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1 Structural and biological evaluation of some loloatin C analogues
article 2009    
Author: Tuin, A.W. · Grotenbreg, G.M. · Spalburg, E. · Neeling, A.J. de · Mars-Groenendijk, R.H. · Noort, D. · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Chemistry · Cationic antimicrobial peptide · Loloatin C · Structure-activity relationship · Sugar amino acid
[Abstract]

2 Summary of the report 'Toxicology-Based Recommended Exposure Limits'
article 1997    
Author: Notten, W.R.F. · Passchier, W.F. · Vliet, P.W. van
Keywords: Toxicology · Environmental Exposure · Guidelines · Humans · Netherlands · Occupational Exposure · Structure-Activity Relationship

3 Using chemical categories to fill data gaps in hazard assessment.
article 2009    
Author: Leeuwen, K. van · Schultz, T.W. · Henry, T. · Diderich, B. · Veith, G.D.
Keywords: Chemistry · Food and Chemical Risk Analysis · dangerous goods · methodology · quantitative structure activity relation · review · safety · Hazardous Substances · Quantitative Structure-Activity Relationship · Safety Management
[Abstract]

4 Evaluation of the factors contributing to fibrin-dependent plasminogen activation
article 1998    
Author: Mosesson, M.W. · Siebenlist, K.R. · Voskuilen, M. · Nieuwenhuizen, W.
Keywords: Afibrinogenemia · Enzyme Activation · Epitopes · Factor XIII · Fibrin · Fibrinogen · Humans · Macromolecular Substances · Plasmin · Plasminogen · Protein Conformation · Sequence Deletion · Structure-Activity Relationship · Tissue Plasminogen Activator
[Abstract]

5 Structural requirements of fibrinogen A alpha-(148-160) for the enhancement of the rate of plasminogen activation by tPA.
article 1990    
Author: Schielen, W.J. · Voskuilen, M. · Adams, P.J. · Tesser, G.I. · Nieuwenhuizen, W.
Keywords: Biology · Amino Acid Sequence · Enzyme Activation · Fibrinogen · Kinetics · Molecular Sequence Data · Molecular Structure · Peptide Fragments · Plasminogen · Structure-Activity Relationship · Tissue Plasminogen Activator
[Abstract]

6 Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps
article 2008    
Author: Loizou, G. · Spendiff, M. · Barton, H.A. · Bessems, J. · Bois, F.Y. · d'Yvoire, M.B. · Buist, H. · Clewell III, H.J. · Meek, B. · Gundert-Remy, U. · Goerlitz, G. · Schmitt, W.
Keywords: Health · Good modelling practice · PBPK · Risk assessment · article · Canada · documentation · dosimetry · Europe · Greece · priority journal · risk assessment · scientific literature · United States · Animals · Humans · Legislation, Drug · Models, Statistical · Pharmacokinetics · Quantitative Structure-Activity Relationship · Risk Assessment
[Abstract]

7 Improvement of the Cramer classification for oral exposure using the database TTC RepDose - A strategy description
article 2011    
Author: Tluczkiewicz, I. · Buist, H.E. · Martin, M.T. · Mangelsdorf, I. · Escher, S.E.
Keywords: Nutrition · Cramer classification · Database · Oral exposure · Refinement · RepDose · Risk assessment · SAR · Structure activity relationship · Threshold of toxicological concern · Toxicology · TTC concept · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

8 Complex mixtures: Hazard identification and risk assessment
article 1996    
Author: Fay, R.M. · Feron, V.J.
Keywords: Toxicology · chemical agent · drug mixture · health hazard · human · methodology · risk assessment · short survey · Chemical Fractionation · Drug Interactions · Guidelines · Hazardous Substances · Hazardous Waste · Humans · Occupational Exposure · Public Health · Reference Standards · Risk Assessment · Structure-Activity Relationship
[Abstract]

9 Binding of tissue-type plasminogen activator by the mannose receptor
article 1991    
Author: Otter, M. · Barrett-Bergshoeff, M.M. · Rijken, D.C.
Keywords: Biology · Animal · Cattle · Cell Membrane · Glucosaminidase · Ligands · Macrophages · Mannose · Pulmonary Alveoli · Receptors, Immunologic · Structure-Activity Relationship · Support, Non-U.S. Gov't · Tissue Plasminogen Activator · Animalia · Bos taurus · Bovinae
[PDF] [Abstract]

10 Aberrant fibrin formation and cross-linking of fibrinogen Nieuwegein, a variant with a shortened Aα-chain, alters endothelial capillary tube formation
article 2001    
Author: Collen, A. · Maas, A. · Kooistra, T. · Lupu, F. · Grimbergen, J. · Haas, F.J.L.M. · Biesma, D.H. · Koolwijk, P. · Koopman, J. · Hinsbergh, V.W.M. van
Keywords: Adult · Afibrinogenemia · Biopolymers · Capillaries · Cells, Cultured · Codon, Terminator · Endothelium, Vascular · Exons · Fibrin · Fibrinogens, Abnormal · Humans · Male · Microscopy, Electron · Molecular Weight · Mutagenesis, Insertional · Neovascularization, Physiologic · Oligopeptides · Partial Thromboplastin Time · Receptors, Vitronectin · Sequence Deletion · Structure-Activity Relationship · Transglutaminases
[Abstract]

11 Improving the applicability of (Q)SARs for percutaneous penetration in regulatory risk assessment.
article 2008    
Author: Bouwman, T. · Cronin, M.T. · Bessems, J.G. · Sandt, J.J. van de
Keywords: Health · xenobiotic agent · article · biological model · chemistry · drug effect · European Union · government regulation · human · legal aspect · physiology · prediction and forecasting · quantitative structure activity relation · risk assessment · skin absorption · European Union · Government Regulation · Humans · Models, Biological · Predictive Value of Tests · Quantitative Structure-Activity Relationship · Risk Assessment · Skin Absorption · Xenobiotics
[Abstract]

12 Carcinogenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Prentice, D. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Health · Biomedical Research · animal testing alternative · carcinogenesis · carcinogenicity · cell communication · cell culture · cell transformation · gap junction · genotoxicity · heterozygosity · nonhuman · priority journal · review · risk assessment · standardization · transgenic mouse · validation process · Animal Testing Alternatives · Animals · Carcinogenicity Tests · Carcinogens · Cell Transformation, Neoplastic · Cells, Cultured · Consumer Product Safety · Cosmetics · European Union · Gap Junctions · Mice · Mice, Transgenic · Quantitative Structure-Activity Relationship · Rats · Animalia · Mus musculus

13 Safety evaluation of chemical mixtures and combinations of chemical and non-chemical stressors
article 2004    
Author: Jonker, D. · Freidig, A.P. · Groten, J.P. · Hollander, A.E.M.de · Stierum, R.H. · Woutersen, R.A. · Feron, V.J.
Keywords: Chemistry Biology · Toxicology and Applied Pharmacology · Combination toxicology · Cumulative risk assessment · chemical agent · bioinformatics · cold stress · environmental exposure · genomics · health hazard · heat stress · human · immobilization stress · indoor air pollution · microorganism · noise · nonhuman · rat · review · risk assessment · safety · stress · toxicokinetics · toxicology · traffic · Dose-Response Relationship, Drug · Drug Interactions · Environmental Exposure · Humans · Models, Statistical · Risk Assessment · Safety · Sequence Analysis, Protein · Structure-Activity Relationship · Toxicology · Xenobiotics
[Abstract]

14 Genotoxicity and mutagenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Toxicology · Physiological sciences · Animal testing replacement · Animal testing alternatives · Chromosome aberration · Comet assay · DNA damage · DNA synthesis · Gene mutation · Genotoxicity · In vitro study · In vivo study · Micronucleus test · Mitotic recombination · Mutagenicity · Sister chromatid exchange · Toxicity testing · Toxicogenetics · Toxicokinetics · Toxicological parameters · Carcinogen testing · Cell culture · Chemistry · Legal aspects · Structure activity relation · Animalia · Consumer product safety · Cosmetics · European Union · Structure-Activity Relationship

15 Chemical respiratory allergy: Opportunities for hazard identification and characterisation
article 2007    
Author: Kimber, I. · Agius, R. · Basketter, D.A. · Corsini, E. · Cullinan, P. · Dearman, R.J. · Gimenez-Arnau, E. · Greenwell, L. · Hartung, T. · Kuper, F. · Maestrelli, P. · Roggen, E. · Rovida, C. · Casati, S.
Keywords: Toxicology and Applied Pharmacology · cell assay · clinical feature · conference paper · nonhuman · occupational asthma · occupational exposure · pathogenesis · priority journal · quantitative structure activity relation · respiratory tract allergy · risk assessment · risk factor · sensitization · skin test · Animal Testing Alternatives · Animals · Hazardous Substances · Humans · Respiratory Hypersensitivity · Skin Tests · Structure-Activity Relationship

16 The acute toxicity of selected alkylphenols to young and adult Daphnia magna
article 1998    
Author: Gerritsen, A. · Hoeven, N. van der · Pielaat, A.
Keywords: alkylphenol · alkyphenol · elimination rate · mortality rate · no-observed-effect concentration · toxicity · article · daphnia · ecotoxicity · ecotoxicology · nonhuman · statistical analysis · survival · toxicity testing · Animals · Chromatography, High Pressure Liquid · Daphnia · Female · Hazardous Substances · Hydrogen-Ion Concentration · Phenols · Structure-Activity Relationship · Toxicity Tests · Cladocera · Daphnia · Daphnia magna · Daphnia pulex · Pulex
[Abstract]

17 Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships
article 2005    
Author: Netzeva, T.I. · Worth, A.P. · Aldenberg, T. · Benigni, R. · Cronin, M.T.D. · Gramatica, P. · Jaworska, J.S. · Kahn, S. · Klopman, G. · Marchant, C.A. · Myatt, G. · Nikolova-Jeliazkova, N. · Patlewicz, G.Y. · Perkins, R. · Roberts, D.W. · Schultz, T.W. · Stanton, D.T. · Sandt, J.J.M. van de · Tong, W. · Veith, G. · Yang, C.
Keywords: Biology · Food and Chemical Risk Analysis · chemical environment · chemical industry · conference paper · decision theory · geometry · mathematical analysis · priority journal · probability · quantitative structure activity relation · skin sensitization · statistical analysis · water contamination · Animal Testing Alternatives · Animals · Education · European Union · Health Planning Guidelines · Quantitative Structure-Activity Relationship · Reproducibility of Results · Toxicity Tests

18 Role of the glycosaminoglycan component of thrombomodulin in its acceleration of the inactivation of single-chain urokinase-type plasminogen activator by thrombin
article 1993    
Author: Munk, G.A.W. de · Parkinson, J.F. · Groeneveld, E. · Bang, N.U. · Rijken, D.C.
Keywords: chondroitin 4 sulfate · chondroitin abc lyase · glycosaminoglycan · mutant protein · thrombomodulin · urokinase · dissociation constant · enzyme inactivation · enzyme inhibitor interaction · Chondroitin Lyases · Dose-Response Relationship, Drug · Glycosaminoglycans · Glycosylation · Human · Receptors, Cell Surface · Receptors, Thrombin · Recombinant Proteins · Structure-Activity Relationship · Support, Non-U.S. Gov't · Thrombin · Urinary Plasminogen Activator
[Abstract]

19 Platinum compounds with anti-tumour activity
article 1980    
Author: Plooy, A.C.M. · Lohman, P.H.M.
Keywords: Biology · Antineoplastic agent · Cisplatin · Platinum derivative · Radioisotope · Animal experiment · Cytotoxicity · DNA damage · DNA strand breakage · DNA synthesis · Drug toxicity · Endocrine system · Female genital system · Heredity · In vitro study · Intoxication · Mutagenesis · Mutagenicity · Ovary cell · Structure activity relation · Thymidine h 3 · Alkalies · Animal · Antineoplastic Agents · DNA · DNA Replication · Hamsters · In Vitro · Platinum · Structure-Activity Relationship · Support, Non-U.S. Gov't
[Abstract]

20 The bispyridinium-dioxime HLö-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman
article 1989    
Author: Jong, L.P.A.de · Verhagen, M.A.A. · Langenberg, J.P. · Hagedorn, I. · Löffler, M.
Keywords: Biology · Bis(pyridinium oxime) derivative · Enzyme inhibitor · Organophosphorus compound · Radioisotope · Enzyme reactivation · Fish · Human · Nonbiological model · Nonhuman · Normal human · Rat · Stereoisomerism · Acetylcholinesterase 9000-81-1 · Animal · Cholinesterase Reactivators · Eels · Human · In Vitro · Organophosphorus Compounds · Oximes · Phosphoric Acid Esters · Pyridines · Pyridinium Compounds · Stereoisomerism · Structure-Activity Relationship · Organophosphorus compounds · Oximes · Phosphoric acid esters · Pyridines · Pyridinium compounds · Soman, 96-64-0 · Tabun, 77-81-6
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 43 found. Next | Sort by date