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1 Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis
article 2007    
Author: Nieuwenhuizen, W.F. · Duivenvoorden, I. · Voshol, P.J. · Rensen, P.C.N. · Duyvenvoorde, W. van · Romijn, J.A. · Emeis, J.J. · Havekes, L.M.
Keywords: Food technology · APOE*3Leiden mice · Cholesterol · Free fatty acid · Sphingolipid · Steatosis · Triacylglycerol · Mus
[Abstract]

2 Use of transgenic mice in lipoprotein metabolism and atherosclerosis research
article 1997    
Author: Havekes, L.M. · Vlijmen, B.J.M. van · Jong, M.C. · Dijk, K.W. van · Hofker, M.H.
Keywords: Biology · Age Factors · Animals · Apolipoprotein E3 · Apolipoproteins C · Apolipoproteins E · Arteriosclerosis · Cholesterol · Female · Humans · Lipids · Lipoproteins · Lipoproteins, VLDL · Male · Mice · Mice, Transgenic · Sex Factors · Animalia · Mus musculus
[Abstract]

3 Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo
article 2008    
Author: Haan, W. de · Out, R. · Berbée, J.F.P. · Hoogt, C.C. van der · Dijk, K.W.v. · Berkel, T.J.C. van · Romijn, J.A. · Wouter Jukema, J. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · Physiological Sciences · High density lipoprotein · Oxidized LDL · SR-BI · Transgenic mice · cholesterol ester · high density lipoprotein cholesterol · scavenger receptor BI · Adenovirus · animal cell · cholesterol metabolism · dose response · in vivo study · liver cell · mouse · nonhuman · particle size · protein expression · Adenoviridae · Animals · Apolipoprotein C-I · Cholesterol, HDL · Gene Transfer Techniques · Hepatocytes · Humans · Mice · Mice, Knockout · Scavenger Receptors, Class B · Adenoviridae · Murinae · Mus · Mus musculus
[Abstract]

4 MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
article 2007    
Author: Bernhagen, J. · Krohn, R. · Lue, H. · Gregory, J.L. · Zernecke, A. · Koenen, R.R. · Dewor, M. · Georgiev, I. · Schober, A. · Leng, L. · Kooistra, T. · Fingerle-Rowson, G. · Ghezzi, P. · Kleemann, R. · McColl, S.R. · Bucala, R. · Hickey, M.J. · Weber, C.
Keywords: Biology · Biomedical Research · T lymphocyte · Aorta · Atherosclerosis · Chemotaxis · Endothelium, Vascular · Humans · Inflammation · Leukocytes · Ligands · Macrophage Migration-Inhibitory Factors · Monocytes · Receptors, CXCR4 · Receptors, Interleukin-8B · T-Lymphocytes · Mus
[Abstract]

5 In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 → Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice
article 1996    
Author: Vlijmen, B.J.M. van · Dijk, K.W. van · Hof, H.B. van 't · Gorp, P.J.J. van · Zee, A. van der · Boom, H. van der · Breuer, M.L. · Hofker, M.H. · Havekesf, L.M.
Keywords: Animals · Apolipoproteins E · Arginine · Cells, Cultured · Cysteine · Genes, Dominant · Heymann Nephritis Antigenic Complex · Hyperlipoproteinemias · Lipoproteins, LDL · Lipoproteins, VLDL · Membrane Glycoproteins · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL · Adenoviridae · Animalia · Mus musculus
[PDF] [Abstract]

6 Effect of eugenol on the mutagenicity of benzo[a]pyrene and the formation of benzo[a]pyrene-DNA adducts in the X-lacZ-transgenic mouse.
article 1996    
Author: Rompelberg, C.J.M. · Steenwinkel, M.J.S.T. · Asten, J.G. van · Delft, J.H.M. van · Baan, R.A. · Verhagen, H.
Keywords: Toxicology · Antimutagenicity · Benzo[a]pyrene · DNA adduct · Eugenol · Transgenic mouse · benzo[a]pyrene · eugenol · animal experiment · article · controlled study · dna adduct · genotoxicity · male · mouse · mutagenicity · mutation rate · nonhuman · oral drug administration · priority journal · transgenic mouse · Animals · Antimutagenic Agents · Benzo(a)pyrene · Biotransformation · Body Weight · Diet · DNA Adducts · Eugenol · Glutathione Transferase · Lac Operon · Liver · Male · Mice · Mice, Transgenic · Mutagens · Phosphorus Radioisotopes · Animalia · Gale · Mus musculus
[Abstract]

7 Induction of somatic mutations but not methylated DNA adducts in λlacZ transgenic mice by dichlorvos
article 1999    
Author: Pletsa, V. · Steenwinkel, M.-J.S.T. · Delft, J.H.M. van · Baan, R.A. · Kyrtopoulos, S.A.
Keywords: Nutrition · Dimethylsulphate · Methylating agents · N7-Methylguanine · O6-Methylguanine · Organosphosphate insecticides · 6 o methylguanine · 7 methylguanine · Dichlorvos · Dimethyl sulfate · Animal cell · Bone marrow cell · Controlled study · DNA adduct · DNA methylation · Genotoxicity · Liver cell · Mouse · Mutation rate · Nonhuman · Priority journal · Somatic mutation · Transgenic mouse · Animals · Dichlorvos · DNA Methylation · Guanine · Insecticides · Lac Operon · Mice · Mice, Transgenic · Mutation · Mus musculus
[Abstract]

8 Reduced very-low-density lipoprotein fractional catabolic rate in apolipoprotein C1-deficient mice
article 1997    
Author: Jong, M.C. · Ree, J.H. van · Dahlmans, V.E.H. · Frants, R.R. · Hofker, M.H. · Havekes, L.M.
Keywords: Biology · very low density lipoprotein · animal experiment · catabolism · controlled study · human · hyperlipoproteinemia · lipolysis · metabolism · mouse · nonhuman · priority journal · protein degradation · protein metabolism · transgenic mouse · Animals · Apolipoprotein C-I · Apolipoproteins B · Apolipoproteins C · Cholesterol, Dietary · Female · Lipolysis · Lipoproteins, VLDL · Mice · Mice, Mutant Strains · Triglycerides · Ultracentrifugation · Animalia · Mus musculus
[Abstract]

9 Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
article 2002    
Author: Grefhorst, A. · Elzinga, B.M. · Voshol, P.J. · Plösch, T. · Kok, T. · Bloks, V.W. · Sluijs, F.H. van der · Havekes, L.M. · Romijn, J.A. · Verkade, H.J. · Kuipers, F.
Keywords: Animals · Anticholesteremic Agents · Apolipoproteins E · Carrier Proteins · Cell Line · DNA-Binding Proteins · Hypertriglyceridemia · Lipids · Lipoproteins, VLDL · Liver · Male · Membrane Proteins · Mice · Mice, Inbred C57BL · Phospholipid Transfer Proteins · Rats · Receptors, Cytoplasmic and Nuclear · Receptors, LDL · Receptors, Retinoic Acid · Receptors, Thyroid Hormone · Sulfonamides · Triglycerides · Animalia · Mus musculus
[PDF] [Abstract]

10 Carcinogenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Prentice, D. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Health · Biomedical Research · animal testing alternative · carcinogenesis · carcinogenicity · cell communication · cell culture · cell transformation · gap junction · genotoxicity · heterozygosity · nonhuman · priority journal · review · risk assessment · standardization · transgenic mouse · validation process · Animal Testing Alternatives · Animals · Carcinogenicity Tests · Carcinogens · Cell Transformation, Neoplastic · Cells, Cultured · Consumer Product Safety · Cosmetics · European Union · Gap Junctions · Mice · Mice, Transgenic · Quantitative Structure-Activity Relationship · Rats · Animalia · Mus musculus

11 PXR agonism decreases plasma HDL levels in ApoE*3-Leiden.CETP mice
article 2009    
Author: Haan, W. de · Vries-van der Weij, J. de · Mol, I.M. · Hoekstra, M. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Princen, H.M.G. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Cholesteryl ester transfer protein · Gene expression · High density lipoprotein · Pregnane X Receptor · Transgenic mice · Triglycerides · 5 pregnen 3beta ol 20 one 16alpha carbonitrile · ABC transporter A1 · apolipoprotein E3 · cholesterol · cholesterol ester transfer protein · cholesterol oleate · complementary DNA · high density lipoprotein · low density lipoprotein · messenger RNA · pregnane X receptor · pregnenolone derivative · triacylglycerol · tritium · unclassified drug · animal experiment · animal tissue · article · atherosclerosis · cholesterol blood level · controlled study · female · gene expression · lipid liver level · lipoprotein metabolism · mouse · nonhuman · plasma · polyacrylamide gel electrophoresis · priority journal · reverse transcription polymerase chain reaction · transgenic mouse · triacylglycerol blood level · Animals · Apolipoprotein E3 · ATP-Binding Cassette Transporters · Cholesterol Ester Transfer Proteins · Cholesterol, HDL · Female · Immunoblotting · Lipids · Lipoproteins · Liver · Mice · Mice, Transgenic · Pregnenolone Carbonitrile · Receptors, Steroid · RNA, Messenger · Scavenger Receptors, Class B · Mus · Mus musculus
[Abstract]

12 Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male mice
article 2007    
Author: Korsheninnikova, E. · Voshol, P.J. · Baan, B. · Zon, G.C.M. van der · Havekes, L.M. · Romijn, J.A. · Maassen, J.A. · Ouwens, D.M.
Keywords: Biology · Biomedical Research · Hepatic glucose production · High-fat diet · Insulin resistance · Insulin signalling · Liver · glucose · insulin · insulin receptor · phosphatidylinositol 3 kinase · protein kinase B · animal · article · blood · C57BL mouse · drug effect · fat intake · gene expression regulation · glucose clamp technique · hyperinsulinism · liver · male · metabolism · mouse · signal transduction · 1-Phosphatidylinositol 3-Kinase · Animals · Dietary Fats · Gene Expression Regulation, Enzymologic · Glucose · Glucose Clamp Technique · Hyperinsulinism · Insulin · Liver · Male · Mice · Mice, Inbred C57BL · Proto-Oncogene Proteins c-akt · Receptor, Insulin · Signal Transduction · Mus
[Abstract]

13 Gene-mutation assays in lambda-lacZ transgenic mice : comparison of lacZ with endogenous genes in splenocytes and small intestinal epithelium
article 1998    
Author: Delft, J.H.M. van · Bergmans, A. · Dam, F.J. van · Tates, A.D. · Howard, L. · Winton, D.J. · Baan, R.A.
Keywords: Biology · λlacZ · Dlb-1 · hprt · Mutagenesis · Transgenic mouse · ethylnitrosourea · hypoxanthine phosphoribosyltransferase · mesylic acid ethyl ester · methylnitrosourea · mutagenic agent · animal cell · animal experiment · animal tissue · article · controlled study · gene · gene mutation · intestine epithelium · mouse · mutagenesis · mutagenicity · nonhuman · priority journal · small intestine mucosa · spleen cell · transgenic mouse · Alkylating Agents · Animals · Ethyl Methanesulfonate · Ethylnitrosourea · Genetic Markers · Hypoxanthine Phosphoribosyltransferase · Intestinal Mucosa · Intestine, Small · Lac Operon · Methylnitrosourea · Mice · Mice, Inbred C57BL · Mice, Transgenic · Mutagenicity Tests · Mutagens · Mutation · Spleen · Animalia · Mus musculus
[Abstract]

14 Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in Marfan syndrome
article 2015    
Author: Busnadiego, O. · Gorbenko del Blanco, D. · González-Santamaría, J. · Habashi, J.P. · Calderon, J.F. · Sandoval, P. · Bedja, D. · Guinea-Viniegra, J. · Lopez-Cabrera, M. · Rosell-Garcia, T. · Snabel, J.M. · Hanemaaijer, R. · Forteza, A. · Dietz, H.C. · Egea, G. · Rodriguez-Pascual, F.
Keywords: Biology · Aneurysm · Collagen · Extracellular matrix · Lysyl oxidases · Marfan syndrome · Transforming growth factor-β · Losartan · Oxidoreductase · Protein LOXL1 · Protein lysine 6 oxidase · Transforming growth factor beta · Unclassified drug · Animal tissue · Aorta aneurysm · Clinical article · Collagen fiber · Controlled study · Disease association · Disease course · Disease severity · Elastic fiber · Enzyme inhibition · Human tissue · Marfan syndrome · Mouse · Mouse model · Nonhuman · Prophylaxis · Protein expression · Signal transduction · Upregulation · Wild type · Animalia · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

15 Phenotype characterisation using integrated gene transcript, protein and metabolite profiling
article 2004    
Author: Orešič, M. · Clish, C.B. · Davidov, E.J. · Verheij, E. · Vogels, J. · Havekes, L.M. · Neumann, E. · Adourian, A. · Naylor, S. · Greef, J. van der · Plasterer, T.
Keywords: Biology · Analytical research · Biomedical research · Apolipoprotein E3 · Protein · Animal experiment · Animal tissue · Atherosclerosis · Cohort analysis · Controlled study · Disease course · Electrospray · Genetic transcription · Information processing · Liquid chromatography · Male · Mass spectrometry · Metabolite · Metabolomics · Mouse · Nonhuman · Nucleotide sequence · Onset age · Pathophysiology · Proteomics · Transgenic mouse · Wild type · Algorithms · Animals · Cells, Cultured · Computer Simulation · Gene Expression Regulation · Liver · Mass Spectrometry · Mice · Models, Biological · Peptide Mapping · Phenotype · Proteome · Signal Transduction · Systems Integration · Transcription Factors · Mus musculus
[Abstract]

16 Apolipoprotein CI deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl ester transfer protein (CETP) in CETP transgenic/apoCI-knocked out mice
article 2002    
Author: Gautier, T. · Masson, D. · Jong, M.C. · Duverneuil, L. · Guern, N.L. · Deckert, V. · Barros, J.-P.P.de · Dumont, L. · Bataille, A. · Zak, Z. · Jiang, X.-C. · Tall, A.R. · Havekes, L.M. · Lagrost, L.
Keywords: Biology · Cholesterol · Chromatographic analysis · Esters · Proteins · Apolipoproteins · Biochemistry · High density lipoprotein · Very low density lipoprotein · Animal experiment · Concentration response · Controlled study · Gel permeation chromatography · Knockout mouse · Lipoprotein blood level · Mouse · Nonhuman · Protein deficiency · Protein expression · Transgenic mouse · Animals · Apolipoprotein C-I · Apolipoproteins C · Carrier Proteins · Cholesterol Ester Transfer Proteins · Glycoproteins · Humans · Kinetics · Lipoproteins · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Animalia · Mus musculus
[PDF] [Abstract]

17 Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression
article 2014    
Author: Kim, E.S. · Cha, Y. · Ham, M. · Jung, J. · Kim, S.G. · Hwang, S. · Kleemann, R. · Moon, A.
Keywords: Biology · C-reactive protein · Invasion · MMP-9 · S1P · 2 (2 amino 3 methoxyphenyl)chromone · C reactive protein · CCAAT enhancer binding protein beta · Fingolimod · Gelatinase B · Mitogen activated protein kinase kinase · Reactive oxygen metabolite · Sphingosine 1 phosphate · Animal experiment · Animal model · Breast carcinoma · Breast cell · Cancer growth · Cell invasion · Controlled study · Enzyme activation · Epithelium cell · Female · Human · Human cell · In vitro study · In vivo study · Inflammation · Inflammatory breast cancer · Mouse · Nonhuman · Oncogene c fos · Phenotype · Priority journal · Protein expression · Transcription initiation · Tumor invasion · Upregulation · Xenograft · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

18 Human CD46-transgenic mice in studies involving replication-incompetent adenoviral type 35 vectors
article 2006    
Author: Verhaagh, S. · Jong, E. de · Goudsmit, J. · Lecollinet, S. · Gillissen, G. · Vries, M. de · Leuven, K. van · Que, I. · Ouwehand, K. · Mintardjo, R. · Weverling, G.J. · Radošević, K. · Richardson, J. · Eloit, M. · Lowik, C. · Quax, P. · Havenga, M.
Keywords: Biology · Biomedical Research · Adenovirus vector · Beta galactosidase · CD8 antigen · Gag protein · Luciferase · Membrane cofactor protein · Simian immunodeficiency virus vaccine · Animal cell · Animal experiment · Antigen expression · Antigen function · Camera · CD8+ T lymphocyte · Cellular immunity · Controlled study · Dendritic cell · Drug potency · Drug safety · Female · Gene expression · Human adenovirus · Imaging system · Kidney cell · Lung alveolus epithelium · Male · Mouse · Mouse strain · Muscle cell · Nonhuman · Receptor affinity · Transgenic mouse · Viral gene delivery system · Virus replication · Wild type · Adenoviruses, Human · Animals · Antigens, CD46 · Genetic Vectors · Humans · Mice · Mice, Transgenic · Virus Replication · Adenoviridae · Animalia · Human adenovirus · Mus musculus · Simian immunodeficiency virus
[Abstract]

19 Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
article 2015    
Author: Berbeé, J.F.P. · Boon, M.R. · Khedoe, P.P.S.J. · Bartelt, A. · Schlein, C. · Worthmann, A. · Kooijman, S. · Hoeke, G. · Mol, I.M. · John, C. · Jung, C. · Vazirpanah, N. · Brouwers, L.P.J. · Gordts, P.L.S.M. · Esko, J.D. · Hiemstra, P.S. · Havekes, L.M. · Scheja, L. · Heeren, J. · Rensen, P.C.N.
Keywords: Biology · 5 [2 [[2 (3 chlorophenyl) 2 hydroxyethyl]amino]propyl] 1,3 benzodioxole 2,2 dicarboxylic acid · Apolipoprotein E · Cholesterol · Fatty acid · Low density lipoprotein receptor · Triacylglycerol · Bioenergetics · Fat · Fatty acid · Obesity · Plasma · Rodent · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Beta adrenergic stimulation · Brown adipose tissue · Cholesterol blood level · Cholesterol metabolism · Controlled study · Energy expenditure · Fatty acid transport · Female · Hypercholesterolemia · Lipolysis · Liver clearance · Mouse · Triacylglycerol blood level · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

20 Evaluation of the Xpa-Deficient Transgenic Mouse Model for Short-Term Carcinogenicity Testing: 9-Month Studies with Haloperidol, Reserpine, Phenacetin, and D-Mannitol
article 2004    
Author: Lina, B.A.R. · Woutersen, R.A. · Bruijntjes, J.P. · Benthem, J. van · Berg, J.A.H. van den · Monbaliu, J. · Thoolen, B.J.J.M. · Beems, R.B. · Kreijl, C.F. van
Keywords: Biology · Toxicology and Applied Pharmacology · Carcinogenicity testing · Carcinogens · DNA repair deficient · Knockout mice · Xpa · Xpa/p53 · haloperidol · mannitol · phenacetin · reserpine · animal experiment · animal tissue · article · cancer incidence · carcinogen testing · controlled study · DNA repair · evaluation · female · hyperplasia · kidney tumor · knockout mouse · male · maximum tolerated dose · mouse · nonhuman · priority journal · rare disease · survival · target organ · transgenic mouse · Administration, Oral · Animals · Carcinogenicity Tests · Diet · Disease Models, Animal · DNA-Binding Proteins · Dose-Response Relationship, Drug · Haloperidol · Mannitol · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Neoplasms, Experimental · Phenacetin · Reproducibility of Results · Reserpine · Time Factors · Xeroderma Pigmentosum Group A Protein · Animalia · Mus musculus · Rodentia
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 36 found. Next | Sort by date