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1 A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line
article 2004    
Author: Verhoeckx, K.C.M. · Bijlsma, S. · Groene, E.M. de · Witkamp, R.F. · Greef, J. van der · Rodenburg, R.J.T.
Keywords: Pharmacology · Analytical research · Differentiation markers · Macrophage maturation · Oligonucleotide microarray · Principal component analysis · Two-dimensional gel electrophoresis · complementary DNA · oligonucleotide · peptide · protein · RNA · analytic method · article · cell differentiation · cell strain U937 · genetic transcription · human · human cell · immunoblotting · lymphoma cell · macrophage · mass spectrometry · matrix assisted laser desorption ionization time of flight mass spectrometry · monocyte · nucleotide sequence · peptide analysis · polyacrylamide gel electrophoresis · polymerase chain reaction · principal component analysis · priority journal · proteomics · two dimensional gel electrophoresis · Cell Differentiation · Electrophoresis, Gel, Two-Dimensional · Gene Expression Profiling · Gene Expression Regulation · Humans · Macrophages · Monocytes · Principal Component Analysis · Proteome · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization · Statistics · Tetradecanoylphorbol Acetate · U937 Cells
[Abstract]

2 Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor coupled pathways
article 2006    
Author: Verhoeckx, K.C.M. · Korthout, H.A.A.J. · Meeteren-Kreikamp, A.P. van · Ehlert, K.A. · Wang, M. · Greef, J. van der · Rodenburg, R.J.T. · Witkamp, R.F.
Keywords: Health · Analytical research · Biomedical research · Δ9-tetrahydrocanabinoid · Δ9-tetrahydrocanabinoid acid · cAMP · Cannabis sativa · Inflammation · PC-PLC · TNF-alpha · 1 (2,4 dichlorophenyl) 5 (4 iodophenyl) 4 methyl n morpholino 1h pyrazole 3 carboxamide · 6 iodo 3 (4 methoxybenzoyl) 2 methyl 1 (2 morpholinoethyl)indole · Beta 2 adrenergic receptor stimulating agent · Cannabidiol · Cannabidiolic acid · Cannabinoid 1 receptor · Cannabinoid 2 receptor · Cannabinoid derivative · Cannabis · Delta 9 tetrahydrocannabinoid acid · Dronabinol · Immunomodulating agent · Lipopolysaccharide · Phosphatidylcholine · Phospholipase C · Tumor necrosis factor alpha · Unclassified drug · Zilpaterol · Cell strain U937 · Concentration response · Controlled study · Cytokine production · Down regulation · Drug effect · Drug mechanism · Enzyme activity · Heating · Human cell · Immunomodulation · Immunopharmacology · Immunostimulation · Long term exposure · Macrophage · Metabolism · Protein induction · Protein synthesis regulation · Supernatant · Upregulation · Cannabis · Cell Line · Cells, Cultured · Cyclic AMP · Dose-Response Relationship, Drug · Heat · Humans · Immunologic Factors · Macrophage Activation · Macrophages · Phospholipase C · Plant Extracts · Receptor, Cannabinoid, CB1 · Receptor, Cannabinoid, CB2 · Signal Transduction · Tetrahydrocannabinol · Tumor Necrosis Factor-alpha
[Abstract]

3 Inhibitory effects of the β2-adrenergic receptor agonist zilpaterol on the LPS-induced production of TNF-α in vitro and in vivo
article 2005    
Author: Verhoeckx, K.C.M. · Doornbos, R.P. · Greef, J. van der · Witkamp, R.F. · Rodenburg, R.J.T.
Keywords: Biology Pharmacology · Analytical research · 3 isopropylamino 1 (7 methyl 4 indanyloxy) 2 butanol · alprenolol · atenolol · bacterium lipopolysaccharide · beta 1 adrenergic receptor blocking agent · beta 2 adrenergic receptor blocking agent · beta 2 adrenergic receptor stimulating agent · clenbuterol · cyclic AMP · formoterol · isoprenaline · propranolol · salbutamol · tumor necrosis factor alpha · unclassified drug · zilpaterol · animal experiment · antiinflammatory activity · article · cattle · cell strain U937 · controlled study · cytokine production · dose response · drug effect · drug receptor binding · drug structure · human · human cell · inflammation · macrophage · male · nonhuman · priority journal · rat · rat strain · Adrenergic beta-Agonists · Animals · Cattle · Cyclic AMP · Dose-Response Relationship, Drug · Escherichia coli · Humans · Immunologic Factors · Lipopolysaccharides · Macrophage Activation · Male · Rats · Rats, Wistar · Trimethylsilyl Compounds · Tumor Necrosis Factor-alpha · U937 Cells · Animalia · Bacteria (microorganisms) · Bos taurus · Rattus norvegicus
[Abstract]

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