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Showing 1 to 11 of 11 found. | Sort by date

1 On the in vivo and in vitro interaction of tissue-type plasminogen activator with liver cells
article 1993    
Author: Otter, M.
Keywords: Biology · Tissue plasminogen activator · Animal cell · Animal experiment · Animal tissue · Drug blood level · Drug clearance · Drug receptor binding · Fibrinolysis · Liver cell · Nonhuman · Note · Rat
[Abstract]

2 Interaction of mutants of tissue-type plasminogen activator with liver cells: Effect of domain deletions
article 1996    
Author: Kuiper, J. · Hof, A. van 't · Otter, M. · Biessen, E.A.L. · Rijken, D.C. · Berkel, T.J.C. van
Keywords: Biology · tissue plasminogen activator · animal cell · animal experiment · article · controlled study · deletion mutant · drug clearance · drug structure · gene cassette · kringle domain · liver cell · male · molecular interaction · nonhuman · plasma clearance · priority journal · protein domain · rat · Animals · Binding Sites · Biological Transport, Active · Endothelium · Epidermal Growth Factor · Half-Life · Kringles · Liver · Male · Molecular Structure · Mutation · Rats · Rats, Wistar · Tissue Plasminogen Activator · Animalia
[Abstract]

3 The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: A longitudinal study
article 1994    
Author: Groen, K. · Breimer, D.D. · Jansen, E.J. · Bezooijen, C.F.A. van
Keywords: Health · 3 hydroxymethylphenazone · 4 hydroxyphenazone · Norphenazone · Phenazone · Adolescent · Aged · Body weight · Controlled study · Drug blood level · Drug clearance · Drug metabolism · Drug urine level · Enantiomer · Enzyme activity · Enzyme specificity · High performance liquid chromatography · Nonhuman · Survival rate · Aging · Animal · Antipyrine · Cytochrome P-450 Enzyme System · Enzyme Induction · Hexobarbital · Longitudinal Studies · Male · Metabolic Clearance Rate · Phenobarbital · Rats · Rats, Inbred BN · Stereoisomerism
[Abstract]

4 Modeling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich-cultured rat hepatocytes
article 2004    
Author: Treijtel, N. · Barendregt, A. · Freidig, A.P. · Blaauboer, B.J. · Eijkeren, J.C.H. van
Keywords: Biology · Physiological Sciences · 4 tolylsulfonylurea · carboxytolbutamide · hydroxytolbutamide · sulfonylurea derivative · tolbutamide · unclassified drug · addition reaction · animal cell · article · cell culture · controlled study · drug blood level · drug clearance · in vitro study · in vivo study · liquid chromatography · liver cell · mass spectrometry · mathematical model · nonhuman · priority journal · radiochemistry · rat · Animals · Cells, Cultured · Hepatocytes · Male · Metabolic Clearance Rate · Models, Biological · Rats · Rats, Wistar · Tolbutamide · Animalia
[Abstract]

5 Release of 5-aminosalicylate from an MMX mesalamine tablet during transit through a simulated gastrointestinal tract system
article 2007    
Author: Tenjarla, S. · Romasanta, V. · Zeijdner, E. · Villa, R. · Moro, L.
Keywords: Biology · Biomedical Research · 5-Aminosalicylate · Bioaccessibility · Gastrointestinal system · In vitro · Mesalamine · MultiMatrix System · Ulcerative colitis · mesalazine · mezavant · nonsteroid antiinflammatory agent · adult · article · controlled study · dialysis · drug clearance · drug coating · drug release · gastrointestinal transit · human · human experiment · in vitro study · normal human · tablet formulation · upper gastrointestinal tract · biological model · chemistry · delayed release formulation · gastrointestinal tract · kinetics · pH · pharmaceutics · Anti-Inflammatory Agents, Non-Steroidal · Delayed-Action Preparations · Gastrointestinal Tract · Hydrogen-Ion Concentration · Kinetics · Mesalamine · Models, Biological · Technology, Pharmaceutical
[Abstract]

6 Observational infant exploratory [14C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis
article 2015    
Author: Garner, C.R. · Park, K.B. · French, N.S. · Earnshaw, C. · Schipani, A. · Selby, A.M. · Byrne, L. · Siner, S. · Crawley, F.P. · Vaes, W.H.J. · Duijn, E. van · ligt, R. de · Varendi, H. · Lass, J. · Grynkiewicz, G. · Maruszak, W. · Turner, M.A.
Keywords: Biology · Exploratory clinical study · Microdosing · Paediatric pharmacokinetics · Paracetamol · Unclassified drug · Accelerator mass spectrometry · Area under the curve · Child · Drug blood level · Drug clearance · Drug half life · Female · Human · Infant · Major clinical study · Male · Mass spectrometry · Maximum plasma concentration · Pharmacokinetics · Plasma concentration-time curve · Time to maximum plasma concentration · Ultra performance liquid chromatography · Volume of distribution · Healthy for Life · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

7 The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi
article 2003    
Author: Joosten, V. · Lokman, C. · Hondel, C.A.M.J.J. van den · Punt, P.J.
Keywords: Biology · Biotechnology · cancer antibody · cell antibody · fungus antibody · hybrid protein · immunoglobulin · immunoglobulin F(ab) fragment · immunoglobulin Fc fragment · immunoglobulin heavy chain · immunoglobulin light chain · intrabody · recombinant antibody · single chain fragment variable antibody · unclassified drug · antibody combining site · antibody production · antigen binding · Aspergillus awamori · Candida boidinii · clinical trial · drug clearance · drug delivery system · Escherichia coli · eukaryote · gene expression system · Hansenula polymorpha · human · immunotherapy · Kluyveromyces · methylotrophic bacterium · mycology · nonhuman · Pichia · Pichia methanolica · Pichia pastoris · protein protein interaction · protein synthesis · review · Saccharomyces cerevisiae · Schizosaccharomyces pombe · Trichoderma reesei · Yarrowia lipolytica · Eukaryota · Fungi
[Abstract]

8 Transdermal administration of radiolabelled [14C]rotigotine by a patch formulation: A mass balance trial
article 2007    
Author: Cawello, W. · Wolff, H.M. · Meuling, W.J.A. · Horstmann, R. · Braun, M.
Keywords: Biomedical Research · carbon 14 · dopamine receptor stimulating agent · rotigotine · silicone · adult · article · clinical trial · diarrhea · dizziness · drug absorption · drug clearance · drug delivery system · drug distribution · drug elimination · drug formulation · drug metabolism · drug penetration · drug release · drug structure · drug tolerability · fatigue · human · human experiment · isotope labeling · liquid chromatography · liquid scintillation counting · male · mass balance · normal human · phase 1 clinical trial · priority journal · radioactivity · single drug dose · tandem mass spectrometry · Administration, Cutaneous · Adolescent · Adult · Carbon Radioisotopes · Chromatography, Liquid · Dopamine Agonists · Humans · Male · Middle Aged · Tandem Mass Spectrometry · Tetrahydronaphthalenes · Thiophenes
[Abstract]

9 The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab
article 2014    
Author: Mierlo, G.J.D. van · Cnubben, N.H.P. · Wouters, D. · Wolbink, G.J. · Hart, M.H.L. · Rispens, T. · Ganderup, N.C. · Kuper, C.F. · Aarden, L. · Penninks, A.H.
Keywords: Biology · Adalimumab · Alternative model · Anti-drug antibodies · Immunogenicity · Infliximab · Minipig · Pharmacokinetics Ddrug antibody · Animal experiment · Animal model · Animal tissue · Antibody response · Antibody titer · Area under the curve · Body weight · Clinical chemistry · Clinical feature · Clinical observation · Controlled study · Drug blood level · Drug clearance · Drug half life · Drug megadose · Female · Hematological parameters · Histopathology · Immune function test · Immune system · Low drug dose · Maximum plasma concentration · Mean residence time · Nonhuman · Organ weight · Predictive value · Priority journal · Time to maximum plasma concentration · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

10 Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes
article 2009    
Author: Treijtel, N. · Eijkeren, J.C.H.v. · Nijmeijer, S. · Greef de - Sandt, I.C.J. van der · Freidig, A.P.
Keywords: Health · Biomedical Research · HIV-protease inhibitors · Metabolism · P-Glycoprotein · Rat hepatocytes · rat liver microsomes · Sandwich-culture · cyclosporin A · drug metabolite · glycoprotein P · ketoconazole · proteinase inhibitor · ritonavir · saquinavir · testosterone derivative · valspodar · verapamil · animal cell · article · cell culture · controlled study · drug clearance · drug excretion · drug metabolism · drug transport · Human immunodeficiency virus 1 · hydroxylation · intrahepatic bile duct · liver cell · liver metabolism · male · microsome · nonhuman · rat · sandwich culture · Animals · Biological Transport, Active · Cell Culture Techniques · Cell Survival · Cells, Cultured · Cyclosporine · Cyclosporins · Dose-Response Relationship, Drug · Hepatocytes · HIV Protease Inhibitors · Ketoconazole · Male · Metabolic Clearance Rate · Microsomes, Liver · Rats · Rats, Wistar · Ritonavir · Saquinavir · Human immunodeficiency virus 1 · Rattus
[Abstract]

11 Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
article 2014    
Author: Bosgra, S. · Steeg, E. van de · Vlaming, M.L. · Verhoeckx, K.C. · Huisman, M.T. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Transporter · Hepatic disposition · Transfected cell-lines · Protein abundance · LC–MS · Hepatic disposition · OATP · PBPK model · Polymorphisms · Protein abundance · Transfected cell-lines · Drug carrier · Organic anion transporter B · Rosuvastatin · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Controlled study · Drug clearance · Drug disposition · Drug transport · Enterohepatic circulation · Gene overexpression · Genetic transfection · Genetic variability · HEK293 cell line cell tissue · In vitro study · In vivo study · Intrinsic clearance · Liquid chromatography · Liver · Liver cell · Model · Outer membrane · Physiology based pharmacokinetic model · Prediction · Protein analysis · Simulation · Single drug dose · Tandem mass spectrometry · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 11 of 11 found. | Sort by date