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1 Regulation of bile acid synthesis in cultured hepatocytes
dissertation 1990    
Author: Kwekkeboom, J.
Keywords: Biology · Bile acid
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2 Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys
article 2006    
Author: Kitayama, K. · Nakai, D. · Kono, K. · Hoop, A.G. van der · Kurata, H. · Wit, E.C. de · Cohen, L.H. · Inaba, T. · Kohama, T.
Keywords: Biology · Apical sodium-dependent bile acid transporter · Cholesterol · Enterohepatic circulation · Hamster · Hypocholesterolemic agent · Monkey · Carbon 14 · Cholesterol · High density lipoprotein cholesterol · Ileum apical bile acid transporter inhibitor · Phospholipid · Piperidine derivative · R 146224 · Taurocholic acid · Triacylglycerol · Tritium · Unclassified drug · Bile acid · Carrier protein · Cotransporter · Organic anion transporter · Quinoline derivative · Sodium · Sodium bile acid cotransporter · Sodium-bile acid cotransporter · Absorption · Animal experiment · Animal tissue · Bile duct fistula · Bile flow · Cholesterol blood level · Cholesterol esterification · Concentration response · Controlled study · Diet · Dose response · Drug mechanism · Embryo · Feeding · Human cell · Hypercholesterolemia · Hypolipemia · Inhibition kinetics · Time · Triacylglycerol blood level · Urinary excretion · Biosynthesis · Blood · Cell line · Drug antagonism · Drug effect · Genetics · In vitro study · Macaca · Metabolism · Physiology · Sprague Dawley rat · Syrian hamster · Animals · Anticholesteremic Agents · Bile Acids and Salts · Cell Line · Cholesterol · Cricetinae · Humans · Ileum · Macaca fascicularis · Male · Membrane Transport Proteins · Mesocricetus · Organic Anion Transporters, Sodium-Dependent · Piperidines · Quinolines · Rats · Rats, Sprague-Dawley · Sodium · Symporters · Taurocholic Acid
[Abstract]

3 Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion
article 2013    
Author: Sugimoto-Kawabata, K. · Shimada, H. · Sakai, K. · Suzuki, K. · Kelder, T. · Pieterman, E.J. · Cohen, L.H. · Havekes, L.M. · Princen, H.M. · Hoek, A.M. van den
Keywords: Biology · Adipose tissue · Bile acid sequestrant · Hyperinsulinemic-euglycemic clamp · Insulin sensitivity · Nonesterified fatty acid · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

4 Bile acids and lipids in isolated rat hepatocytes : Content, synthesis, and release, as affected by cholestyramine treatment of the donor rats
article 1982    
Author: Kempen, H.J.M. · Vos-Holstein, P.M. van · Lange, J. de
Keywords: Biology · Bile acid · Radioisotope · Triacylglycerol · Animal cell · Beta muricholic acid · Cell culture · Controlled study · Drug mechanism · In vitro study · Liver cell · Nonhuman · Oral drug administration · Therapy · Animal · Bile Acids and Salts · Cholestyramine · Lipids · Liver · Male · Rats · Rats, Inbred Strains · Triglycerides
[PDF] [Abstract]

5 Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs
article 2018    
Author: Notenboom, S. · Weigand, K.M. · Proost, J.H. · Lipzig, M.M.H. van · Steeg, E. van de · Broek, P.H.H. van den · Greupink, R. · Russel, F.G.M. · Groothuis, G.M.M.
Keywords: Biology · Bile acid handling · Biokinetic model · BSEP · Cholestasis · Human · In silico · NTCP · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology ADME - ADME/DMPK · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[PDF] [Abstract]

6 Cholesterol 7α-Hydroxylase Deficiency in Mice on an APOE*3-Leiden Background Impairs Very-Low-Density Lipoprotein Production
article 2004    
Author: Post, S.M. · Groenendijk, M. · Solaas, K. · Rensen, P.C.N. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · Bile acid biosynthesis · Cholesterol 7α-hydroxylase · SREBP-1 · Bile acid · Cholesterol · Cholesterol 7alpha monooxygenase · Cholesterol ester · Cytochrome P450 isoenzyme · Messenger RNA · Sterol · Sterol regulatory element binding protein 1 · Unclassified drug · Very low density lipoprotein · Vitamin · Acyltransferase · Alpha tocopherol · Apolipoprotein E3 (Leidein) · Dgat1 protein, mouse · Diacylglycerol acyltransferase · Retinol · Animal experiment · Animal model · Animal tissue · Antioxidant activity · Bile acid synthesis · Catalysis · Cholesterol blood level · Cholesterol metabolism · Controlled study · Enzyme deficiency · Feces level · Gene · Gene expression · Hyperlipidemia · Knockout mouse · Lipid diet · Lipid metabolism · Lipogenesis · Lipoprotein synthesis · Nonhuman · Srebf1 gene · Triacylglycerol blood level · Atherogenic diet · Biosynthesis · Blood · Cross breeding · Feces · Genetics · Metabolism · Mouse mutant · Physiology · Acyltransferases · Animals · Apolipoprotein E3 · Apolipoproteins B · Apolipoproteins E · Bile Acids and Salts · Cholesterol 7-alpha-Hydroxylase · Cholesterol Esters · Crosses, Genetic · Diacylglycerol O-Acyltransferase · Diet, Atherogenic · Feces · Female · Hyperlipoproteinemia Type III · Ketone Bodies · Lipid Metabolism · Lipolysis · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Knockout · RNA, Messenger · Sterols · Triglycerides · Vitamin A · Vitamin E
[Abstract]

7 Differential feedback regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes
article 1993    
Author: Twisk, J. · Lehmann, E.M. · Princen, H.M.G.
Keywords: Health · bile acid · chenodeoxycholic acid · cholesterol 7alpha monooxygenase · deoxycholic acid · glycocholic acid · messenger rna · animal cell · bile acid synthesis · controlled study · culture medium · dose time effect relation · down regulation · enzyme activity · enzyme regulation · feedback system · gene expression regulation · gene repression · genetic transcription · hydrophobicity · kinetics · liver cell · liver cell culture · monolayer culture · negative feedback · nonhuman · transcription regulation · Animal · Base Sequence · Bile Acids and Salts · Cells, Cultured · Chenodeoxycholic Acid · Cholesterol 7-alpha-Hydroxylase · Cholic Acid · Cholic Acids · Feedback · Gene Expression Regulation · Glycocholic Acid · Kinetics · Liver · Male · Molecular Sequence Data · Rats · RNA, Messenger · Support, Non-U.S. Gov't · Taurocholic Acid · Transcription, Genetic
[Abstract]

8 Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes
article 1995    
Author: Twisk, J. · Wit, E.C.M. de · Princen, H.M.G.
Keywords: Biology · bile acid · chenodeoxycholic acid · cholesterol 7alpha monooxygenase · cholic acid · deoxycholic acid · lithocholic acid · messenger rna · oxygenase · sterol · taurocholic acid · animal cell · article · bile acid synthesis · cholesterol metabolism · controlled study · enzyme inhibition · gene repression · liver cell culture · nonhuman · priority journal · rat · transcription regulation · Adenosine Triphosphate · Animal · Bile Acids and Salts · Cells, Cultured · Cholesterol 7-alpha-Hydroxylase · Cytochrome P-450 Enzyme System · Dose-Response Relationship, Drug · Down-Regulation · Gene Expression Regulation, Enzymologic · Liver · Male · Mitochondria · Oxidoreductases · Rats · Rats, Wistar · RNA, Messenger · Steroid Hydroxylases · Support, Non-U.S. Gov't · Taurocholic Acid · Transcription, Genetic
[Abstract]

9 Cholesterol 7α-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol
article 2006    
Author: Post, S.M. · Groenendijk, M. · Hoogt, C.C. van der · Fievet, C. · Luc, G. · Hoekstra, M. · Princen, H.M.G. · Staels, B. · Rensen, P.C.N.
Keywords: Health · Biomedical Research · High-density lipoprotein · ABC transporter A1 · High density lipoprotein cholesterol · Intermediate density lipoprotein · Low density lipoprotein · Messenger RNA · Phosphatidylcholine sterol acyltransferase · Very low density lipoprotein · Bile acid · Phospholipid transfer protein · Phospholipid transfer protein, mouse · Animal experiment · Animal tissue · Bile acid synthesis · Biosynthesis · Catabolism · Cholesterol blood level · Cholesterol metabolism · cholesterol transport · Conhuman · Protein expression · Transgenic mouse · Genetics · Metabolism · Mouse · Mouse mutant · Physiology · Animals · Apolipoprotein E3 · ATP-Binding Cassette Transporters · Bile Acids and Salts · Cholesterol 7-alpha-Hydroxylase · Cholesterol, HDL · Female · Gene Expression Regulation · Gene Expression Regulation, Enzymologic · Humans · Liver · Mice · Mice, Knockout · Mice, Transgenic · Phosphatidylcholine-Sterol O-Acyltransferase · Phospholipid Transfer Proteins · RNA, Messenger
[Abstract]

10 Analysis of fecal bile acids and neutral steroids using gas-liquid chromatography
article 1998    
Author: Srikumar, T.S. · Wezendonk, B. · Dokkum, W. van
Keywords: Nutrition · Bile acids · Gas chromatography · Neutral steroids · Bile acid · Oligosaccharide · Steroid · Accuracy · Bile · European union · Feces analysis · Gas liquid chromatography · Human · Human experiment · Methodology · Normal human · Pilot study · Priority journal · Bile Acids and Salts · Cholestanol · Cholesterol · Chromatography, Gas · Feces · Humans · Phytosterols · Sensitivity and Specificity · Sitosterols · Steroids · Stigmasterol
[Abstract]

11 Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein
article 2007    
Author: Gautier, T. · Tietge, U.J.F. · Boverhof, R. · Perton, F.G. · Le Guern, N. · Masson, D. · Rensen, P.C.N. · Havekes, L.M. · Lagrost, L. · Kuipers, F.
Keywords: Biology · Biomedical Research · Bile · Cholesterol · Triglycerides · bile acid · cholesterol · cholesterol ester transfer protein · high density lipoprotein · triacylglycerol · very low density lipoprotein · animal model · bile secretion · cholesterol blood level · controlled study · insulin metabolism · lipid metabolism · lipid storage · mouse · nonhuman · stress · Animals · Apolipoprotein C-I · Cholesterol Ester Transfer Proteins · Gallbladder · Lipids · Liver · Mice · Mice, Inbred C57BL · Mice, Knockout · Polymerase Chain Reaction · RNA
[PDF] [Abstract]

12 Bile acids and lipids in isolated rat hepatocytes. II. Source of cholesterol used for bile acid formation, estimated by incorporation of tritium from tritiated water, and by the effect of ML-236B
article 1983    
Author: Kempen, H.J. · Vos Van Holstein, M. · Lange, J.de
Keywords: Biology · Bile acid · Cholic acid · Compactin · Ml 236 b · Radioisotope · Tritium oxide · Unclassified drug · Animal cell · Beta muricholic acid · Cholesterol c 14 · Cholesterol h 3 · Cholesterol synthesis · Dihydroxycholanoic acid · In vitro study · Liver cell · Muricholic acid · Nonhuman · Taurocholic acid c 14 · Animal · Bile Acids and Salts · Cholesterol · Cholestyramine · Lipids · Liver · Naphthalenes · Rats · Tritium
[PDF] [Abstract]

13 Increased fecal bile acid excretion in transgenic mice with elevated expression of human phospholipid transfer protein
article 2003    
Author: Post, S.M. · Crom, R. de · Haperen, R. van · Tol, A. van · Princen, H.M.G.
Keywords: Biology · Biomedical Research · Bile acid · HDL · Mouse · Phospholipid transfer protein · Reverse cholesterol transport · Animals · Bile Acids and Salts · Biological Transport · Carrier Proteins · Cholesterol · Cholesterol, HDL · Feces · Humans · Lipase · Lipoprotein Lipase · Liver · Male · Membrane Proteins · Mice · Mice, Inbred C57BL · Mice, Transgenic · Phospholipid Transfer Proteins · Sterols
[Abstract]

14 Determinants of postprandial plasma bile acid kinetics in human volunteers
article 2017    
Author: Fiamoncini, J. · Yiorkas, A.M. · Gedrich, K. · Rundle, M. · Alsters, S.I. · Roeselers, G. · Broek, T.J. van den · Clavel, T. · Lagkouvardos, I. · Wopereis, S. · Frost, G. · Ommen, B. van · Blakemore, A.I. · Daniel, H.
Keywords: Biology · Bile acids · Mixed-meal tolerance test · Oral glucose tolerance test · Postprandial · SLCO1A2 · Chenodeoxycholic acid · Cholic acid · Deoxycholic acid · Genomic DNA · Glycine · Glycochenodeoxycholic acid · Glycocholic acid · Glycodeoxycholic acid · Glycoursodeoxycholic acid · Solute carrier organic anion transporter 1A2 · Taurine · Taurochenodeoxycholic acid · Taurocholic acid · Taurodeoxycholic acid · Taurolitocholic acid · Tauroursodeoxycholic acid · Unclassified drug · Ursodeoxycholic acid · Bile acid blood level · Bile acid synthesis · Clinical trial · Diet restriction · Dietary intake · Enterohepatic circulation · Feces microflora · Gene expression · Genome analysis · Kinetics · Liquid chromatography-mass spectrometry · Oral glucose tolerance test · Phenotype · Postprandial state · Quantitative analysis · Sex difference · Weight reduction · Whole exome sequencing · Blood · Controlled study · Physiology · Randomized controlled trial · Bile Acids and Salts · Fasting · Female · Humans · Male · Metabolic Clearance Rate · Middle Aged · Postprandial Period · Weight Loss · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

15 Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene transcription
article 1995    
Author: Twisk, J. · Hoekman, M.F.M. · Lehmann, E.M. · Meijer, P. · Mager, W.H. · Princen, H.M.G.
Keywords: Biology · cholesterol 7alpha monooxygenase · insulin · oxygenase · sterol 27 hydroxylase · unclassified drug · animal cell · article · bile acid synthesis · controlled study · down regulation · enzyme activity · gene expression regulation · hormone action · liver cell culture · nonhuman · transcription regulation · Animal · Bile Acids and Salts · Cells, Cultured · Chloramphenicol O-Acetyltransferase · Cholesterol 7-alpha-Hydroxylase · Cytochrome P-450 Enzyme System · Down-Regulation · Gene Expression Regulation, Enzymologic · Insulin · Liver · Male · Membrane Glycoproteins · Nuclear Proteins · Rats · Rats, Wistar · RNA, Messenger · Steroid Hydroxylases · Support, Non-U.S. Gov't · Transcription, Genetic · Transfection
[Abstract]

16 Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin
article 2014    
Author: Kühnast, S. · Hoorn, J.W.A. van der · Pieterman, E.J. · Hoek, A.M. van den · Sasiela, W.J. · Gusarova, V. · Peyman, A. · Schäfer, H.L. · Schwahn, U. · Jukema, J.W. · Princen, H.M.G.
Keywords: Biology · 3Leiden.CETP mice · APOE · Atorvastatin · Proprotein convertase subtilisin/kexin type 9 · Alirocumab · Apolipoprotein E · Atorvastatin · Bile acid · Cholesterol · Collagen · Low density lipoprotein receptor · Sterol · Triacylglycerol · Animal experiment · Animal model · Atherosclerosis · Atherosclerotic plaque · Controlled study · Disease severity · Dose response · Drug effect · Drug potentiation · Drug safety · Fat content · Female · Lipid blood level · Monocyte · Monotherapy · Mouse · Nonhuman · Protein degradation · Smooth muscle fiber · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

17 Quantitative profiling of bile acids in biofluids and tissues based on accurate mass high resolution LC-FT-MS: Compound class targeting in a metabolomics workflow
article 2008    
Author: Bobeldijk, I. · Hekman, M. · Vries de- Weij, J.van der · Coulier, L. · Ramaker, R. · Kleemann, R. · Kooistra, T. · Rubingh, C. · Freidig, A. · Verheij, E.
Keywords: Analytical research · Accurate mass · Bile acids · Body fluids · High performance liquid chromatography · Metabolomics · Targeted metabolite profiling · Tissues · Acids · Arsenic compounds · Chlorine compounds · Cholesterol · Chromatographic analysis · Complexation · Electrospray ionization · Fourier transforms · High performance liquid chromatography · Histology · Ionization · Ionization of liquids · Liquid chromatography · Liquid phase epitaxy · Liver · Mass spectrometers · Mass spectrometry · Metabolites · Phase separation · Plasmas · Separation · Spectrometers · Spectrometry · Sulfate minerals · Accurate mass · Bile acid synthesis · Bile acids · Bio-fluids · Biological fluids · Cholesterol homeostasis · Chromatography-mass spectrometry · Electro spraying · Fourier Transform Mass Spectrometer · Generic methods · High resolutions · HPLC-MS · Human plasmas · Human urine · Linear ion trap · Metabolomics · Mouse liver · Pooled samples · Reversed-phase high performance · Sample preparations · Targeted metabolite profiling · Tissues · Body fluids · Bile acid · Glycine · Sulfate · Accuracy · Animal experiment · Animal tissue · Article · Bile acid synthesis · Body fluid · Cholesterol intake · Cholesterol liver level · Controlled study · Electrospray · Fourier transform mass spectrometry · Homeostasis · Human · Liver · Metabolite · Metabolomics · Nonhuman · Priority journal · Quantitative analysis · Reversed phase high performance liquid chromatography · Statistical significance · Tissue · Animals · Bile Acids and Salts · Cholesterol, Dietary · Chromatography, Liquid · Computational Biology · Fourier Analysis · Humans · Liver · Mass Spectrometry · Metabolism · Mice · Reproducibility of Results
[Abstract]

18 Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects
article 1999    
Author: Dokkum, W. van · Wezendonk, B. · Srikumar, T.S. · Heuvel, E.G.H.M. van den
Keywords: Nutrition · Blood lipids · Bowel function · Faecal parameters · Glucose absorption · Humans · Oligosaccharides · Acetic acid · Beta glucuronidase · Bile acid · Deoxycholic acid · Enzyme · Fructose oligosaccharide · Glucose · Inulin · Lipid · Oligosaccharide · Short chain fatty acid · Valeric acid · Adult · Clinical trial · Controlled clinical trial · Controlled study · Double blind procedure · Feces analysis · Glucose absorption · Human · Human experiment · Intestine function · Large intestine · Latin square design · Lipid blood level · Male · Normal human · PH · Randomized controlled trial · Statistical analysis · Beta-Glucosidase · Blood Chemical Analysis · Dietary Fiber · Double-Blind Method · Eating · Feces · Glucose · Glucose Tolerance Test · Glucuronidase · Humans · Intestinal Absorption · Intestine, Large · Lipids · Oligosaccharides · Questionnaires · Tryptophanase · Urease
[Abstract]

19 Heterogeneous expression of cholesterol 7α-hydroxylase and sterol 27- hydroxylase genes in the rat liver lobulus
article 1995    
Author: Twisk, J. · Hoekman, M.F.M. · Mager, W.H. · Moorman, A.F.M. · Boer, P.A.J. de · Scheja, L. · Princen, H.M.G. · Gebhardt, R.
Keywords: Health · 3 hydroxy 3 methylglutaryl coenzyme a · alanine aminotransferase · cholesterol 7alpha monooxygenase · colestipol · glutamate ammonia ligase · glyceraldehyde 3 phosphate dehydrogenase · messenger rna · pyruvate kinase · sterol 27 hydroxylase · unclassified drug · animal cell · animal experiment · bile acid synthesis · controlled study · enterohepatic circulation · enzyme isolation · enzyme localization · gene expression · in situ hybridization · liver metabolism · sterol analysis · Animal · Biological Markers · Blotting, Northern · Cell Separation · Cholesterol 7-alpha-Hydroxylase · Colestipol · Cytochrome P-450 Enzyme System · Gene Expression Regulation, Enzymologic · In Situ Hybridization · Liver · Male · Rats · Rats, Sprague-Dawley · RNA, Messenger · Steroid Hydroxylases · Support, Non-U.S. Gov't · Tissue Distribution · Transcription, Genetic
[Abstract]

20 In vitro models for the prediction of in vivo performance of oral dosage forms
article 2014    
Author: Kostewicz, E.S. · Abrahamsson, B. · Brewster, M. · Brouwers, J. · Butler, J. · Carlert, S. · Dickinson, P.A. · Dressman, J. · Holm, R. · Klein, S. · Mann, J. · McAllister, M. · Minekus, M. · Muenster, U. · Müllertz, A. · Verwei, M. · Vertzoni, M. · Weitschies, W. · Augustijns, P.
Keywords: Biology · Biorelevant · In vitro evaluation · In vivo biopharmaceutical performance · Innovative Medicines Initiative (IMI) · Oral Biopharmaceutical Tools (OrBiTo) · Oral drug formulations · Albendazole · Amprenavir · Bile acid · Celecoxib · Cinnarizine · Cyclodextrin · Danazol · Diclofenac · Dipyridamole · Excipient · Gelucire · Ketoconazole · Loviride · Montelukast · Octanol · Propranolol · Saquinavir · Controlled drug release · Drug absorption · Drug bioavailability · Drug development · Drug dosage form · Drug formulation · Drug penetration · Drug solubility · Gastrointestinal motility · Human · Hydrodynamics · In vitro study · In vivo study · Lipolysis · Nonhuman · Precipitation · Prediction · Priority journal · Quality control · Review · Simulation · Tablet disintegration · Food and Nutrition · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 23 found. Next | Sort by date