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1 Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular Traps against degradation by bacterial nucleases
article 2014    
Author: Neumann, A. · Völlger, L. · Berends, E.T.M. · Molhoek, E.M. · Stapels, D.A.C. · Midon, M. · Friães, A. · Pingoud, A. · Rooijakkers, S.H.M. · Gallo, R.L. · Mörgelin, M. · Nizet, V. · Naim, H.Y. · Köckritz-Blickwede, M. von
Keywords: Antimicrobial peptides · Cathelicidin · Neutrophil extracellular traps · Nucleases · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps
article 2014    
Author: Neumann, A. · Berends, E.T.M. · Nerlich, A. · Molhoek, E.M. · Gallo, R.L. · Meerloo, T. · Nizet, V. · Naim, H.Y. · Köckritz-Blickwede, M. von
Keywords: Cathelicidin · Cell death · Hydrophobicity · NETosis · Neutrophil extracellular trap · Nuclear membrane · Beta defensin 1 · Cathelicidin antimicrobial peptide LL 37 · Lamin B · Polymyxin B · Animal cell · Bacterial membrane · Cell nucleus membrane · Controlled study · Electron microscopy · Extracellular matrix · Fluorescence microscopy cell · Hydrophobicity · Immunofluorescence microscopy · Male · Mouse · Neutrophil · Neutrophil extracellular trap · Nonhuman · Normal human · Phenotype · Staphylococcus aureus · Polymyxin B, 1404-26-8, 1405-20-5 · Biomedical Innovation · Healthy Living · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content
article 2009    
Author: Abdul-Hussien, H. · Hanemaaijer, R. · Verheijen, J.H. · Bockel, J.H. van · Geelkerken, R.H. · Lindeman, J.H.N.
Keywords: Biology · Biomedical Research · antihypertensive agent · antithrombocytic agent · cystatin C · cysteine proteinase · doxycycline · gelatinase B · hydroxymethylglutaryl coenzyme A reductase inhibitor · messenger RNA · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · abdominal aorta aneurysm · adult · aged · aorta wall · article · clinical article · clinical trial · controlled clinical trial · controlled study · dose response · drug effect · drug megadose · drug tolerability · enzyme activity · enzyme assay · female · gene expression · human · human tissue · immunohistochemistry · low drug dose · male · neutrophil · polymerase chain reaction · priority journal · protein degradation · quantitative analysis · randomized controlled trial · treatment duration · Western blotting · Aged · Aged, 80 and over · Aorta, Abdominal · Aortic Aneurysm, Abdominal · Cardiovascular Agents · Cystatin C · Cysteine Endopeptidases · Dose-Response Relationship, Drug · Doxycycline · Female · Gene Expression Regulation, Enzymologic · Humans · Male · Matrix Metalloproteinases · Middle Aged · Neutrophil Infiltration · Neutrophils · Prospective Studies · Protease Inhibitors · RNA, Messenger · Time Factors · Tissue Inhibitor of Metalloproteinase-1 · Treatment Outcome · Vascular Surgical Procedures
[Abstract]

4 A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice
article 1993    
Author: HogenEsch, H. · Gijbels, M.J.J. · Offerman, E. · Hooft, J. van · Bekkum, D.W. van · Zurcher, C.
Keywords: Biology · broxuridine · intercellular adhesion molecule 1 · triamcinolone · epidermis hyperplasia · gene mutation · hematopoietic cell · histopathology · immunohistochemistry · macrophage function · neutrophil · remission · squamous epithelium · Adrenal Cortex Hormones · Animal · Chronic Disease · Cyclosporine · Dermatitis · Disease Models, Animal · Immunohistochemistry · Mast Cells · Mice · Mice, Inbred C57BL · Mutation · Rodent Diseases · Skin
[PDF] [Abstract]

5 The effect of PPE-induced emphysema and chronic LPS-induced pulmonary inflammation on atherosclerosis development in APOE*3-LEIDEN mice
article 2013    
Author: Khedoe, P.P.S.J. · Wong, M.C. · Wagenaar, G.T.M. · Plomp, J.J. · Eck, M. van · Havekes, L.M. · Rensen, P.C.N. · Hiemstra, P.S. · Berbée, J.F.P.
Keywords: Biology · Apolipoprotein E3 · Blood clotting factor 5 Leiden · Cholesterol · Interleukin 6 · Lipopolysaccharide · Pancreatic elastase · Phospholipid · Triacylglycerol · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Cardiovascular disease · Cholesterol blood level · Chronic inflammation · Controlled study Ccytokine release · Hyperlipidemia · Lung emphysema · Macrophage · Mouse · Neutrophil · Nonhuman · Phospholipid blood level · Pneumonia · Triacylglycerol blood level · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

6 Gingival tissue and crevicular fluid co-operation in adult periodontitis
article 2006    
Author: Beklen, A. · Tüter, G. · Sorsa, T. · Hanemaaijer, R. · Virtanen, I. · Tervahartiala, T. · Konttinen, Y.T.
Keywords: Health · Collagenase · Gelatinase · Periodontitis · Stromelysin · collagenase · enzyme precursor · gelatinase · gelatinase B · metalloproteinase · neutrophil collagenase · procollagenase · progelatinase · stromelysin · adult · article · cell culture · enzyme activation · enzymology · female · fibroblast · gingiva · gingivitis · human · immunohistochemistry · male · middle aged · pathology · periodontitis · Adult · Cells, Cultured · Collagenases · Enzyme Activation · Enzyme Precursors · Female · Fibroblasts · Gelatinases · Gingiva · Gingival Crevicular Fluid · Humans · Immunohistochemistry · Male · Matrix Metalloproteinase 3 · Matrix Metalloproteinase 8 · Matrix Metalloproteinase 9 · Metalloendopeptidases · Middle Aged · Periodontitis
[Abstract]

7 Henoch-Schönlein purpura in children: An epidemiological study among Dutch paediatricians on incidence and diagnostic criteria
article 2007    
Author: Aalberse, J. · Dolman, K. · Ramnath, G. · Pereira, R.R. · Davin, J.C.
Keywords: Health · Jeugd en Gezondheid · antibiotic agent · dipeptidyl carboxypeptidase inhibitor · meprednisone · prednisone · antinuclear antibody · biological marker · complement component C3 · neutrophil cytoplasmic antibody · abdominal disease · adolescent · adult · anaphylactoid purpura · arthritis · controlled study · diagnostic test · epidemiological data · human tissue · incidence · infant · kidney disease · major clinical study · skin biopsy · biopsy · blood · epidemiology · immunology · Antibodies, Antineutrophil Cytoplasmic · Antibodies, Antinuclear · Biological Markers · Biopsy · Child · Complement C3 · Epidemiologic Studies · Female · Humans · Immunoglobulin A · Incidence · Kidney · Male · Netherlands · Pediatrics · Purpura, Schoenlein-Henoch · Sensitivity and Specificity · Skin
[Abstract]

8 Increased matrix metalloproteinase-8 and -9 activity in patients with infarct rupture after myocardial infarction
article 2009    
Author: Borne, S.W.M. van den · Cleutjens, J.P.M. · Hanemaaijer, R. · Creemers, E.E. · Smits, J.F.M. · Daemen, M.J.A.P. · Blankesteijn, W.M.
Keywords: Biology · Biomedical Research · Infarct rupture · Inflammation · Matrix metalloproteinases · MMP activity assay · MMP immunohistochemistry · Myocardial infarction · gelatinase A · gelatinase B · neutrophil collagenase · tissue inhibitor of metalloproteinase 1 · adult · aged · article · clinical article · controlled study · enzyme activity · female · heart · heart disease · heart infarction · human · human tissue · immunohistochemistry · infarct rupture · inflammatory cell · male · priority journal · zymography · Aged · Aged, 80 and over · Cell Count · Female · Heart Rupture, Post-Infarction · Humans · Immunohistochemistry · Male · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 8 · Matrix Metalloproteinase 9 · Middle Aged · Myocardial Infarction · Myocarditis
[Abstract]

9 Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis
article 2003    
Author: Tchetverikov, I. · Lard, L.R. · Groot, J. de · Verzijl, N. · TeKoppele, J.M. · Breedveld, F.C. · Huizinga, T.W.J. · Hanemaaijer, R.
Keywords: Biology · Biomedical Research · gelatinase B · neutrophil collagenase · stromelysin · aged · arthropathy · disease activity · disease course · disease marker · enzyme activity · enzyme blood level · enzyme linked immunosorbent assay · female · human · joint destruction · longitudinal study · major clinical study · male · prediction · rheumatoid arthritis · Adult · alpha-Macroglobulins · Arthritis, Rheumatoid · Biological Markers · C-Reactive Protein · Disease Progression · Female · Humans · Joints · Male · Matrix Metalloproteinase 3 · Matrix Metalloproteinase 9 · Matrix Metalloproteinases · Middle Aged · Prospective Studies · Statistics, Nonparametric
[Abstract]

10 Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with L-lysine
article 2001    
Author: Peschel, A. · Jack, R.W. · Otto, M. · Collins, L.V. · Staubitz, P. · Nicholson, G. · Kalbacher, H. · Nieuwenhuizen, W.F. · Jung, G. · Tarkowski, A. · Kessel, K.P.M. van · Strijp, J.A.G. van
Keywords: Toxicology · Host defense peptides · Innate immunity · Oxygen-independent killing · Phospholipids · Staphylococcus aureus virulence · antibiotic agent · defensin · gallidermin · gramicidin D · gramicidin S · lysine · magainin 2 · melittin · membrane lipid · nisin · phosphatidylglycerol · protegrin · tachyplesin · unclassified drug · virulence factor · virulence factor mprf · animal model · antibiotic resistance · article · bacterial count · bactericidal activity · controlled study · Enterococcus faecalis · female · gene inactivation · mouse · Mycobacterium tuberculosis · neutrophil · nonhuman · nucleotide sequence · pathogenicity · priority journal · Pseudomonas aeruginosa · Staphylococcus aureus · surface charge · alpha-Defensins · Amino Acid Sequence · Animals · Anti-Bacterial Agents · Bacterial Proteins · Base Sequence · Cell Membrane · Defensins · DNA, Bacterial · Drug Resistance, Microbial · Esterification · Genes, Bacterial · Humans · Lysine · Molecular Sequence Data · Neutrophils · Peptides · Phosphatidylglycerols · Staphylococcus aureus · Swine · Virulence
[Abstract]

11 Preexposure to amorphous silica particles attenuates but also enhances allergic reactions in trimellitic anhydride-sensitized brown Norway rats
article 2008    
Author: Arts, J.H.E. · Schijf, M.A. · Kuper, C.F.
Keywords: Biology · Toxicology and Applied Pharmacology · silicon dioxide · trimellitic anhydride · animal experiment · animal model · animal tissue · article · biochemistry · breathing pattern · brown Norway rat · cell infiltration · controlled study · eosinophil · female · histopathology · inflammation · laryngeal inflammation · laryngeal ulceration · larynx disorder · liver weight · lung edema · lung function · lung lavage · lung weight · lymph node · lymphocyte count · macrophage · neutrophil · nonhuman · priority journal · rat · respiratory tract allergy · squamous cell metaplasia · tidal volume · Allergens · Animals · Body Weight · Drug Administration Schedule · Female · Immunoglobulin E · Liver · Lung · Lymph Nodes · Organ Size · Phthalic Anhydrides · Rats · Respiratory Function Tests · Silicon Dioxide · Animalia · Rattus norvegicus
[Abstract]

12 Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer
article 2006    
Author: Kubben, F.J.G.M. · Sier, C.F.M. · Duijn, W. van · Griffioen, G. · Hanemaaijer, R. · Velde, C.J.H. van de · Krieken, J.H.J.M. van · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Health · Biomedical Research · Gelatinases · MMP-7 · MMP-8 · MMP-9 · TIMP · Tissue inhibitor of metalloproteinases · gelatinase A · gelatinase B · matrilysin · neutrophil collagenase · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 2 · bioassay · cancer classification · cancer patient · cancer staging · cancer survival · cancer tissue · comparative study · controlled study · correlation analysis · enzyme analysis · enzyme assay · enzyme linked immunosorbent assay · histopathology · human tissue · major clinical study · prognosis · protein variant · stomach cancer · stomach mucosa · tissue section · world health organization · Adult · Aged · Aged, 80 and over · Enzyme-Linked Immunosorbent Assay · Female · Humans · Male · Matrix Metalloproteinase 2 · Middle Aged · Predictive Value of Tests · Prognosis · Stomach Neoplasms · Survival Analysis
[PDF] [Abstract]

13 MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis
article 2004    
Author: Tchetverikov, I. · Ronday, H.K. · El, B. van · Kiers, G.H. · Verzijl, N. · TeKoppele, J.M. · Huizinga, T.W.J. · Groot, J. de · Hanemaaijer, R.
Keywords: alpha 2 macroglobulin · biological marker · gelatinase A · gelatinase B · hydroxyproline · interstitial collagenase · matrix metalloproteinase · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · aged · circulation · clinical article · collagen degradation · concentration (parameters) · controlled study · correlation analysis · enzyme activity · enzyme assay · enzyme linked immunosorbent assay · female · high performance liquid chromatography · human · male · osteoarthritis · priority journal · rheumatoid arthritis · sampling · serum · statistical significance · synovial fluid · Adult · Aged · alpha-Macroglobulins · Arthritis, Rheumatoid · Case-Control Studies · Collagenases · Enzyme Precursors · Enzyme-Linked Immunosorbent Assay · Female · Humans · Hydroxyproline · Male · Matrix Metalloproteinase 8 · Matrix Metalloproteinase 9 · Matrix Metalloproteinases · Metalloendopeptidases · Middle Aged · Osteoarthritis, Knee · Statistics, Nonparametric · Synovial Fluid · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

14 Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE
article 2008    
Author: Dijkstra, S. · Kooij, G. · Verbeek, R. · Pol, S.M.A. van der · Amor, S. · Geisert Jr., E.E. · Dijkstra, C.D. · Noort, J.M. van · Vries, H.E.d.
Keywords: Biology · Biomedical Research · CD81 · EAE · Multiple sclerosis · Tetraspanins · Therapeutic antibodies · Transendothelial migration · CD81 antigen · monoclonal antibody · monoclonal antibody 1 3 3 22 · monoclonal antibody 1D6 · monoclonal antibody 2F7 · monoclonal antibody AMP1 · monoclonal antibody CD81 · monoclonal antibody Eat2 · monoclonal antibody JS81 · monoclonal antibody TA2 · tetraspanin · unclassified drug · very late activation antigen 4 antibody · allergic encephalomyelitis · animal cell · animal experiment · animal model · animal tissue · antiinflammatory activity · article · controlled study · drug effect · endothelium cell · female · human · human cell · in vitro study · in vivo study · monocyte · monolayer culture · mouse · myelitis · neurologic disease · neutrophil chemotaxis · nonhuman · priority journal · protein targeting · rat · treatment outcome · Animals · Antibodies, Monoclonal · Antigens, CD · Blood-Brain Barrier · Cell Line, Transformed · Cerebral Arteries · Chemotaxis, Leukocyte · Disease Models, Animal · Encephalomyelitis, Autoimmune, Experimental · Endothelial Cells · Female · Humans · Immunosuppression · Immunosuppressive Agents · Mice · Monocytes · Multiple Sclerosis · Rats · Treatment Outcome
[Abstract]

15 Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor from macrophages
article 2006    
Author: Verhoeckx, K.C.M. · Doornbos, R.P. · Witkamp, R.F. · Greef, J. van der · Rodenburg, R.J.T.
Keywords: Biology · Analytical research · β2-adrenergic receptor · β2-adrenergic receptor agonist · cAMP · Clenbuterol · CXCL6 · GCP-2 · Oncostatin M · VEGF · Zilpaterol · 3 isopropylamino 1 (7 methyl 4 indanyloxy) 2 butanol · beta 2 adrenergic receptor · beta 2 adrenergic receptor blocking agent · beta 2 adrenergic receptor stimulating agent · bronchodilating agent · butyryl cyclic AMP · chemokine · chemokine cxcl 6 · clenbuterol · Escherichia coli lipopolysaccharide · forskolin · oncostatin M · prostaglandin E2 · unclassified drug · vasculotropin · zilpaterol · angiogenesis · article · asthma · controlled study · drug potency · histiocytic lymphoma · human · human cell · lymphoma cell · macrophage · neutrophil · priority journal · upregulation · Adrenergic beta-Agonists · Bucladesine · Chemokines, CXC · Clenbuterol · Cyclic AMP · Cytokines · Dinoprostone · Forskolin · Humans · Lipopolysaccharides · Macrophage Activation · Macrophages · Oncostatin M · Trimethylsilyl Compounds · U937 Cells · Up-Regulation · Vascular Endothelial Growth Factor A
[Abstract]

16 The Netherlands twin register biobank: A resource for genetic epidemiological studies
article 2010    
Author: Willemsen, G. · Geus, E.J.C. de · Bartels, M. · Beijsterveldt, C.E.M.T. van · Brooks, A.I. · Estourgie-van Burk, G.F. · Fugman, D.A. · Hoekstra, C. · Hottenga, J.-J. · Kluft, K. · Meijer, P. · Montgomery, G.W. · Rizzu, P. · Sondervan, D. · Smit, A.B. · Spijker, S. · Suchiman, H.E.D. · Tischfield, J.A. · Lehner, T. · Slagboom, P.E. · Boomsma, D.I.
Keywords: Biology · Biomedical Research · DNA · GWAS · Mental health · Physical health · RNA · alanine aminotransferase · aspartate aminotransferase · C reactive protein · cholesterol · creatinine · fibrinogen · gamma glutamyltransferase · glucose · hemoglobin · hemoglobin A1c · high density lipoprotein cholesterol · insulin · low density lipoprotein cholesterol · triacylglycerol · adult · alanine aminotransferase blood level · article · aspartate aminotransferase blood level · basophil · blood sampling · body composition · cell line · cholesterol blood level · creatinine blood level · DNA isolation · eosinophil count · erythrocyte count · female · fibrinogen blood level · gamma glutamyl transferase blood level · gene expression · genetic epidemiology · genotype · glucose blood level · glucose metabolism · hematocrit · hemoglobin blood level · heredity · human · insulin blood level · leukocyte count · lifestyle · lipoprotein blood level · lymphocyte count · male · mean corpuscular hemoglobin · mean corpuscular volume · menstrual cycle · mental health · monocyte · Netherlands · Netherlands twin register biobank · neutrophil count · phenotype · priority journal · professional practice · register · single nucleotide polymorphism · thrombocyte count · thrombocyte volume · triacylglycerol blood level · urinalysis
[Abstract]

17 Inhibition of complement component C3 reduces vein graft atherosclerosis in apolipoprotein E3-Leiden transgenic mice
article 2006    
Author: Schepers, A. · Vries, M.R. de · Leuven, C.J. van · Grimbergen, J.M. · Holers, V.M. · Daha, M.R. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · Atherosclerosis · Bypass · Complement system proteins · Immunology · CD59 antigen · cobrotoxin · complement component C1q · complement component C3 · complement component C9 · complement inhibitor · complement receptor related protein immunoglobulin G1 fusion protein · messenger RNA · regulator protein · animal experiment · animal model · animal tissue · antiinflammatory activity · apoptosis · artery intima proliferation · atherosclerosis · cell proliferation · common carotid artery · complement activation · complement inhibition · controlled study · drug effect · drug efficacy · experimental model · gene expression · immunohistochemistry · inflammatory cell · male · monocyte · mouse · neutrophil chemotaxis · nonhuman · priority journal · quantitative analysis · RNA analysis · T lymphocyte · treatment outcome · vein graft disease · Animals · Apolipoprotein E3 · Atherosclerosis · Complement C3 · Diet, Atherogenic · Disease Models, Animal · Humans · Mice · Mice, Transgenic · Transplantation, Isogeneic · Venae Cavae
[Abstract]

18 Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm
article 2008    
Author: Lindeman, J.H.N. · Abdul-Hussien, H. · Schaapherder, A.F.M. · Bockel, J.H. van · Thüsen, J.H. vonder · Roelen, D.L. · Kleemann, R.
Keywords: Health · Abdominal aortic aneurysm · Atherosclerosis · Inflammation · Interleukin · Transcription factor · CCAAT enhancer binding protein alpha · CCAAT enhancer binding protein beta · CCAAT enhancer binding protein delta · Cytokine · Gamma interferon · Interleukin 10 · Interleukin 13 · Interleukin 1alpha · Interleukin 2 · Interleukin 4 · Interleukin 6 · Interleukin 8 · Messenger RNA · Perforin · STAT3 protein · transcription factor · transcription factor AP 1 · transcription factor GATA 3 · transcription factor RelA · transcription factor T bet · tumor necrosis factor alpha · autacoid · biological marker · abdominal aorta aneurysm · adult · aged · aorta atherosclerosis · aorta wall · B lymphocyte · Cellular immunity · Clinical article · Controlled study · Cytotoxic T lymphocyte · Enzyme linked immunosorbent assay · Female · Human · Human tissue · Immunohistochemistry · Male · Medical parameters · Neutrophil · Plasma cell · Protein expression · Real time polymerase chain reaction · Th1 cell · Th2 cell · Vasa vasorum · Western blotting · Aorta valve stenosis · Biosynthesis · Differential diagnosis · Genetics · Immunology · Metabolism · Methodology · Physiology · Reverse transcription polymerase chain reaction · Aged · Aortic Aneurysm, Abdominal · Aortic Valve Stenosis · Atherosclerosis · Biological Markers · Diagnosis, Differential · Female · Gene Expression Profiling · Humans · Inflammation Mediators · Male · Middle Aged · Reverse Transcriptase Polymerase Chain Reaction · Th1 Cells · Th2 Cells · Transcription Factors
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 18 of 18 found. | Sort by date