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Showing 1 to 14 of 14 found. | Sort by date

1 Half-lives of pesticides on greenhouse crops
article 1997    
Author: Brouwer, D.H. · Haan, M. de · Leenheers, L.H. · Vreede, S.A.F. de · Hemmen, J.J. van
Keywords: pesticide · analytic method · article · crop · drug half life · environmental factor · exposure · nonhuman · pesticide spraying · residue analysis · risk assessment · Analysis of Variance · Chromatography, High Pressure Liquid · Crops, Agricultural · Fungicides, Industrial · Half-Life · Hydrogen-Ion Concentration · Insecticides · Pesticide Residues · Plants · Risk Assessment

2 Insulin suppresses apolipoprotein(a) synthesis in cultured cynomolgus monkey hepatocytes
article 1999    
Author: Princen, H.M.G.
Keywords: Biology · Apolipoprotein a · Apolipoprotein b · Cholesterol · Insulin · Lipoprotein a · Very low density lipoprotein · Animal cell · Drug half life · Hepatoma cell · Human · Hyperinsulinemia · Insulin dependent diabetes mellitus · Letter · Lipoprotein synthesis · Liver cell · Monkey · Nonhuman

3 Influence of amifostine on the pharmacokinetics of cisplatin in cancer patients
article 1998    
Author: Korst, A.E.C. · Sterre, M.L.T. van der · Gall, H.E. · Fichtinger-Schepman, A.M.J. · Vermorken, J.B. · Vijgh, W.J.F. van der
Keywords: Nutrition · Amifostine · Cisplatin · Creatinine · Adult · Aged · Area under the curve · Clinical article · Creatinine blood level · Dna adduct · Dna drug complex · Drug blood level · Drug effect · Drug half life · Female · Human · Intravenous drug administration · Kidney function · Male · Malignant neoplastic disease · Priority journal · Amifostine · Antineoplastic Agents · Cisplatin · DNA Adducts · Drug Interactions · Female · Half-Life · Hemofiltration · Humans · Leukocytes · Male · Middle Aged · Neoplasms · Platinum · Radiation-Protective Agents
[Abstract]

4 In vitro stabililty of a tissue-type plasminogen activator mutant, BM 06.022, in human plasma
article 1994    
Author: Rijken, D.C. · Groeneveld, E. · Barrett-Bergshoeff, M.M.
Keywords: Biology · alpha 1 antitrypsin · alpha 2 antiplasmin · alteplase · fibrinogen · plasmin · reteplase · tissue plasminogen activator · fibrinolytic agent · proteinase inhibitor · recombinant protein · dose response · drug activity · drug half life · drug inactivation · drug stability · immunoblotting · plasma · polyacrylamide gel electrophoresis · blood · genetics · half life time · mutation · Drug Stability · Fibrinolytic Agents · Half-Life · Human · Mutation · Protease Inhibitors · Recombinant Proteins · Tissue Plasminogen Activator
[Abstract]

5 Pharmacokinetics of carboplatin with and without amifostine in patients with solid tumors
article 1997    
Author: Korst, A.E.C. · Sterre, M.L.T. van der · Eeltink, C.M. · Fichtinger-Schepman, A.M.J. · Vermorken, J.B. · Vijgh, W.J.F. van der
Keywords: Pharmacology · Amifostine · Carboplatin · Adult · Blood sampling · Clinical article · Clinical trial · Controlled clinical trial · Creatinine blood level · Creatinine clearance · Drug blood level · Drug efficacy · Drug half life · Enzyme linked immunosorbent assay · Female · Human · Intravenous drug administration · Male · Phase 1 clinical trial · Solid tumor · Amifostine · Animals · Antineoplastic Agents · Carboplatin · Dose-Response Relationship, Drug · Half-Life · Kidney · Kidney Function Tests · Metabolic Clearance Rate · Mice · Mice, Nude · Neoplasms
[Abstract]

6 Prophylactic and therapeutic effects of a humanized monoclonal antibody against the IL-2 receptor (DACLIZUMAB) on collagen-induced arthritis (CIA) in rhesus monkeys
article 2001    
Author: Brok, H.P.M. · Tekoppele, J.M. · Hakimi, J. · Kerwin, J.A. · Nijenhuist, E.M. · Groot, C.W.de · Bontrop, R.E. · Hart 't, B.A.
Keywords: Biology · Biomedical Research · Animal model · Inflammation · Joint destruction · Nonhuman primate · Rheumatoid arthritis · Collagen · Interleukin 2 receptor · Interleukin 2 receptor antibody · Monoclonal antibody · Animal experiment · Animal model · Autoimmune disease · Controlled study · Drug blood level · Drug half life · Immunization · Immunogenicity · Inflammation · Joint destruction · Male · Nonhuman · Priority journal · Prophylaxis · Rhesus monkey · Rheumatoid arthritis · Animals · Antibodies, Monoclonal · Antibody Specificity · Arthritis, Rheumatoid · Autoantibodies · Autoimmune Diseases · C-Reactive Protein · Collagen · Disease Models, Animal · Drug Evaluation, Preclinical · Humans · Hydroxyproline · Immunization · Immunoglobulin G · Macaca mulatta · Male · Receptors, Interleukin-2 · Weight Loss
[Abstract]

7 Observational infant exploratory [14C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis
article 2015    
Author: Garner, C.R. · Park, K.B. · French, N.S. · Earnshaw, C. · Schipani, A. · Selby, A.M. · Byrne, L. · Siner, S. · Crawley, F.P. · Vaes, W.H.J. · Duijn, E. van · ligt, R. de · Varendi, H. · Lass, J. · Grynkiewicz, G. · Maruszak, W. · Turner, M.A.
Keywords: Biology · Exploratory clinical study · Microdosing · Paediatric pharmacokinetics · Paracetamol · Unclassified drug · Accelerator mass spectrometry · Area under the curve · Child · Drug blood level · Drug clearance · Drug half life · Female · Human · Infant · Major clinical study · Male · Mass spectrometry · Maximum plasma concentration · Pharmacokinetics · Plasma concentration-time curve · Time to maximum plasma concentration · Ultra performance liquid chromatography · Volume of distribution · Healthy for Life · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

8 A randomized three-way cross-over study in healthy pituitary-suppressed women to compare the bioavailability of human chorionic gonadotrophin (Pregnyl®) after intramuscular and subcutaneous administration
article 1998    
Author: Mannaerts, B.M.J.L. · Geurts, T.B.P. · Odink, J.
Keywords: Nutrition · Bioequivalence · Human chorionic gonadotrophin · Intramuscular · Pharmacokinetics · Subcutaneous · Chorionic gonadotropin · Adult · Area under the curve · Bioequivalence · Clinical trial · Controlled study · Dose response · Drug absorption · Drug bioavailability · Drug blood level · Drug elimination · Drug half life · Female · Human · Human experiment · Hypopituitarism · Intramuscular drug administration · Normal human · Randomized controlled trial · Subcutaneous drug administration · Administration, Oral · Adolescent · Adult · Chorionic Gonadotropin · Contraceptives, Oral · Cross-Over Studies · Dose-Response Relationship, Drug · Female · Humans · Injections, Intramuscular · Pituitary Gland
[Abstract]

9 Feasibility of SPECT-CT imaging to study the pharmacokinetics of antisense oligonucleotides in a mouse model of Duchenne muscular dystrophy
article 2017    
Author: Steeg, E. van de · Läppchen, T. · Aguilera, B. · Jansen, H.T. · Muilwijk, D. · Vermue, R. · Hoorn, J.W. van der · Donato, K. · Rossin, R. · Visser, P.C. de · Vlaming, M.L.H.
Keywords: Nutrition · SPECT imaging · Antisense oligonucleotides · RNA-based therapeutics · Duchenne muscular dystrophy · Antisense oligonucleotides · Antisense oligonucleotide i 123 · Antisense oligonucleotide in 111 · Indium 111 · Iodine 123 · Tracer · Unclassified drug · Animal experiment · Animal model · Animal tissue · Controlled study · Drug distribution · Drug half life · Drug tissue level · Drug uptake · In vivo study · Male · Mouse · Mouse model · Nonhuman · Single photon emission computed tomography-computed tomography · Skeletal muscle · Target tissue · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

10 The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab
article 2014    
Author: Mierlo, G.J.D. van · Cnubben, N.H.P. · Wouters, D. · Wolbink, G.J. · Hart, M.H.L. · Rispens, T. · Ganderup, N.C. · Kuper, C.F. · Aarden, L. · Penninks, A.H.
Keywords: Biology · Adalimumab · Alternative model · Anti-drug antibodies · Immunogenicity · Infliximab · Minipig · Pharmacokinetics Ddrug antibody · Animal experiment · Animal model · Animal tissue · Antibody response · Antibody titer · Area under the curve · Body weight · Clinical chemistry · Clinical feature · Clinical observation · Controlled study · Drug blood level · Drug clearance · Drug half life · Drug megadose · Female · Hematological parameters · Histopathology · Immune function test · Immune system · Low drug dose · Maximum plasma concentration · Mean residence time · Nonhuman · Organ weight · Predictive value · Priority journal · Time to maximum plasma concentration · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

11 Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous System only in insulin-sensitive mice
article 2011    
Author: Coomans, C.P. · Geerling, J.J. · Guigas, B. · Hoek, A.M. van den · Parlevliet, E.T. · Ouwens, D.M. · Pijl, H. · Voshol, P.J. · Rensen, P.C.N. · Havekes, L.M. · Romijn, J.A.
Keywords: Health Biology · Brain · Brown adipose tissue · Insulin resistance · Lipid metabolism · Lipoprotein lipase · Triglycerides · adenosine triphosphate sensitive potassium channel · CD36 antigen · cyclic AMP · fatty acid · insulin · leptin · serum albumin · tolbutamide · triacylglycerol · animal experiment · animal model · animal tissue · brown adipose tissue · central nervous system · channel gating · controlled study · drug administration route · drug distribution · drug half life · drug targeting · fatty acid metabolism · fatty acid retention · hormone action · hyperinsulinemia · insulin action · insulin sensitivity · male · mouse · nonhuman · signal transduction · white adipose tissue · wild type · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

12 Recent methodology in the phytochemical analysis of ginseng
article 2008    
Author: Angelova, N. · Kong, H.-W. · Heijden, R. van de · Yang, S.-Y. · Choi, Y.H. · Kim, H.K. · Wang, M. · Hankemeier, T. · Greef, J. van der · Xu, G. · Verpoorte, R.
Keywords: Health · Biomedical Research · Ginsenosides · Mass spectrometry · Metabolomics · Panax ginseng · Ginseng extract · Phenol · Saponin · Analytic method · Antineoplastic activity · Biosensor · Drug absorption · Drug determination · Drug distribution · Drug efficacy · Drug excretion · Drug half life · Drug metabolism · Drug safety · Drug structure · Electrospray mass spectrometry · Enzyme linked immunosorbent assay · Fourier transform mass spectrometry · Ginseng · High performance liquid chromatography · Human · Immunoregulation · Ion cyclotron resonance mass spectrometry · Liquid chromatography · Liver protection · Mass spectrometry · Metabolomics · Near infrared reflectance spectroscopy · Nonhuman · Nuclear magnetic resonance spectroscopy · Plant root · Quality control · Review · Sensitivity analysis · Structure analysis · Systems biology · Drugs, Chinese Herbal · Ginsenosides · Mass Spectrometry · Panax · Spectroscopy, Fourier Transform Infrared · Spectroscopy, Near-Infrared · Panax ginseng
[Abstract]

13 Comparison of in vitro assays in selecting radiotracers for in vivo P-glycoprotein PET imaging
article 2017    
Author: Raaphorst, R.M. · Savolainen, H. · Cantore, M. · Steeg, E. van de · Waarde, A. van · Colabufo, N.A. · Elsinga, P.H. · Lammertsma, A.A. · Windhorst, A.D. · Luurtsema, G.
Keywords: Biology · Apical and basolateral membrane · Bidirectional transport · Blood-brain barrier · Calcein-AM · Tritium labeling · Calcein · Mc 224 f 18 · Mc 225 f 18 · Multidrug resistance protein · N fluoroethylverapamil f 18 · O fluoroethyl norverapamil f 18 · Radiopharmaceutical agent · Unclassified drug · Verapamil c 11 · Animal experiment · Animal tissue · Chemical analysis · Controlled study · Drug accumulation · Drug blood level · Drug brain level · Drug half life · Enzyme inhibition · Fluoroethylation · In vitro study · In vivo study · Isotope labeling · Male · Mouse · Nonhuman · Positron emission tomography · Predictive value · Protein function · Radioactivity · Rat · Synthesis · Transport assay · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

14 Antidotes to organophosphate poisoning. 2. Thiadiazole-5-carboxaldoximes
article 1979    
Author: Benschop, H.P. · Berg, G.R. van den · Hooidonk, C. van · Jong, L.P.A. de · Kientz, C.E. · Berends, F. · Kepner, L.A. · Meeter, E. · Visser, R.P.L.S.
Keywords: Biology · Acetylcholinesterase · Antidote · Atropine · Cholinesterase reactivator · Diacetyl oxime · Enzyme · Obidoxime P · Paraoxon · Sarin · Tri ortho cresyl phosphate · 1,2,3 thiadiazole 5 carboxaldoxime · 2 (hydroximinomethyl) 1 methylpyridinium salt · 2 methyl 1,2,3 thiadiazolium salt carboxaldoxime · 3 methyl 1,2,3 thiadiazolium salt 5 carboxaldoxime · Animal experiment · Blood · Blood and hemopoietic system · Dose response · Drug administration · Drug analysis · Drug blood level · Drug comparison · Drug elimination · Drug half life · Drug interaction · Drug intoxication · Drug metabolism · Drug response · Drug screening · Drug synthesis · Drug tolerance · Drug toxicity · Drug urine level · Goat · Guinea pig · High performance liquid chromatography · Hydroximinoacetone · In vitro study · Intoxication · Intraperitoneal drug administration · Intravenous drug administration · Mouse · Nuclear magnetic resonance · Oral drug administration · Organophosphate intoxication · Pharmacokinetics · Prevention · Prophylaxis · Rabbit · Rat · Subcutaneous drug administration · Theoretical study · Therapy · Thiadiazole 5 carboxaldoxime derivative · Ultraviolet spectrophotometry · Urine · Acetylcholinesterase · Animal · Antidotes · Body Temperature · Cattle · Chemistry · Dose-Response Relationship, Drug · Enzyme Reactivators · Female · Goats · Guinea Pigs · Half-Life · In Vitro · Lethal Dose 50 · Male · Mice · Organophosphorus Compounds · Oximes · Rabbits · Rats · Rats, Inbred Strains · Sarin · Solubility · Structure-Activity Relationship
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 14 of 14 found. | Sort by date