophages · Mice · Radioligand Assay · Receptors, Lipoprotein
[Abstract]

12 Apolipoproteins modulate the inflammatory response to lipopolysaccharide
article 2005    
Author: Berbée, J.F.P. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Apolipoprotein E · Hepatocyte · Lipid metabolism · Lipopolysaccharide · Lipoprotein · Apolipoprotein · Apolipoprotein A1 · Apolipoprotein E · Cholesterol · High density lipoprotein · Lipid transfer protein · Low density lipoprotein · Triacylglycerol · Very low density lipoprotein · Cholesterol blood level · Death · Enzyme blood level · In vitro study · Inflammation · Lipid analysis · Lipoprotein metabolism · Nonhuman · Protein binding · Rodent · Triacylglycerol blood level · Animals · Apolipoproteins · Apolipoproteins E · Humans · Inflammation · Lipids · Lipopolysaccharides · Lipoproteins · Sepsis · Bacteria (microorganisms) · Rodentia
[Abstract]

13 Methods for the differential integrative omic analysis of plasma from a transgenic disease animal model
article 2004    
Author: Davidov, E. · Clish, C.B. · Oresic, M. · Meys, M. · Stochaj, W. · Snell, P. · Lavine, G. · Londo, T.R. · Adourian, A. · Zhang, X. · Johnston, M. · Morel, N. · Marple, E.W. · Plasterer, T.N. · Neumann, E. · Verheij, E. · Vogels, J.T.W.E. · Havekes, L.M. · Greef, J. van der · Naylor, S.
Keywords: Biology · Analytical research · Biomedical research · Apolipoprotein E3 · Lipid · Protein · Analytic method · Animal experiment · Animal model · Computer program · Controlled study · Correlation analysis · DNA modification · Gene mutation · Information processing · Lipoprotein metabolism · Metabolic regulation · Metabolite · Mouse · Multivariate analysis · Nonhuman · Plasma · Quantitative analysis · Transgenic mouse · Animals · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Chromatography, Liquid · Crosses, Genetic · Female · Genes, Dominant · Genetic Techniques · Humans · Hyperlipoproteinemias · Lipid Metabolism · Lipoproteins · Magnetic Resonance Spectroscopy · Male · Mass Spectrometry · Mice · Mice, Inbred C57BL · Mice, Transgenic · Multivariate Analysis · Mutation · Peptides · Principal Component Analysis · Proteins · Software · Time Factors · Trypsin
[Abstract]

14 Response of apolipoprotein E*3-Leiden transgenic mice to dietary fatty acids: Combining liver proteomics with physiological data
article 2005    
Author: Roos, B. de · Duivenvoorden, I. · Rucklidge, G. · Reid, M. · Ross, K. · Lamers, R.J.A.N. · Voshol, P.J. · Havekes, L.M. · Teusink, B.
Keywords: Biology · Biomedical Research · Conjugated linoleic acid · Elaidic acid · Fenofibrate · Glucose · Liver protein · Membrane protein · Animal model · Atherosclerosis · Controlled study · Diet · Diet therapy · Fat intake · Fatty acid oxidation · Glucose metabolism · Insulin resistance · Ischemic heart disease · Lipoprotein metabolism · Metabolic syndrome X · Mouse · Nonhuman · Principal component analysis · Structural proteomics · Transgenic mouse · 3-Hydroxybutyric Acid · Animals · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Blood Glucose · Cell Membrane · Cholesterol · Cytosol · Dietary Fats · Disease Models, Animal · Electrophoresis, Gel, Two-Dimensional · Fatty Acids · Female · Fish Oils · Insulin · Linoleic Acids, Conjugated · Lipid Metabolism · Lipids · Liver · Mice · Mice, Transgenic · Oleic Acid · Organ Size · Proteins · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization · Triglycerides · Animalia · Mus musculus

15 Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity
article 2014    
Author: Boon, M.R. · Kooijman, S. · Dam, A.D. van · Pelgrom, L.R. · Berbée, J.F.P. · Visseren, C.A.R. · Aggele, R.C. van · Hoek, A.M. van den · Sips, H.C.M. · Lombès, M. · Havekes, L.M. · Tamsma, J.T. · Guigas, B. · Meijer, O.C. · Jukema, J.W. · Rensen, P.C.N.
Keywords: Biology · Rimonabant · Sympathetic nervous system · Uncoupling protein 1 · Adrenergic receptor · Am 6545 · Cannabinoid 1 receptor · Cannabinoid 1 receptor antagonist · Cyclic AMP · Fat droplet · Lipoprotein · Triacylglycerol · Unclassified drug · Adrenergic system · Animal experiment · Animal model · Animal tissue · Appetite · Brown adipocyte · Alorimetry · Controlled study · Diet induced obesity · Dyslipidemia · Energy expenditure · Energy metabolism · Food intake · In vitro study · In vivo study · Lipid analysis · Lipid storage · Lipolysis · Lipoprotein metabolism · Male · Mouse · Nonhuman · Oxygen consumption · Physical activity · Thermogenesis · Triacylglycerol blood level · Weight change · Weight reduction · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

16 Effect of 17β-estradiol on plasma lipids and LDL oxidation in postmenopausal women with type II diabetes mellitus
article 1997    
Author: Brussaard, H.E. · Leuven, J.A.G. · Kluft, C. · Krans, H.M.J. · Duyvenvoorde, W. van · Buytenhek, R. · Laarse, A. van der · Princen, H.M.G.
Keywords: Biology · 17β- estradiol · Antioxidant · LDL oxidation · Non-insulin-dependent diabetes mellitus · Plasma lipid · Apolipoprotein a1 · Apolipoprotein b · Estradiol · Hemoglobin a · High density lipoprotein cholesterol · Insulin · Low density lipoprotein · Sulfonylurea derivative · Triacylglycerol · Adult · Controlled clinical trial · Controlled study · Coronary risk · Double blind procedure · Hormonal regulation · Human cell · Human tissue · Lipoprotein metabolism · Metabolic regulation · Non insulin dependent diabetes mellitus · Oral drug administration · Oxidation · Randomized controlled trial · Treatment outcome · Aged · Diabetes Mellitus, Type 2 · Estradiol · Female · Humans · Lipids · Lipoproteins, LDL · Middle Aged · Oxidation-Reduction · Particle Size · Postmenopause
[Abstract]

17 Increased response to cholesterol feeding in apolipoprotein C1-deficient mice
article 1995    
Author: Ree, J.H. van · Hofker, M.H. · Broek, J.A.A. van den · Deursen, J.M.A. van · Boom, H. van der · Frants, R.R. · Wieringa, B. · Havekes, L.M.
Keywords: Biology · apolipoprotein c1 · apolipoprotein e · very low density lipoprotein · animal cell · animal experiment · animal model · article · cholesterol blood level · cholesterol intake · controlled study · embryo · female · gene targeting · hep 2 cell · homozygosity · hypercholesterolemia · lipoprotein deficiency · lipoprotein metabolism · mouse · mutant · nonhuman · priority journal · stem cell · triacylglycerol blood level · Animal · Apolipoproteins C · Cholesterol · Cholesterol, Dietary · Gene Targeting · Heterozygote · Homozygote · Lipoproteins, HDL Cholesterol · Lipoproteins, LDL Cholesterol · Lipoproteins, VLDL Cholesterol · Mice · Mice, Inbred C57BL · Mice, Inbred CBA · Mice, Transgenic · Mutation · Receptors, LDL · Support, Non-U.S. Gov't · Triglycerides
[Abstract]

18 Hepatic Steatosis: A Mediator of the Metabolic Syndrome. Lessons from Animal Models
article 2004    
Author: Boer, M. den · Voshol, P.J. · Kuipers, F. · Havekes, L.M. · Romijn, J.A.
Keywords: Biology · Biomedical Research · Fatty acid metabolism · Glucose metabolism · Insulin resistance · Lipoprotein metabolism · Mouse models · Alcohol · Triacylglycerol · Animal experiment · Animal model · Disease association · Dyslipidemia · Endocrine system · Genetic transcription · Glucose metabolism · Lnsulin resistance · Lipid liver level · Metabolic syndrome X · Mouse · Non insulin dependent diabetes mellitus · Nonhuman · Partition coefficient · Pathophysiology · Rodent · Short survey · Adipose Tissue · Animals · Diabetes Mellitus, Type 2 · Dogs · Fatty Acids · Fatty Liver · Glucose · Homeostasis · Humans · Hyperlipidemias · Insulin Resistance · Liver · Metabolic Syndrome X · Mice · Models, Animal · Models, Biological · Obesity · Rats · Rats, Zucker · Transcription, Genetic · Triglycerides
[Abstract]

19 Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice
article 2008    
Author: Haan, W. de · Hoogt, C.C. van der · Westerterp, M. · Hoekstra, M. · Dallinga-Thie, G.M. · Princen, H.M.G. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · CETP · High-density lipoprotein · HMGCoA reductase · Statin · Transgenic mice · ABC transporter A1 · apolipoprotein A1 · apolipoprotein E3 · atorvastatin · cholesterol ester transfer protein · high density lipoprotein · high density lipoprotein cholesterol · messenger RNA · phospholipid transfer protein · scavenger receptor BI · very low density lipoprotein · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · cholesterol diet · controlled study · drug effect · gene expression · hypercholesterolemia · lipoprotein blood level · lipoprotein metabolism · male · mouse · nonhuman · priority journal · protein expression · transgenic mouse · Animals · Apolipoprotein E3 · Cholesterol Ester Transfer Proteins · Cholesterol, Dietary · Cholesterol, HDL · Cholesterol, VLDL · Dose-Response Relationship, Drug · Female · Gene Expression · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypercholesterolemia · Liver · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Pyrroles · RNA, Messenger
[Abstract]

20 PXR agonism decreases plasma HDL levels in ApoE*3-Leiden.CETP mice
article 2009    
Author: Haan, W. de · Vries-van der Weij, J. de · Mol, I.M. · Hoekstra, M. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Princen, H.M.G. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Cholesteryl ester transfer protein · Gene expression · High density lipoprotein · Pregnane X Receptor · Transgenic mice · Triglycerides · 5 pregnen 3beta ol 20 one 16alpha carbonitrile · ABC transporter A1 · apolipoprotein E3 · cholesterol · cholesterol ester transfer protein · cholesterol oleate · complementary DNA · high density lipoprotein · low density lipoprotein · messenger RNA · pregnane X receptor · pregnenolone derivative · triacylglycerol · tritium · unclassified drug · animal experiment · animal tissue · article · atherosclerosis · cholesterol blood level · controlled study · female · gene expression · lipid liver level · lipoprotein metabolism · mouse · nonhuman · plasma · polyacrylamide gel electrophoresis · priority journal · reverse transcription polymerase chain reaction · transgenic mouse · triacylglycerol blood level · Animals · Apolipoprotein E3 · ATP-Binding Cassette Transporters · Cholesterol Ester Transfer Proteins · Cholesterol, HDL · Female · Immunoblotting · Lipids · Lipoproteins · Liver · Mice · Mice, Transgenic · Pregnenolone Carbonitrile · Receptors, Steroid · RNA, Messenger · Scavenger Receptors, Class B · Mus · Mus musculus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 22 found. Next | Sort by date