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1 Pharmacokinetics of oestriol after repeated oral administration to dogs
article 2003    
Author: Hoeijmakers, M. · Janszen, B. · Coert, A. · Horspool, L.
Keywords: Drugs Chemistry · Physiological Sciences · estriol · incurin · animal experiment · area under the curve · article · blood sampling · calculation · controlled study · dog · dose response · drug accumulation · drug blood level · enterohepatic circulation · female · individualization · nonhuman · radioimmunoassay · statistical analysis · tablet formulation · urine incontinence · Administration, Oral · Animals · Dogs · Estriol · Female · Urinary Incontinence · Animalia · Canidae · Canis familiaris
[Abstract]

2 Influence of amifostine on the pharmacokinetics of cisplatin in cancer patients
article 1998    
Author: Korst, A.E.C. · Sterre, M.L.T. van der · Gall, H.E. · Fichtinger-Schepman, A.M.J. · Vermorken, J.B. · Vijgh, W.J.F. van der
Keywords: Nutrition · Amifostine · Cisplatin · Creatinine · Adult · Aged · Area under the curve · Clinical article · Creatinine blood level · Dna adduct · Dna drug complex · Drug blood level · Drug effect · Drug half life · Female · Human · Intravenous drug administration · Kidney function · Male · Malignant neoplastic disease · Priority journal · Amifostine · Antineoplastic Agents · Cisplatin · DNA Adducts · Drug Interactions · Female · Half-Life · Hemofiltration · Humans · Leukocytes · Male · Middle Aged · Neoplasms · Platinum · Radiation-Protective Agents
[Abstract]

3 Betaine supplementation lowers plasma homocysteine in healthy men and women
article 2003    
Author: Steenge, G.R. · Verhoef, P. · Katan, M.B.
Keywords: Health · Physiological Sciences · Betaine · Folic acid · Homocysteine metabolism · Intervention study · Methionine-loading test · 5 methyltetrahydrofolic acid · betaine · homocysteine · methionine · placebo · adult · amino acid blood level · amino acid metabolism · area under the curve · article · body mass · cardiovascular disease · cardiovascular risk · clinical trial · controlled clinical trial · controlled study · diet restriction · diet supplementation · drug efficacy · female · human · loading test · male · randomized controlled trial · Adult · Betaine · Blood Glucose · Blood Pressure · Body Mass Index · Diet · Dietary Supplements · Eating · Fasting · Female · Folic Acid · Homocysteine · Humans · Lipids · Male · Reference Values
[Abstract]

4 Application of physiologically based toxicokinetic modelling to study the impact of the exposure scenario on the toxicokinetics and the behavioural effects of toluene in rats
article 2003    
Author: Asperen, J. van · Rijcken, W.R.P. · Lammers, J.H.C.M.
Keywords: Toxicology · Toxicology and Applied Pharmacology · Peak exposure · Physiologically based toxicokinetic modelling · Rat · Toluene · toluene · animal experiment · area under the curve · article · behavior · blood level · brain level · concentration response · controlled study · exposure · male · model · nonhuman · prediction · priority journal · rat · reliability · task performance · tissue level · toxicokinetics · visual discrimination · Administration, Inhalation · Animals · Behavior, Animal · Brain · Discrimination Learning · Dose-Response Relationship, Drug · Inhalation Exposure · Models, Biological · Rats · Toluene · Visual Perception
[Abstract]

5 Short-term digestive tolerance of different doses of NUTRIOSE®FB, a food dextrin, in adult men
article 2004    
Author: Heuvel, E.G.H.M. van den · Wils, D. · Pasman, W.J. · Bakker, M. · Saniez, M.-H. · Kardinaal, A.F.M.
Keywords: Nutrition · Physiological Sciences · Dextrin · Gastro-intestinal symptoms · NUTRIOSE®FB · Tolerance · dextrin · glucidex 6 · hydrogen · maltodextrin · nutriose fb · placebo · starch · abdominal discomfort · adult · area under the curve · article · clinical trial · controlled clinical trial · controlled study · defecation · diarrhea · diet supplementation · digestion · drug decomposition · drug tolerability · exhalation · flatulence · frequency analysis · human · human experiment · male · normal human · satiety · statistical significance · wheat · Adult · Cross-Over Studies · Defecation · Dextrins · Diarrhea · Dose-Response Relationship, Drug · Double-Blind Method · Fermentation · Flatulence · Humans · Intestinal Absorption · Male · Middle Aged · Triticum aestivum
[Abstract]

6 Observational infant exploratory [14C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis
article 2015    
Author: Garner, C.R. · Park, K.B. · French, N.S. · Earnshaw, C. · Schipani, A. · Selby, A.M. · Byrne, L. · Siner, S. · Crawley, F.P. · Vaes, W.H.J. · Duijn, E. van · ligt, R. de · Varendi, H. · Lass, J. · Grynkiewicz, G. · Maruszak, W. · Turner, M.A.
Keywords: Biology · Exploratory clinical study · Microdosing · Paediatric pharmacokinetics · Paracetamol · Unclassified drug · Accelerator mass spectrometry · Area under the curve · Child · Drug blood level · Drug clearance · Drug half life · Female · Human · Infant · Major clinical study · Male · Mass spectrometry · Maximum plasma concentration · Pharmacokinetics · Plasma concentration-time curve · Time to maximum plasma concentration · Ultra performance liquid chromatography · Volume of distribution · Healthy for Life · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

7 Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in type 2 diabetic men
article 2006    
Author: Manders, R.J. · Koopman, R. · Sluijsmans, W.E. · Berg, R. van den · Verbeek, K. · Saris, W.H. · Wagenmakers, A.J. · Loon, L.J. van
Keywords: Biology · Analytical research · Amino acids · Insulin · Postprandial glucose · Type 2 diabetes · amino acid · carbohydrate · glucose · insulin · leucine · metformin · protein hydrolysate · sulfonylurea · amino acid blood level · area under the curve · article · body mass · controlled study · demography · glucose blood level · human · ingestion · insulin blood level · insulin like activity · insulin response · male · non insulin dependent diabetes mellitus · Administration, Oral · Amino Acids · Beverages · Blood Glucose · Body Mass Index · Body Size · Diabetes Mellitus, Type 2 · Diabetic Diet · Humans · Leucine · Male · Middle Aged · Postprandial Period · Protein Hydrolysates · Reference Values
[Abstract]

8 Predicting the duration of sickness absence for patients with common mental disorders in occupational health care
article 2006    
Author: Nieuwenhuijsen, K. · Verbeek, J.H.A.M. · Boer, A.G.E.M. de · Blonk, R.W.B. · Dijk, F.J.H. van
Keywords: Workplace · Arbeidsparticipatie · Mental health problems · Prediction rule · Prospective cohort · Return to work · Mental health · Absenteeism · Academic achievement · Adult · Age · Area under the curve · Cohort analysis · Consultation · Controlled study · Depression · Major clinical study · Occupational health service · Occupational physician · Prediction · Probability · Prognosis · Proportional hazards model · Receiver operating characteristic · Scoring system · Teacher · Time · Work resumption · Adjustment Disorders · Anxiety Disorders · Depressive Disorder · Female · Humans · Male · Mental Disorders · Middle Aged · Models, Biological · Occupational Health · Sick Leave · Socioeconomic Factors · Workplace
[PDF] [Abstract]

9 Carotenoid interactions
article 1999    
Author: Berg, H. van den
Keywords: Nutrition · Chemistry · Analyse · Alpha carotene · Beta carotene · Canthaxanthin · Carotenoid · Chylomicron · High density lipoprotein · Low density lipoprotein · Lycopene · Triacylglycerol · Very low density lipoprotein · Xanthophyll · Zeaxanthin · Area under the curve · Dietary intake · Dose response · Ferret · Fruit · Human · Intestine absorption · Liver · Metabolism · Mitosis inhibition · Nonhuman · Nutrition · Postprandial state · Prophylaxis · Review · Small intestine mucosa · Smoking · Tissue distribution · Transport kinetics · Vegetable · Vitamin blood level · Administration, Oral · Animals · Carotenoids · Chylomicrons · Drug Interactions · Humans · Intestinal Absorption
[Abstract]

10 A randomized three-way cross-over study in healthy pituitary-suppressed women to compare the bioavailability of human chorionic gonadotrophin (Pregnyl®) after intramuscular and subcutaneous administration
article 1998    
Author: Mannaerts, B.M.J.L. · Geurts, T.B.P. · Odink, J.
Keywords: Nutrition · Bioequivalence · Human chorionic gonadotrophin · Intramuscular · Pharmacokinetics · Subcutaneous · Chorionic gonadotropin · Adult · Area under the curve · Bioequivalence · Clinical trial · Controlled study · Dose response · Drug absorption · Drug bioavailability · Drug blood level · Drug elimination · Drug half life · Female · Human · Human experiment · Hypopituitarism · Intramuscular drug administration · Normal human · Randomized controlled trial · Subcutaneous drug administration · Administration, Oral · Adolescent · Adult · Chorionic Gonadotropin · Contraceptives, Oral · Cross-Over Studies · Dose-Response Relationship, Drug · Female · Humans · Injections, Intramuscular · Pituitary Gland
[Abstract]

11 Pharmacokinetics of cisplatin with and without amifostine in tumour- bearing nude mice
article 1998    
Author: Korst, A.E.C. · Boven, E. · Sterre, M.L.T. van der · Fichtinger-Schepman, A.M.J. · Vijgh, W.J.F. van der
Keywords: Nutrition · Amifostine · Cisplatin · Ethyol · Pharmacokinetics · WR-2721 · Amifostine · Cisplatin · Dna · Animal cell · Animal experiment · Animal model · Animal tissue · Area under the curve · Article · Bone marrow · Controlled study · Dna adduct · Drug blood level · Drug tissue level · Female · Human · Human tissue · Intraperitoneal drug administration · Intravenous drug administration · Kidney · Liver · Mouse · Nonhuman · Nude mouse · Ovary cancer · Pharmacokinetics · Priority journal · Tumor xenograft · Amifostine · Animals · Antineoplastic Agents · Cisplatin · Drug Combinations · Drug Synergism · Female · Humans · Kidney · Liver · Mice · Neoplasm Transplantation · Ovarian Neoplasms · Platinum · Radiation-Protective Agents · Transplantation, Heterologous
[Abstract]

12 Effect of simultaneous, single oral doses of beta-carotene with lutein or lycopene on the beta-carotene and retinyl ester responses in the triacylglycerol-rich lipoprotein fraction of men
article 1998    
Author: Berg, H. van den · Vliet, T. van
Keywords: Nutrition · β-Carotene · Chylomicrons · Humans · Interactions · Lutein · Lycopene · Retinyl esters · Retinyl palmitate · Triacylglycerol-rich lipoprotein · Vegetables · Beta carotene · Carotenoid · Chylomicron · Lipoprotein · Lycopene · Retinol ester · Retinol palmitate · Triacylglycerol · Xanthophyll · Adult · Antioxidant activity · Area under the curve · Carrot · Cell communication · Data analysis · Food intake · Human · Immunosurveillance · Intestine absorption · Lipoprotein metabolism · Male · Oral drug administration · Quantitative diagnosis · Spinach · Statistical analysis · Test meal · Tomato · Absorption · Adult · beta Carotene · Carotenoids · Humans · Kinetics · Lipoproteins · Lutein · Male · Triglycerides · Vegetables · Vitamin A · Daucus carota · Lycopersicon esculentum · Spinacia oleracea
[Abstract]

13 Bioavailability of tryptophan from a single oral dose of a trytophan-enriched peptide mixture in healthy men
article 2004    
Author: Brink, E.J. · Boelsma, E. · Steijns, J. · Hendriks, H.F.J.
Keywords: Biology Health · Physiological Sciences · Amino acids · Dietary supplements · Serotonergic activity · Tryptophan · 5 hydroxyindoleacetic acid · 6 hydroxymelatonin o sulfate · Alanine · Arginine · Aspartic acid · Cystine · Glucose · Glutamic acid · Histidine · Insulin · Isoleucine · Leucine · Lysine · Melatonin · Methionine · Phenylalanine · Prolactin · Proline · Protein hydrolysate · Serine · Serotonin · Threonine · Tryptophan · Valine · Adult · Amino acid blood level · Area under the curve · Blood analysis · Brain function · Chemical binding · Clinical trial · Controlled clinical trial · Controlled study · Crossover procedure · Double blind procedure · Drug bioavailability · Human · Human experiment · Insulin blood level · Male · Metabolic parameters · Normal human · Prolactin blood level · Randomized controlled trial · Review · Serotonin blood level · Serotonin brain level · Serotonin metabolism · Urinalysis · Urine level
[Abstract]

14 The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab
article 2014    
Author: Mierlo, G.J.D. van · Cnubben, N.H.P. · Wouters, D. · Wolbink, G.J. · Hart, M.H.L. · Rispens, T. · Ganderup, N.C. · Kuper, C.F. · Aarden, L. · Penninks, A.H.
Keywords: Biology · Adalimumab · Alternative model · Anti-drug antibodies · Immunogenicity · Infliximab · Minipig · Pharmacokinetics Ddrug antibody · Animal experiment · Animal model · Animal tissue · Antibody response · Antibody titer · Area under the curve · Body weight · Clinical chemistry · Clinical feature · Clinical observation · Controlled study · Drug blood level · Drug clearance · Drug half life · Drug megadose · Female · Hematological parameters · Histopathology · Immune function test · Immune system · Low drug dose · Maximum plasma concentration · Mean residence time · Nonhuman · Organ weight · Predictive value · Priority journal · Time to maximum plasma concentration · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

15 Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age
article 2006    
Author: Nohynek, G.J. · Meuling, W.J.A. · Vaes, W.H.J. · Lawrence, R.S. · Shapiro, S. · Schulte, S. · Steiling, W. · Bausch, J. · Gerber, E. · Sasa, H. · Nau, H.
Keywords: Nutrition · Analytical research · Biomonitoring · CAS 68-26-8 · CAS 79-81-2 · Human subjects · Plasma concentrations · Retinoic acids · Retinol · Retinyl palmitate · Teratogenicity · Topical and oral administration · 4 oxoretinoic acid · oleic acid · retinoic acid · retinol · retinol ester · retinol palmitate · stearic acid · absence of side effects · adult · area under the curve · article · blood sampling · body surface · clinical article · controlled study · dose response · female · human · pregnancy · priority journal · retinol deficiency · skin irritation · statistical analysis · vitamin blood level · Administration, Oral · Administration, Topical · Adult · Cosmetics · Female · Humans · Risk Assessment · Vitamin A
[Abstract]

16 A high-protein diet increases postprandial but not fasting plasma total homocysteine concentrations: A dietary controlled, crossover trial in healthy volunteers
article 2005    
Author: Verhoef, P. · Vliet, T. van · Olthof, M.R. · Katan, M.B.
Keywords: Health · Biomedical Research · Crossover study · Dietary protein · Fasting · Homocysteine · Humans · Postprandial · homocysteine · methionine · adult · amino acid blood level · article · controlled study · demography · diet supplementation · human · human experiment · male · normal human · nutrition · postprandial state · protein diet · adolescent · area under the curve · blood · cardiovascular disease · clinical trial · controlled clinical trial · crossover procedure · diet restriction · dose response · physiology · protein intake · protein restriction · randomized controlled trial · risk factor · Adolescent · Adult · Area Under Curve · Cardiovascular Diseases · Cross-Over Studies · Diet, Protein-Restricted · Dietary Proteins · Dose-Response Relationship, Drug · Fasting · Homocysteine · Humans · Male · Methionine · Postprandial Period · Risk Factors
[Abstract]

17 Dietary serine and cystine attenuate the homocysteine-raising effect of dietary methionine: A randomized crossover trial in humans
article 2004    
Author: Verhoef, P. · Steenge, G.R. · Boelsma, E. · Vliet, T. van · Olthof, M.R. · Katan, M.B.
Keywords: Nutrition · Physiological Sciences · Crossover study · Cysteine · Dietary protein · Homocysteine · Methionine · Serine · cysteine · homocysteine · methionine · serine · cystine · amino acid blood level · area under the curve · article · attenuation · body weight · clinical trial · concentration (parameters) · controlled clinical trial · controlled study · dietary intake · food intake · human · male · meal · measurement · normal human · postprandial state · protein restriction · randomized controlled trial · adult · analysis of variance · blood · cardiovascular disease · crossover procedure · diet restriction · drug effect · metabolism · protein intake · Adult · Analysis of Variance · Area Under Curve · Cardiovascular Diseases · Cross-Over Studies · Cystine · Dietary Proteins · Fasting · Homocysteine · Humans · Male · Methionine · Serine
[Abstract]

18 Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages
article 2015    
Author: Vlaming, M.L. · Duijn, E. van · Dillingh, M.R. · Brands, R. · Windhorst, A.D. · Hendrikse, N.H. · Bosgra, S. · Burggraaf, J. · Koning, M.C. de · Fidder, A. · Mocking, J.A. · Sandman, H. · Ligt, R.A. de · Fabriek, B.O. · Pasman, W.J. · Seinen, W. · Alves, T. · Carrondo, M. · Peixoto, C. · Peeters, P.A. · Vaes, W.H.
Keywords: Biology · Alkaline phosphatase, placental · Carbon · Glycosylphosphatidylinositol anchored protein · Isoenzyme · Recombinant protein · Area under the curve · Biological model · Clinical trial · Controlled study · Dose calculation · Double blind procedure · Half life time · Intravenous drug administration · Phase 1 clinical trial · Procedures · Randomized controlled trial · Statistical model · Administration, Intravenous · Adolescent · Adult · Alkaline Phosphatase · Area Under Curve · Carbon Radioisotopes · Double-Blind Method · Drug Dosage Calculations · GPI-Linked Proteins · Half-Life · Healthy Volunteers · Humans · Isoenzymes · Linear Models · Male · Mass Spectrometry · Metabolic Clearance Rate · Models, Biological · Netherlands · Recombinant Proteins · Young Adult · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology ARPC - Analytical Research (Pharm & Chemistry) · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[Abstract]

19 The effect of Korean pine nut oil on in vitro CCK release, on appetite sensations and on gut hormones in post-menopausal overweight women
article 2008    
Author: Pasman, W.J. · Heimerikx, J. · Rubingh, C.M. · Berg, R. van den · O'Shea, M. · Gambelli, L. · Hendriks, H.F.J. · Einerhand, A.W.C. · Scott, C. · Keizer, H.G. · Mennen, L.I.
Keywords: Health · Physiological Sciences · Anorexigenic agent · Arachis oil · Cholecystokinin · Decanoic acid · Fatty acid · Gastrointestinal hormone · Ghrelin · Glucagon like peptide 1 · Korean pine nut oil · Linoleic acid · Linolenic acid · Oleic acid · Olive oil · Peptide YY · Placebo · Insulin · Triacylglycerol · Vegetable oil · Adult · Article · Cell culture · Cholecystokinin blood level · Clinical trial · Comparative study · Control group · Controlled clinical trial · Controlled study · Double blind procedure · Drug effect · Fat intake · Female · Food intake · Hormone release · Human · In vitro study · Obesity · Postmenopause · Randomized controlled trial · Statistical significance · Animal · Appetite · Area under the curve · Blood · Chemistry · Feeding behavior · Glucose blood level · Korea · Metabolism · Middle aged · Mouse · Nut · Pathophysiology · Physiology · Pine · Postprandial state · Psychophysiology · Secretion · Tumor cell line · Pinus koraiensis · Pinus pinea · Animals · Appetite · Area Under Curve · Blood Glucose · Cell Line, Tumor · Cholecystokinin · Fatty Acids · Feeding Behavior · Female · Gastrointestinal Hormones · Humans · Insulin · Korea · Mice · Middle Aged · Nuts · Overweight · Pinus · Plant Oils · Postmenopause · Postprandial Period · Satiety Response · Triglycerides · Healthy for Life · Healthy Living
[PDF] [Abstract]

20 Effect of a high-protein breakfast on the postprandial ghrelin response
article 2006    
Author: Blom, W.A.M. · Lluch, A. · Stafleu, A. · Vinoy, S. · Holst, J.J. · Schaafsma, G. · Hendriks, H.F.J.
Keywords: Biology · Biomedical Research · Dietary protein · Gastric emptying · Gut hormones · Satiety · cholecystokinin · gastric inhibitory polypeptide · ghrelin · glucagon · paracetamol · glucagon like peptide 1 · insulin · peptide hormone · adult · article · blood sampling · caloric intake · carbohydrate intake · controlled study · hormone release · human · male · meal · normal human · postprandial state · protein diet · satiety · stomach emptying · adolescent · area under the curve · blood · clinical trial · controlled clinical trial · crossover procedure · drug effect · glucose blood level · metabolism · physiology · protein intake · questionnaire · randomized controlled trial · secretion · single blind procedure · time · Acetaminophen · Adolescent · Adult · Area Under Curve · Blood Glucose · Cholecystokinin · Cross-Over Studies · Dietary Proteins · Gastric Emptying · Gastric Inhibitory Polypeptide · Glucagon · Glucagon-Like Peptide 1 · Humans · Insulin · Male · Peptide Hormones · Postprandial Period · Questionnaires · Satiation · Single-Blind Method · Time Factors
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 22 found. Next | Sort by date