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1 Stimulation of the in Vivo Production of Very Low Density Lipoproteins by Apolipoprotein E Is Independent of the Presence of the Low Density Lipoprotein Receptor
article 2001    
Author: Teusink, B. · Mensenkamp, A.R. · Boom, H. van der · Kuipers, F. · Dijk, K.W. van · Havekes, L.M.
Keywords: Animalia · Gillia · Animals · Apolipoproteins E · Lipoproteins, VLDL · Male · Mice · Mice, Inbred C57BL · Mice, Knockout · Receptors, LDL
[PDF] [Abstract]

2 Identification of three new mutations of the low density lipoprotein receptor gene in dutch familial hypercholesterolemic patients
article 1998    
Author: Lombardi, P. · Sijbrands, E.J.G. · Kamerling, S. · Smelt, A.H. · Havekes, L.M.
Keywords: Health · Adult · Aged · Codon, Terminator · DNA · DNA Mutational Analysis · Exons · Humans · Hyperlipoproteinemia Type II · Introns · Mutagenesis, Insertional · Mutation · Netherlands · Point Mutation · Receptors, LDL

3 Mutations in the low density lipoprotein receptor gene of familial hypercholesterolemic patients detected by denaturing gradient gel electrophoresis and direct sequencing
article 1995    
Author: Lombardi, P. · Sijbrands, E.J.G. · Giessen, K. van de · Smelt, A.H.M. · Kastelein, J.J.P. · Frants, R.R. · Havekes, L.M.
Keywords: Base Sequence · DNA Primers · Electrophoresis, Agar Gel · Human · Hypercholesterolemia, Familial · Molecular Sequence Data · Point Mutation · Polymorphism (Genetics) · Receptors, LDL · Sequence Analysis · Support, Non-U.S. Gov't
[PDF] [Abstract]

4 Protection from obesity in mice lacking the VLDL receptor
article 2001    
Author: Goudriaan, J.R. · Tacken, P.J. · Dahlmans, V.E.H. · Gijbels, M.J.J. · Dijk, K.W. van · Havekes, L.M. · Jong, M.C.
Keywords: Adipose Tissue · Animals · Diet, Atherogenic · Fatty Acids · Glucose Tolerance Test · Insulin Resistance · Mice · Mice, Knockout · Mice, Obese · Mice, Transgenic · Obesity · Receptors, LDL · Triglycerides · Weight Gain
[Abstract]

5 Decreased expression of both the low-density lipoprotein receptor-related protein/α2-macroglobulin receptor and its receptor-associated protein in late stages of cutaneous melanocytic tumor progression
article 1996    
Author: Vries, T.J. de · Verheijen, J.H. · Bart, A.C.W. de · Weidle, U.H. · Ruiter, D.J. · Muijen, G.N.P. van
Keywords: Animals · Flow Cytometry · Fluorescent Antibody Technique · Humans · LDL-Receptor Related Protein 1 · Melanoma · Neoplasm Proteins · Rats · Rats, Nude · Receptors, Immunologic · Receptors, LDL · RNA, Messenger · Skin Neoplasms · Transplantation, Heterologous
[Abstract]

6 An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins
article 1999    
Author: Vlijmen, B.J.M. van · Rohlmann, A. · Page, S.T. · Bensadoun, A. · Bos, I.S.T. · Berkel, T.J.C. van · Havekes, L.M. · Herz, J.
Keywords: Animals · Binding Sites · Cholesterol · Chylomicrons · Detergents · Gene Transfer Techniques · Heymann Nephritis Antigenic Complex · Immunoblotting · LDL-Receptor Related Protein 1 · Lipase · Lipoprotein Lipase · Liver · Membrane Glycoproteins · Mice · Mice, Transgenic · Polyethylene Glycols · Rats · Receptors, Immunologic · Receptors, LDL · Time Factors · Transfection · Triglycerides
[PDF] [Abstract]

7 Hyperlipidemia of ApoE2(Arg158-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression
article 1999    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Winther, M.P.J. de · Hof, B. van 't · Zee, A. van der · Boom, H. van der · Havekes, L.M. · Hofker, M.H.
Keywords: Biology · Apolipoprotein E · Hypertriglyceridemia · LDL receptor · LDL receptor-related protein · VLDL triglyceride lipolysis · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol, VLDL · Gene Expression · Hypertriglyceridemia · Lipolysis · Mice · Mice, Knockout · Point Mutation · Receptors, LDL · Triglycerides
[Abstract]

8 The binding of human lipoprotein lipase treated VLDL by the human hepatoma cell line HepG2
article 1991    
Author: Mulder, M. · Wit, E.de · Havekes, L.M.
Keywords: Biology · HepG2 cell line · LDLD receptor · Lipoprotein lipase · Remnant receptor · VLDL · VLDL remnant · Binding, Competitive · Carcinoma, Hepatocellular · Human · Lipoprotein Lipase · Lipoproteins, LDL · Lipoproteins, VLDL · Liver Neoplasms · Receptors, LDL · Triglycerides · Tumor Cells, Cultured · Bovinae
[Abstract]

9 Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor
article 1998    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Zee, A. van der · Hof, B. van 't · Boom, H. van der · Kobayashi, K. · Chan, L. · Havekes, L.M. · Hofker, M.H.
Keywords: Health · ApoE variants · Atherosclerosis · Gene therapy · VLDL receptor · Adenoviridae · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Female · Gene Transfer Techniques · Humans · Hypercholesterolemia · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL · Triglycerides
[Abstract]

10 Similar response to simvastatin in patients heterozygous for familial hypercholesterolemia with mRNA negative and mRNA positive mutations
article 1998    
Author: Sijbrands, E.J.G. · Lombardi, M.P. · Westendorp, R.G.J. · Gevers Leuven, J.A. · Meinders, A.E. · Laarse, A. van der · Frants, R.R. · Havekes, L.M. · Smelt, A.H.M.
Keywords: Health · Familial hypercholesterolemia · LDL receptor gene · Simvastatin · Xanthomas · Anticholesteremic Agents · Cholesterol, HDL · Cholesterol, LDL · Female · Heterozygote · Humans · Hyperlipoproteinemia Type II · Male · Middle Aged · Mutation · Receptors, LDL · RNA, Messenger · Simvastatin
[Abstract]

11 Cafestol increases serum cholesterol levels in apolipoprotein E*3- leiden transgenic mice by suppression of bile acid synthesis
article 2000    
Author: Post, S.M. · Roos, B.de · Vermeulen, M. · Afman, L. · Jong, M.C. · Dahlmans, V.E.H. · Havekes, L.M. · Stellaard, F. · Katan, M.B. · Princen, H.M.G.
Keywords: Biology · Animals · Apolipoprotein E3 · Apolipoproteins E · Bile Acids and Salts · Cholesterol · Diet · Diterpenes · Feces · Female · Lipid Metabolism · Lipoproteins · Lipoproteins, IDL · Lipoproteins, VLDL · Liver · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Receptors, LDL
[Abstract]

12 In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE
article 1999    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Hof, H.B. van 't · Zee, A. van der · Santamarina-Fojo, S. · Berkel, T.J.C. van · Havekes, L.M. · Hofker, M.H.
Keywords: Health · Adenovirus-mediated gene transfer · Hepatic VLDL triglyceride production · Hypertriglyceridemia · LDL receptor-related protein · VLDL-triglyceride lipolysis · Adenovirus · Adenoviridae · Animals · Apolipoproteins E · Cholesterol · Female · Humans · Immunohistochemistry · Lipolysis · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Receptors, LDL · Transfection · Triglycerides
[PDF] [Abstract]

13 Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice
article 2000    
Author: Herijgers, N. · Winther, M.P.J. de · Eck, M. van · Havekes, L.M. · Hofker, M.H. · Hoogerbrugge, P.M. · Berkel, T.J.C. van
Keywords: Acetylation · Animals · Arteriosclerosis · Bone Marrow Cells · Bone Marrow Transplantation · Cell Adhesion Molecules · Female · Humans · Lipoproteins · Lipoproteins, LDL · Macrophages, Peritoneal · Mice · Mice, Knockout · Mice, Transgenic · Receptors, Immunologic · Receptors, LDL · Receptors, Scavenger · Scavenger Receptors, Class A
[PDF] [Abstract]

14 In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 → Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice
article 1996    
Author: Vlijmen, B.J.M. van · Dijk, K.W. van · Hof, H.B. van 't · Gorp, P.J.J. van · Zee, A. van der · Boom, H. van der · Breuer, M.L. · Hofker, M.H. · Havekesf, L.M.
Keywords: Animals · Apolipoproteins E · Arginine · Cells, Cultured · Cysteine · Genes, Dominant · Heymann Nephritis Antigenic Complex · Hyperlipoproteinemias · Lipoproteins, LDL · Lipoproteins, VLDL · Membrane Glycoproteins · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL · Adenoviridae · Animalia · Mus musculus
[PDF] [Abstract]

15 Binding of LP(a) to the low density lipoprotein receptor of human fibroblasts
article 1981    
Author: Havekes, L. · Vermeer, B.J. · Brugman, T. · Emeis, J.
Keywords: low density lipoprotein · fibroblast culture · human cell · in vitro study · Cells, Cultured · Fibroblasts · Fluorescent Antibody Technique · Human · Hypercholesterolemia, Familial · Lipoprotein(a) · Lipoproteins · Lipoproteins, LDL · Male · Microscopy, Electron · Middle Age · Receptors, Cell Surface · Receptors, LDL
[PDF] [Abstract]

16 The role of the low-density lipoprotein receptor-related protein (LRP) in the plasma clearance and liver uptake of recombinant single-chain urokinase-type plasminogen activator in rats
article 1997    
Author: Kaaden, M.E. van der · Rijken, D.C. · Kruijt, J.K. · Berkel, T.J.C. van · Kuiper, J.
Keywords: Animals · Drug Evaluation, Preclinical · Iodine Radioisotopes · Kupffer Cells · LDL-Receptor Related Protein 1 · Liver · Male · Metabolic Clearance Rate · Plasminogen Activators · Rats · Rats, Wistar · Receptors, Immunologic · Receptors, LDL · Recombinant Proteins · Tissue Distribution · Urinary Plasminogen Activator
[Abstract]

17 Characterization of atherosclerotic lesions in apo E3-leiden transgenic mice
article 1998    
Author: Leppänen, P. · Luoma, J.S. · Hofker, M.H. · Havekes, L.M. · Ylä-Herttuala, S.
Keywords: Health · Apo E · Familial dyslipoproteinemia · LRP · Oxidized LDL · Scavenger receptor · Animals · Aorta · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Cholesterol · Electrophoresis, Agar Gel · Foam Cells · Humans · LDL-Receptor Related Protein 1 · Lipoproteins, LDL · Mice · Mice, Inbred C57BL · Mice, Transgenic · Receptors, Immunologic · Receptors, LDL
[Abstract]

18 Low-density lipoproteins are degraded in HepG2 cells with low efficiency
article 1993    
Author: Lombardi, P. · Mulder, M. · Wit, E. de · Berkel, T.J.C. van · Frants, R.R. · Havekes, L.M.
Keywords: Low density lipoprotein · Low density lipoprotein receptor · Cell density · Cell fractionation · Comparative study · Density gradient centrifugation · Endosome · Hepatoma cell · Human cell · Internalization · Isotope labeling · Lipoprotein metabolism · Protein degradation · Receptor down regulation · Biological Transport · Cell Aggregation · Cell Line · Cells, Cultured · Down-Regulation · Fibroblasts · Human · Iodine Radioisotopes · Kinetics · Lipoproteins, LDL · Liver · Lysosomes · Receptors, LDL · Support, Non-U.S. Gov't
[Abstract]

19 Low density lipoprotein receptor internalizes low density and very low density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase
article 1993    
Author: Mulder, M. · Lombardi, P. · Jansen, H. · Berkel, T.J.C. van · Frants, R.R. · Havekes, L.M.
Keywords: Biology · Animal · Biological Transport · Carcinoma, Hepatocellular · Cattle · Female · Fibroblasts · Heparan Sulfate Proteoglycan · Heparin Lyase · Heparitin Sulfate · Human · Kinetics · Lipoprotein Lipase · Lipoproteins, LDL · Lipoproteins, VLDL · Liver Neoplasms · Milk · Models, Biological · Polysaccharide-Lyases · Protein Binding · Proteoglycans · Receptors, LDL · Support, Non-U.S. Gov't · Tumor Cells, Cultured
[PDF] [Abstract]

20 An acceptor splice site mutation in intron 16 of the low density lipoprotein receptor gene leads to an elongated, internalization defective receptor
article 1993    
Author: Lombardi, P. · Hoffer, M.J.V. · Top, B. · Wit, E. de · Gevers Leuven, J.A. · Frants, R.R. · Havekes, L.M.
Keywords: Denaturating gradient gel electrophoresis · Polymerase chain reaction · Complementary dna · Low density lipoprotein receptor · Case report · Dna sequence · Familial hypercholesterolemia · Gel electrophoresis · Mutation · Pedigree analysis · Polymerase chain reaction · Adult · Amino Acid Sequence · Base Sequence · Cells, Cultured · Electrophoresis · Female · Homozygote · Human · Hypercholesterolemia, Familial · Introns · Molecular Sequence Data · Pedigree · Point Mutation · Reading Frames · Receptors, LDL · RNA Splicing · Sequence Analysis, DNA · Support, Non-U.S. Gov't
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 34 found. Next | Sort by date