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Showing 1 to 16 of 16 found. | Sort by date

1 The evaluation of the immunomodulating properties of ERA-63 a pharmaceutical with estrogenic activity
article 2008    
Author: Janssen, G.B. · Penninks, A.H. · Knippels, L.M.J. · Zijverden, M. van · Spanhaak, S.
Keywords: Chemistry · Ethinyl estradiol · Host resistance · Immunotoxicity · Listeria monocytogenes · PFC · Plaque-forming cell assay · T cell-dependent antibody response · bilirubin · era 63 · ethinylestradiol · gamma glutamyltransferase · immunomodulating agent · unclassified drug · animal experiment · antibody response · article · bilirubin blood level · body weight · controlled study · drug dose comparison · drug megadose · drug screening · estrogen activity · female · gamma glutamyl transferase blood level · immunomodulation · Listeria monocytogenes · low drug dose · male · nonhuman · priority journal · qualitative analysis · rat · testis weight · thymus · Animals · Antibody Formation · Body Weight · Estrogens · Ethinyl Estradiol · Female · Hemolytic Plaque Technique · Immunologic Factors · Listeria Infections · Male · Organ Size · Rats · Rats, Sprague-Dawley · Risk Assessment · T-Lymphocytes · Listeria monocytogenes · Rattus
[Abstract]

2 gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory
article 1994    
Author: Foy, T.M. · Laman, J.D. · Ledbetter, J.A. · Aruffo, A. · Claassen, E. · Noelle, R.J.
Keywords: cd4 antigen · Ligand · Antibody production · Antibody response · Antigen specificity · Cell maturation · Germinal center · Helper cell · Humoral immunity · Immune response · Immunization · Immunohistochemistry · Memory cell · Mouse · Animal · Antibody Formation · Antigens, CD · Antigens, CD40 · B-Lymphocytes · CD40 Ligand · Immunologic Memory · Membrane Glycoproteins · Mice · Mice, Inbred BALB C
[Abstract]

3 Instruments for oral disease-intervention strategies : recombinant Lactobacillus casei expressing tetanus toxin fragment C for vaccination or myelin proteins for oral tolerance induction in multiple sclerosis
article 1999    
Author: Maassen, C.B.M. · Laman, J.D. · Heijne den Bak-Glashouwer, M.J. · Tielen, F.J. · Holten-Neelen, J.C.P.A. van · Hoogteijling, L. · Antonissen, C. · Leer, R.J. · Pouwels, P.H. · Boersma, W.J.A. · Shaw, D.M.
Keywords: Experimental autoimmune/allergic encephalomyelitis (EAE) · Heterologous gene expression · Mucosal vaccines · lactobacillus vaccine · Myelin protein · Recombinant vaccine · Antibody response · Immunization · Immunoblotting · Immunogenicity · Nonhuman · Oral drug administration · Priority journal · Tetanus · Vaccination · Administration, Oral · Animals · Bacterial Vaccines · Cattle · Flow Cytometry · Genetic Vectors · Guinea Pigs · Humans · Immune Tolerance · Immunohistochemistry · Lactobacillus casei · Mice · Multiple Sclerosis · Myelin Basic Proteins · Peptide Fragments · Rabbits · Recombinant Fusion Proteins · Tetanus · Tetanus Toxin
[Abstract]

4 Clonal antibody dominance after influenza vaccination in IgA nephropathy patients and controls
article 1995    
Author: Radl, J. · Hoogeveen, C.M. · Wall Bake, A.W.L. van den · Mestecky, J.
Keywords: Biology · hemagglutinin · immunoglobulin a antibody · immunoglobulin g antibody · immunoglobulin m antibody · sialidase · virus vaccine · antibody response · antigen specificity · clinical article · conference paper · controlled study · immunoblotting · immunoglobulin a nephropathy · influenza · influenza virus · vaccination · Antibodies, Monoclonal · Antibodies, Viral · Case-Control Studies · Glomerulonephritis, IGA · Hemagglutinins, Viral · Human · Immunoglobulin A · Immunoglobulin G · Influenza A Virus, Human · Influenza Vaccine · Neuraminidase
[Abstract]

5 Stimulation of tissue-type plasminogen activator expression by retinoic acid in human endothelial cells requires retinoic acid receptor β2 induction
article 1996    
Author: Lansink, M. · Kooistra, T.
Keywords: Biology · Antisense oligodeoxynucleotide · Cycloheximide · Tetinoic acid receptor · Alternative rna splicing · Antibody response · Cell stimulation · competitive inhibition · Endothelium cell · Enzyme active site · Fibrinolysis · Gene induction · Human cell · Protein degradation · Base Sequence · Benzoates · Cells, Cultured · Chromans · Cycloheximide · DNA, Complementary · Endothelium, Vascular · Gene Expression Regulation · Humans · Molecular Sequence Data · Oligonucleotides, Antisense · Protein Synthesis Inhibitors · Receptors, Retinoic Acid · Tissue Plasminogen Activator · Tretinoin · Umbilical Veins
[Abstract]

6 Brown Norway rat ovalbumin-specific immunoglobulin E antibodies increase the human basophil expression of CD63 marker
article 2003    
Author: Bellou, A. · Saint-Laudy, J. · Knippels, L. · Montémont, C. · Vauthier, E. · Gerard, P. · Pellegrom, H. · Koerkamp, E.K. · Lesesve, J.F. · Guéant, J.L. · Lambert, H. · Mallié, J.P.
Keywords: Toxicology Biology · Toxicology and Applied Pharmacology · CD63 antigen · immunoglobulin E · ovalbumin · adolescent · allergy test · anaphylactic shock · animal model · antibody response · antibody specificity · antigen expression · article · basophil · cell activation · enzyme linked immunosorbent assay · histamine release · human · human cell · immunization · nonhuman · passive skin anaphylaxis · priority journal · rat · rat strain · sensitization · serum · Th2 cell · Anaphylaxis · Animals · Antigens, CD · Basophils · Enzyme-Linked Immunosorbent Assay · Histamine Release · Humans · Immunization · Immunoglobulin E · Ovalbumin · Passive Cutaneous Anaphylaxis · Platelet Membrane Glycoproteins · Rats · Rats, Inbred BN
[Abstract]

7 Comparison of adjuvants for immune potentiating properties and side effects in mice
article 1995    
Author: Leenaars, P.P.A.M. · Hendriksen, C.F.M. · Koedam, M.A. · Claassen, I. · Claassen, E.
Keywords: Biology · Adjuvants · Antibody · Evaluation · Pathology · T-cell activation · Freund adjuvant · Immunological adjuvant · Immunostimulating agent · Iscom · Quil a · Saponin · Specol · Spikoside · Unclassified drug · Animal experiment · Antibody response · Controlled study · Enzyme linked immunosorbent assay · Intraperitoneal drug administration · Lactobacillus · Lymphocyte activation · Mouse · Nonhuman · Subcutaneous drug administration · T lymphocyte · Adjuvants, Immunologic · Animal · Antibodies, Bacterial · Behavior, Animal · Comparative Study · Female · Hindlimb · Injections, Intraperitoneal · Injections, Subcutaneous · Intestines · Lymphocyte Activation · Male · Mice · Mice, Inbred BALB C · Peritonitis · Serous Membrane · T-Lymphocytes · Animalia · Lactobacillus · Rabies virus
[Abstract]

8 T- and B-cell nonresponsiveness to self-αB-crystallin in SJL mice prevents the induction of experimental allergic encephalomyelitis
article 2000    
Author: Stipdonk, M.J.B. van · Willems, A.A. · Verbeek, R. · Boog, C.J.P. · Noort, J.M. van
Keywords: Health · Antigens · Rodents · Tolerance · Alpha crystallin · Beta crystallin · Peptide · Active immunization · Adoptive transfer · Allergic encephalomyelitis · Animal cell · Animal experiment · Animal model · Antibody response · Autoimmunity · Cell line · Cell proliferation · Cytokine production · Immunological tolerance · Immunopathogenesis · Lymphocyte function · Lymphoid organ · Nonhuman · Protein expression · Adoptive Transfer · Animals · Autoimmunity · B-Lymphocytes · Cattle · Crystallins · Encephalomyelitis, Autoimmune, Experimental · Female · H-2 Antigens · Immune Tolerance · Interferon Type II · Interleukin-4 · Lymphocytes · Lymphoid Tissue · Mice · Mice, Inbred Strains · Myelin Sheath · Nerve Tissue Proteins · Species Specificity · T-Lymphocytes · Vaccination
[Abstract]

9 Assessment of the allergic potential of food protein extracts and proteins on oral application using the Brown Norway rat model
article 2003    
Author: Knippels, L.M.J. · Penninks, A.H.
Keywords: Toxicology · Toxicology and Applied Pharmacology · Allergic potential · Brown Norway rats · Challenge effects · Egg-white proteins · Food allergy · Food proteins · IgE · Milk proteins · Oral sensitization · Ovalbumin · Passive cutaneous anaphylaxis · adjuvant · egg white · food allergen · immunoglobulin E · immunoglobulin G · ovalbumin · allergenicity · animal experiment · animal model · antibody response · antigen specificity · breathing rate · controlled study · feeding · food allergy · immune response · intestine mucosa permeability · male · milk allergy · nonhuman · peanut allergy · priority journal · protein intake · protein purification · provocation test · rat · rat strain · review · risk assessment · sensitization · symptomatology · systolic blood pressure · Administration, Oral · Allergens · Animals · Disease Models, Animal · Egg Proteins · Food Hypersensitivity · Humans · Immunoglobulin E · Immunoglobulin G · Male · Milk Proteins · Rats · Animalia · Arachis hypogaea · Rattus norvegicus
[Abstract]

10 The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab
article 2014    
Author: Mierlo, G.J.D. van · Cnubben, N.H.P. · Wouters, D. · Wolbink, G.J. · Hart, M.H.L. · Rispens, T. · Ganderup, N.C. · Kuper, C.F. · Aarden, L. · Penninks, A.H.
Keywords: Biology · Adalimumab · Alternative model · Anti-drug antibodies · Immunogenicity · Infliximab · Minipig · Pharmacokinetics Ddrug antibody · Animal experiment · Animal model · Animal tissue · Antibody response · Antibody titer · Area under the curve · Body weight · Clinical chemistry · Clinical feature · Clinical observation · Controlled study · Drug blood level · Drug clearance · Drug half life · Drug megadose · Female · Hematological parameters · Histopathology · Immune function test · Immune system · Low drug dose · Maximum plasma concentration · Mean residence time · Nonhuman · Organ weight · Predictive value · Priority journal · Time to maximum plasma concentration · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

11 Comparison of antibody responses to hen's egg and cow's milk proteins in orally sensitized rats and food-allergic patients
article 2000    
Author: Knippels, L.M.J. · Kleij, H.P.M. van der · Koppelman, S.J. · Houben, G.F. · Penninks, A.H. · Felius, A.A.
Keywords: Nutrition · Allergic patients · Brown Norway · Cow's milk · Food allergy · Hen's egg white · IgE · Rat · Sensitization · Egg protein · Egg white · Food allergen · Immunoglobulin E antibody · Immunoglobulin G antibody · Milk protein · Ovalbumin · Allergenicity · Animal experiment · Animal model · Antibody response · Antibody specificity · Antigen recognition · Child · Clinical article · Controlled study · Food allergy · Human · Immunoblotting · Infant · Male · Milk allergy · Nonhuman · Priority journal · Protein intake · Rat · Sensitization · Allergens · Animals · Antibody Specificity · Blotting, Western · Child · Child, Preschool · Dietary Proteins · Electrophoresis, Polyacrylamide Gel · Enzyme-Linked Immunosorbent Assay · Food Hypersensitivity · Humans · Immune System · Immunoglobulin E · Infant · Male · Milk · Milk Hypersensitivity · Milk Proteins · Ovalbumin · Passive Cutaneous Anaphylaxis · Rats · Rats, Inbred BN
[Abstract]

12 Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains
article 2000    
Author: Maassen, C.B.M. · Holten-Neelen, C. van · Balk, F. · Bak-Glashouwer, M.-J.H. den · Leer, R.J. · Laman, J.D. · Boersma, W.J.A. · Claassen, E.
Keywords: Immunohistochemistry · Mucosal immune response · Probiotic · adjuvant · cytokine · gamma interferon · immunoglobulin A · interleukin 10 · interleukin 1alpha · interleukin 1beta · interleukin 2 · interleukin 4 · probiotic agent · tumor necrosis factor alpha · animal experiment · animal model · antibody response · article · controlled study · cytokine production · enzyme linked immunosorbent assay · female · humoral immunity · immune response · immunohistochemistry · intestine mucosa · Lactobacillus · Lactobacillus brevis · Lactobacillus casei · Lactobacillus fermentum · Lactobacillus plantarum · Lactobacillus reuteri · mouse · mucosa · nonhuman · priority journal · Adjuvants, Immunologic · Administration, Oral · Animals · Chickens · Chikungunya virus · Cytokines · Duodenum · Female · Food Microbiology · gamma-Globulins · Haptens · Injections, Intraperitoneal · Interleukin-2 · Intestinal Mucosa · Lactobacillus · Lactobacillus casei · Mice · Mice, Inbred BALB C · Microvilli · Peyer's Patches · Species Specificity · Th2 Cells · Viral Vaccines
[Abstract]

13 Recombinant Lactobacillus plantarum inhibits house dust mite-specific T-cell responses
article 2001    
Author: Kruisselbrink, A. · Heijne Den Bak-Glashouwer, M.J. · Havenith, C.E.G. · Thole, J.E.R. · Janssen, R.
Keywords: Health · Allergy · Mucosal immunity · Th1/Th2 · Antibody · Epitope · Gamma interferon · Peptide · Peptide der p 1 · Unclassified drug · Allergic disease · Animal cell AAnimal experiment · Animal model · Animal tissue · Antibody response · Controlled study · Cytokine production · Dermatophagoides pteronyssinus · Immune response · Immunization · Immunomodulation · Lactobacillus plantarum · Mouse · Nonhuman · T lymphocyte · Animals · Antigens, Dermatophagoides · Cells, Cultured · Dust · Female · Glycoproteins · Hypersensitivity, Immediate · Immunoglobulin E · Immunoglobulin G · Interferon Type II · Interleukin-5 · Lactobacillus · Lymphocyte Activation · Mice · Mice, Inbred C57BL · Mites · Recombinant Fusion Proteins · T-Lymphocytes · Th1 Cells · Th2 Cells · Transformation, Bacterial
[Abstract]

14 Mixed antibody and T cell responses to peanut and the peanut allergens Ara h 1, Ara h 2, Ara h 3 and Ara h 6 in an oral sensitization model
article 2004    
Author: Wijk, F. van · Hartgring, S. · Koppelman, S.J. · Pieters, R. · Knippels, L.M.J.
Keywords: Biology · Food technology · Cytokines · Oral mouse model · Peanut allergens · Peanut hyper-sensitivity · Sensitization · Th1/Th2 responses · antibody · cholera toxin · cytokine · food allergen · gamma interferon · immunoglobulin E · immunoglobulin G1 · immunoglobulin G2a · interleukin 10 · interleukin 4 · interleukin 5 · protein Ara h 1 · protein Ara h 2 · protein Ara h 3 · protein Ara h 6 · unclassified drug · anaphylaxis · animal cell · animal experiment · animal model · antibody detection · antibody response · article · controlled study · cytokine production · disease model · exposure · female · humoral immunity · immune response · mouse · nonhuman · peanut · peanut allergy · priority journal · sensitization · serum · spleen · T lymphocyte · Th1 cell · Th2 cell · Administration, Oral · Allergens · Animals · Arachis hypogaea · Cells, Cultured · Cytokines · Disease Models, Animal · Female · Glycoproteins · Immunoglobulin A · Immunoglobulin E · Immunoglobulin G · Immunoglobulins · Mice · Mice, Inbred C3H · Peanut Hypersensitivity · Plant Proteins · Spleen · T-Lymphocytes, Helper-Inducer · Th1 Cells · Th2 Cells
[Abstract]

15 Tolerization of an established αb-crystallin-reactive T-cell response by intravenous antigen
article 2007    
Author: Verbeek, R. · Mark, K. van der · Wawrousek, E.F. · Plomp, A.C. · Noort, J.M. van
Keywords: Biology · Biomedical Research · αB-crystallin · Autoimmunity · Multiple sclerosis · T cells · Tolerance · alpha crystallin · alphab crystallin · antibody · autoantigen · Freund adjuvant · ovalbumin · epitope · gamma interferon · immunoglobulin G · recombinant protein · animal cell · animal experiment · antibody blood level · antibody response · antigen specificity · article · cellular immunity · controlled study · delayed hypersensitivity · dose response · drug dose comparison · drug efficacy · immune response · immunization · immunological tolerance · immunoregulation · mouse · multiple sclerosis · nonhuman · priority journal · protein deficiency · T lymphocyte activation · animal · biosynthesis · cell culture · dendritic cell · immunology · intravenous drug administration · lymphocyte activation · T lymphocyte subpopulation · time · alpha-Crystallin B Chain · Animals · Autoantigens · Cells, Cultured · Dendritic Cells · Dose-Response Relationship, Immunologic · Epitopes · Hypersensitivity, Delayed · Immune Tolerance · Immunoglobulin G · Injections, Intravenous · Interferon Type II · Lymphocyte Activation · Mice · Multiple Sclerosis · Recombinant Proteins · T-Lymphocyte Subsets · Time Factors
[Abstract]

16 Developmental immunotoxicity of methylmercury: The relative sensitivity of developmental and immune parameters
article 2010    
Author: Tonk, E.C.M. · Groot, D.M.G. de · Penninks, A.H. · Waalkens - Berendsen, I.D.H. · Wolterbeek, A.P.M. · Slob, W. · Piersma, A.H. · Loveren, H. van
Keywords: Toxicology · Biomedical Research · Benchmark dose · Developmental immunotoxicity · Developmental toxicity · Dose-response modeling · Methylmercury · Perinatal exposure · Rat · gamma interferon · interleukin 10 · interleukin 13 · interleukin 2 · interleukin 4 · interleukin 6 · keyhole limpet hemocyanin · methylmercury · T lymphocyte antibody · adherent cell · animal tissue · antibody response · article · basophil · body weight · CD3+ T lymphocyte · CD4 CD8 ratio · CD8+ T lymphocyte · clinical evaluation · controlled study · cytokine production · delayed hypersensitivity · developmental screening · diagnostic value · environmental exposure · epididymis · erythrocyte · female · gestational age · immunological parameters · immunotoxicity · kidney mass · leukocyte count · litter size · liver weight · lymphocyte proliferation · natural killer cell · newborn mortality · nonhuman · rat · reticulocyte count · sensitivity and specificity · spleen cell · spleen weight · stillbirth · testis weight · thrombocyte count · thymus · weight reduction
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 16 of 16 found. | Sort by date