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Showing 1 to 12 of 12 found. | Sort by date

1 Chemogenomics approaches for receptor deorphanization and extensions of the chemogenomics concept to phenotypic space
article 2011    
Author: Horst, E. van der · Peironcely, J.E. · Westen, G.J.P. van · Hoven, O.O. van den · Galloway, W.R.J.D. · Spring, D.R. · Wegner, J.K. · Vlijmen, H.W.T. van · Ijzerman, A.P. · Overington, J.P. · Bender, A.
Keywords: Nutrition · Chemogenomics · Deorphanization · G-protein coupled receptors · GPCR · Mode of action analysis · Orphan receptors · Proteochemometrics · Target prediction · Virtual screening · G protein coupled receptor · ligand · Bayes theorem · chemical genetics · chemistry · chemogenomic · drug activity · drug industry · genomics · phenotype · proteochemometrics · review · Healthy for Life · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin
article 2008    
Author: Haan, W. de · Vries-van der Weij, J. de · Hoorn, J.W.A. van der · Gautier, T. · Hoogt, C.C. van der · Westerterp, M. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Princen, H.M.G. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Atherosclerosis · Cholesteryl ester transfer proteins · Drugs · Lipids · Lipoproteins · Apolipoprotein E · Atorvastatin · Cholesterol · Cholesterol ester transfer protein · Collagen · High density lipoprotein cholesterol · Monocyte chemotactic protein 1 · Torcetrapib · Atherosclerosis · Cholesterol blood level · Drug activity · Evaluation · Female · Inflammation · Macrophage · Monocyte · Mouse · Nonhuman · Phenotype · Sham feeding · Statistical significance · Animals · Atherosclerosis · Cholesterol Ester Transfer Proteins · Drug Synergism · Heptanoic Acids · Inflammation · Mice · Mice, Inbred Strains · Pyrroles · Quinolines
[PDF] [Abstract]

3 Short-term tests of estrogenic potential of plant stanols and plant stanol esters
article 1999    
Author: Turnbull, D. · Frankos, V.H. · Leeman, W.R. · Jonker, D.
Keywords: Nutrition · Fatty acid ester · Phytosterol · Sitostanol · Sitosterol · Body weight · Cell proliferation · Chemical structure · Cytotoxicity · Drug activity · Drug screening · Estrogen activity · Food intake · Priority journal · Structure analysis · Analysis of Variance · Animals · Breast · Cell Division · Dihydrotestosterone · Esters · Estrogens, Non-Steroidal · Female · Humans · Isoflavones · Phytoestrogens · Phytosterols · Plant Preparations · Rats · Rats, Wistar · Tumor Cells, Cultured · Uterus
[Abstract]

4 In vitro stabililty of a tissue-type plasminogen activator mutant, BM 06.022, in human plasma
article 1994    
Author: Rijken, D.C. · Groeneveld, E. · Barrett-Bergshoeff, M.M.
Keywords: Biology · alpha 1 antitrypsin · alpha 2 antiplasmin · alteplase · fibrinogen · plasmin · reteplase · tissue plasminogen activator · fibrinolytic agent · proteinase inhibitor · recombinant protein · dose response · drug activity · drug half life · drug inactivation · drug stability · immunoblotting · plasma · polyacrylamide gel electrophoresis · blood · genetics · half life time · mutation · Drug Stability · Fibrinolytic Agents · Half-Life · Human · Mutation · Protease Inhibitors · Recombinant Proteins · Tissue Plasminogen Activator
[Abstract]

5 Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis
article 2005    
Author: Zuurmond, A.M. · Slot van der-Verhoeven, A.J. · Dura, E.A. van · Groot, J. de · Bank, R.A.
Keywords: Biology · Biomedical Research · Lysyl hydroxylase · Pyridinoline cross-links · Messenger RNA · Procollagen lysine 2 oxoglutarate 5 dioxygenase · Pyridinoline · Concentration response · Controlled study · Dose time effect relation · Drug activity · Drug inhibition · Drug sensitivity · Enzyme specificity · Enzyme substrate · Extracellular matrix · Fibroblast culture · Human cell · Protein cross linking · Protein structure · Skin fibrosis · 2-Aminoadipic Acid · Cells, Cultured · Chromatography, High Pressure Liquid · Collagen · Fibrosis · Gene Expression Regulation, Enzymologic · Humans · Hydroxylation · Minoxidil · Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
[Abstract]

6 Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models
article 2011    
Author: Kleemann, R. · Verschuren, L. · Morrison, M. · Zadelaar, A.S.M. · Erk, M.J. van · Wielinga, P.Y. · Kooistra, T.
Keywords: Nutrition · Anti-inflammatory · Atherosclerosis · Cholesterol · CRP · Inflammation · Polyphenol · Proliferation · Quercetin · C reactive protein · endothelial leukocyte adhesion molecule 1 · fibrinogen · immunoglobulin enhancer binding protein · quercetin · vascular cell adhesion molecule 1 · animal experiment · animal model · antiinflammatory activity · article · atherosclerosis · cardiovascular risk · controlled study · drug activity · drug blood level · drug effect · endothelium cell · human · human cell · inflammation · liver cell · male · mouse · nonhuman · priority journal · protein expression · risk factor · transgenic mouse · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

7 Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates
article 2003    
Author: Beek, E.R. van · Cohen, L.H. · Leroy, I.M. · Ebetino, F.H. · Löwik, C.W.G.M. · Papapoulos, S.E.
Keywords: Biomedical Research · Bisphosphonates · Bone resorption · FPP synthase · Geranylgeranylation · Osteoclasts · alendronic acid · bisphosphonic acid derivative · etidronic acid · geranylgeraniol · geranyltransferase · isopentenyl diphosphate delta isomerase · ne 10575 · ne 11808 · ne 21650 · ne 58086 · nitrogen · pamidronic acid · risedronic acid · unclassified drug · animal experiment · animal tissue · article · controlled study · drug activity · drug effect · drug mechanism · drug potency · enzyme activity · enzyme repression · female · fetus · nonhuman · osteoclast · osteolysis · structural homology · Animals · Bone Resorption · Calcium · Diphosphonates · Dose-Response Relationship, Drug · Female · Metatarsal Bones · Mice · Nitrogen · Organ Culture Techniques · Pregnancy
[Abstract]

8 Eradication of Helicobacter pylori infection favourably affects altered gastric mucosal MMP-9 levels
article 2007    
Author: Kubben, F.J.G.M. · Sier, C.F.M. · Schram, M. · Witte, T.A.M.C. · Veenendaal, R.A. · Duijn, W. van · Verheijen, J.H. · Hanemaaijer, R. · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Biomedical Research · Bioactivity assay (BIA) · ELISA · Gastritis · Helicobacter pylori · Matrix metalloproteinases · MMP-2 (gelatinase A) · MMP-9 (gelatinase B) · Zymography · antibiotic agent · clarithromycin · gelatin · gelatinase A · gelatinase B · metronidazole · omeprazole · proton pump inhibitor · ranitidine · adult · aged · article · controlled study · drug activity · enzyme analysis · enzyme linked immunosorbent assay · eradication therapy · female · Helicobacter infection · Helicobacter pylori · human · major clinical study · male · priority journal · quantitative analysis · statistical significance · stomach mucosa · zymography · Adult · Aged · Anti-Infective Agents · Anti-Ulcer Agents · Biopsy · Clarithromycin · Drug Therapy, Combination · Endoscopy, Gastrointestinal · Enzyme-Linked Immunosorbent Assay · Female · Gastric Mucosa · Helicobacter Infections · Helicobacter pylori · Humans · Male · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 9 · Metronidazole · Middle Aged · Omeprazole · Ranitidine · Treatment Outcome · Helicobacter pylori
[Abstract]

9 Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with α2 macroglobulin in serum of rheumatoid arthritis patients
article 2008    
Author: Tchetverikov, I. · Kraan, M.C. · El, B. van · Hanemaaijer, R. · Groot, J. de · Huizinga, T.W.J.
Keywords: Biology · Biomedical Research · alpha 2 macroglobulin · C reactive protein · leflunomide · matrix metalloproteinase · methotrexate · teriflunomide · tissue inhibitor of metalloproteinase 1 · analysis · blood sampling · clinical study · complex formation · controlled study · disease activity · drug activity · drug dose increase · drug effect · drug efficacy · drug exposure · loading drug dose · major clinical study · priority journal · protein blood level · quantitative analysis · rheumatoid arthritis · serum · systemic circulation · Aged · alpha-Macroglobulins · Antirheumatic Agents · Arthritis, Rheumatoid · Biological Markers · C-Reactive Protein · Down-Regulation · Enzyme Inhibitors · Female · Humans · Isoxazoles · Male · Matrix Metalloproteinases · Methotrexate · Middle Aged · Multiprotein Complexes · Phenylalanine · Statistics, Nonparametric · Thiophenes
[Abstract]

10 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro
article 2005    
Author: Erk, M.J. van · Roepman, P. · Lende, T.R. van der · Stierum, R.H. · Aarts, J.M.M.J.G. · Bladeren, P.J. van · Ommen, B. van
Keywords: Health Biology · Biomedical Research · (anti-)carcinogenic mechanisms · Caco-2 · Cell proliferation · Gene expression · Quercetin · beta catenin · mitogen activated protein kinase · quercetin · T cell factor protein · antineoplastic activity · apoptosis · article · cancer cell · cell adhesion · cell cycle · cell cycle G1 phase · cell differentiation · cell interaction · cell proliferation · cell strain CACO 2 · cellular distribution · colon carcinoma · controlled study · DNA microarray · down regulation · drug activity · energy metabolism · gene expression · genetic analysis · human · human cell · in vitro study · nucleotide sequence · oncogene · signal transduction · tumor suppressor gene · unindexed sequence · upregulation · Antineoplastic Agents · Apoptosis · Caco-2 Cells · Cell Cycle · Cell Division · Colonic Neoplasms · Dose-Response Relationship, Drug · Gene Expression · Gene Expression Profiling · Gene Expression Regulation · Humans · Quercetin
[Abstract]

11 Food allergy: What do we learn from animal models?
article 2004    
Author: Knippels, L.M.J. · Wijk, F. van · Penninks, A.H.
Keywords: Health · Toxicology and Applied Pharmacology · Allergenicity · Animal models · Food allergy · Therapy · Ara h 1 allergen · Ara h 2 allergen · Ara h 3 allergen · DNA vaccine · food allergen · fungal immunomodulatory protein · fungal protein · immunoglobulin E antibody · protein fip fve · recombinant antigen · recombinant cytokine · recombinant peanut allergen · unclassified drug · allergenicity · antigen specificity · article · bacterium · clinical research · desensitization · dog · dose response · drug activity · drug mechanism · drug research · drug screening · food allergy · genetic susceptibility · health hazard · hypothesis · immunological tolerance · immunopathogenesis · immunoprophylaxis · mouse strain · nonhuman · pathophysiology · prediction · priority journal · protein degradation · protein diet · protein intake · protein structure · publication · rat strain · review · screening test · sensitization · swine · Th1 cell · Th2 cell · Animals · Food Hypersensitivity · Humans · Immunotherapy · Interleukin-10 · Interleukin-4 · Models, Animal · T-Lymphocytes
[Abstract]

12 Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells
article 2004    
Author: Zanden, J.J. van · Geraets, L. · Wortelboer, H.M. · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Biology Toxicology · Physiological Sciences · 1-chloro-2,4-dinitrobenzene · 50% inhibition concentration · CDNB · DNP-SG · Glutathione · Glutathione conjugate · Glutathione S-transferase · GS-X · GSH · GST · IC50 · MRP · Multidrug resistance associated protein · P-gp · S-(2,4-dinitrophenyl)glutathione · 3',4' dihydroxyflavone · carbon · catechin · catechol derivative · eriodictyol · flavanoid · flavone derivative · galanin · glutathione transferase · hydroxyl group · kaempferol · luteolin · morin · multidrug resistance protein 1 · multidrug resistance protein 2 · myricetin · quercetin · taxifolin · unclassified drug · animal cell · article · breast cancer · cell strain MCF 7 · chemical bond · controlled study · drug activity · drug potency · enzyme activity · enzyme inhibition · genetic transfection · human · human cell · IC 50 · lipophilicity · nonhuman · priority journal · structure activity relation · toxicokinetics · Biological Transport · Breast Neoplasms · Carrier Proteins · Drug Resistance, Multiple · Drug Resistance, Neoplasm · Flavonoids · Glutathione · Glutathione S-Transferase pi · Glutathione Transferase · Humans · Isoenzymes · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Structure-Activity Relationship · Tumor Cells, Cultured
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 12 of 12 found. | Sort by date