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1 Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male mice
article 2007    
Author: Korsheninnikova, E. · Voshol, P.J. · Baan, B. · Zon, G.C.M. van der · Havekes, L.M. · Romijn, J.A. · Maassen, J.A. · Ouwens, D.M.
Keywords: Biology · Biomedical Research · Hepatic glucose production · High-fat diet · Insulin resistance · Insulin signalling · Liver · glucose · insulin · insulin receptor · phosphatidylinositol 3 kinase · protein kinase B · animal · article · blood · C57BL mouse · drug effect · fat intake · gene expression regulation · glucose clamp technique · hyperinsulinism · liver · male · metabolism · mouse · signal transduction · 1-Phosphatidylinositol 3-Kinase · Animals · Dietary Fats · Gene Expression Regulation, Enzymologic · Glucose · Glucose Clamp Technique · Hyperinsulinism · Insulin · Liver · Male · Mice · Mice, Inbred C57BL · Proto-Oncogene Proteins c-akt · Receptor, Insulin · Signal Transduction · Mus
[Abstract]

2 Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice
article 2003    
Author: Voshol, P.J. · Haemmerle, G. · Ouwens, D.M. · Zimmermann, R. · Zechner, R. · Teusink, B. · Maassen, J.A. · Havekes, L.M. · Romijn, J.A.
Keywords: Health · Glucose · Hormone sensitive lipase · Insulin receptor · Protein kinase B · Triacylglycerol · Triacylglycerol lipase · Unclassified drug · Animal tissue · Controlled study · Enzyme activity · Enzyme deficiency · Enzyme mechanism · Enzyme phosphorylation · Fatty acid blood level · Gluconeogenesis · Glucose transport · Hormone sensitivity · Hyperinsulinemia · Insulin sensitivity · Knockout mouse · Lipid liver level · Lipolysis · Mouse · Nonhuman · Western blotting · Adiponectin · Animals · Blood Glucose · Cholesterol · Cholesterol Esterase · Fasting · Fatty Acids, Nonesterified · Glucose · Insulin · Intercellular Signaling Peptides and Proteins · Liver · Male · Mice · Mice, Knockout · Muscle, Skeletal · Proteins · Receptor, Insulin · Triglycerides
[Abstract]

3 CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice
article 2003    
Author: Goudriaan, J.R. · Dahlmans, V.E.H. · Teusink, B. · Ouwens, D.M. · Febbraio, M. · Maassen, J.A. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Biology · Biomedical Research · Fatty acid transport · Glucose metabolism · Hepatic steatosis · Hyperinsulinemic clamp · CD36 antigen · fatty acid · glucose · protein kinase B · triacylglycerol · unclassified drug · animal experiment · animal model · animal tissue · controlled study · enzyme activation · enzyme deficiency · fatty acid blood level · glucose blood level · glucose transport · hyperinsulinemia · insulin sensitivity · male · mouse · muscle · nonhuman · spontaneously hypertensive rat · triacylglycerol blood level · Western blotting · wild type · Animals · Antigens, CD36 · Blood Glucose · Body Weight · Eating · Gene Deletion · Insulin · Insulin Resistance · Lipids · Liver · Mice · Mice, Inbred C57BL · Muscle, Skeletal · Rats · Signal Transduction · Triglycerides · Tritium
[PDF] [Abstract]

4 Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice
article 2006    
Author: Boer, M.A.M. den · Voshol, P.J. · Schröder-van Der Elst, J.P. · Korsheninnikova, E. · Ouwens, D.M. · Kuipers, F. · Havekes, L.M. · Romijn, J.A.
Keywords: Biology · Biomedical Research · Amyloid A protein · fibrinogen · interleukin 10 · protein kinase B · Animal experiment · Calorimetry · Cholesterol blood level · Controlled study · Experimental model · Fatty liver · Feeding · Glucose blood level · Hlucose metabolism · High performance liquid chromatography · Hyperinsulinemia · Insulin sensitivity · Lipid diet · Lipid metabolism · Mouse · Nonhuman · Phosphorylation · Steatosis · Triacylglycerol blood level · Adipose Tissue · Animals · Blood Glucose · Chromatography, Thin Layer · Diet · Dietary Fats · Energy Metabolism · Fibrinogen · Genotype · Glucose · Glucose Clamp Technique · Insulin Resistance · Interleukin-10 · Lipid Metabolism · Lipids · Liver Diseases · Male · Mice · Mice, Inbred C57BL · Mice, Knockout · Phenotype · Serum Amyloid A Protein
[Abstract]

5 Modulating angiogenesis: The yin and the yang in ginseng
article 2004    
Author: Sengupta, S. · Toh, S.A. · Sellers, L.A. · Skepper, J.N. · Koolwijk, P. · Leung, H.W. · Yeung, H.W. · Wong, R.N.S. · Sasisekharan, R. · Fan, T.P.D.
Keywords: Biology · Biomedical Research · Angiogenesis · Nitric oxide · ginseng extract · ginseng polysaccharide · herbaceous agent · nitric oxide synthase · Panax notoginseng extract · panax quinquefolium extract · phosphatidylinositol 3 kinase · polymer · protein kinase B · sterol derivative · animal experiment · animal model · antiangiogenic activity · cell invasion · cell proliferation · chemical analysis · chemical composition · controlled study · drug effect · drug identification · drug isolation · drug mechanism · drug screening · drug structure · endothelium cell · herbal medicine · human cell · human tissue · in vitro study · in vivo study · law · mass spectrometry · neovascularization (pathology) · nonhuman · phenotype · protein expression · regulatory mechanism · species differentiation · standardization · wound healing · 1-Phosphatidylinositol 3-Kinase · Americas · Angiogenesis Inducing Agents · Angiogenesis Inhibitors · Animals · Cells, Cultured · China · Drug Implants · Endothelial Cells · Endothelium, Vascular · Enzyme Inhibitors · Ginsenosides · Humans · Korea · Male · Mice · Mice, Inbred C57BL · Molecular Structure · Neovascularization, Pathologic · NG-Nitroarginine Methyl Ester · Panax · Phytotherapy · Signal Transduction · Species Specificity · Spectrometry, Mass, Electrospray Ionization · Surgical Sponges · Umbilical Veins
[Abstract]

6 Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
article 2006    
Author: Korsheninnikova, E. · Zon, G.C.M. van der · Voshol, P.J. · Janssen, G.M. · Havekes, L.M. · Grefhorst, A. · Kuipers, F. · Reijngoud, D.-J. · Romijn, J.A. · Ouwens, D.M. · Maassen, J.A.
Keywords: Biology · Biomedical Research · Hepatic steatosis · High-fat feeding · Nutrient sensing · Enzyme inhibitor · Glucose · Hydroxymethylglutaryl coenzyme A reductase kinase · Mammalian target of rapamycin · Protein kinase B · Protein S6 · S6 kinase · Tetradecylglycidic acid · Unclassified drug · Animal experiment · Animal model · Animal tissue · Controlled study · Diabetic obesity · Diabetogenesis · Enzyme activation · Glucose clamp technique · Hyperinsulinemia · Insulin resistance · Lipid diet · Liver homogenate · Liver mitochondrion · Mitochondrial membrane · Nonhuman · Nutrient concentration · Nutrient content · Protein blood level · Protein induction · Protein phosphorylation · Protein synthesis · Protein targeting · Species comparison · 1-Phosphatidylinositol 3-Kinase · Animals · Blood Glucose · Dietary Fats · DNA, Mitochondrial · Electron Transport Complex IV · Fatty Acids · Fatty Liver · Insulin · Insulin Resistance · Leucine · Liver · Male · Mice · Mice, Inbred C57BL · Phosphorylation · Protein Kinases · Ribosomal Proteins
[Abstract]

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Showing 1 to 6 of 6 found. | Sort by date