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Showing 1 to 14 of 14 found. | Sort by date

1 Clearance capacity of rat liver Kupffer, endothelial, and parenchymal cells
article 1981    
Author: Praaning-van Dalen, D.P. · Brouwer, A. · Knook, D.L.
Keywords: Albumins · Animal · Antimony · Endothelium · Endotoxins · Heparin · Kupffer Cells · Liver · Metabolic Clearance Rate · Povidone · Rats · Reticuloendothelial System · Tissue Distribution
[Abstract]

2 Moderate cholecalciferol supplementation depresses intestinal calcium absorption in growing dogs
article 2002    
Author: Tryfonidou, M.A. · Stevenhagen, J.J. · Bemd, G.J.C.M. van den · Oosterlaken-Dijksterhuis, M.A. · Deluca, H.F. · Mol, J.A. · Brom, W.E. van den · Leeuwen, J.P.T.M. van · Hazewinkel, H.A.W.
Keywords: Nutrition · Animals · Calcitriol · Calcium · Calcium Radioisotopes · Calcium, Dietary · Cholecalciferol · Cytochrome P-450 Enzyme System · Dogs · Down-Regulation · Female · Gene Expression Regulation, Enzymologic · Intestinal Absorption · Intestines · Kidney · Male · Metabolic Clearance Rate · Models, Animal · Phosphates · Receptors, Calcitriol · Steroid Hydroxylases · Animalia · Canis familiaris
[Abstract]

3 The role of the low-density lipoprotein receptor-related protein (LRP) in the plasma clearance and liver uptake of recombinant single-chain urokinase-type plasminogen activator in rats
article 1997    
Author: Kaaden, M.E. van der · Rijken, D.C. · Kruijt, J.K. · Berkel, T.J.C. van · Kuiper, J.
Keywords: Animals · Drug Evaluation, Preclinical · Iodine Radioisotopes · Kupffer Cells · LDL-Receptor Related Protein 1 · Liver · Male · Metabolic Clearance Rate · Plasminogen Activators · Rats · Rats, Wistar · Receptors, Immunologic · Receptors, LDL · Recombinant Proteins · Tissue Distribution · Urinary Plasminogen Activator
[Abstract]

4 Modeling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich-cultured rat hepatocytes
article 2004    
Author: Treijtel, N. · Barendregt, A. · Freidig, A.P. · Blaauboer, B.J. · Eijkeren, J.C.H. van
Keywords: Biology · Physiological Sciences · 4 tolylsulfonylurea · carboxytolbutamide · hydroxytolbutamide · sulfonylurea derivative · tolbutamide · unclassified drug · addition reaction · animal cell · article · cell culture · controlled study · drug blood level · drug clearance · in vitro study · in vivo study · liquid chromatography · liver cell · mass spectrometry · mathematical model · nonhuman · priority journal · radiochemistry · rat · Animals · Cells, Cultured · Hepatocytes · Male · Metabolic Clearance Rate · Models, Biological · Rats · Rats, Wistar · Tolbutamide · Animalia
[Abstract]

5 Pharmacokinetics of carboplatin with and without amifostine in patients with solid tumors
article 1997    
Author: Korst, A.E.C. · Sterre, M.L.T. van der · Eeltink, C.M. · Fichtinger-Schepman, A.M.J. · Vermorken, J.B. · Vijgh, W.J.F. van der
Keywords: Pharmacology · Amifostine · Carboplatin · Adult · Blood sampling · Clinical article · Clinical trial · Controlled clinical trial · Creatinine blood level · Creatinine clearance · Drug blood level · Drug efficacy · Drug half life · Enzyme linked immunosorbent assay · Female · Human · Intravenous drug administration · Male · Phase 1 clinical trial · Solid tumor · Amifostine · Animals · Antineoplastic Agents · Carboplatin · Dose-Response Relationship, Drug · Half-Life · Kidney · Kidney Function Tests · Metabolic Clearance Rate · Mice · Mice, Nude · Neoplasms
[Abstract]

6 The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: A longitudinal study
article 1994    
Author: Groen, K. · Breimer, D.D. · Jansen, E.J. · Bezooijen, C.F.A. van
Keywords: Health · 3 hydroxymethylphenazone · 4 hydroxyphenazone · Norphenazone · Phenazone · Adolescent · Aged · Body weight · Controlled study · Drug blood level · Drug clearance · Drug metabolism · Drug urine level · Enantiomer · Enzyme activity · Enzyme specificity · High performance liquid chromatography · Nonhuman · Survival rate · Aging · Animal · Antipyrine · Cytochrome P-450 Enzyme System · Enzyme Induction · Hexobarbital · Longitudinal Studies · Male · Metabolic Clearance Rate · Phenobarbital · Rats · Rats, Inbred BN · Stereoisomerism
[Abstract]

7 In vivo and in vitro interaction of high and low molecular weight single-chain urokinase-type plasminogen activator with rat liver cells
article 1992    
Author: Kuiper, J. · Rijken, D.C. · Munk, G.A. · Berkel, T.J. van
Keywords: Biology · Biological Transport · Cells, Cultured · Embryo, Mammalian · Humans · Iodine Radioisotopes · Isoenzymes/blood · Isoenzymes/metabolism · Isoenzymes/pharmacokinetics · Kidney/enzymology · Kinetics · Liver/metabolism · Male · Metabolic Clearance Rate · Molecular Weight · Radioisotope Dilution Technique · Rats · Rats, Inbred Strains · Tissue Distribution · Urokinase-Type Plasminogen Activator/blood · Urokinase-Type Plasminogen Activator/metabolism · Urokinase-Type Plasminogen Activator/pharmacokinetics · Iodine Radioisotopes · Isoenzymes · Urokinase-Type Plasminogen Activator
[PDF] [Abstract]

8 Dietary 135-fold cholecalciferol supplementation severely disturbs the endochondral ossification in growing dogs
article 2003    
Author: Tryfonidou, M.A. · Holl, M.S. · Stevenhagen, J.J. · Buurman, C.J. · Deluca, H.F. · Oosterlaken-Dijksterhuis, M.A. · Brom, W.E. van den · Leeuwen, J.P.T.M. van · Hazewinkel, H.A.W.
Keywords: Health Toxicology · Analytical research · 1,25-Dihydroxycholecalciferol · 24, 25-Dihydroxycholecalciferol · Ca absorption · Endochondral ossification · 24,25 dihydroxycolecalciferol · Calcitriol receptor · Growth hormone · Parathyroid hormone · Phosphate · Somatomedin C · Aging · Animal · Blood · Bone development · Diet supplementation · Drug effect · Growth plate · Growth, development and aging · Histology · Physiology · 24,25-Dihydroxyvitamin D 3 · Aging · Animals · Calcifediol · Calcitonin · Calcitriol · Calcium · Cholecalciferol · Dietary Supplements · Dogs · Female · Growth Hormone · Growth Plate · Insulin-Like Growth Factor I · Intestinal Absorption · Kidney · Male · Metabolic Clearance Rate · Osteogenesis · Parathyroid Hormone · Phosphates · Receptors, Calcitriol · Canis familiaris
[Abstract]

9 Thrombolytic properties in a rabbit jugular vein thrombosis model of a tissue-type plasminogen activator mutant lacking the growth factor- and kringle 1-domains
article 1992    
Author: Emeis, J.J. · Verheijen, J.H.
Keywords: Biology · Alpha 2 antiplasmin · Alteplase · Fk 2p · Gowth factor · Plasminogen · Unclassified drug · Animal experiment · Animal model · Blood clot lysis · Conference paper · Dose response · Dose time effect relation · Drug efficacy · Fibrinogen blood level · Intravenous drug administration · Mutant · Nonhuman · Protein domain · Spectrophotometry · Vein thrombosis · Animal · Comparative Study · Fibrinolysis · Infusions, Intravenous · Injections, Intravenous · Jugular Veins · Metabolic Clearance Rate · Rabbits · Recombinant Proteins · Thrombosis · Tissue Plasminogen Activator · Animalia · Oryctolagus cuniculus
[Abstract]

10 Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes
article 2009    
Author: Treijtel, N. · Eijkeren, J.C.H.v. · Nijmeijer, S. · Greef de - Sandt, I.C.J. van der · Freidig, A.P.
Keywords: Health · Biomedical Research · HIV-protease inhibitors · Metabolism · P-Glycoprotein · Rat hepatocytes · rat liver microsomes · Sandwich-culture · cyclosporin A · drug metabolite · glycoprotein P · ketoconazole · proteinase inhibitor · ritonavir · saquinavir · testosterone derivative · valspodar · verapamil · animal cell · article · cell culture · controlled study · drug clearance · drug excretion · drug metabolism · drug transport · Human immunodeficiency virus 1 · hydroxylation · intrahepatic bile duct · liver cell · liver metabolism · male · microsome · nonhuman · rat · sandwich culture · Animals · Biological Transport, Active · Cell Culture Techniques · Cell Survival · Cells, Cultured · Cyclosporine · Cyclosporins · Dose-Response Relationship, Drug · Hepatocytes · HIV Protease Inhibitors · Ketoconazole · Male · Metabolic Clearance Rate · Microsomes, Liver · Rats · Rats, Wistar · Ritonavir · Saquinavir · Human immunodeficiency virus 1 · Rattus
[Abstract]

11 Human systemic exposure to a [14C]-para-phenylenediamine- containing oxidative hair dye and correlation with in vitro percutaneous absorption in human or pig skin
article 2004    
Author: Hueber-Becker, F. · Nohynek, G.J. · Meuling, W.J.A. · Benech-Kieffer, F. · Toutain, H.
Keywords: Biology · Physiological Sciences · Bioavailability · Hair dyes · Human · MOS, margin of safety · PAP, para-aminophenol · Para-phenylenediamine · Percutaneous absorption · Pig · PPD, para-phenylenediamine · SCCNFP, EU Scientific Committee of Cosmetic and Non-Food Products Intended for Consumers · Skin · hair dye · phenylenediamine · animal tissue · article · bioavailability · blood analysis · controlled study · feces analysis · hair level · health hazard · human · human tissue · metabolic clearance rate · nonhuman · normal human · radioactivity · risk assessment · skin absorption · tissue distribution · urinalysis · Adolescent · Adult · Animals · Clinical Trials · Diffusion · Ear, External · Feces · Hair · Hair Dyes · Humans · Male · Oxidation-Reduction · Phenylenediamines · Skin Absorption · Swine · Sus scrofa
[Abstract]

12 Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages
article 2015    
Author: Vlaming, M.L. · Duijn, E. van · Dillingh, M.R. · Brands, R. · Windhorst, A.D. · Hendrikse, N.H. · Bosgra, S. · Burggraaf, J. · Koning, M.C. de · Fidder, A. · Mocking, J.A. · Sandman, H. · Ligt, R.A. de · Fabriek, B.O. · Pasman, W.J. · Seinen, W. · Alves, T. · Carrondo, M. · Peixoto, C. · Peeters, P.A. · Vaes, W.H.
Keywords: Biology · Alkaline phosphatase, placental · Carbon · Glycosylphosphatidylinositol anchored protein · Isoenzyme · Recombinant protein · Area under the curve · Biological model · Clinical trial · Controlled study · Dose calculation · Double blind procedure · Half life time · Intravenous drug administration · Phase 1 clinical trial · Procedures · Randomized controlled trial · Statistical model · Administration, Intravenous · Adolescent · Adult · Alkaline Phosphatase · Area Under Curve · Carbon Radioisotopes · Double-Blind Method · Drug Dosage Calculations · GPI-Linked Proteins · Half-Life · Healthy Volunteers · Humans · Isoenzymes · Linear Models · Male · Mass Spectrometry · Metabolic Clearance Rate · Models, Biological · Netherlands · Recombinant Proteins · Young Adult · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology ARPC - Analytical Research (Pharm & Chemistry) · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[Abstract]

13 Inhibition of mannose receptor-mediated-clearance of tissue-type plasminogen activator (t-PA) by dextran : A new explanation for its antithrombotic effect
article 1997    
Author: Noorman, F. · Barrett-Bergshoeff, M.M. · Bekkers, M. · Emeis, J.J. · Rijken, D.C.
Keywords: Biology · Anticoagulant agent · Dextran · Dextran 40 · Dextran 70 · Low density lipoprotein receptor · Mannose receptor · Tissue plasminogen activator · Animal experiment · Bolus injection · Controlled study · Deep vein thrombosis · Drug infusion · Drug mechanism · Human · Human cell · Macrophage · Male · Monocyte · Nonhuman · Plasma clearance · Priority journal · Protein blood level · Rat · Thrombogenesis · Acetylgalactosamine · Animals · Cells, Cultured · Depression, Chemical · Dextrans · Fibrinolytic Agents · Glucose · Humans · Lectins, C-Type · Macrophages · Male · Mannose · Mannose-Binding Lectins · Metabolic Clearance Rate · Protein Binding · Rats · Rats, Wistar · Receptors, Cell Surface · Receptors, LDL · Recombinant Proteins · Tissue Plasminogen Activator
[Abstract]

14 Determinants of postprandial plasma bile acid kinetics in human volunteers
article 2017    
Author: Fiamoncini, J. · Yiorkas, A.M. · Gedrich, K. · Rundle, M. · Alsters, S.I. · Roeselers, G. · Broek, T.J. van den · Clavel, T. · Lagkouvardos, I. · Wopereis, S. · Frost, G. · Ommen, B. van · Blakemore, A.I. · Daniel, H.
Keywords: Biology · Bile acids · Mixed-meal tolerance test · Oral glucose tolerance test · Postprandial · SLCO1A2 · Chenodeoxycholic acid · Cholic acid · Deoxycholic acid · Genomic DNA · Glycine · Glycochenodeoxycholic acid · Glycocholic acid · Glycodeoxycholic acid · Glycoursodeoxycholic acid · Solute carrier organic anion transporter 1A2 · Taurine · Taurochenodeoxycholic acid · Taurocholic acid · Taurodeoxycholic acid · Taurolitocholic acid · Tauroursodeoxycholic acid · Unclassified drug · Ursodeoxycholic acid · Bile acid blood level · Bile acid synthesis · Clinical trial · Diet restriction · Dietary intake · Enterohepatic circulation · Feces microflora · Gene expression · Genome analysis · Kinetics · Liquid chromatography-mass spectrometry · Oral glucose tolerance test · Phenotype · Postprandial state · Quantitative analysis · Sex difference · Weight reduction · Whole exome sequencing · Blood · Controlled study · Physiology · Randomized controlled trial · Bile Acids and Salts · Fasting · Female · Humans · Male · Metabolic Clearance Rate · Middle Aged · Postprandial Period · Weight Loss · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 14 of 14 found. | Sort by date