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1 Efficacy of prophylaxis and treatment against soman intoxication
article 2004    
Author: Philippens, I.H.C.H.M. · Jongsma, M.J. · Vanwersch, R.A.P.
Keywords: Warfare · Prophylaxis · Soman
[Abstract]

2 Treatment efficacy in a soman-poisoned guinea pig model: Added value of physostigmine?
article 2011    
Author: Joosen, M.J.A. · Smit, A.B. · Helden, H.P.M. van
Keywords: Chemistry · Obidoxime · Organophosphate · Physostigmine · Seizures · Soman · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 GLC-analysis and pharmacokinetics of the four stereoisomers of soman
article 1981    
Author: Benschop, H.P. · Berends, F. · Jong, L.P.A. de
Keywords: Biology · Organophosphorus compound · Soman · Animal · Gas chromatography · Kinetics · Metabolism · Rat · Stereoisomerism · Animal · Chromatography, Gas · Kinetics · Organophosphorus Compounds · Rats · Soman · Stereoisomerism · organophosphorus compound · G agents · Prophylaxis · Therapy · Blood · Skin (anatomy) · GC - Gas chromatography · Reaction kinetics · Stereochemistry · Degradation
[Abstract]

4 Persistence of the anti-cholinesterase soman in rats: Antagonism with a non-toxic simulator of this organophosphate
article 1981    
Author: Wolthuis, O.L. · Benschop, H.P. · Berends, F.
Keywords: Biology · Acetylcholinesterase · Atropine · Soman · Animal experiment · Controlled study · Drug intoxication · Intoxication · Intravenous drug administration · Rat · Simulator · Sustained release preparation · Acetylcholinesterase · Animal · Male · Organophosphorus Compounds · Pyridinium Compounds · Rats · Soman · Time Factors
[Abstract]

5 Increasing nerve agent treatment efficacy by P-glycoprotein inhibition
article 2016    
Author: Joosen, M.J.A. · Vester, S.M. · Hamelink, J. · Klaassen, S.D. · Berg, R.M. van den
Keywords: Atropine · Oxime · p-Glycoprotein · Seizures · Soman · Tariquidar · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

6 On the development of behavioral tolerance to organophosphates IV: EEG and visual evoked responses
article 1991    
Author: Wolthuis, O.L. · Philippens, I.H.C.H.M. · Vanwersch, R.A.P.
Keywords: Vision · DFP · EEG · Organophosphates · Soman · Tolerance · VER · Dyflos · Soman · Animal experiment · Behavior · Controlled study · Drug tolerance · Electric shock · Electroencephalogram · Evoked visual response · Male · Nonhuman · Pupil · RatS · Rectum temperature · Animal · Behavior, Animal · Body Temperature · Conditioning, Operant · Drug Tolerance · Electroencephalography · Electroshock · Evoked Potentials, Visual · Isoflurophate · Male · Organophosphorus Compounds · Rats, Inbred Strains · Isoflurophate, 55-91-4 · Organophosphorus Compounds · Soman, 96-64-0
[Abstract]

7 Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning
article 2009    
Author: Joosen, M.J.A. · Jousma, E. · Boom, T.M. van den · Kuijpers, W.C. · Smit, A.B. · Lucassen, P.J. · Helden, H.P.M. van
Keywords: Toxicology · Learning · Memory · Neurogenesis · Olanzapine · Organophosphate · Soman · acetylcholine · acetylcholinesterase · atropine · doublecortin · olanzapine · soman · animal experiment · animal model · animal tissue · article · body weight · cell survival · cognitive defect · controlled study · corpus striatum · developmental disorder · drug efficacy · drug treatment failure · histopathology · learning disorder · male · maze test · memory disorder · nervous system development · neurotoxicity · nonhuman · osmotic minipump · priority journal · rat · recurrent disease · seizure · Acetylcholine · Acetylcholinesterase · Animals · Atropine · Benzodiazepines · Cholinesterase Reactivators · Corpus Striatum · Hippocampus · Male · Maze Learning · Neurogenesis · Pyridinium Compounds · Rats · Rats, Sprague-Dawley · Seizures · Soman · Animalia · Rattus
[Abstract]

8 New generic approach to the treatment of organophosphate poisoning: Adenosine receptor mediated inhibition of ACh-release
article 1998    
Author: Helden, H.P.M. van · Groen, B. · Moor, E. · Westerink, B.H.C. · Bruijnzeel, P.L.B.
Keywords: Adenosine-5'-(N-ethylcarboxamide) · Animals · Brain Chemistry · Cholinesterase Inhibitors · Dinucleoside Phosphates · Injections, Intramuscular · Injections, Subcutaneous · Poisoning · Rats · Receptors, Purinergic P1 · Soman · Survival Rate · Time Factors
[Abstract]

9 Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs
article 1998    
Author: Benschop, H.P. · Trap, H.C. · Spruit, H.E.T. · Wiel, H.J. van der · Langenberg, J.P. · Jong, L.P.A. de
Keywords: Perception · Atropine · Carboxylesterase · Cholinesterase · Animal cell · Blood level · Enzyme inhibition · Exposure · Guinea pig · Inhalation · Male · Neurotoxicity · Nonhuman · Stereoisomerism · Toxicokinetics · Administration, Inhalation · Animals · Carboxylic ester hydrolases · Chemical warfare agents · Dose-response relationship · Drugs · Erythrocytes · Soman · Stereoisomerism · Time factors · Atropine, 51-55-8 · Carboxylesterase, EC 3.1.1.1 · Carboxylic ester hydrolases, EC 3.1.1.- · Soman, 96-64-0
[Abstract]

10 The dependence of the blood level of the oxime HS 6 on the severity of organophosphate poisoning
article 1976    
Author: Wolthuis, O.L. · Clason-van der Wiel, H.J. · Visser, R.P.L.S.
Keywords: Biology · 1 (3 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Atropine · Cholinesterase inhibitor · Dimethyl ether · Soman · Drug analysis · Drug blood level · Drug intoxication · Intoxication · Intravenous drug administration · Pharmacokinetics · Plasma · Pralidoxime derivative · Rat · Respiratory failure · Theoretical study · Animal · Antidotes · Atropine · Dose-Response Relationship, Drug · Lethal Dose 50 · Male · Organophosphorus Compounds · Oximes · Rats · Soman
[Abstract]

11 Semi-continuous high speed gas analysis of generated vapors of chemical warfare agents
article 1999    
Author: Trap, H.C. · Langenberg, J.P.
Keywords: Automation · Data acquisition · Nerve agents · Sulfur mustard · Valve injection · Vapor analysis · Mustard gas · Nerve gas · Neurotoxin · Sarin · Soman · Analytic method · Animal experiment · Article · Autoanalysis · Chemical warfare · Chromatography · Gas analysis · Gas chromatography · Guinea pig · Neurotoxicity · Nonhuman · Toxicokinetics · Vapor · Mustard gas, 505-60-2 · Neurotoxin, 39386-17-9 · Sarin, 107-44-8 · Soman, 96-64-0
[Abstract]

12 A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodents
article 1978    
Author: Kepner, L.A. · Wolthuis, O.L.
Keywords: Biology · Atropine · Cholinesterase reactivator · Oxime · Soman · 1 (3 carbamoylpyridinio) 1 (2 hydroximinoethylpyridinio)dimethyl ether · Animal experiment · Breathing · Drug comparison · Drug intoxication · Drug response · Intoxication · Intraperitoneal drug administration · Mouse · Muscle · Musculoskeletal system · Neuromuscular transmission · Organophosphate poisoning · Rat · Respiratory system · Subcutaneous drug administration · Animal · Atropine · Comparative Study · Drug Synergism · Female · Male · Mice · Neuromuscular Junction · Organophosphorus Compounds · Oximes · Rats · Rats, Inbred Strains · Respiration · Soman
[Abstract]

13 On the oscillatory decay of the myotonic action of 9 anthroic acid. Influence of cholinesterase inhibition
article 1977    
Author: Velsen, F.L. van · Nickolson, V.J.
Keywords: Biology · 9 Anthroic acid · Acetylcholinesterase · Adenosine triphosphatase (potassium sodium) · Cholinesterase inhibitor · Curare · Ouabain · Soman · In vitro study · Muscle contraction · Myotonia · Rat · Theoretical study · Animal · Anthracenes · Calcium · Carboxylic Acids · Chlorides · Cholinesterase Inhibitors · Diaphragm · Drug Interactions · Electric Stimulation · In Vitro · Magnesium · Male · Motor Endplate · Muscle Contraction · Neuromuscular Junction · Ouabain · Potassium · Rats · Sodium · Soman
[Abstract]

14 Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers
article 1999    
Author: Ordentlich, A. · Barak, D. · Kronman, C. · Benschop, H.P. · Jong, L.P.A. de · Ariel, N. · Barak, R. · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Cholinesterase reactivator · Soman · Binding site · Chirality · Dealkylation · Enzyme activity · Enzyme analysis · Enzyme binding · Enzyme specificity · Enzyme structure · Enzyme substrate · Human cell · Protein expression · Stereochemistry · Stereoisomerism · Alkylation · Amino acid substitution · Binding sites · Cell line · Cholinesterase inhibitors · Humans · Hydrogen Bonding · Kidney · Macromolecular substances · Models, Molecular · Mutagenesis, Site-Directed · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Alanine, 56-41-7 · Phenylalanine, 63-91-2 · Phosphorus, 7723-14-0 · Soman, 96-64-0
[Abstract]

15 Successful oxime therapy one hour after soman intoxication in the rat
article 1978    
Author: Wolthuis, O.L. · Kepner, L.A.
Keywords: Biology · 1 (3 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Atropine · Cholinesterase · Oxime · Radioisotope · Soman · Acetylcholine h 3 · Aging · Animal experiment · Breathing · Cytology · Diaphragm · Drug comparison · Drug intoxication · In vitro study · Intoxication · Muscle · Neuromuscular transmission · Peripheral nervous system · Phrenic nerve · Rat · Respiratory failure · Respiratory system · Animal · Atropine · Cholinesterases · Diaphragm · Male · Muscle Contraction · Organophosphorus Compounds · Oximes · Phrenic Nerve · Rats · Soman · Time Factors
[Abstract]

16 Improvements of the fluoride reactivation method for the verification of nerve agent exposure
article 2004    
Author: Degenhardt, C.E.A.M. · Pleijsier, K. · Schans, M.J. van der · Langenberg, J.P. · Preston, K.E. · Solano, M.I. · Maggio, V.L. · Barr, J.R.
Keywords: Warfare · Biological marker · Cholinesterase · Cyclosarin · Organophosphorus compound · Potassium fluoride · Sarin · Soman · Tabun · Unclassified drug · Calibration · Chemical analysis · Chemical warfare · Enzyme activity · Gas chromatography · Human · Mass spectrometry · Methodology · Neurotoxicity · Plasma · Solid phase extraction · Biological Markers · Butyrylcholinesterase · Chemical warfare agents · Cholinesterase reactivators · Environmental exposure · Environmental monitoring · Erythrocytes · Fluorides · Gas Chromatography-Mass Spectrometry · Humans · Reproducibility of results · Sensitivity and specificity · Cholinesterase, 9001-08-5 · Cyclosarin, 329-99-7 · Potassium fluoride, 7789-23-3 · Sarin, 107-44-8 · Soman, 96-64-0 · Tabun, 77-81-6 · Biological Markers · Butyrylcholinesterase, EC 3.1.1.- · Chemical Warfare Agents · Cholinesterase reactivators · Fluorides
[Abstract]

17 The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including man
article 1981    
Author: Wolthuis, O. · Vanwersch, R.A.P. · Wiel, H.J. van der
Keywords: Biology · 1 (3 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · [(3 isobutyryl 1 pyridiniomethyl) (2 hydroxyiminomethyl 1 pyridiniomethyl)] ether · Sarin · Soman · Tubocurarine chloride · Unclassified drug · Animal experiment · Bispyridinium oxime · Diaphragm · Dog · Dose response · Drug comparison · Drug response · Guinea pig · Human cell · In vitro study · Intercostal muscle · Intravenous drug administration · Neuromuscular transmission · Rat · Adult · Aged · Animal · Antidotes · Chorionic Gonadotropin · Comparative Study · Dogs · Electric Stimulation · Female · Guinea Pigs · Human · In Vitro · Male · Middle Age · Neuromuscular Junction · Organophosphorus Compounds · Pralidoxime Compounds · Pyridinium Compounds · Rats · Sarin · Soman · Species Specificity · Synaptic Transmission
[Abstract]

18 The bispyridinium-dioxime HLö-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman
article 1989    
Author: Jong, L.P.A.de · Verhagen, M.A.A. · Langenberg, J.P. · Hagedorn, I. · Löffler, M.
Keywords: Biology · Bis(pyridinium oxime) derivative · Enzyme inhibitor · Organophosphorus compound · Radioisotope · Enzyme reactivation · Fish · Human · Nonbiological model · Nonhuman · Normal human · Rat · Stereoisomerism · Acetylcholinesterase 9000-81-1 · Animal · Cholinesterase Reactivators · Eels · Human · In Vitro · Organophosphorus Compounds · Oximes · Phosphoric Acid Esters · Pyridines · Pyridinium Compounds · Stereoisomerism · Structure-Activity Relationship · Organophosphorus compounds · Oximes · Phosphoric acid esters · Pyridines · Pyridinium compounds · Soman, 96-64-0 · Tabun, 77-81-6
[Abstract]

19 A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes for soman in multiple species
article 2006    
Author: Sweeney, R.E. · Langenberg, J.P. · Maxwell, D.M.
Keywords: Toxicology · Acetylcholinesterase · Carboxylesterase · Enzyme · Soman · Adipose tissue · Allometry · Animal experiment · Animal tissue · Arterial blood · Blood flow velocity · BLood level · Body weight · Breathing rate · Computer language · Computer simulation · Controlled study · Exposure · Guinea pig · In vitro study · Kidney perfusion · LD 50 · Liver perfusion · Lung perfusion · Male · Marmoset · Metabolism · Nonhuman · Partition coefficient · Priority journal · Provocation test · Rat · Regression analysis · Sensitivity analysis · Stereoisomerism · Tidal volume · Tissue level · Toxicokinetics · Venous blood · Administration, Inhalation · Animals · Callithrix · Chemical Warfare Agents · Cholinesterase Inhibitors · Computer Simulation · Guinea Pigs · Injections, Intravenous · Injections, Subcutaneous · Male · Models, Biological · Rats · Rats, Wistar · Animalia · Cavia porcellus · Marmosets · Acetylcholinesterase, 9000-81-1 · Carboxylesterase, 59536-71-9, 83380-83-0, 9016-18-6, 9028-01-7 · Soman, 96-64-0 · Chemical warfare agents · Cholinesterase inhibitors
[Abstract]

20 Retrospective detection of exposure to nerve agents: Analysis of phosphofluoridates originating from fluoride-induced rectivation of phospylated BuChE
article 2004    
Author: Schans, M.J. van der · Polhuijs, M. · Dijk, C. van · Degenhardt, C.E.A.M. · Pleijsier, K. · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Biomarker · Biomonitoring · Butyryl cholinesterase · Fluoride ions · Lexposure · Nerve agents · Organophosphates · Reactivation · Retrospective detection · Cholinesterase · Cholinesterase inhibitor · Cyclosarin · Fluoride · Nerve gas · Organophosphate · Paraoxon · Parathion · Phosphorus derivative · Sarin · Soman · Tabun · Unclassified drug · Biological monitoring · Biological warfare · Chemical structure · Concentration (parameters) · Environmental exposure · Enzyme activation · Enzyme active site · Enzyme inhibition · Gas chromatography · Half life time · Human · Nonhuman · pH · Priority journal · Retrospective study · Rhesus monkey · Animals · Butyrylcholinesterase · Chemical Warfare Agents · Cholinesterase Inhibitors · Cholinesterase Reactivators · Gas chromatography · Female · Fluorides · Half-Life · Humans · Injections, Intravenous · Macaca mulatta · Male · Organophosphorus compounds · Paraoxon · Reference standards · Time factors · Macaca mulatta · Cholinesterase, 9001-08-5 · Cyclosarin, 329-99-7 · Fluoride, 16984-48-8 · Paraoxon, 311-45-5 · Parathion, 3270-86-8, 56-38-2, 597-88-6 · Sarin, 107-44-8 · Soman, 96-64-0 · Tabun, 77-81-6 · Butyrylcholinesterase, EC 3.1.1.- · Chemical warfare agents · Cholinesterase inhibitors · Cholinesterase reactivators · Fluorides · Organophosphorus compounds
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 25 found. Next | Sort by date