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1 Chronic quercetin exposure affects fatty acid catabolism in rat lung
article 2006    
Author: Boer, V.C.J. de · Schothorst, E.M. van · Dihal, A.A. · Woude, H. van der · Arts, I.C.W. · Rietjens, I.M.C.M. · Hollman, P.C.H. · Keijer, J.
Keywords: Biomedical Research · Fatty acid metabolism · Flavonoids · Microarray · Nutrigenomics · Polyphenols · Quercetin · fatty acid · quercetin · animal experiment · article · catabolism · controlled study · diet · genomics · health · ketogenesis · lung parenchyma · male · microarray analysis · nonhuman · nucleotide sequence · oxidation · quantitative analysis · rat · real time polymerase chain reaction · unindexed sequence · upregulation · Animals · Diet · Fatty Acids · Gene Expression Regulation · Lung · Male · Oligonucleotide Array Sequence Analysis · Quercetin · Rats · Rats, Inbred F344
[Abstract]

2 Subtoxic concentrations of allergenic haptens induce LC migration and maturation in a human organotypic skin explant culture model: A novel method for identifying potential contact allergens
article 2006    
Author: Lehé, C.L. · Jacobs, J.J.L. · Hua, C.M. · Courtellemont, P. · Elliott, G.R. · Das, P.K.
Keywords: Activation markers · Allergen · HOSEC · Langerhans cell · Migration · CD83 antigen · Contact allergen · Hapten · HLA DR antigen · Irritant agent · T6 antigen · Allergenicity · Antigen expression · Article · Cell maturation · Cell migration · Controlled study · Delayed hypersensitivity · Epidermis · Epidermis cell · Explant · Flow cytometry · Human · Human tissue · immunohistochemistry · Langerhans cell · Quantitative analysis · Skin biopsy · Skin culture · Upregulation · Allergens · Antigens, CD · Cell Differentiation · Cell Movement · Dermatitis, Allergic Contact · Haptens · Humans · Immunoglobulins · Langerhans Cells · Membrane Glycoproteins · Models, Biological · Skin · Tissue Culture Techniques
[Abstract]

3 Probing the proteome response to toluene exposure in the solvent tolerant pseudomonas putida S12
article 2011    
Author: Wijte, D. · Baar, B.L.M. van · Heck, A.J.R. · Altelaar, A.F.M.
Keywords: Biocatalysis · Efflux pumps · Organic solvent tolerance · P. putida S12 · Quantitative proteomics · Stable isotope dimethyl labeling · Toluene · ABC transporter · Acetate symporter · Cotransporter · Isotope · Membrane protein · Organic solvent · Toluene · Unclassified drug · Article · Biocatalysis · Biotransformation · Controlled study · Degradation kinetics · Demethylation · Energy metabolism · Molecular probe · Nonhuman · Nutrient · Priority journal · Protein expression · Proteomics · Pseudomonas putida · Quantitative analysis · Upregulation · Chemicals/CAS: toluene, 108-88-3 · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 Comparative transcriptomic and metabolomic analysis of fenofibrate and fish oil treatments in mice
article 2011    
Author: Lu, Y. · Boekschoten, M.V. · Wopereis, S. · Müller, M. · Kersten, S.
Keywords: Biology · Complement and coagulation cascades · Lipid metabolism · Liver · Peroxisome proliferator-activated receptor · amino acid · cholesterol · fenofibrate · fish oil · peroxisome proliferator activated receptor alpha · triacylglycerol · amino acid blood level · animal experiment · arachidonic acid metabolism · article · cardiovascular risk · cholesterol blood level · citric acid cycle · comparative study · controlled study · down regulation · fatty acid metabolism · fatty acid synthesis · gene control · male · metabolomics · mouse · nonhuman · priority journal · transcriptomics · treatment duration · triacylglycerol blood level · upregulation · Healthy Living · Life · MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Transcriptome analysis of sorbic acid-stressed Bacillus subtilis reveals a nutrient limitation response and indicates plasma membrane remodeling
article 2008    
Author: Beek, A. ter · Keijser, B.J.F. · Boorsma, A. · Zakrzewska, A. · Orij, R. · Smits, G.J. · Brul, S.
Keywords: Biology · Biotechnology · cerulenin · sorbic acid · tricarboxylic acid · acidity · article · Bacillus subtilis · bacterial gene · bacterial genome · bacterial growth · bkdr regulated gene · ccpa gene · cell membrane · codY gene · fag bene · fur gene · genetic transcription · growth inhibition · nonhuman · nutrient limitation · priority journal · regulon · sigh mediated gene · sigl mediated gene · sporogenesis · transcriptomics · upregulation · Anions · Bacillus subtilis · Bacterial Proteins · Cell Membrane · Cerulenin · Gene Expression Profiling · Gene Expression Regulation, Bacterial · Hydrogen-Ion Concentration · Oligonucleotide Array Sequence Analysis · Regulon · Reverse Transcriptase Polymerase Chain Reaction · Sorbic Acid · Bacillus subtilis
[Abstract]

6 Achilles tendinosis: Changes in biochemical composition and collagen turnover rate
article 2007    
Author: Mos, M. de · El, B. van · Groot, J. de · Jahr, H. · Schie, H.T.M. van · Arkel, E.R. van · Tol, H. · Heijboer, R. · Osch, G.J.V.M. van · Verhaar, J.A.N.
Keywords: Biology · Biomedical Research · Achilles tendon · Collagen · Crosslinks · Matrix metalloproteinase · Pentosidine · Tendinopathy · Tendinosis · collagen · collagen type 1 · collagen type 2 · lysine · matrix metalloproteinase · pentosidine · achilles tendinitis · article · biochemical composition · biopsy · clinical article · controlled study · cross linking · enzyme activity · gene expression · genetic analysis · human · human tissue · hydroxylation · laboratory test · nucleotide sequence · priority journal · turnover time · upregulation · water content · Achilles Tendon · Adult · Aged · Biomechanics · Collagen · Female · Gene Expression · Humans · Male · Matrix Metalloproteinase 3 · Middle Aged · Tendinopathy · Water
[Abstract]

7 Differentiation of adipose stem cells by nucleus pulposus cells: Configuration effect
article 2007    
Author: Lu, Z.F. · Zandieh Doulabi, B. · Wuisman, P.I. · Bank, R.A. · Helder, M.N.
Keywords: Biomedical Research · Adipose tissue · Chondrogenic differentiation · Co-culture · Disc regeneration · Gene expression · Mesenchymal stem cells · Nucleus pulposus · aggrecan · collagen type 1 · collagen type 3 · osteopontin · peroxisome proliferator activated receptor gamma · adipose tissue cell · chondrogenesis · controlled study · down regulation · gene expression · genetic analysis · monolayer culture · nucleus pulposus · phenotype · priority journal · real time polymerase chain reaction · stem cell · upregulation · Adipocytes · Cell Culture Techniques · Cell Differentiation · Cells, Cultured · Coculture Techniques · Humans · Intervertebral Disk · Stem Cells
[Abstract]

8 Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in Marfan syndrome
article 2015    
Author: Busnadiego, O. · Gorbenko del Blanco, D. · González-Santamaría, J. · Habashi, J.P. · Calderon, J.F. · Sandoval, P. · Bedja, D. · Guinea-Viniegra, J. · Lopez-Cabrera, M. · Rosell-Garcia, T. · Snabel, J.M. · Hanemaaijer, R. · Forteza, A. · Dietz, H.C. · Egea, G. · Rodriguez-Pascual, F.
Keywords: Biology · Aneurysm · Collagen · Extracellular matrix · Lysyl oxidases · Marfan syndrome · Transforming growth factor-β · Losartan · Oxidoreductase · Protein LOXL1 · Protein lysine 6 oxidase · Transforming growth factor beta · Unclassified drug · Animal tissue · Aorta aneurysm · Clinical article · Collagen fiber · Controlled study · Disease association · Disease course · Disease severity · Elastic fiber · Enzyme inhibition · Human tissue · Marfan syndrome · Mouse · Mouse model · Nonhuman · Prophylaxis · Protein expression · Signal transduction · Upregulation · Wild type · Animalia · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

9 Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels
article 2005    
Author: Slot, A.J. van der · Dura, E.A. van · Wit, E.C. de · Groot, J. de · Huizinga, T.W.J. · Bank, R.A. · Zuurmond, A.M.
Keywords: Lysyl hydroxylase 2b · Pyridinoline · TGF-β · Activin A · Protein lysine 6 oxidase · Transforming growth factor beta · Tumor necrosis factor alpha · Controlled study · Cross linking · Human cell · Protein expression · Skin fibroblast · Skin fibrosis · Upregulation · Activins · Amino Acids · Cells, Cultured · Collagen Type I · Cross-Linking Reagents · Cytokines · Fibroblasts · Fibrosis · Gene Expression Regulation, Enzymologic · Humans · Inhibin-beta Subunits · Interleukin-4 · Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase · Protein Isoforms · RNA, Messenger · Skin · Time Factors · Transforming Growth Factor beta · Tumor Necrosis Factor-alpha · Up-Regulation
[Abstract]

10 Toxicogenomics directory of chemically exposed human hepatocytes
article 2014    
Author: Grinberg, M. · Stöber, R.M. · Edlund, K. · Rempel, E. · Godoy, P. · Reif, R. · Widera, A. · Madjar, K. · Schmidt-Heck, W. · Marchan, R. · Sachinidis, A. · Spitkovsky, D. · Hescheler, J. · Carmo, H. · Arbo, M.D. · Water, B. van de · Wink, S. · Vinken, M. · Rogiers, V. · Escher, S. · Hardy, B. · Mitic, D. · Myatt, G. · Waldmann, T. · Mardinoglu, A. · Damm, G. · Seehofer, D. · Nüssler, A. · Weiss, T.S. · Oberemm, A. · Lampen, A. · Schaap, M.M. · Luijten, M. · van Steeg, H. · Thasler, W.E. · Kleinjans, J.C.S. · Stierum, R.H. · Leist, M. · Rahnenführer, J. · Hengstler, J.G.
Keywords: Biology · Bioinformatics · Biomarker identification · Cirrhosis · Hepatocellular cancer · Hepatotoxicity · In vivo validation · SEURAT-1 · Steatosis · Toxicotranscriptomics · Unsupervised clustering · allyl alcohol · biological marker · chemical compound · cytochrome P450 1A1 · cytochrome P450 3A4 · galactosamine · isoniazid · ketoconazole · liver protein · paracetamol · propranolol · thyroid hormone · transcription factor · triazolam · valproic acid · binding site · cell stress · data base · down regulation · fatty liver · gene expression · gene ontology · human · liver cell · liver cell carcinoma · liver cirrhosis · liver disease · microarray analysis · mutation · nonalcoholic fatty liver · quantitative analysis · real time polymerase chain reaction · RNA extraction · toxicogenomics · transcriptomics · upregulation · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

11 Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice
article 2009    
Author: Eefting, D. · Bot, I. · Vries, M.R. de · Schepers, A. · Bockel, J.H. van · Berkel, T.J.C. van · Biessen, E.A.L. · Quax, P.H.A.
Keywords: Biology · Biomedical Research · apolipoprotein E3 · chemokine receptor CCR2 · lentiviral short hairpin RNA · lentivirus vector · messenger RNA · monocyte chemotactic protein 1 · unclassified drug · animal cell · animal model · article · atherosclerosis · carotid artery · cell migration · cell proliferation · clinical feature · controlled study · disease course · drug delivery system · drug efficacy · drug targeting · gene silencing · gene therapy · hypercholesterolemia · in vitro study · in vivo study · infection · Lentivirinae · male · morphometrics · mouse · nonhuman · priority journal · protein expression · receptor upregulation · smooth muscle fiber · treatment outcome · vein graft · vein graft disease · vein surgery · viral gene delivery system · Animals · Apolipoprotein E3 · Atherosclerosis · Chemokine CCL2 · Disease Models, Animal · Graft Occlusion, Vascular · Hypercholesterolemia · Lentivirus · Male · Mice · Receptors, CCR2 · RNA Interference · Veins
[Abstract]

12 Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis
article 2007    
Author: Fabriek, B.O. · Møller, H.J. · Vloet, R.P.M. · Winsen, L.M. van · Hanemaaijer, R. · Teunissen, C.E. · Uitdehaag, B.M.J. · Berg, T.K. van den · Dijkstra, C.D.
Keywords: Health · Biomedical Research · CD163 · Metalloproteinase · Monocytes · Multiple sclerosis · Scavenger receptor · sCD163 · CD163 antigen · cytokine · gelatinase B · scavenger receptor · adult · aged · analytic method · article · comparative study · controlled study · cytokine production · down regulation · enzyme activity · female · human · major clinical study · male · multiple sclerosis · priority journal · protein degradation · upregulation · Adolescent · Adult · Aged · Aged, 80 and over · Animals · Antigens, CD · Antigens, Differentiation, Myelomonocytic · Cell Line, Transformed · Cricetinae · Cricetulus · Cytokines · Enzyme Inhibitors · Enzyme-Linked Immunosorbent Assay · Female · Humans · Hydrocortisone · Male · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 9 · Middle Aged · Multiple Sclerosis · Receptors, Cell Surface · Statistics, Nonparametric · Transfection
[Abstract]

13 Sirolimus and paclitaxel provoke different vascular pathological responses after local delivery in a murine model for restenosis on underlying atherosclerotic arteries
article 2007    
Author: Pires, N.M.M. · Eefting, D. · Vries, M.R.de · Quax, P.H.A. · Jukema, J.W.
Keywords: Biology · Biomedical Research · collagen · Fas antigen · gelatinase B · messenger RNA · paclitaxel · protein Bax · protein bcl 2 · rapamycin · tissue inhibitor of metalloproteinase 1 · animal experiment · animal model · animal tissue · apoptosis · article · atherosclerosis · blood vessel reactivity · cell disruption · controlled study · dose response · drug eluting stent · drug megadose · femoral artery · histopathology · hypercholesterolemia · male · mouse · nonhuman · priority journal · protein expression · real time polymerase chain reaction · restenosis · upregulation · Actins · Animals · Apoptosis · Atherosclerosis · Cell Proliferation · Collagen · Drug Implants · Femoral Artery · Image Interpretation, Computer-Assisted · In Situ Nick-End Labeling · Male · Mice · Mice, Mutant Strains · Models, Animal · Muscle, Smooth, Vascular · Paclitaxel · Recurrence · Reverse Transcriptase Polymerase Chain Reaction · RNA, Messenger · Sirolimus · Stents · Tunica Intima
[Abstract]

14 Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression
article 2014    
Author: Kim, E.S. · Cha, Y. · Ham, M. · Jung, J. · Kim, S.G. · Hwang, S. · Kleemann, R. · Moon, A.
Keywords: Biology · C-reactive protein · Invasion · MMP-9 · S1P · 2 (2 amino 3 methoxyphenyl)chromone · C reactive protein · CCAAT enhancer binding protein beta · Fingolimod · Gelatinase B · Mitogen activated protein kinase kinase · Reactive oxygen metabolite · Sphingosine 1 phosphate · Animal experiment · Animal model · Breast carcinoma · Breast cell · Cancer growth · Cell invasion · Controlled study · Enzyme activation · Epithelium cell · Female · Human · Human cell · In vitro study · In vivo study · Inflammation · Inflammatory breast cancer · Mouse · Nonhuman · Oncogene c fos · Phenotype · Priority journal · Protein expression · Transcription initiation · Tumor invasion · Upregulation · Xenograft · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

15 Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes
article 2015    
Author: Liang, W. · Verschuren, L. · Mulder, P. · Hoorn, J.W.A. van der · Verheij, J. · Dam, A.D. van · Boon, M.R. · Princen, H.M.G. · Havekes, L.M. · Kleemann, R. · Hoek, A.M. van den
Keywords: Biology · Alanine aminotransferase · Aspartate aminotransferase · Glucose · High density lipoprotein cholesterol · Insulin · Interleukin 6 · Low density lipoprotein cholesterol · Peroxisome proliferator activated receptor alpha · Salsalate · Triacylglycerol · Alanine aminotransferase blood level · Animal cell · Animal experiment · Animal model · Animal tissue · Aspartate aminotransferase blood level · Body weight · Controlled study · Down regulation · Drug efficacy · Drug response · Dyslipidemia · Energy metabolism · Fatty acid oxidation · Fatty liver · Gene expression · Glucose blood level · Glycemic control · Hepatitis · Insulin blood level · Insulin resistance · Lipid metabolism · Lipogenesis · Male · Mouse · Nonalcoholic fatty liver · Nonhuman · Treatment duration · Treatment outcome · Triacylglycerol blood level · Upregulation · Weight gain · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

16 Time series analysis of benzo[a]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets
article 2010    
Author: Delft, J.H.M. van · Mathijs, K. · Staal, Y.C.M. · Herwijnen, M.H.M. van · Brauers, K.J.J. · Boorsma, A. · Kleinjans, J.C.S.
Keywords: Nutrition · Biomedical Research · Carcinogen · Network · Time series · Transcription factor · Transcriptome · benzo[a]pyrene · immunoglobulin enhancer binding protein · Myc protein · serum response factor · transcription factor · transcription factor AP 1 · transcription factor E2F1 · transcriptome · amino acid metabolism · apoptosis · article · carcinogenesis · cell cycle G1 phase · cell cycle S phase · controlled study · correlation analysis · DNA adduct · DNA repair · down regulation · functional genomics · gene expression · gene regulatory network · hepatoma cell · human · human cell · lipid metabolism · named inventories, questionnaires and rating scales · proto oncogene · Short Time series Expression Miner · signal transduction · time series analysis · transcription regulation · tumor suppressor gene · upregulation
[Abstract]

17 Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models
article 2015    
Author: Schmeits, P.C.J. · Schaap, M.M. · Luijten, M. · Someren, E. van · Boorsma, A. · Loveren, H. van · Peijnenburg, A.A.C.M. · Hendriksen, P.J.M.
Keywords: Biology · C57BL/6 · CTLL-2 · Cyclosporine A · Interspecies comparison · Splenocytes · Interleukin 2 · Messenger RNA · Transcription factor Nrf2 · Animal cell · Animal experiment · Cell cycle regulation · Controlled study · Cytotoxic T lymphocyte · Down regulation · Endoplasmic reticulum stress · HepG2 cell line · Human · Human cell · Immune response · Immunotoxicity · In vitro study · In vivo study · Jurkat cell line · Male · Mouse · Nonhuman · Dpleen cell · T lymphocyte activation · Thymoma cell line · Transcriptomics · Unfolded protein response · Upregulation · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

18 The probiotic mixture VSL#3 has differential effects on intestinal immune parameters in healthy female BALB/c and C57BL/6 mice
article 2015    
Author: Mariman, R. · Tielen, F. · Koning, F. · Nagelkerken, L.
Keywords: Biology · Flow cytometry · Host genetics · Immune modulation · Microarray · Probiotics · Chemokine receptor CCR5 · Chemokine receptor CXCR3 · Eosinophil peroxidase · Gamma interferon inducible protein 10 · Interleukin 12 receptor beta1 · Retinoid related orphan receptor gamma · Transcription factor GATA 3 · VSL3 · Adaptive immunity · Animal experiment · Colon · Controlled study · Female · Gene expression · Genetic variability · Homeostasis · Immunomodulation · Innate immunity · Intestine mucosa · Major histocompatibility complex · Mesentery lymph node · Microarray analysis · Mouse · Mouse strain · Nonhuman · Phenotype · Principal component analysis · Protein expression · Single drug dose · Small intestine · Upregulation · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

19 Multivariate analysis of microarray data by principal component discriminant analysis: Prioritizing relevant transcripts linked to the degradation of different carbohydrates in Pseudomonas putida S12
article 2006    
Author: Werf, M.J. van der · Pieterse, B. · Luijk, N. van · Schuren, F. · Werff van der - Vat, B. van der · Overkamp, K. · Jellema, R.H.
Keywords: Biology · Biotechnology · bacterial RNA · cytochrome · fructose · gluconic acid · glucose · glucose dehydrogenase · iron · quinone derivative · succinic acid · article · bacterial gene · bacterium culture · carbohydrate metabolism · carbon source · cluster analysis · controlled study · discriminant analysis · down regulation · fermentation medium · fructose metabolism · gene identification · genetic transcription · glucose metabolism · intermethod comparison · metabolic regulation · microarray analysis · molecular cloning · multivariate analysis · nonhuman · plots and curves · principal component analysis · priority journal · Pseudomonas putida · regulatory mechanism · respiratory chain · RNA analysis · RNA isolation · transcriptomics · upregulation · Carbohydrate Metabolism · Culture Media · Genes, Bacterial · Multivariate Analysis · Oligonucleotide Array Sequence Analysis · Pseudomonas putida · Bacteria (microorganisms) · Pseudomonas putida
[Abstract]

20 Endoplasmic reticulum stress leads to the selective transcriptional downregulation of the glucoamylase gene in Aspergillus niger
article 2004    
Author: Al-Sheikh, H. · Watson, A.J. · Lacey, G.A. · Punt, P.J. · MacKenzie, D.A. · Jeenes, D.J. · Pakula, T. · Penttilä, M. · Alcocer, M.J.C. · Archer, D.B.
Keywords: Biology · Biotechnology · actin · chaperone · dithiothreitol · gamma actin · glucan 1,4 alpha glucosidase · glyceraldehyde 3 phosphate dehydrogenase · protein HacA · unclassified drug · article · Aspergillus niger · bipa gene · down regulation · endoplasmic reticulum · fungal cell · fungal gene · fungal strain · gene expression · gene induction · genetic code · glaa gene · nonhuman · pdiA gene · priority journal · promoter region · protein folding · protein secretion · RNA splicing · RNA stability · stress · transcription regulation · upregulation · Aspergillus niger · Dithiothreitol · Down-Regulation · Endoplasmic Reticulum · Fungal Proteins · Gene Expression Regulation, Enzymologic · Gene Expression Regulation, Fungal · Glucan 1,4-alpha-Glucosidase · HSP70 Heat-Shock Proteins · Oligonucleotides, Antisense · Promoter Regions (Genetics) · Protein Folding · Transcription, Genetic · Aspergillus · Aspergillus niger · Fungi
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 40 found. Next | Sort by date