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1 Determination of polar organophosphorus pesticides in aqueous samples by direct injection using liquid chromatography : tandem mass spectrometry
article 2001    
Author: Ingelse, B.A. · Dam, R.C.J. van · Vreeken, R.J. · Mol, H.G.J. · Steijger, O.M.
Keywords: Nutrition · Organophosphorus compounds · Pesticides · Water analysis · Atmospheric pressure · Ionization · Liquid chromatography · Mass spectrometry · Sensitivity analysis · Polar endcapping · Pesticides · Chromatography, Gas · Chromatography, High Pressure Liquid · Insecticides · Mass Spectrometry · Organophosphorus Compounds · Reproducibility of Results · Sensitivity and Specificity · Water
[Abstract]

2 Protective activity of adenosine receptor agonists in the treatment of organophosphate poisoning
article 1999    
Author: Helden, H.P.M. van · Bueters, T.J.H.
Keywords: Toxicology · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · 6 n cyclopentyladenosine · Animals · Humans · Organophosphorus Compounds · Poisoning · Receptors, Purinergic P1

3 Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro
article 2018    
Author: Horn, G. · Koning, M.C. de · Grol, M. van · Thiermann, H. · Worek, F.
Keywords: Organophosphorus compounds · Acetylcholinesterase · Non-oxime reactivator · Reactivation · In vitro · Defence, Safety and Security · Observation, Weapon & Protection Systems 2015 Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

4 On the development of behavioral tolerance to organophosphates IV: EEG and visual evoked responses
article 1991    
Author: Wolthuis, O.L. · Philippens, I.H.C.H.M. · Vanwersch, R.A.P.
Keywords: Vision · DFP · EEG · Organophosphates · Soman · Tolerance · VER · Dyflos · Soman · Animal experiment · Behavior · Controlled study · Drug tolerance · Electric shock · Electroencephalogram · Evoked visual response · Male · Nonhuman · Pupil · RatS · Rectum temperature · Animal · Behavior, Animal · Body Temperature · Conditioning, Operant · Drug Tolerance · Electroencephalography · Electroshock · Evoked Potentials, Visual · Isoflurophate · Male · Organophosphorus Compounds · Rats, Inbred Strains · Isoflurophate, 55-91-4 · Organophosphorus Compounds · Soman, 96-64-0
[Abstract]

5 The bispyridinium-dioxime HLö-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman
article 1989    
Author: Jong, L.P.A.de · Verhagen, M.A.A. · Langenberg, J.P. · Hagedorn, I. · Löffler, M.
Keywords: Biology · Bis(pyridinium oxime) derivative · Enzyme inhibitor · Organophosphorus compound · Radioisotope · Enzyme reactivation · Fish · Human · Nonbiological model · Nonhuman · Normal human · Rat · Stereoisomerism · Acetylcholinesterase 9000-81-1 · Animal · Cholinesterase Reactivators · Eels · Human · In Vitro · Organophosphorus Compounds · Oximes · Phosphoric Acid Esters · Pyridines · Pyridinium Compounds · Stereoisomerism · Structure-Activity Relationship · Organophosphorus compounds · Oximes · Phosphoric acid esters · Pyridines · Pyridinium compounds · Soman, 96-64-0 · Tabun, 77-81-6
[Abstract]

6 Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry
article 1997    
Author: Barak, R. · Ordentlich, A. · Barak, D. · Fischer, M. · Benschop, H.P. · Jong, L.P.A. de · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Determination · Chemical compounds · Acetylcholinesterase · Electrospray · Mass spectroscopy · Ionization · Aging (biology) · Inhibitors · Organic phosphates · Acetylcholinesterase, EC 3.1.1.7 · Cholinesterase Inhibitors · Organophosphorus Compounds · Recombinant Proteins · Acetylcholinesterase · Aging · ESI-MS · Organophosphonate inhibitor · Enzyme activity · Enzyme phosphorylation · Mass spectrometry · Alkylation · Cholinesterase inhibitors · Humans · Mass spectrometry · Molecular structure · Molecular weight · Organophosphorus compounds · Recombinant proteins
[PDF] [Abstract]

7 Persistence of the anti-cholinesterase soman in rats: Antagonism with a non-toxic simulator of this organophosphate
article 1981    
Author: Wolthuis, O.L. · Benschop, H.P. · Berends, F.
Keywords: Biology · Acetylcholinesterase · Atropine · Soman · Animal experiment · Controlled study · Drug intoxication · Intoxication · Intravenous drug administration · Rat · Simulator · Sustained release preparation · Acetylcholinesterase · Animal · Male · Organophosphorus Compounds · Pyridinium Compounds · Rats · Soman · Time Factors
[Abstract]

8 GLC-analysis and pharmacokinetics of the four stereoisomers of soman
article 1981    
Author: Benschop, H.P. · Berends, F. · Jong, L.P.A. de
Keywords: Biology · Organophosphorus compound · Soman · Animal · Gas chromatography · Kinetics · Metabolism · Rat · Stereoisomerism · Animal · Chromatography, Gas · Kinetics · Organophosphorus Compounds · Rats · Soman · Stereoisomerism · organophosphorus compound · G agents · Prophylaxis · Therapy · Blood · Skin (anatomy) · GC - Gas chromatography · Reaction kinetics · Stereochemistry · Degradation
[Abstract]

9 Determination of polar organophosphorus pesticides in vegetables and fruits using liquid chromatography with tandem mass spectrometry: Selection of extraction solvent
article 2003    
Author: Mol, H.G.J. · Dam, R.C.J. van · Steijger, O.M.
Keywords: Packaging · Analytical research · Acephate · Fruits · Methamidophos · Monocrotophos · Omethoate · Organophosphorus compounds · Oxydemeton-methyl · Pesticides · Vamidothion · Vegetables · Fruits · Ionization · Mass spectrometry · Pesticides · Solvent extraction · Extraction efficiency · Liquid chromatography · acephate · acetic acid ethyl ester · methamidophos · monocrotophos · omethoate · organophosphate pesticide · oxydemeton methyl · solvent · unclassified drug · vamidothion · water · cabbage · conference paper · evaporation · extraction · fruit · grape · ionization · liquid chromatography · priority journal · spectrometer · tandem mass spectrometry · validation process · vegetable · Chromatography, High Pressure Liquid · Fruit · Insecticides · Mass Spectrometry · Organophosphorus Compounds · Reproducibility of Results · Vegetables · Brassica oleracea var. capitata · Vitaceae
[Abstract]

10 Capillary gas chromatographic analysis of nerve agents using large volume injections
article 1996    
Author: Degenhardt, C.E.A.M. · Kientz, C.E.
Keywords: Biology · GC - Gas chromatography · Nerve agents · Capillarity · Phosphorus organic compounds · GB agent · Military chemical agents · Cholinesterase Inhibitors · Isoflurophate, 55-91-4 · Organophosphorus compounds · Organothiophosphorus compounds · Sarin, 107-44-8 · Soman, 96-64-0 · VX, 50782-69-9 · Water, 7732-18-5 · Chemical warfare agents · DFP · Large volume injection · Organophosphorus compounds · Tabun · Dflos · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester · Capillary gas chromatography · Drug determination · Nonhuman · Sample · Technique · Water analysis · Water pollution · Cholinesterase Inhibitors · Chromatography, Gas · Hydrogen-Ion Concentration
[Abstract]

11 Quantitative analysis of O-isopropyl methylphosphonic acid in serum samples of Japanese citizens allegedly exposed to sarin: Estimation of internal dosage
article 1998    
Author: Noort, D. · Hulst, A.G. · Platenburg, D.H.J.M. · Polhuijs, M. · Benschop, H.P.
Keywords: Defence · Chemical warfare agents · LC tandem MS · Multiple reaction monitoring · O-isopropyl methylphosphonic acid · Sarin · Cholinesterase · Fluoride ion · Methylphosphonic acid · O isopropyl metylphosphonic acid · Sarin · Unclassified drug · Anion exchange chromatography · Article · Blood level · Chemical structure · Chemical warfare · Diagnostic value · Enzyme activity · Enzyme binding · Enzyme inhibition · Human · Hydrolysis · Japan · Lethal dose · Methodology · Population exposure · Priority journal · Tandem mass spectrometry · Toxicity testing · Butyrylcholinesterase · Chemistry, Analytical · Chromatography, Liquid · Environmental Exposure · Female · Humans · Male · Mass Spectrometry · Molecular Structure · Organophosphorus Compounds · Butyrylcholinesterase, EC 3.1.1.- · Isopropyl methylphosphonic acid, 1832-54-8 · Organophosphorus Compounds · Sarin, 107-44-8
[Abstract]

12 Comprehensive gas chromatography with Time of Flight MS and large volume introduction for the detection of fluoride-induced regenerated nerve agent in biological samples
article 2010    
Author: Meer, J.A. van der · Trap, H.C. · Noort, D. · Schans, M.J. van der
Keywords: Defence · Comprehensive GC · Time of Flight MS · Nerve agents · Fluoride reactivation · Diagnosis · Chemicals/CAS: · Fluoride, 16984-48-8 · Sarin, 107-44-8 · Tabun, 77-81-6 · Chemical warfare agents · Cholinesterase inhibitors · Fluorides · Organophosphorus compounds · Phosphoric acid esters · Organophosphate · Organophosphorus compound · Blood · Chemistry · Human · Mass fragmentography · Methodology · Reproducibility · Sensitivity and specificity · Statistical model · Gas Chromatography-Mass Spectrometry · Linear models
[Abstract]

13 A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodents
article 1978    
Author: Kepner, L.A. · Wolthuis, O.L.
Keywords: Biology · Atropine · Cholinesterase reactivator · Oxime · Soman · 1 (3 carbamoylpyridinio) 1 (2 hydroximinoethylpyridinio)dimethyl ether · Animal experiment · Breathing · Drug comparison · Drug intoxication · Drug response · Intoxication · Intraperitoneal drug administration · Mouse · Muscle · Musculoskeletal system · Neuromuscular transmission · Organophosphate poisoning · Rat · Respiratory system · Subcutaneous drug administration · Animal · Atropine · Comparative Study · Drug Synergism · Female · Male · Mice · Neuromuscular Junction · Organophosphorus Compounds · Oximes · Rats · Rats, Inbred Strains · Respiration · Soman
[Abstract]

14 The dependence of the blood level of the oxime HS 6 on the severity of organophosphate poisoning
article 1976    
Author: Wolthuis, O.L. · Clason-van der Wiel, H.J. · Visser, R.P.L.S.
Keywords: Biology · 1 (3 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Atropine · Cholinesterase inhibitor · Dimethyl ether · Soman · Drug analysis · Drug blood level · Drug intoxication · Intoxication · Intravenous drug administration · Pharmacokinetics · Plasma · Pralidoxime derivative · Rat · Respiratory failure · Theoretical study · Animal · Antidotes · Atropine · Dose-Response Relationship, Drug · Lethal Dose 50 · Male · Organophosphorus Compounds · Oximes · Rats · Soman
[Abstract]

15 Retrospective detection of exposure to nerve agents: Analysis of phosphofluoridates originating from fluoride-induced rectivation of phospylated BuChE
article 2004    
Author: Schans, M.J. van der · Polhuijs, M. · Dijk, C. van · Degenhardt, C.E.A.M. · Pleijsier, K. · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Biomarker · Biomonitoring · Butyryl cholinesterase · Fluoride ions · Lexposure · Nerve agents · Organophosphates · Reactivation · Retrospective detection · Cholinesterase · Cholinesterase inhibitor · Cyclosarin · Fluoride · Nerve gas · Organophosphate · Paraoxon · Parathion · Phosphorus derivative · Sarin · Soman · Tabun · Unclassified drug · Biological monitoring · Biological warfare · Chemical structure · Concentration (parameters) · Environmental exposure · Enzyme activation · Enzyme active site · Enzyme inhibition · Gas chromatography · Half life time · Human · Nonhuman · pH · Priority journal · Retrospective study · Rhesus monkey · Animals · Butyrylcholinesterase · Chemical Warfare Agents · Cholinesterase Inhibitors · Cholinesterase Reactivators · Gas chromatography · Female · Fluorides · Half-Life · Humans · Injections, Intravenous · Macaca mulatta · Male · Organophosphorus compounds · Paraoxon · Reference standards · Time factors · Macaca mulatta · Cholinesterase, 9001-08-5 · Cyclosarin, 329-99-7 · Fluoride, 16984-48-8 · Paraoxon, 311-45-5 · Parathion, 3270-86-8, 56-38-2, 597-88-6 · Sarin, 107-44-8 · Soman, 96-64-0 · Tabun, 77-81-6 · Butyrylcholinesterase, EC 3.1.1.- · Chemical warfare agents · Cholinesterase inhibitors · Cholinesterase reactivators · Fluorides · Organophosphorus compounds
[Abstract]

16 Successful oxime therapy one hour after soman intoxication in the rat
article 1978    
Author: Wolthuis, O.L. · Kepner, L.A.
Keywords: Biology · 1 (3 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Atropine · Cholinesterase · Oxime · Radioisotope · Soman · Acetylcholine h 3 · Aging · Animal experiment · Breathing · Cytology · Diaphragm · Drug comparison · Drug intoxication · In vitro study · Intoxication · Muscle · Neuromuscular transmission · Peripheral nervous system · Phrenic nerve · Rat · Respiratory failure · Respiratory system · Animal · Atropine · Cholinesterases · Diaphragm · Male · Muscle Contraction · Organophosphorus Compounds · Oximes · Phrenic Nerve · Rats · Soman · Time Factors
[Abstract]

17 Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation
article 1991    
Author: Helden, H.P.M. van · Lange, J. de · Busker, R.W. · Melchers, B.P.C.
Keywords: Biology · Acetylcholinesterase · Direct effect · HGG-12 · HI-6 · Obidoxime · Organophosphate poisoning · P2S · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · [(3 benzoyl 1 pyridiniomethyl) (2 hydroxyiminomethyl 1 pyridiniomethyl)] ether · Obidoxime · Organophosphate · Oxime · Soman · Animal experiment · Animal tissue · Diaphragm · Enzyme inhibition · Enzyme reactivation · Intravenous drug administration · Male · Nonhuman · Priority journal · Rat · Animal · Antidotes · Blood-Brain Barrier · Cholinesterase Reactivators · Diaphragm · In Vitro · Male · Neuromuscular Junction · Obidoxime Chloride · Organophosphorus Compounds · Oximes · Pralidoxime Compounds · Pyridinium Compounds · Rats · Respiratory Insufficiency · Synaptic Transmission · Animalia
[Abstract]

18 The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including man
article 1981    
Author: Wolthuis, O. · Vanwersch, R.A.P. · Wiel, H.J. van der
Keywords: Biology · 1 (3 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · [(3 isobutyryl 1 pyridiniomethyl) (2 hydroxyiminomethyl 1 pyridiniomethyl)] ether · Sarin · Soman · Tubocurarine chloride · Unclassified drug · Animal experiment · Bispyridinium oxime · Diaphragm · Dog · Dose response · Drug comparison · Drug response · Guinea pig · Human cell · In vitro study · Intercostal muscle · Intravenous drug administration · Neuromuscular transmission · Rat · Adult · Aged · Animal · Antidotes · Chorionic Gonadotropin · Comparative Study · Dogs · Electric Stimulation · Female · Guinea Pigs · Human · In Vitro · Male · Middle Age · Neuromuscular Junction · Organophosphorus Compounds · Pralidoxime Compounds · Pyridinium Compounds · Rats · Sarin · Soman · Species Specificity · Synaptic Transmission
[Abstract]

19 Antidotes to organophosphate poisoning. 2. Thiadiazole-5-carboxaldoximes
article 1979    
Author: Benschop, H.P. · Berg, G.R. van den · Hooidonk, C. van · Jong, L.P.A. de · Kientz, C.E. · Berends, F. · Kepner, L.A. · Meeter, E. · Visser, R.P.L.S.
Keywords: Biology · Acetylcholinesterase · Antidote · Atropine · Cholinesterase reactivator · Diacetyl oxime · Enzyme · Obidoxime P · Paraoxon · Sarin · Tri ortho cresyl phosphate · 1,2,3 thiadiazole 5 carboxaldoxime · 2 (hydroximinomethyl) 1 methylpyridinium salt · 2 methyl 1,2,3 thiadiazolium salt carboxaldoxime · 3 methyl 1,2,3 thiadiazolium salt 5 carboxaldoxime · Animal experiment · Blood · Blood and hemopoietic system · Dose response · Drug administration · Drug analysis · Drug blood level · Drug comparison · Drug elimination · Drug half life · Drug interaction · Drug intoxication · Drug metabolism · Drug response · Drug screening · Drug synthesis · Drug tolerance · Drug toxicity · Drug urine level · Goat · Guinea pig · High performance liquid chromatography · Hydroximinoacetone · In vitro study · Intoxication · Intraperitoneal drug administration · Intravenous drug administration · Mouse · Nuclear magnetic resonance · Oral drug administration · Organophosphate intoxication · Pharmacokinetics · Prevention · Prophylaxis · Rabbit · Rat · Subcutaneous drug administration · Theoretical study · Therapy · Thiadiazole 5 carboxaldoxime derivative · Ultraviolet spectrophotometry · Urine · Acetylcholinesterase · Animal · Antidotes · Body Temperature · Cattle · Chemistry · Dose-Response Relationship, Drug · Enzyme Reactivators · Female · Goats · Guinea Pigs · Half-Life · In Vitro · Lethal Dose 50 · Male · Mice · Organophosphorus Compounds · Oximes · Rabbits · Rats · Rats, Inbred Strains · Sarin · Solubility · Structure-Activity Relationship
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 19 of 19 found. | Sort by date