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1 Disposition of 14C-erythritol in germfree and conventional rats
article 1996    
Author: Ommen, B. van · Bie, B. de · Bar, A.
Keywords: Toxicology · erythritol · carbon · carbon dioxide · diagnostic agent · sweetening agent · animal experiment · article · controlled study · drug disposition · drug elimination · drug metabolism · female · germfree animal · male · nonhuman · priority journal · rat · absorption · animal · body weight · intestine · kidney · metabolism · microbiology · physiology · tissue distribution · urine · Wistar rat · Absorption · Animals · Body Weight · Carbon Dioxide · Carbon Radioisotopes · Erythritol · Female · Germ-Free Life · Intestines · Kidney · Male · Rats · Rats, Wistar · Sweetening Agents · Tissue Distribution
[Abstract]

2 Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
article 2014    
Author: Bosgra, S. · Steeg, E. van de · Vlaming, M.L. · Verhoeckx, K.C. · Huisman, M.T. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Transporter · Hepatic disposition · Transfected cell-lines · Protein abundance · LC–MS · Hepatic disposition · OATP · PBPK model · Polymorphisms · Protein abundance · Transfected cell-lines · Drug carrier · Organic anion transporter B · Rosuvastatin · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Controlled study · Drug clearance · Drug disposition · Drug transport · Enterohepatic circulation · Gene overexpression · Genetic transfection · Genetic variability · HEK293 cell line cell tissue · In vitro study · In vivo study · Intrinsic clearance · Liquid chromatography · Liver · Liver cell · Model · Outer membrane · Physiology based pharmacokinetic model · Prediction · Protein analysis · Simulation · Single drug dose · Tandem mass spectrometry · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

3 Disposition of [14C]γ-cyclodextrin in germ-free and conventional rats
article 1998    
Author: Bie, A.T.H.J. de · Ommen, B. van · Bär, A.
Keywords: Nutrition · Carbon 14 · Carbon dioxide · Drug metabolite · Gamma cyclodextrin · Carbon · Cyclodextrin · Gamma cyclodextrin derivative · Gamma-cyclodextrin · Animal experiment · Animal tissue · Carcass · Controlled study · Dose response · Drug bile level · Drug blood level · Drug disposition · Drug feces level · Drug identification · Drug metabolism · Drug saliva level · Drug tissue level · Drug urine level · Female · Gastrointestinal tract · Germfree animal · High performance liquid chromatography · Intravenous drug administration · Isotope labeling · Male · Nonhuman · Oral drug administration · Priority journal · Rat · Animal · Animal food · Bile · Breath analysis · Chemistry · Comparative study · Digestive system · Feces · Intestine absorption · Metabolism · Wistar rat · Administration, Oral · Animal Feed · Animals · Breath Tests · Carbon Dioxide · Carbon Radioisotopes · Cyclodextrins · Digestive System · Feces · Female · gamma-Cyclodextrins · Germ-Free Life · Injections, Intravenous · Intestinal Absorption · Male · Rats · Rats, Wistar
[Abstract]

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