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Showing 1 to 11 of 11 found. | Sort by date

1 Peripheral site ligand-oxime conjugates: A novel concept towards reactivation of nerve agent-inhibited human acetylcholinesterase
article 2011    
Author: Koning, M.C. de · Joosen, M.J.A. · Noort, D. · Zuylen, A. van · Tromp, M.C.
Keywords: Pharmacology · Acetylcholinesterase · Nerve agent · Oxime · Peripheral site · Reactivation · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 The impact of skin decontamination on the time window for effective treatment of percutaneous VX exposure
article 2017    
Author: Joosen, M.J.A. · Berg, R.M. van den · Jong, A.L. de · Schans, M.J. van der · Noort, D. · Langenberg, J.P.
Keywords: Nerve agent · Organophosphate · Percutaneous · Skin decontamination · Treatment · VX · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

3 Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs
article 2018    
Author: Joosen, M.J.A. · Klaassen, S.D. · Verheij, E. · Groningen, T. van · Cornelissen, A.S. · Skiadopoulos, M.H. · Cochrane, L. · Shearer, J.D.
Keywords: Atropine sulfate · Autoinjector · EEG · Nerve agent · Obidoxime · Sarin · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

4 Timing of decontamination and treatment in case of percutaneous VX poisoning: A mini review
article 2013    
Author: Joosen, M.J.A. · Schans, M.J. van der · Kuijpers, W.C. · Helden, H.P.M. van · Noort, D.
Keywords: Biology · Decontamination · Nerve agent · Percutaneous · Repeated treatment · VX · Defence Research · Defence, Safety and Security · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Studies on a surface acoustic wave (SAW) dosimeter sensor for organophosphorous nerve agents
article 1997    
Author: Nieuwenhuizen, M.S. · Harteveld, J.L.N.
Keywords: Biology · Coating · Dosimeter · Lanthanum (III) complexes · Nerve agent · SAW sensor · Acoustic surface wave devices · Coatings · Dosimeters · Lanthanum compounds · Organophosphorus nerve agents · Surface acoustic wave (SAW) dosimeter sensor · Chemical sensors
[Abstract]

6 Increasing oxime efficacy by blood-brain barrier modulation
article 2011    
Author: Joosen, M.J.A. · Schans, M.J. van der · Dijk, C.G.M. van · Kuijpers, W.C. · Wortelboer, H.M. · Helden, H.P.M. van
Keywords: HI6 · Nerve agent · P-glycoprotein · Seizures · Tariquidar · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Acetylcholinesterase · Atropine · Tariquidar · Animal experiment · Animal model · Article · Blood brain barrier · Blood level · Brain blood volume · Controlled study · Convulsion · Drug effect · Drug efficacy · Drug intoxication · Drug penetration · Male · Microdialysis · Modulation · Nerve agent poisoning · Nonhuman · Priority journal · Quantitative analysis · Rat · Seizure · Rattus · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether, 34433-31-3 · Acetylcholinesterase, 9000-81-1 · Atropine, 51-55-8, 55-48-1 · Tariquidar, 206873-63-4 · Tradenames: hi 6, TNO; xr 9576, avaant · Manufacturers: TNO; avaant · Life · CBRN - CBRN Protection PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

7 Biomonitoring of exposure to chemical warfare agents: A review
article 2002    
Author: Noort, D. · Benschop, H.P. · Black, R.M.
Keywords: Warfare · Biomonitoring · Chemical warfare agents · Mass spectrometry · Nerve agent · Review · Sulfur mustard · Terrorism · Biological marker · DNA · Glutathione · Protein · Biological monitoring · Blood analysis · Chemical analysis · Chemical warfare · Conjugation · Dosimetry · Exposure · Health survey · Humans · Hydrolysis · Immunochemistry · Mass spectrometry · Metabolite · Review · Urinalysis · Animals · Cholinesterase inhibitors · DNA adducts · Environmental monitoring · Protein binding · Arsenicals · Cholinesterase inhibitors · Lewisite, 541-25-3 · Mustard gas, 505-60-2
[Abstract]

8 Peripheral site ligand conjugation to a non-quaternary oxime enhances reactivation of nerve agent-inhibited human acetylcholinesterase
article 2011    
Author: Koning, M.C. de · Grol, M. van · Noort, D.
Keywords: Acetylcholinesterase · Nerve agent · Non-quaternary oxime · Peripheral site · Reactivation · 4 methoxyphenyl oxo ethanaloxime · Acetylcholinesterase · Cholinesterase reactivator · Oxime · Pyridinium derivative · Unclassified drug · Article · Binding affinity · Blood brain barrier · Drug conjugation · Drug inhibition · Drug structure · Drug synthesis · Electrospray mass spectrometry · Enzyme active site · High performance liquid chromatography · Liquid chromatography · Priority journal · Purification · Chemicals/CAS: acetylcholinesterase, 9000-81-1 · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

9 Long-term, low-level exposure of guinea pigs and marmosets to sarin vapor in air: Lowest observable effect level
article 2003    
Author: Helden, H.P.M. van · Trap, H.C. · Oostdijk, J.P. · Kuijpers, W.C. · Langenberg, J.P. · Benschop, H.P.
Keywords: Fluoride-induced reactivation · Guinea pigs · Internal dose · Lowest observable effect level (LOEL) · Marmosets · Nerve agent · O-Isopropyl methylphosphonofluoridate · Occupational exposure limits · Respiratory exposure · Sarin · Worker population limit (WPL) · Cholinesterase · Sarin · Animal experiment · Animal trapping · Article · Binding site · Chemical warfare · Cholinesterase inhibition · Controlled study · Enzyme activity · Gas chromatography · Gas mask · Guinea pig · Long term exposure · Male · Marmoset · Measurement · Nonhuman · Occupational exposure · Species comparison · Vaporization · Worker · Animals · Atmosphere Exposure Chambers · Callithrix · Dose-Response Relationship, Drug · Female · Gases · Guinea Pigs · Male · No-Observed-Adverse-Effect Level · Sarin · Threshold Limit Values · Volatilization · Animalia · Cavia · Cholinesterase, 9001-08-5 · Sarin, 107-44-8 · Gases
[Abstract]

10 Low levels of sarin affect the EEG in marmoset monkeys: A pilot study
article 2004    
Author: Helden, H.H.P.M. van · Vanwersch, R.A.P. · Kuijpers, W.C. · Trap, H.C. · Philippens, I.H.C. · Benschop, H.P.
Keywords: EEG · Exposure limits · Field alarm · Lowest observable adverse effect level (LOAEL) · Nerve agent · O-isopropyl methylphosphonofluoridate · Pyridostigmine · Sarin · Sleep-spindles · Whole-body exposure · Pyridostigmine · Sarin · Animal experiment · Blood · Cholinergic system · Controlled study · Electroencephalogram · Energy · Female · Male · Marmoset · Nonhuman · Oscillation · Pilot study · Priority journal · Sleep spindle · Animals · Callithrix · Chemical Warfare Agents · Cholinesterase Inhibitors · Dose-Response Relationship, Drug · Electroencephalography · Female · Humans · Inhalation Exposure · Male · Pyridostigmine Bromide · Sarin · Time Factors · Animalia · marmosets · Pyridostigmine, 101-26-8, 155-97-5 · Sarin, 107-44-8 · Chemical warfare agents · Cholinesterase inhibitors · Pyridostigmine Bromide, 101-26-8
[Abstract]

11 Low-level exposure of guinea pigs and marmosets to sarin vapour in air: Lowest-observable-adverse-effect level (LOAEL) for miosis
article 2004    
Author: Helden, H.P.M. van · Trap, H.C. · Kuijpers, W.C. · Oostdijk, J.P. · Benschop, H.P. · Langenberg, J.P.
Keywords: Biology · Exposure limits · Field alarm · Lowest-observable-adverse-effect level (LOAEL) · Miosis · Nerve agent · o-isopropyl methylphosphonofluoridate · Pupil size · Pyridostigmine · Sarin · Whole-body exposure · Acetylcholinesterase · Erythrocyte enzyme · Pyridostigmine · Sarin · Air · Animal experiment · Article · Calculation · Concentration (parameters) · Controlled study · Data analysis · Environmental exposure · Eye photography · Guinea pig · Iris · Male · Marmoset · Miosis · Nonhuman · Pilot study · Priority journal · Pupil · Statistical analysis · Vapor · Acetylcholinesterase · Administration, Inhalation · Animals · Callithrix · Chemical Warfare Agents · Dose-Response Relationship, Drug · Guinea Pigs · Inhalation Exposure · Pyridostigmine Bromide · Sarin · Volatilization · Animalia · Cavia · Marmosets · Acetylcholinesterase, 9000-81-1 · Pyridostigmine, 101-26-8, 155-97-5 · Sarin, 107-44-8 · Chemical warfare agents
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 11 of 11 found. | Sort by date