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Showing 1 to 14 of 14 found. | Sort by date

1 Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain
article 2003    
Author: Gerritsen, G. · Kypreos, K.E. · Zee, A. van der · Teusink, B. · Zannis, V.I. · Havekes, L.M. · Dijk, K.W. van
Keywords: Biology · Adenoviridae · Animals · Apolipoprotein E2 · Apolipoprotein E4 · Apolipoproteins E · Cholesterol · Humans · Hyperlipidemias · Lipids · Lipoproteins · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Protein Isoforms · Protein Structure, Tertiary · Triglycerides
[PDF] [Abstract]

2 Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158→Cys) homozygotes is associated with hyperinsulinemia
article 2002    
Author: Beer, F. de · Stalenhoef, A.F.H. · Hoogerbrugge, N. · Kastelein, J.J.P. · Leuven, J.A.G. · Duijn, C.M. van · Havekes, L.M. · Smelt, A.H.M.
Keywords: Adult · Age of Onset · Aging · Apolipoprotein E2 · Apolipoproteins E · Comorbidity · Coronary Disease · Estrogens · Female · Gene Expression · Gene Frequency · Homozygote · Humans · Hyperinsulinism · Hyperlipoproteinemia Type III · Male · Menopause · Middle Aged · Netherlands · Peripheral Vascular Diseases · Prevalence · Regression Analysis · Sex Factors
[Abstract]

3 Apolipoprotein E2 (Lys146→Gln) causes hypertriglyceridemia due to an apolipoprotein E variant-specific inhibition of lipolysis of very low density lipoproteins-triglycerides
article 2000    
Author: Beer, F. de · Dijk, K.W. van · Jong, M.C. · Vark, L.C. van · Zee, A. van der · Hofker, M.H. · Fallaux, F.J. · Hoeben, R.C. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Adenoviridae · Alleles · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Gene Expression · Gene Transfer Techniques · Humans · Hydrolysis · Hyperlipoproteinemia Type III · Hypertriglyceridemia · Lipolysis · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Knockout · Point Mutation · RNA, Messenger · Triglycerides
[Abstract]

4 Hyperlipidemia of ApoE2(Arg158-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression
article 1999    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Winther, M.P.J. de · Hof, B. van 't · Zee, A. van der · Boom, H. van der · Havekes, L.M. · Hofker, M.H.
Keywords: Biology · Apolipoprotein E · Hypertriglyceridemia · LDL receptor · LDL receptor-related protein · VLDL triglyceride lipolysis · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol, VLDL · Gene Expression · Hypertriglyceridemia · Lipolysis · Mice · Mice, Knockout · Point Mutation · Receptors, LDL · Triglycerides
[Abstract]

5 Binding of β-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas apoE only modulates binding affinity
article 1999    
Author: Beer, F. de · Hendriks, W.L. · Vark, L.C. van · Kamerling, S.W.A. · Dijk, K.W. van · Hofker, M.H. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Biology · β-VLDL · apoE · Heparan sulfate proteoglycans · Lipoprotein lipase · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Binding, Competitive · Cell Line · Cholesterol, VLDL · Heparan Sulfate Proteoglycans · Iodine Radioisotopes · Lipoprotein Lipase · Macrophages · Mice · Mice, Knockout
[Abstract]

6 Effect of apolipoprotein E variants on lipolysis of very low density lipoproteins by heparan sulphate proteoglycan-bound lipoprotein lipase
article 1998    
Author: Man, F.H.A.F. de · Beer, F. de · Laarse, A. van der · Smelt, A.H.M. · Leuven, J.A.G. · Havekes, L.M.
Keywords: Health · Atherosclerosis · Familial dysbetalipoproteinemia · Metabolism · Triglyceride · VLDL · Adult · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Female · Heparan Sulfate Proteoglycans · Heterozygote · Homozygote · Humans · Hyperlipoproteinemia Type III · Lipolysis · Lipoprotein Lipase · Lipoproteins, VLDL · Male · Middle Aged
[Abstract]

7 Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor
article 1998    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Zee, A. van der · Hof, B. van 't · Boom, H. van der · Kobayashi, K. · Chan, L. · Havekes, L.M. · Hofker, M.H.
Keywords: Health · ApoE variants · Atherosclerosis · Gene therapy · VLDL receptor · Adenoviridae · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Female · Gene Transfer Techniques · Humans · Hypercholesterolemia · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL · Triglycerides
[Abstract]

8 Effect of macrophage-derived mouse ApoE, human ApoE3-Leiden, and human ApoE2 (Arg158→Cys) on cholesterol levels and atherosclerosis in ApoE- deficient mice
article 2000    
Author: Eck, M. van · Herijgers, N. · Dijk, K.W. van · Havekes, L.M. · Hofker, M.H. · Groot, P.H.E. · Berkel, T.J.C. van
Keywords: Atherosclerosis · Hyperlipidemia · Low density lipoprotein · Animal model · Animal tissue · Cholesterol blood level · Cholesterol transport · Mouse · Nonhuman · Transgenic mouse · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Bone Marrow Transplantation · Cholesterol · Humans · Liver · Macrophages, Peritoneal · Mice · Mice, Knockout · Mice, Transgenic
[Abstract]

9 Immunological discrimination between the human apolipoprotein E2(Arg158→Cys) and E3 isoforms
article 1992    
Author: Gerritse, K. · Knijff, P. de · Ierssel, G.V. · Havekes, L.M. · Frants, R.R. · Schellekens, M.M. · Zegers, N.D. · Claassen, E. · Boersma, W.J.A.
Keywords: Synthetic peptides · Type III hyperlipoproteinemia · Apolipoprotein e2 · Apolipoprotein e3 · Lipoprotein receptor · Monoclonal antibody · Amino acid sequence · Antigenicity · Binding affinity · Immunological tolerance · Lipid metabolism · Lipoprotein blood level · Nonhuman · Sequence homology · Amino Acid Sequence · Animal · Antibodies, Monoclonal · Antibody Specificity · Apolipoproteins E · Arginine · Cysteine · Enzyme-Linked Immunosorbent Assay · Epitopes · Female · Human · Immunoblotting · Isoelectric Focusing · Mice · Mice, Inbred BALB C · Molecular Sequence Data · Phenotype · Sequence Alignment
[PDF] [Abstract]

10 Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyperinsulinemia and an SstI polymorphism
article 1999    
Author: Sijbrands, E.J.G. · Hoffer, M.J.V. · Meinders, A.E. · Havekes, L.M. · Frants, R.R. · Smelt, A.H.M. · Knijff, P. de
Keywords: Apolipoprotein E · Hyperinsulinemia · Hyperlipoproteinemia type III · Xanthomas · Adult · Aged · Aged, 80 and over · Apolipoprotein A-I · Apolipoprotein C-III · Apolipoprotein E2 · Apolipoproteins A · Apolipoproteins C · Apolipoproteins E · Cholesterol, HDL · Cholesterol, LDL · Cholesterol, VLDL · Family Health · Female · Gene Expression · Haplotypes · Homozygote · Humans · Hyperinsulinism · Hyperlipidemias · Male · Middle Aged · Pedigree · Polymorphism, Single Nucleotide · Promoter Regions (Genetics) · Xanthomatosis
[Abstract]

11 ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency
article 2008    
Author: Gerritsen, G. · Hoogt, C.C. van der · Schaap, F.G. · Voshol, P.J. · Kypreos, K.E. · Maeda, N. · Groen, A.K. · Havekes, L.M. · Rensen, P.C.N. · Dijk, K.W. van
Keywords: Health · Physiological Sciences · Adenovirus-mediated gene transfer · APOE2-knockin mice · Apolipoprotein A-V · Apolipoprotein C-III · Apolipoprotein E2 · Lipoprotein lipase-mediated very low density lipoprotein-triglyceride hydrolysis · apolipoprotein A · apolipoprotein A5 · apolipoprotein B · apolipoprotein C · apolipoprotein C3 · apolipoprotein D · apolipoprotein E · apolipoprotein M · beta2 glycoprotein 1 · clusterin · heparin · Apoa5 protein, mouse · apolipoprotein · Adenovirus · animal experiment · animal model · cholesterol blood level · conference paper · controlled study · disease association · female · gene overexpression · hypertriglyceridemia · in vivo study · lipoprotein deficiency · mouse · nonhuman · stimulation · triacylglycerol blood level · animal · blood · gene transfer · genetics · mouse mutant · physiology · Adenoviridae · Animals · Apolipoprotein C-III · Apolipoprotein E2 · Apolipoproteins · Gene Transfer Techniques · Hypertriglyceridemia · Lipids · Lipoprotein Lipase · Male · Mice · Mice, Knockout
[PDF] [Abstract]

12 The expression of type III hyperlipoproteinemia: Involvement of lipolysis genes
article 2009    
Author: Henneman, P. · Sman-de Beer, F. van der · Moghaddam, P.H. · Huijts, P. · Stalenhoef, A.F.H. · Kastelein, J.J.P. · Duijn, C.M. van · Havekes, L.M. · Frants, R.R. · Dijk, K.W. van · Smelt, A.H.M.
Keywords: Biology · Biomedical Research · adenine · apolipoprotein A5 · apolipoprotein C3 · apolipoprotein E2 · cytosine · guanine · lipoprotein lipase · liver triacylglycerol lipase · thymine · adult · aged · article · controlled study · disease severity · female · gene expression · gene frequency · gene function · gene linkage disequilibrium · genetic association · genetic polymorphism · genetic variability · human · human cell · hyperlipidemia · hyperlipoproteinemia type 3 · hypertriglyceridemia · lipolysis · lipoprotein blood level · major clinical study · male · mutational analysis · Netherlands · priority journal
[Abstract]

13 Combined Association and Linkage Analysis Applied to the APOE Locus
article 2004    
Author: Beekman, M. · Posthuma, D. · Heijmans, B.T. · Lakenberg, N. · Suchiman, H.E.D. · Snieder, H. · Knijff, P. de · Frants, R.R. · Ommen, G.J.B. van · Kluft, C. · Vogler, G.P. · Slagboom, P.E. · Boomsma, D.I.
Keywords: ApoE level · Fine-mapping · Quantitative trait locus · Twin pairs · chromosome 19 · cohort analysis · gene locus · gene mapping · genetic association · genetic linkage · genetic polymorphism · genotype · linkage analysis · lipoprotein blood level · quantitative trait locus · short tandem repeat · twins · Adolescent · Adult · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoprotein E4 · Apolipoproteins E · Chromosomes, Human, Pair 19 · Cohort Studies · Female · Genotype · Humans · Linkage (Genetics) · Lod Score · Male · Netherlands · Polymorphism, Genetic · Quantitative Trait, Heritable · Genetta
[Abstract]

14 Interactions between lifestyle-related factors and the ApoE polymorphism on plasma lipids and apolipoproteins: The ears study
article 1997    
Author: Boer, J.M.A. · Ehnholm, C. · Menzel, H.J. · Havekes, L.M. · Rosseneu, M. · O'Reilly, D.S.J. · Tiret, L.
Keywords: Biology · Adiposity · Apolipoprotein · Apolipoprotein E polymorphism · Lifestyle · Lipids · Apolipoprotein · Apolipoprotein b · Apolipoprotein e · Apolipoprotein e2 · Apolipoprotein e3 · Cholesterol · Cholesterol oleate · Linoleic acid · Lipid · Polyunsaturated fatty acid · Saturated fatty acid · Triacylglycerol · Adult · Alcohol consumption · Anthropometry · Body mass · Cigarette smoking · Controlled study · Female · Genetic polymorphism · Human · Lifestyle · Lipid blood level · Major clinical study · Male · Phenotype · Physical activity · Priority journal · Adolescent · Adult · Apolipoprotein E4 · Apolipoproteins · Apolipoproteins B · Apolipoproteins E · Body Mass Index · Cholesterol Esters · Coronary Arteriosclerosis · Female · Heterozygote · Humans · Life Style · Lipids · Male · Polymorphism, Genetic · Risk Factors
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 14 of 14 found. | Sort by date