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1 Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells
article 1998    
Author: Hanemaaijer, R. · Visser, H. · Koolwijk, P. · Sorsa, T. · Salo, T. · Golub, L.M. · Hinsbergh, V.W. van
Keywords: Health · Anti-Bacterial Agents · Cells, Cultured · Doxycycline · Endothelium · Humans · Metalloendopeptidases · Protease Inhibitors · Tetracyclines · Tetradecanoylphorbol Acetate · Tumor Necrosis Factor-alpha
[Abstract]

2 Metalloproteinase inhibition reduces constrictive arterial remodeling after balloon angioplasty: A study in the atherosclerotic Yucatan micropig
article 2000    
Author: Smet, B.J.G.L. de · Kleijn, D. de · Hanemaaijer, R. · Verheijen, J.H. · Robertus, L. · Helm, Y.J.M. van der · Borst, C. · Post, M.J.
Keywords: Angiography · Angioplasty, Balloon · Animals · Arteriosclerosis · Iliac Artery · Immunohistochemistry · Macrophages · Metalloendopeptidases · Phenylalanine · Postoperative Period · Protease Inhibitors · Swine · Swine, Miniature · Thiophenes · Tunica Intima · Ultrasonography, Interventional
[Abstract]

3 Matrix degradation by chondrocytes cultured in alginate : IL-1β induces proteoglycan degradation and proMMP synthesis but does not result in collagen degradation
article 1998    
Author: Beekman, B. · Verzijl, N. · Roos, J.A.D.M. de · TeKoppele, J.M.
Keywords: Biology · Biomedical Research · Matrix degradation · Matrix metalloproteinases · alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid · collagen · glycosaminoglycan · interleukin 1beta · metalloproteinase · proteoglycan · cartilage cell · degradation · enzyme synthesis · extracellular matrix · Alginates · Animals · Cattle · Cells, Cultured · Chondrocytes · Collagen · Extracellular Matrix · Interleukin-1 · Metalloendopeptidases · Microspheres · Proteoglycans
[Abstract]

4 Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha
article 1995    
Author: Bart, A.C.W. de · Quax, P.H.A. · Löwik, C.W.G.M. · Verheijen, J.H.
Keywords: Health · collagenase · gelatinase · interleukin 1alpha · messenger rna · metalloproteinase · plasminogen · stromelysin · tissue inhibitor of metalloproteinase · urokinase · animal cell · animal tissue · article · bone matrix · bone turnover · calvaria · cattle · controlled study · extracellular matrix · human · human cell · mouse · nonhuman · osteolysis · osteosarcoma · protein degradation · Extracellular Matrix · Human · Interleukin-1 · Metalloendopeptidases · Osteoblasts · Osteosarcoma · Plasminogen Activators · Plasminogen Inactivators · Support, Non-U.S. Gov't · Tumor Cells, Cultured · Urinary Plasminogen Activator
[Abstract]

5 Matrix metalloproteinase (MMP)-9 type IV collagenase/gelatinase implicated in the pathogenesis of Sjogren's syndrome
article 1998    
Author: Konttinen, Y.T. · Halinen, S. · Hanemaaijer, R. · Sorsa, T. · Hietanen, J. · Ceponis, A. · Xu, J.W. · Manthorpe, R. · Whittington, J. · Larsson, Å. · Salo, T. · Kjeldsen, L. · Stenman, U.-H. · Eisen, A.Z.
Keywords: Health · Gelatinase associated lipocalin · Matrix metalloproteinase · Sjogren syndrome · Tissue inhibitor of metalloproteinases-1 (TIMP-1) · Tumor associated trypsin-2 (TAT-2) · Blotting, Western · Collagenases · Gelatinases · Humans · Immunohistochemistry · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 9 · Metalloendopeptidases · Microscopy, Electron · Polymerase Chain Reaction · Salivary Glands · Sjogren's Syndrome
[Abstract]

6 Matrix metalloproteinase activity in equine synovial fluid: Influence of age, osteoarthritis, and osteochondrosis
article 1998    
Author: Brama, P.A.J. · TeKoppele, J.M. · Beekman, B. · Weeren, P.R. van · Barneveld, A.
Keywords: Biology · Biomedical Research · matrix metalloproteinase · age · animal tissue · article · cartilage degeneration · cartilage matrix · controlled study · enzyme activity · horse · metacarpophalangeal joint · nonhuman · osteoarthritis · osteochondrosis · priority journal · synovial fluid · tarsal joint · Age Factors · Animals · Biological Markers · Fluorometry · Horse Diseases · Horses · Metalloendopeptidases · Osteoarthritis · Osteochondritis · Synovial Fluid
[Abstract]

7 Interactions between staphylokinase, plasmin(ogen), and fibrin. Staphylokinase discriminates between free plasminogen and plasminogen bound to partially degraded fibrin
article 1996    
Author: Sakharov, D.V. · Lijnen, H.R. · Rijken, D.C.
Keywords: Biology · Fluorescein isothiocyanate · Staphylokinase · Blood clot lysis · Fluorescence microscopy · Molecular weight · Plasma · Protein protein interaction · Chromatography, Gel · Fibrin · Fibrinolysis · Fibrinolytic Agents · Fluorescein-5-isothiocyanate · Fluorescence Polarization · Humans · Kinetics · Metalloendopeptidases · Microscopy, Confocal · Plasmin · Plasminogen · Protein Binding · Recombinant Proteins · Substrate Specificity · Bacteria (microorganisms)
[PDF] [Abstract]

8 Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma
article 1996    
Author: Sier, C.F.M. · Kubben, F.J.G.M. · Ganesh, S. · Heerding, M.M. · Griffioen, G. · Hanemaaijer, R. · Krieken, J.H.J.M. van · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Biology · Gastric carcinoma · Gelatinases · Matrix metalloproteinase · Quantitative zymography · gelatinase b · proteinase · adult · cancer classification · cancer invasion · cancer survival · clinical article · controlled study · histopathology · human tissue · metastasis · priority journal · prognosis · stomach carcinoma · stomach mucosa · Aged · Collagenases · Female · Gelatinases · Humans · Male · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 9 · Metalloendopeptidases · Middle Aged · Stomach Neoplasms · Survival Rate
[PDF] [Abstract]

9 Degenerated human articular cartilage at autopsy represents preclinical osteoarthritic cartilage : comparison with clinically defined osteoarthritic cartilage
article 1997    
Author: Valburg, A.A. van · Wenting, M.J.G. · Beekman, B. · TeKoppele, J.M. · Lafeber, F.P.G.J. · Bijlsma, J.W.J.
Keywords: Health · Biomedical Research · cartilage · metalloproteinases · osteoarthritis · proteoglycans · metalloproteinase · proteoglycan · adult · aged · article · articular cartilage · autopsy · cartilage degeneration · controlled study · female · histochemistry · histology · human · human tissue · male · osteoarthritis · priority journal · Aged · Aged, 80 and over · Cartilage, Articular · Female · Humans · Knee Joint · Male · Metalloendopeptidases · Middle Aged · Osteoarthritis · Proteoglycans · Synovial Fluid · Synovial Membrane

10 Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: Implication for angiogenesis in fibrin matrices
article 2001    
Author: Koolwijk, P. · Sidenius, N. · Peters, E. · Sier, C.F.M. · Hanemaaijer, R. · Blasi, F. · Hinsbergh, V.W.M. van
Keywords: Binding Sites · Blotting, Western · Cells, Cultured · Endothelium, Vascular · Fibrin · Fibroblast Growth Factor 2 · Gene Expression · Humans · Metalloendopeptidases · Microcirculation · Neovascularization, Physiologic · Phenylalanine · Protease Inhibitors · Receptors, Cell Surface · Recombinant Proteins · Reverse Transcriptase Polymerase Chain Reaction · RNA, Messenger · Thiophenes · Transfection · Tumor Necrosis Factor-alpha · Urinary Plasminogen Activator
[Abstract]

11 Fluorogenic MMP activity assay for plasma including MMPs complexed to α2-macroglobulin
article 1999    
Author: Beekman, B. · Drijfhout, J.W. · Ronday, H.K. · TeKoppele, J.M.
Keywords: Health · Biomedical Research · Alpha 2 macroglobulin · Batimastat · Fluorescein · Matrix metalloproteinase · Arthritis · Cancer · Collagen degradation · Conference paper · Controlled study · Enzyme active site · Enzyme activity · Enzyme assay · Fluorescence analysis · Human · Molecular weight · Alpha-Macroglobulins · Collagen · Collagenases · Fluorescent Dyes · Humans · Kinetics · Matrix Metalloproteinase 13 · Metalloendopeptidases · Phenylalanine · Protease Inhibitors · Substrate Specificity · Thiophenes · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

12 Doxycycline inhibits collagen synthesis by differentiated articular chondrocytes.
article 1998    
Author: TeKoppele, J.M. · Beekman, B. · Verzijl, N. · Koopman, J.L. · Groot, J. de · Bank, R.A.
Keywords: Biology · Biomedical Research · antiinfective agent · collagen · doxycycline · metalloproteinase · protein synthesis inhibitor · proteinase inhibitor · animal · article · articular cartilage · biosynthesis · cartilage cell · cattle · cell culture · cytology · dog · drug antagonism · metabolism · osteoarthritis · Animals · Anti-Bacterial Agents · Cartilage, Articular · Cattle · Cells, Cultured · Chondrocytes · Collagen · Dogs · Doxycycline · Metalloendopeptidases · Osteoarthritis · Protease Inhibitors · Protein Synthesis Inhibitors
[Abstract]

13 Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix
article 2003    
Author: Collen, A. · Hanemaaijer, R. · Lupu, F. · Quax, P.H.A. · Lent, N. van · Grimbergen, J. · Peters, E. · Koolwijk, P. · Hinsbergh, V.W.M. van
Keywords: Biology · Biomedical Research · Adenoviridae · Aprotinin · Cells, Cultured · Collagen · Culture Media · Defective Viruses · Drug Synergism · Endothelial Growth Factors · Endothelium, Vascular · Fibrin · Fibroblast Growth Factor 2 · Genetic Vectors · Heart Diseases · Humans · Intercellular Signaling Peptides and Proteins · Lymphokines · Matrix Metalloproteinase 1 · Matrix Metalloproteinase 2 · Matrix Metalloproteinases, Membrane-Associated · Metalloendopeptidases · Neovascularization, Pathologic · Neovascularization, Physiologic · Phenylalanine · Protease Inhibitors · Thiophenes · Thrombosis · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Transduction, Genetic · Tumor Necrosis Factor-alpha · Vascular Endothelial Growth Factor A · Vascular Endothelial Growth Factors
[Abstract]

14 Cathepsin K is the principal protease in giant cell tumor of bone
article 2004    
Author: Lindeman, J.H.N. · Hanemaaijer, R. · Mulder, A. · Dijkstra, P.D.S. · Szuhai, K. · Bromme, D. · Verheijen, J.H. · Hogendoorn, P.C.W.
Keywords: Health · Cathepsin K · Cathepsin L · Cathepsin S · Collagen · Collagenase 3 · Gelatinase B · Matrix metalloproteinase 14 · Messenger RNA · Proteinase · Bone tumor · Clinical article · Enzyme activity · Human tissue · Immunohistochemistry · Metaphysis · Osteolysis · Protein expression · Real time polymerase chain reaction · Adult · Bone Neoplasms · Cathepsins · Collagenases · Cysteine Endopeptidases · Female · Giant Cell Tumor of Bone · Humans · Immunoenzyme Techniques · Male · Matrix Metalloproteinase 13 · Matrix Metalloproteinases, Membrane-Associated · Metalloendopeptidases · Middle Aged · Osteoclasts · Osteolysis · RNA, Messenger
[Abstract]

15 Gingival tissue and crevicular fluid co-operation in adult periodontitis
article 2006    
Author: Beklen, A. · Tüter, G. · Sorsa, T. · Hanemaaijer, R. · Virtanen, I. · Tervahartiala, T. · Konttinen, Y.T.
Keywords: Health · Collagenase · Gelatinase · Periodontitis · Stromelysin · collagenase · enzyme precursor · gelatinase · gelatinase B · metalloproteinase · neutrophil collagenase · procollagenase · progelatinase · stromelysin · adult · article · cell culture · enzyme activation · enzymology · female · fibroblast · gingiva · gingivitis · human · immunohistochemistry · male · middle aged · pathology · periodontitis · Adult · Cells, Cultured · Collagenases · Enzyme Activation · Enzyme Precursors · Female · Fibroblasts · Gelatinases · Gingiva · Gingival Crevicular Fluid · Humans · Immunohistochemistry · Male · Matrix Metalloproteinase 3 · Matrix Metalloproteinase 8 · Matrix Metalloproteinase 9 · Metalloendopeptidases · Middle Aged · Periodontitis
[Abstract]

16 Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate
article 2003    
Author: Heikkilä, P. · Teronen, O. · Hirn, M.Y. · Sorsa, T. · Tervahartiala, T. · Salo, T. · Konttinen, Y.T. · Halttunen, T. · Moilanen, M. · Hanemaaijer, R. · Laitinen, M.
Keywords: Biology · Physiological Sciences · Bisphosphonate · Inhibition · MMP-2 · MT1-MMP · Osteosarcoma · clodronic acid · matrix metalloproteinase 14 · phorbol 13 acetate 12 myristate · article · cancer cell · cell activation · controlled study · cytotoxicity · down regulation · enzyme activation · enzyme activity · enzyme inhibition · human · human cell · immunohistochemistry · Northern blotting · osteosarcoma · priority journal · protein degradation · protein expression · Binding Sites · Blotting, Northern · Clodronic Acid · Collagenases · Culture Media, Conditioned · Enzyme Activation · Enzyme Inhibitors · Enzyme Precursors · Fluorescent Antibody Technique · Gelatinases · Humans · Matrix Metalloproteinase 13 · Matrix Metalloproteinase 2 · Matrix Metalloproteinases, Membrane-Associated · Metalloendopeptidases · Osteosarcoma · Recombinant Proteins · RNA, Messenger · Tetradecanoylphorbol Acetate · Tumor Cells, Cultured
[Abstract]

17 MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis
article 2004    
Author: Tchetverikov, I. · Ronday, H.K. · El, B. van · Kiers, G.H. · Verzijl, N. · TeKoppele, J.M. · Huizinga, T.W.J. · Groot, J. de · Hanemaaijer, R.
Keywords: alpha 2 macroglobulin · biological marker · gelatinase A · gelatinase B · hydroxyproline · interstitial collagenase · matrix metalloproteinase · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · aged · circulation · clinical article · collagen degradation · concentration (parameters) · controlled study · correlation analysis · enzyme activity · enzyme assay · enzyme linked immunosorbent assay · female · high performance liquid chromatography · human · male · osteoarthritis · priority journal · rheumatoid arthritis · sampling · serum · statistical significance · synovial fluid · Adult · Aged · alpha-Macroglobulins · Arthritis, Rheumatoid · Case-Control Studies · Collagenases · Enzyme Precursors · Enzyme-Linked Immunosorbent Assay · Female · Humans · Hydroxyproline · Male · Matrix Metalloproteinase 8 · Matrix Metalloproteinase 9 · Matrix Metalloproteinases · Metalloendopeptidases · Middle Aged · Osteoarthritis, Knee · Statistics, Nonparametric · Synovial Fluid · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

18 Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats
article 2007    
Author: Jonge, J.D. de · Ezendam, J. · Knippels, L.M.J. · Odink, J. · Pourier, M.S. · Penninks, A.H. · Pieters, R. · Loveren, H. van
Keywords: Health · Toxicology and Applied Pharmacology · Bis(tributyltin)oxide · Brown Norway rat · Food allergy · Ovalbumin · Peanut · TBTO · bis(tributyltin) oxide · cytokine · immunoglobulin E · ovalbumin · proteinase · animal cell · animal experiment · animal model · article · basophil · controlled study · cytokine production · eosinophil · female · food allergy · food chain · granulocyte · immunology · immunomodulation · lymphocyte proliferation · mast cell · mesentery lymph node · nonhuman · peanut allergy · Peyer patch · priority journal · rat · risk assessment · spleen cell · Th2 cell · Adjuvants, Immunologic · Administration, Oral · Allergens · Animals · Antibody Formation · Cell Count · Cell Proliferation · Disease Models, Animal · Female · Granulocytes · Immunosuppressive Agents · Lymph Nodes · Lymphocytes · Mast Cells · Metalloendopeptidases · Ovalbumin · Peanut Hypersensitivity · Peyer's Patches · Rats · Rats, Inbred BN · Spleen · Trialkyltin Compounds · Arachis hypogaea · Rattus · Rattus norvegicus
[Abstract]

19 Involvement of Membrane-Type Matrix Metalloproteinases (MT-MMPs) in capillary tube formation by human endometrial microvascular endothelial Cells: Role of MT3-MMP
article 2004    
Author: Plaisier, M. · Kapiteijn, K. · Koolwijk, P. · Fijten, C. · Hanemaaijer, R. · Grimbergen, J.M. · Mulder-Stapel, A. · Quax, P.H.A. · Helmerhorst, F.M. · Hinsbergh, V.W.M. van
Keywords: Biology · Biomedical Research · Fibrin · Gelatinase A · Immunoglobulin G · Interstitial collagenase · Matrix metalloproteinase · Matrix metalloproteinase inhibitor · Membrane type 3 metalloproteinase · Membrane type 4 metalloproteinase · Messenger RNA · Unclassified drug · Urokinase · Adenovirus · Capillary · Cell culture · Controlled study · Endometrium cell · Endothelium cell · Enzyme inhibition · Enzyme regulation · Genetic transduction · Human cell · Immunohistochemistry · Prepuce · Protein expression · Vascular endothelium · Adenoviridae · Cells, Cultured · Collagen Type I · Endometrium · Endothelial Cells · Female · Humans · Matrix Metalloproteinase 16 · Matrix Metalloproteinases, Membrane-Associated · Metalloendopeptidases · Neovascularization, Physiologic · Plasmin · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Urinary Plasminogen Activator · Adenoviridae
[Abstract]

20 The importance of dietary control in the development of a peanut allergy model in Brown Norway rats
article 2007    
Author: Jonge, J.D. de · Knippels, L.M.J. · Ezendam, J. · Odink, J. · Penninks, A.H. · Loveren, H. van
Keywords: Toxicology · Toxicology and Applied Pharmacology · Brown Norway rat · Cholera toxin · Food allergy · Oral sensitization · Peanut · Route of exposure · adjuvant · ara h1 · ara h2 · ara h3 · cholera toxin · food allergen · immunoglobulin E · immunoglobulin G1 · immunoglobulin G2a · animal cell · animal experiment · animal model · article · controlled study · diet · female · food intake · male · nonhuman · peanut · peanut allergy · priority journal · rat · sensitivity analysis · sensitization · soybean · Adjuvants, Immunologic · Administration, Oral · Animal Feed · Animals · Arachis hypogaea · Basophils · Cells, Cultured · Cholera Toxin · Disease Models, Animal · Electrophoresis, Polyacrylamide Gel · Enzyme-Linked Immunosorbent Assay · Eosinophils · Injections, Intraperitoneal · Mast Cells · Metalloendopeptidases · Peanut Hypersensitivity · Rats · Rats, Inbred BN · Soybean Proteins · Spleen · Th1 Cells · Th2 Cells · Animalia · Ara · Arachis hypogaea · Rattus norvegicus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 20 found. | Sort by date