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1 Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes
article 1995    
Author: Bogaards, J.J.P. · Ommen, B. van · Wolf, C.R. · Bladeren, P.J. van
Keywords: Toxicology · Cell Line · Chlorobenzenes · Chlorzoxazone · Chromatography, Gas · Cytochrome P-450 Enzyme System · Ethanolamines · Human · Oxazines · Oxidation-Reduction · Substrate Specificity · Testosterone · Transfection
[Abstract]

2 Bifidobacteria : genetic modification and the study of their role in the colon
article 2001    
Author: Werf, M. van der · Venema, K.
Keywords: Nutrition · In vitro gastrointestinal model · Prebiotics · Transformation · Probiotic agent · Bacterium transformation · Biological model · Colon flora · DNA modification · DNA vector · Gastrointestinal tract · Genetic transfection · Health promotion · Human · Nonhuman · Plasmid · Small intestine · Stomach · Bifidobacterium · Colon · Genetic Engineering · Genetic Vectors · Health Promotion · Humans · Models, Biological · Plasmids · Probiotics · Transfection · Bacteria (microorganisms) · Bifidobacterium
[Abstract]

3 Development of an androgen reporter gene assay (AR-LUX) utilizing a human cell line with an endogenously regulated androgen receptor
article 2001    
Author: Blankvoort, B.M.G. · Groene, E.M. de · Meeteren-Kreikamp, A.P. van · Witkamp, R.F. · Rodenburg, R.J.T. · Aarts, J.M.M.J.G.
Keywords: Nutrition · Aldosterone · Androgen · Androgen receptor · Androstanolone · Bolasterone · Dexamethasone · Epigallocatechin gallate · Estradiol · Forskolin · Luciferase · Progesterone · Retinoic acid · Trenbolone · Vitamin D · Assay · Cancer cell culture · Controlled study · Genetic transcription · Genetic transfection · Human · Human cell · Priority journal · Reliability · Reporter gene · Transcription regulation · Validation process · Aldosterone · Androgens · Breast Neoplasms · Dexamethasone · Down-Regulation · Estradiol · Genes, Regulator · Genes, Reporter · Humans · Luciferases · Metribolone · Receptors, Androgen · Transfection · Tumor Cells, Cultured
[Abstract]

4 Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP
article 1996    
Author: Zaman, G.J.R. · Cnubben, N.H.P. · Bladeren, P.J. van · Evers, R. · Borst, P.
Keywords: Adenosine Monophosphate · ATP-Binding Cassette Transporters · Biological Transport · Carcinoma, Non-Small-Cell Lung · Cell Membrane · Drug Resistance, Multiple · Ethacrynic Acid · Glutathione · Humans · Kinetics · Lung Neoplasms · Multidrug Resistance-Associated Proteins · Recombinant Proteins · Saccharomyces cerevisiae · Sulfinpyrazone · Transfection · Tumor Cells, Cultured
[PDF] [Abstract]

5 In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE
article 1999    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Hof, H.B. van 't · Zee, A. van der · Santamarina-Fojo, S. · Berkel, T.J.C. van · Havekes, L.M. · Hofker, M.H.
Keywords: Health · Adenovirus-mediated gene transfer · Hepatic VLDL triglyceride production · Hypertriglyceridemia · LDL receptor-related protein · VLDL-triglyceride lipolysis · Adenovirus · Adenoviridae · Animals · Apolipoproteins E · Cholesterol · Female · Humans · Immunohistochemistry · Lipolysis · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Receptors, LDL · Transfection · Triglycerides
[PDF] [Abstract]

6 An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins
article 1999    
Author: Vlijmen, B.J.M. van · Rohlmann, A. · Page, S.T. · Bensadoun, A. · Bos, I.S.T. · Berkel, T.J.C. van · Havekes, L.M. · Herz, J.
Keywords: Animals · Binding Sites · Cholesterol · Chylomicrons · Detergents · Gene Transfer Techniques · Heymann Nephritis Antigenic Complex · Immunoblotting · LDL-Receptor Related Protein 1 · Lipase · Lipoprotein Lipase · Liver · Membrane Glycoproteins · Mice · Mice, Transgenic · Polyethylene Glycols · Rats · Receptors, Immunologic · Receptors, LDL · Time Factors · Transfection · Triglycerides
[PDF] [Abstract]

7 Species specificity of human interleukin-3 demonstrated by cloning and expression of the homologous rhesus monkey (Macaca mulatta) gene
article 1990    
Author: Burger, H. · Leen, R.W. van · Dorssers, L.C.J. · Persoon, N.L.M. · Lemson, P.J. · Wagemaker, G.
Keywords: Amino Acid Sequence · Animal · Bacillus · Base Sequence · Cell Line · Cloning, Molecular · Comparative Study · DNA · Exons · Gene Expression · Hematopoietic Stem Cells · Human · Interleukin-3 · Introns · Macaca mulatta · Molecular Sequence Data · Sequence Homology, Nucleic Acid · Species Specificity · Transfection
[Abstract]

8 Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53
article 2002    
Author: Thüsen, J.H. von der · Vlijmen, B.J.M. van · Hoeben, R.C. · Kockx, M.M. · Havekes, L.M. · Berkel, T.J.C. van · Biessen, E.A.L.
Keywords: Health · Carotid arteries · Genes · Muscle · Adenovirus vector · Apolipoprotein E · Beta galactosidase · Phenylephrine · Protein p53 · Animal experiment · Animal model · Atherogenesis · Atherosclerotic plaque · Carotid artery · Cell death · Controlled study · Gene overexpression · Genetic transfection · Knockout mouse · Mouse · Nonhuman · Rupture · Smooth muscle fiber · Thrombosis · Transgene · Tumor suppressor gene · Adenoviridae · Animals · Apolipoproteins E · Apoptosis · Arteriosclerosis · beta-Galactosidase · Biological Markers · Carotid Artery Diseases · Cell Division · Genetic Vectors · Immunohistochemistry · Mice · Mice, Knockout · Muscle, Smooth, Vascular · Transfection · Tumor Suppressor Protein p53
[Abstract]

9 Influence of the H-ras oncogene on radiation responses of a rat rhabdomyosarcoma cell line
article 1992    
Author: Hermens, A.F. · Bentvelzen, P.A.J.
Keywords: animal cell · animal model · animal tissue · cell culture · cell killing · cell survival · cell viability · controlled study · dose response · gastrocnemius muscle · genetic transfection · human · human cell · irradiation · nonhuman · oncogene h ras · priority journal · radiation dose fractionation · radiation injury repair · radiation response · radiosensitivity · tumor growth · 3T3 Cells · Animal · Cell Division · Cell Line · Cell Survival · Cesium Radioisotopes · Dose-Response Relationship, Radiation · Gamma Rays · Genes, ras · Human · Mice · Radiation Tolerance · Rats · Rhabdomyosarcoma · Sarcoma, Experimental · Transfection
[Abstract]

10 Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10
article 1996    
Author: Kappers, W.A. · Groene, E.M. de · Kleij, L.A. · Witkamp, R.F. · Zweers-Zeilmaker, W.M. · Feron, V.J. · Horbach, G.J.
Keywords: Toxicology · CYP2C9 protein, human · cytochrome P450 · diclofenac · enzyme inhibitor · flurbiprofen · ketoprofen · mixed function oxidase · nonsteroid antiinflammatory agent · phenylbutazone · sulfaphenazole · tolbutamide · tolbutamide 4 hydroxylase · tolbutamide 4-hydroxylase · unspecific monooxygenase · animal · article · cell line · Cricetulus · drug interaction · gene expression · genetic transfection · genetics · hamster · human · hydroxylation · lung · metabolism · methylation · Animals · Anti-Inflammatory Agents, Non-Steroidal · Aryl Hydrocarbon Hydroxylases · Cell Line · Cricetinae · Cricetulus · Cytochrome P-450 Enzyme System · Diclofenac · Drug Interactions · Enzyme Inhibitors · Flurbiprofen · Gene Expression · Humans · Hydroxylation · Ketoprofen · Lung · Methylation · Mixed Function Oxygenases · Phenylbutazone · Sulfaphenazole · Tolbutamide · Transfection
[Abstract]

11 ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression
article 2005    
Author: Gerritsen, G. · Rensen, P.C.N. · Kypreos, K.E. · Zannis, V.I. · Havekes, L.M. · Dijk, K.W. van
Keywords: Biology · Biomedical Research · Adenovirus-mediated gene transfer · Lipoprotein lipase-mediated triglyceride hydrolysis · Mice · Very low density lipoprotein · Cholesterol · Fatty acid · Intermediate density lipoprotein · Lipoprotein · Triacylglycerol · Lipid · Lipoprotein lipase · Animal experiment · Animal tissue · Cholesterol blood level · Controlled study · Dose response · Emulsion · Female · Gene dosage · Gene overexpression · Hydrolysis · Hyperlipidemia · In vitro study · In vivo study · Injection · Lipoprotein deficiency · Mouse · Nonhuman · Protein blood level · White adipose tissue · Animal · Biosynthesis · Blood · Genetic transfection · Genetics · Metabolism · Mouse mutant · Animals · Apolipoprotein C-III · Apolipoprotein E4 · Apolipoproteins C · Apolipoproteins E · Humans · Hyperlipidemias · Lipids · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Mice · Mice, Knockout · Transfection · Triglycerides
[PDF] [Abstract]

12 Suitability of PER.C6 cells to generate epidemic and pandemic influenza vaccine strains by reverse genetics
article 2009    
Author: Koudstaal, W. · Hartgroves, L. · Havenga, M. · Legastelois, I. · Ophorst, C. · Siewerts, M. · Zuijdgeest, D. · Vogels, R. · Custers, J. · Boer-Luijtze, E. de · Leeuw, O. de · Cornelissen, L. · Goudsmit, J. · Barclay, W.
Keywords: Biology · Biomedical Research · Animals · Antibodies, Viral · Cell Culture Techniques · Cell Line · Female · Hemagglutination Inhibition Tests · Humans · Influenza A Virus, H1N1 Subtype · Influenza A Virus, H3N2 Subtype · Influenza A Virus, H5N1 Subtype · Influenza Vaccines · Influenza, Human · Mice · Mice, Inbred BALB C · Plaque Assay · Reassortant Viruses · Severity of Illness Index · Survival Analysis · Transfection
[Abstract]

13 Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells
article 1997    
Author: Dane-Oorschot, A.A.A.M. van · Fischer, D.F. · Grimbergen, J.M. · Klein, B. · Zhuang, S.M. · Falkenburg, J.H.F. · Backendorf, C. · Quax, P.H.A. · Eb, A.J. van der · Noteborn, M.H.M.
Keywords: Biology · Apoptosis · Capsid · Capsid Proteins · Cell Line, Transformed · Cell Transformation, Neoplastic · Cells, Cultured · Chicken anemia virus · Fibroblasts · Fluorescent Antibody Technique, Indirect · Humans · Male · Recombinant Proteins · Simian virus 40 · Skin · Skin Physiology · T-Lymphocytes · Transfection · Tumor Cells, Cultured · Chicken anemia virus · Circoviridae · Gallus gallus
[PDF] [Abstract]

14 Functional analysis of three plasmids from Lactobacillus plantarum
article 2005    
Author: Kranenburg, R. van · Golic, N. · Bongers, R. · Leer, R.J. · Vos, W.M. de · Siezen, R.J. · Kleerebezem, M.
Keywords: Biology · Biotechnology · Biomarkers · Genes · Plants (botany) · Functional analysis · Bacteria · Carnobacterium maltaromaticum · Arsenates · Arsenites · Base Sequence · Chromosome Mapping · DNA Replication · DNA, Bacterial · Drug Resistance, Bacterial · Gene Dosage · Genes, Bacterial · Lactobacillus plantarum · Molecular Sequence Data · Plasmids · Replicon · Sequence Homology, Nucleic Acid · Transfection · Bacillus subtilis · Carnobacterium maltaromaticum · Lactobacillus plantarum · Lactococcus lactis · Lactococcus plantarum
[PDF] [Abstract]

15 Adenoviral expression of a urokinase receptor - Targeted protease inhibitor inhibits neointima formation in murine and human blood vessels
article 2001    
Author: Quax, P.H.A. · Lamfers, M.L.M. · Lardenoye, J.H.P. · Grimbergen, J.M. · Vries, M.R. de · Slomp, J. · Ruiter, M.C. de · Kockx, M.M. · Verheijen, J.H. · Hinsbergh, V.W.M. van
Keywords: Adenoviridae · Animals · Aprotinin · Blood Vessels · Cattle · CHO Cells · Cricetinae · Femoral Artery · Femoral Vein · Gene Expression · Genetic Vectors · Humans · Mice · Mice, Inbred C57BL · Muscle, Smooth, Vascular · Organ Culture Techniques · Peptide Fragments · Plasmin · Recombinant Fusion Proteins · Saphenous Vein · Transfection · Tunica Intima · Urinary Plasminogen Activator
[Abstract]

16 Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: Implication for angiogenesis in fibrin matrices
article 2001    
Author: Koolwijk, P. · Sidenius, N. · Peters, E. · Sier, C.F.M. · Hanemaaijer, R. · Blasi, F. · Hinsbergh, V.W.M. van
Keywords: Binding Sites · Blotting, Western · Cells, Cultured · Endothelium, Vascular · Fibrin · Fibroblast Growth Factor 2 · Gene Expression · Humans · Metalloendopeptidases · Microcirculation · Neovascularization, Physiologic · Phenylalanine · Protease Inhibitors · Receptors, Cell Surface · Recombinant Proteins · Reverse Transcriptase Polymerase Chain Reaction · RNA, Messenger · Thiophenes · Transfection · Tumor Necrosis Factor-alpha · Urinary Plasminogen Activator
[Abstract]

17 Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB-C/EBP-β complex formation
article 2003    
Author: Kleemann, R. · Gervois, P.P. · Verschuren, L. · Staels, B. · Princen, H.M.G. · Kooistra, T.
Keywords: Biology · Animals · Antilipemic Agents · Bezafibrate · C-Reactive Protein · CCAAT-Enhancer-Binding Protein-beta · Cell Nucleus · Clofibric Acid · Down-Regulation · Hepatocytes · Humans · Interleukin-1 · Mice · Mice, Knockout · NF-kappa B · NF-kappa B p50 Subunit · Protein Binding · Receptors, Cytoplasmic and Nuclear · Transcription Factors · Transcription, Genetic · Transfection
[Abstract]

18 Negative Regulation of Human Fibrinogen Gene Expression by Peroxisome Proliferator-activated Receptor α Agonists via Inhibition of CCAAT Box/Enhancer-binding Protein β
article 2001    
Author: Gervois, P. · Vu-Dac, N. · Kleemann, R. · Kockx, M. · Dubois, G. · Laine, B. · Kosykh, V. · Fruchart, J.C. · Kooistra, T. · Staels, B.
Keywords: Western blotting · Blotting, Northern · Blotting, Western · CCAAT-Enhancer-Binding Protein-alpha · Cell Line · Dose-Response Relationship, Drug · Down-Regulation · Fibrinogen · Hepatocytes · Humans · Inflammation · Interleukin-6 · Liver · Mutagenesis, Site-Directed · Nuclear Receptor Coactivator 2 · Peroxisome Proliferators · Plasmids · Precipitin Tests · Promoter Regions (Genetics) · Pyrimidines · Receptors, Cytoplasmic and Nuclear · Transcription Factors · Transcription, Genetic · Transfection · Tumor Cells, Cultured
[PDF] [Abstract]

19 Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids
article 2009    
Author: Kersten, S. · Lichtenstein, L. · Steenbergen, E. · Mudde, K. · Hendriks, H.F.J. · Hesselink, M.K. · Schrauwen, P. · Müller, M.
Keywords: Nutrition · Biomedical Research · ANGPTL4 · Caloric restriction · Free fatty acids · angiopoietin · angiopoietin like protein 4 · beta adrenergic receptor stimulating agent · fatty acid · unclassified drug · ANGPTL4 protein, human · Angptl4 protein, mouse · antilipemic agent · Fiaf protein, rat · lipid emulsion · messenger RNA · salbutamol · adult · animal cell · article · blood sampling · caloric restriction · cell strain HepG2 · controlled study · enzyme linked immunosorbent assay · exercise · fatty acid blood level · female · gene expression · genetic variability · hepatoma cell · human · human cell · human experiment · intestine cell · male · mouse · muscle cell · nonhuman · normal human · priority journal · protein blood level · rat · animal · blood · cell culture · clinical trial · controlled clinical trial · genetic transfection · genetics · heart muscle cell · intestine · liver tumor · metabolism · middle aged · randomized controlled trial · time · upregulation · Adrenergic beta-Agonists · Adult · Albuterol · Angiopoietins · Animals · Antilipemic Agents · Caloric Restriction · Cells, Cultured · Enzyme-Linked Immunosorbent Assay · Exercise · Fat Emulsions, Intravenous · Fatty Acids, Nonesterified · Humans · Intestines · Liver Neoplasms · Male · Mice · Middle Aged · Myocytes, Cardiac · Rats · RNA, Messenger · Time Factors · Transfection · Up-Regulation · Young Adult
[Abstract]

20 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 38 found. Next | Sort by date