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Showing 1 to 17 of 17 found. | Sort by date

1 Metabolism of tert-butylhydroquinone to S-substituted conjugates in the male fischer 344 rat
article 1996    
Author: Peters, M.M.C.G. · Lau, S.S. · Dulik, D. · Murphy, D. · Ommen, B. van · Bladeren, P.J. van · Monks, T.J.
Keywords: Toxicology · Animals · Antioxidants · Bile · Butylated Hydroxyanisole · Chromatography, High Pressure Liquid · Glutathione · Hydroquinones · Male · Mass Spectrometry · Rats · Rats, Inbred F344 · Sulfides
[Abstract]

2 Effect of dietary galacto-oligosaccharides on azoxymethane-induced aberrant crypt foci and colorectal cancer in Fischer 344 rats
article 2001    
Author: Wijnands, M.V.W. · Schoterman, H.C. · Bruijntjes, J.P. · Hollanders, V.M.H. · Woutersen, R.A.
Keywords: Nutrition · Animals · Anticarcinogenic Agents · Apoptosis · Azoxymethane · Body Weight · Carcinogens · Colorectal Neoplasms · Diet · Dose-Response Relationship, Drug · Eating · Energy Intake · Galactosides · Male · Oligosaccharides · Precancerous Conditions · Rats · Rats, Inbred F344
[Abstract]

3 Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats
article 2006    
Author: Dihal, A.A. · Boer, V.C.J. de · Woude, H. van der · Tilburgs, C. · Bruijntjes, J.P. · Alink, G.M. · Rietjens, I.M.C.M. · Woutersen, R.A. · Stierum, R.H.
Keywords: Toxicology · Toxicology and Applied Pharmacology · azoxymethane · quercetin · rutoside · animal experiment · animal model · animal tissue · article · body weight · carcinogenesis · colorectal cancer · diet supplementation · drug effect · incidence · male · nonhuman · rat · survival · Animals · Azoxymethane · beta Catenin · Body Weight · Cell Proliferation · Colorectal Neoplasms · Dietary Supplements · Male · Precancerous Conditions · Quercetin · Rats · Rats, Inbred F344 · Rutin
[Abstract]

4 Absence of an inhibitory effect of a vegetables-fruit mixture on the initiation and promotion phases of azoxymethane-induced colorectal carcinogenesis in rats fed low- or high-fat diets
article 1998    
Author: Rijnkels, J.M. · Hollanders, V.M.H. · Woutersen, R.A. · Koeman, J.H. · Alink, G.M.
Keywords: Nutrition · Azoxymethane · Animal experiment · Animal model · Animal tissue · Article · Carcinogenesis · Colorectal cancer · Controlled study · Dietary intake · Fruit · Lipid diet · Low fat diet · Male · Nonhuman · Rat · Tumor promotion · Tumor volume · Vegetable · Adenocarcinoma · Adenoma · Animals · Azoxymethane · Carcinogens · Colorectal Neoplasms · Diet · Diet, Fat-Restricted · Dietary Fats · Fruit · Male · Rats · Rats, Inbred F344 · Vegetables
[Abstract]

5 Local lymph node activation in rats after dermal application of the sensitizers 2,4-dinitrochlorobenzene and trimellitic anhydride
article 1996    
Author: Arts, J.H.E. · Dröge, S.C.M. · Bloksma, N. · Kuper, C.F.
Keywords: Toxicology · Administration, Topical · Allergens · Animals · Antimetabolites · Bromodeoxyuridine · Cell Division · Dinitrochlorobenzene · Dose-Response Relationship, Drug · Ear, External · Female · Irritants · Kidney · Liver · Lymph Nodes · Mice · Mice, Inbred BALB C · Organ Size · Phthalic Anhydrides · Rats · Rats, Inbred BN · Rats, Inbred F344 · Rats, Inbred Strains · Rats, Sprague-Dawley · Rats, Wistar · Skin · Spleen
[Abstract]

6 Chronic quercetin exposure affects fatty acid catabolism in rat lung
article 2006    
Author: Boer, V.C.J. de · Schothorst, E.M. van · Dihal, A.A. · Woude, H. van der · Arts, I.C.W. · Rietjens, I.M.C.M. · Hollman, P.C.H. · Keijer, J.
Keywords: Biomedical Research · Fatty acid metabolism · Flavonoids · Microarray · Nutrigenomics · Polyphenols · Quercetin · fatty acid · quercetin · animal experiment · article · catabolism · controlled study · diet · genomics · health · ketogenesis · lung parenchyma · male · microarray analysis · nonhuman · nucleotide sequence · oxidation · quantitative analysis · rat · real time polymerase chain reaction · unindexed sequence · upregulation · Animals · Diet · Fatty Acids · Gene Expression Regulation · Lung · Male · Oligonucleotide Array Sequence Analysis · Quercetin · Rats · Rats, Inbred F344
[Abstract]

7 Subacute (28-day) toxicity of furfural in Fischer 344 rats: A comparison of the oral and inhalation route
article 2004    
Author: Arts, J.H.E. · Muijser, H. · Appel, M.J. · Kuper, C.F. · Bessems, J.G.M. · Woutersen, R.A.
Keywords: Biology Health · Toxicology and Applied Pharmacology · Fischer rat · Furfural · Inhalation · Oral · Route-to-route extrapolation · Subacute toxicity · corn oil · furfural · air · animal experiment · animal model · animal tissue · article · comparative study · concentration response · controlled study · exposure · female · histopathology · kidney mass · liver weight · male · mortality · nonhuman · olfactory epithelium · rat · survival · toxicity testing · Administration, Inhalation · Administration, Oral · Animals · Dose-Response Relationship, Drug · Female · Furaldehyde · Kidney · Liver · Longevity · Male · No-Observed-Adverse-Effect Level · Olfactory Mucosa · Organ Size · Rats · Rats, Inbred F344 · Zea mays
[Abstract]

8 Differences in cytochrome P450-mediated biotransformation of 1,2- dichlorobenzene by rat and man: Implications for human risk assessment
article 1996    
Author: Hissink, A.M. · Oudshoorn, M.J. · Ommen, B. van · Haenen, G.R.M.M. · Bladeren, P.J. van
Keywords: 1,2 dichlorobenzene · ascorbic acid · cytochrome p450 · epoxide hydrolase · glutathione · glutathione transferase · isoniazid · phenobarbital · animal cell · animal experiment · article · biotransformation · conjugation · controlled study · covalent bond · human · human cell · hydrolysis · liver microsome metabolism · liver toxicity · male · nonhuman · rat · Animals · Biotransformation · Chlorobenzenes · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Humans · Insecticides · Isoenzymes · Male · Microsomes, Liver · Protein Binding · Rats · Rats, Inbred F344 · Rats, Sprague-Dawley · Rats, Wistar · Risk Assessment · Species Specificity · Spectrophotometry, Ultraviolet · Animalia · Rattus norvegicus
[Abstract]

9 Tissue distribution of quercetin in rats and pigs
article 2005    
Author: Boer, V.C.J. de · Dihal, A.A. · Woude, H. van der · Arts, I.C.W. · Wolffram, S. · Alink, G.M. · Rietjens, I.M.C.M. · Keijer, J. · Hollman, P.C.H.
Keywords: Biology · Physiological Sciences · Flavonoids · Glucuronides · Polyphenols · Quercetin · Tissue distribution · carbon 14 · flavonoid · glucuronide · isorhamnetin · polyphenol derivative · quercetin · tamarixetin · unclassified drug · animal experiment · animal tissue · article · bioavailability · brain · controlled study · extraction · feeding · half life time · heart · high performance liquid chromatography · kidney · lung · male · metabolite · nonhuman · nutrition · rat · spleen · statistical analysis · swine · tissue distribution · white adipose tissue · Animals · Biological Availability · Body Weight · Chromatography, High Pressure Liquid · Male · Quercetin · Rats · Rats, Inbred F344 · Swine · Tissue Distribution · Sus scrofa
[Abstract]

10 Increased bioactivation of dihaloalkanes in rat liver due to induction of class Theta glutathione S-transferase T1-1
article 1998    
Author: Sherratt, P.J. · Manson, M.M. · Thomson, A.M. · Hissink, E.A.M. · Neal, G.E. · Bladeren, P.J. van · Green, T. · Hayes, J.D.
Keywords: Nutrition · 3 indolemethanol · Alkane derivative · Antineoplastic agent · Cytochrome p450 · Glutathione transferase · Liver enzyme · Messenger rna · Phenobarbital · Animal tissue · Cancer prevention · Chemoprophylaxis · Controlled study · Cytoplasm · Diet · Enzyme subunit · Female · Immunoblotting · Male · Nonhuman · Priority journal · Rat · Animals · Anticarcinogenic Agents · Biotransformation · Carcinogens · Dietary Supplements · Enzyme Induction · Female · Glutathione Transferase · Humans · Hydrocarbons, Brominated · Isoenzymes · Liver · Male · Methylene Chloride · Phenobarbital · Rats · Rats, Inbred F344 · Sex Characteristics · Xenobiotics · Animalia
[Abstract]

11 Effects of high fat fish oil and high fat corn oil diets on initiation of AOM-induced colonic aberrant crypt foci in male F344 rats
article 2003    
Author: Dommels, Y.E.M. · Heemskerk, S. · Berg, H. van den · Alink, G.M. · Bladeren, P.J. van · Ommen, B. van
Keywords: Nutrition Biology · Physiological Sciences · Aberrant crypt foci · Corn oil · Fish oil · Lipid peroxidation · PGE2 · azoxymethane · corn oil · cytochrome P450 1A1 · cytochrome P450 2B1 · fish oil · liver enzyme · polyunsaturated fatty acid · prostaglandin E2 · animal experiment · animal model · animal tissue · article · ascending colon · blood level · cancer incidence · cancer prevention · colon carcinogenesis · controlled study · detoxification · early cancer · enzyme activity · fat intake · feeding · lipid peroxidation · male · metabolic activation · nonhuman · oxidative stress · rat · reduction · species comparison · Animals · Azoxymethane · Body Weight · Carcinogens · Cecum · Choristoma · Colonic Diseases · Corn Oil · Diet · Dinoprostone · Eating · Epithelial Cells · Feces · Fish Oils · Lipid Peroxidation · Liver · Male · Organ Size · Rats · Rats, Inbred F344 · Zea mays
[Abstract]

12 Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis
article 2008    
Author: Dihal, A.A. · Woude, H. van der · Hendriksen, P.J.M. · Charif, H. · Dekker, L.J. · IJsselstijn, L. · Boer, V.C.J. de · Alink, G.M. · Burgers, P.C. · Rietjens, I.M.C.M. · Woutersen, R.A. · Stierum, R.H.
Keywords: Biology · Toxicology and Applied Pharmacology · Biomarker · Colorectal cancer · Quercetin · Transcriptomics · fatty acid · glutathione peroxidase 2 · heat shock protein · mitogen activated protein kinase · peroxisome proliferator activated receptor alpha · quercetin · transcriptome · animal experiment · animal model · article · cancer prevention · cell cycle · colon mucosa · colorectal cancer · controlled study · down regulation · energy metabolism · Fischer 344 rat · gene expression · gene targeting · genetic analysis · glycolysis · lipid degradation · male · nonhuman · nucleotide sequence · priority journal · proteomics · rat · statistical significance · tumor biopsy · Animals · Colon · Colorectal Neoplasms · Diet · Down-Regulation · Fatty Acids · Gene Expression Profiling · Glycolysis · Intestinal Mucosa · Male · Mitochondria · Proteome · Quercetin · Rats · Rats, Inbred F344 · Rattus
[Abstract]

13 Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure
article 2005    
Author: Heijne, W.H.M. · Jonker, D. · Stierum, R.H. · Ommen, B. van · Groten, J.P.
Keywords: Toxicology Biology · Toxicology and Applied Pharmacology · Benzene · cDNA microarrays · Gene expression · Hepatotoxicity · Metabolomics · Toxicogenomics · Transcriptomics · benzene · bromobenzene · paracetamol · animal experiment · animal tissue · biotransformation · blood toxicity · cholesterol metabolism · conference paper · DNA microarray · gene expression · genetic analysis · genetic toxicology · glutathione metabolism · liver necrosis · liver weight · male · nonhuman · nuclear magnetic resonance spectroscopy · nucleotide sequence · priority journal · rat · rat strain · unindexed sequence · Animals · Benzene · Blood Cell Count · Cholesterol · Fatty Acids · Gene Expression Profiling · Gene Expression Regulation · Hemoglobins · Liver · Male · Mutagens · Oligonucleotide Array Sequence Analysis · Organ Size · Rats · Rats, Inbred F344 · Spleen · Thymus Gland · Time Factors · Urinalysis · Martes pennanti
[Abstract]

14 Intestinal T lymphocytes of different rat strains in immunotoxicity
article 1999    
Author: Bruder, M.C. · Spanhaak, S. · Bruijntjes, J.P. · Michielsen, C.P.P.C. · Vos, J.G. · Kuper, C.F.
Keywords: Nutrition · Azathioprine · Gut mucosal immunity · Hexachlorobenzene · Intraepithelial lymphocytes · Lamina propria lymphocytes · Azathioprine · Hexachlorobenzene · Animal experiment · Blood toxicity · Cell count · Cell isolation · Controlled study · Drug effect · Drug targeting · Female · Flow cytometry · Gastrointestinal toxicity · Immunomodulation · Immunotoxicity · Intestine epithelium · Intestine mucosa · Male · Nonhuman · Oral drug administration · Priority journal · Rat · T lymphocyte · Animals · Azathioprine · Body Weight · CD4-CD8 Ratio · CD4-Positive T-Lymphocytes · CD8-Positive T-Lymphocytes · Female · Flow Cytometry · Hexachlorobenzene · Immunohistochemistry · Immunosuppressive Agents · Intestinal Mucosa · Intestines · Killer Cells, Natural · Lymphocyte Count · Male · Rats · Rats, Inbred F344 · Rats, Inbred Lew · Rats, Wistar · Receptors, Antigen, T-Cell, gamma-delta · Species Specificity · T-Lymphocytes · Animalia · Rattus norvegicus
[Abstract]

15 Parallelogram approach using rat-human In vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans
article 2009    
Author: Kienhuis, A.S. · Poll, M.C.G. van de · Wortelboer, H. · Herwijnen, M. van · Gottschalk, R. · Jong, C.H.C. de · Boorsma, A. · Paules, R.S. · Kleinjans, J.C.S. · Stierum, R.H. · Delft, J.H.M. van
Keywords: Toxicology · Biotechnology · Acetaminophen · Gene expression profiling · Hepatocyte-based in vitro models · Interspecies extrapolation · Liver injury · T-profiler · oxidoreductase · paracetamol · adult · aged · animal cell · animal experiment · animal model · animal tissue · article · biological activity · cell function · chemical analysis · controlled study · energy consumption · enzyme activity · female · gene expression profiling · gene repression · human · human cell · human tissue · human versus animal comparison · in vitro study · in vivo study · liver cell · liver metabolism · liver mitochondrion · liver toxicity · male · nonhuman · rat · species comparison · toxicogenetics · Acetaminophen · Adult · Aged · Analgesics, Non-Narcotic · Animals · Cell Survival · Cells, Cultured · Female · Hepatitis, Toxic · Hepatocytes · Humans · In Situ Hybridization · Male · Predictive Value of Tests · Rats · Rats, Inbred F344 · Rats, Wistar · RNA · Species Specificity · Toxicogenetics · Rattus · Rodentia
[Abstract]

16 Do aberrant crypt foci have predictive value for the occurrence of colorectal tumours? Potential of gene expression profiling in tumours
article 2004    
Author: Wijnands, M.V.W. · Erk, M.J. van · Doornbos, R.P. · Krul, C.A.M. · Woutersen, R.A.
Keywords: Biology · Analytical research · AC, aberrant crypt · ACF, aberrant crypt focus · AIN, American Institute of Nutrition · ANOVA, analysis of variance · AOM, azoxymethane · BIT, benzyl isothiocyanate · CA2, carbonic anhydrase II · CDK4, cyclin-dependent kinase 4 · cDNA, complementary DNA · benzyl isothiocyanate · curcumin · rutoside · animal experiment · animal model · animal tissue · antineoplastic activity · article · carcinogenesis · colorectal tumor · controlled study · correlation analysis · crypt cell · dietary intake · disease marker · drug effect · gene expression profiling · intestine crypt · male · nonhuman · oncogene · prediction · protein expression · rat · scoring system · statistical significance · time series analysis · wheat bran · Animals · Anticarcinogenic Agents · Body Weight · Colorectal Neoplasms · Diet · DNA Primers · DNA, Complementary · Eating · Energy Metabolism · Gene Expression Profiling · Gene Expression Regulation, Neoplastic · Intestinal Mucosa · Male · Predictive Value of Tests · Rats · Rats, Inbred F344 · Reverse Transcriptase Polymerase Chain Reaction · RNA, Neoplasm · Survival Analysis · Tissue Inhibitor of Metalloproteinase-1 · Tumor Markers, Biological · Triticum aestivum
[Abstract]

17 Transcriptomics analysis of interactive effects of benzene, trichloroethylene and methyl mercury within binary and ternary mixtures on the liver and kidney following subchronic exposure in the rat
article 2007    
Author: Hendriksen, P.J.M. · Freidig, A.P. · Jonker, D. · Thissen, U. · Bogaards, J.J.P. · Mumtaz, M.M. · Groten, J.P. · Stierum, R.H.
Keywords: Biology · Analytical research · Biomedical research · Benzene · Mercury · Microarrays · Mixtures · Toxicogenomics · Trichloroethylene · benzene · biological marker · messenger RNA · methylmercury · trichloroethylene · animal experiment · animal tissue · apoptosis · article · Ccng1 gene · cell proliferation · cell viability · controlled study · gene · gene expression profiling · gene induction · id2 gene · liver toxicity · long term exposure · male · MDM2 gene · microarray analysis · nephrotoxicity · NFKB1 gene · nonhuman · Nr2f6 gene · rat · stress · tissue specificity · tnfrsf1a gene · toxicogenetics · transcriptomics · Animals · Benzene · Cell Survival · Drug Interactions · Drug Synergism · Environmental Pollutants · Gene Expression Profiling · Gene Expression Regulation · Kidney · Liver · Male · Methylmercury Compounds · No-Observed-Adverse-Effect Level · Oligonucleotide Array Sequence Analysis · Rats · Rats, Inbred F344 · RNA, Messenger · Toxicity Tests · Trichloroethylene · Rattus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 17 of 17 found. | Sort by date