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Showing 1 to 17 of 17 found. | Sort by date

1 Relative developmental toxicity potencies of retinoids in the embryonic stem cell test compared with their relative potencies in in vivo and two other in vitro assays for developmental toxicity
article 2011    
Author: Louisse, J. · Gönen, S. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Pharmacology · Benchmark dose · Developmental toxicity · Embryonic stem cell test · Embryotoxicity · In vitro · Retinoids · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay
article 2012    
Author: Strikwold, M. · Woutersen, R.A. · Spenkelink, B. · Punt, A. · Rietjens, I.M.C.M.
Keywords: Alternative toxicity testing · Developmental toxicity · Embryonic stem cell test · Embryotoxicity · Potency ranking · Substituted phenols · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 Cisplatin-DNA adduct formation in rat spermatozoa and its effect on fetal development
article 2000    
Author: Hooser, S.T. · Dijk-Knijnenburg, C.M. van · Waalkens-Berendsen, I.D.H. · Smits-van Prooije, A.E. · Snoeij, N.J. · Baan, R.A. · Fichtinger-Schepman, M.J.
Keywords: Nutrition · Cisplatin · Development · DNA adducts · Embryotoxicity · Rats · Spermatozoa · Cisplatin · Animal cell · Antibody specificity · Carcinogenesis · Cell killing · Cross linking · DNA adduct · DNA binding · DNA damage · Embryotoxicity · Fetus development · Infertility · Nonhuman · Priority journal · Rat · Spermatogenesis · Spermatozoon · Animals · Body Weight · Cisplatin · DNA Adducts · DNA Damage · Embryonic and Fetal Development · Female · Fetal Death · Male · Pregnancy · Rats · Rats, Wistar · Spermatozoa · Animalia
[Abstract]

4 Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context
article 2015    
Author: Kroese, E.D. · Bosgra, S. · Buist, H.E. · Lewin, G. · Linden, S.C. van der · Man, H.Y. · Piersma, A.H. · Rorije, E. · Schulpen, S.H.W. · Schwarz, M. · Uibel, F. · Vugt-Lussenburg, B.M.A. van · Wolterbeek, A.P.M. · Burg, B. van der
Keywords: Biology · Alternative model · CALUX · Developmental toxicity · Embryonic stem cell test · Grouping · Read across · ReProGlo · Zebrafish embryotoxicity assay · 2 ethylhexanoic acid · 2 methylhexanoic acid · Dibutyltin dichloride · monobutyltin trichloride · Monoethylhexyl phthalate · Monomethyl phthalate · Toxic substance · Tributyltin chloride · Unclassified drug · Valproic acid · Analytic method · Animal cell · Assay · CALUX battery · Chemical analysis · Chemical procedures · Chemical structure · Controlled study · Developmental toxicity · Dosimetry · Embryonic stem cell test · Embryotoxicity · Fertilization · In vitro study · Morphology · Mouse · Nonhuman · ReProGlo assay · Toxicokinetics · Zebrafish embryotoxicity test · Animalia · Danio rerio · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

5 Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation
article 2012    
Author: Louisse, J. · Verwei, M. · Woutersen, R.A. · Blaauboer, B.J. · Rietjens, I.M.C.M.
Keywords: Biology · 3Rs · Biomarkers · Developmental toxicity · Embryotoxicity · in vitro · Kinetic modeling · Biomedical Innovation · Healthy Living Healthy Living · Life · PHS - Pharmacokinetics & Human Studies RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[Abstract]

6 Evaluation of an alternative in vitro test battery for detecting reproductive toxicants
article 2013    
Author: Piersma, A.H. · Bosgra, S. · Duursen, M.B.M. van · Hermsen, S.A.B. · Jonker, L.R.A. · Kroese, E.D. · Linden, S.C. van der · Man, H. · Roelofs, M.J.E. · Schulpen, S.H.W. · Schwarz, M. · Uibel, F. · Vugt-Lussenburg, B.M.A. van · Westerhout, J. · Wolterbeek, A.P.M. · Burg, B. van der
Keywords: Biology · Alternative assay · Aromatase · CALUX · Embryonic stem cell test · ReProGlo · Test battery · Toxicokinetics · Zebrafish embryotoxicity assay · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[Abstract]

7 A category approach to predicting the developmental (neuro) toxicity of organotin compounds: The value of the zebrafish (Danio rerio) embryotoxicity test (ZET)
article 2013    
Author: Beker van Woudenberg, A. · Wolterbeek, A. · Brake, L. te · Snel, C. · Menke, A. · Rubingh, C. · Groot, D. de · Kroese, D.
Keywords: Health · Alternative model · Biological verification · Developmental (neuro) toxicity · Grouping · Organotins · Read across · Zebrafish embryotoxicity test (ZET) · Biomedical Innovation · Healthy Living · Life Triskelion BV · QS - Quality & Safety TARA - Toxicology and Risk Assessment · EELS - Earth, Environmental and Life Sciences
[Abstract]

8 Embryotoxicity and teratogenicity study with erythritol in rats
article 1996    
Author: Smits- Prooije, A.E. van · Waalkens-Berendsen, D.H. · Bär, A.
Keywords: erythritol · animal experiment · animal model · article · embryo · embryotoxicity · female · fetotoxicity · fetus · male · nonhuman · priority journal · rat · teratogenicity · Abnormalities, Drug-Induced · Animals · Body Weight · Diet · Embryo · Erythritol · Female · Fertility · Male · Pregnancy · Rats · Rats, Wistar · Sweetening Agents · Teratogens · Animalia
[Abstract]

9 Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs
article 2014    
Author: Beker van Woudenberg, A. · Snel, C. · Rijkmans, E. · Groot, D. de · Bouma, M. · Hermsen, S. · Piersma, A. · Menke, A. · Wolterbeek, A.
Keywords: Biology · Antiepileptic drugs · Behavior · Developmental (neuro)toxicity · Gene expression · Histopathology · Integrated test strategy · Kinetics · Zebrafish embryotoxicity test (ZET) · Anticonvulsive agent · Carbamazepine · Cytochrome P450 26A1 · Ethosuximide · Etiracetam · Valproic acid · ALDH1A2 gene · Animal cell · Animal experiment · Animal model · Animal tissue · Case study · Cell vacuole · Concentration (parameters) · Controlled study · CYP26A1 gene · Demo case study · Developmental toxicity · Edema · Embryo · Embryotoxicity · Experimental design · Female · Gene · Gene expression · Histopathology · In situ hybridization · Larva · Liver cell · Male · Morphology · Motor activity · Nerve degeneration · Neurotoxicity · Nonhuman · Nucleotide sequence · Pericardial disease · Pericardial edema · Phenotype · Predictive value · Sensitivity analysis · Swimming · Toxicity testing · Toxicokinetics · Whole mount in situ hybridization · Zebra fish · Zebrafish embryotoxicity test · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

10 Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites
article 2010    
Author: Louisse, J. · Bai, Y. · Verwei, M. · Sandt, J.J.M. van de · Blaauboer, B.J. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · BALB/c-3T3 cells · Embryonic stem cells · Embryotoxicity · Glycol ethers · Intracellular pH · Mechanism · acetazolamide · acetic acid derivative · alkoxyacetic acid glycol ether derivative · amiloride · butoxyacetic acid · ethoxyacetic acid · fluorouracil · methoxyacetic acid · phenoxyacetic acid · retinoic acid · unclassified drug · valproic acid · acidification · animal cell · animal cell culture · article · cell differentiation · cell pH · cell strain 3T3 · controlled study · embryonic stem cell · embryotoxicity · metabolite · mouse · nonhuman · pH measurement · Acetazolamide · Acetic Acids · Animals · BALB 3T3 Cells · Cell Differentiation · Embryo, Mammalian · Embryonic Stem Cells · Ethylene Glycols · Glycolates · Hydrogen-Ion Concentration · Intracellular Fluid · Mice · Teratogens · Valproic Acid
[Abstract]

11 Embryotoxicity and teratogenicity study with γ-cyclodextrin in rats
article 1998    
Author: Waalkens-Berendsen, D.H. · Verhagen, F.J.J. · Bär, A.
Keywords: Biology · gamma cyclodextrin · lactose · animal experiment · animal tissue · article · body weight · controlled study · dose response · embryotoxicity · female · fetus · fetus weight · fluid intake · food intake · male · nonhuman · oral drug administration · priority journal · rat · sexual behavior · teratogenicity · uterus weight · Animal Feed · Animals · Body Weight · Cyclodextrins · Drinking · Eating · Female · Fetal Viability · Fetus · gamma-Cyclodextrins · Gestational Age · Male · Pregnancy · Rats · Rats, Wistar · Teratogens · Weight Gain · Animalia · Solanum tuberosum
[Abstract]

12 Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats
article 2004    
Author: Waalkens-Berendsen, D.H. · Kuilman-Wahls, M.E.M. · Bär, A.
Keywords: Biology · Toxicology and Applied Pharmacology · Hesperidin · Neohesperidin dihydrochalcone · Unclassified drug · Animal experiment · Autopsy · Cesarean section · Controlled study · Embryotoxicity · Female · Female fertility · Fetotoxicity · Gestation period · Male · Nonhuman · Ovary · Placenta · Priority journal · Rat · Teratogenicity · Uterus · Weight gain · Animals · Chalcone · Chalcones · Female · Fetus · Hesperidin · Male · Maternal Exposure · Pregnancy · Rats · Reproduction · Sweetening Agents · Teratogens · Animalia
[Abstract]

13 Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
article 2006    
Author: Verwei, M. · Burgsteden, J.A. van · Krul, C.A.M. · Sandt, J.J.M. van de · Freidig, A.P.
Keywords: Biology · Biomedical Research · Alternative test method · Developmental toxicity · Embryonic stem cells · PBPK model · 2 ethoxyethanol · 2 methoxyethanol · acetic acid derivative · ethoxyacetic acid · fluorouracil · methotrexate · methoxyacetic acid · retinoic acid · unclassified drug · animal cell · article · computer model · controlled study · embryo · embryo development · embryonic stem cell · embryotoxicity · exposure · metabolism · mouse · nonhuman · prediction · priority journal · risk assessment · rodent · Animal Testing Alternatives · Animals · Cell Line · Cell Survival · Dose-Response Relationship, Drug · Embryo · Mice · Models, Biological · Predictive Value of Tests · Rats · Risk Assessment · Stem Cells · Teratogens · Toxicity Tests · Rodentia
[Abstract]

14 Embryotoxicity and teratogenicity study with y-cyclodextrin in rabbits
article 1998    
Author: Waalkens-Berendsen, D.H. · Smits-van Prooije, A.E. · Bär, A.
Keywords: gamma cyclodextrin · lactose · animal experiment · article · body weight · controlled study · diarrhea · dose response · embryotoxicity · female · fetus · fetus weight · food intake · male · nonhuman · oral drug administration · placenta weight · priority journal · rabbit · sex ratio · sexual behavior · teratogenicity · uterus weight · weight gain · Animal Feed · Animals · Body Weight · Cyclodextrins · Diarrhea · Dose-Response Relationship, Drug · Eating · Female · Fetus · gamma-Cyclodextrins · Gestational Age · Lactose · Litter Size · Male · Organ Size · Placenta · Pregnancy · Rabbits · Teratogens · Uterus · Weight Gain · Animalia · Oryctolagus cuniculus
[Abstract]

15 Embryotoxicity and teratogenicity study with α-cyclodextrin in rats
article 2004    
Author: Waalkens-Berendsen, D.H. · Bär, A.
Keywords: Biology · Toxicology and Applied Pharmacology · alpha cyclodextrin · lactose · starch · animal experiment · animal model · animal tissue · article · chemical teratogenesis · controlled study · crown rump length · embryotoxicity · female · fetotoxicity · fetus disease · fetus weight · fluid intake · food intake · gestation period · gestational age · medical assessment · nonhuman · priority journal · rat · rat strain · sexual behavior · species comparison · teratogenicity · weight gain · Abnormalities, Drug-Induced · Administration, Oral · alpha-Cyclodextrins · Animals · Cyclodextrins · Embryonic and Fetal Development · Female · Male · Pregnancy · Prenatal Exposure Delayed Effects · Rats · Rats, Wistar · Solanum tuberosum
[Abstract]

16 Embryotoxicity and teratogenicity study with α-cyclodextrin in rabbits
article 2004    
Author: Waalkens-Berendsen, D.H. · Smits-Van Prooije, A.E. · Bär, A.
Keywords: Biology · Toxicology and Applied Pharmacology · Cyclodextrin · Dietary Fiber · Lactose · Reproductive toxicity · alpha cyclodextrin · animal experiment · animal model · animal tissue · article · artificial insemination · body weight · chemical teratogenesis · controlled study · corpus luteum · diarrhea · embryotoxicity · female · fetus weight · food intake · gestational age · male · nidation · nonhuman · placenta weight · priority journal · sex ratio · sexual behavior · species comparison · teratogenicity · uterus weight · weight reduction · Abnormalities, Drug-Induced · Administration, Oral · alpha-Cyclodextrins · Animals · Cyclodextrins · Embryonic and Fetal Development · Female · Male · Pregnancy · Prenatal Exposure Delayed Effects · Rabbits · Animalia · Oryctolagus cuniculus
[Abstract]

17 Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds
article 2009    
Author: Jong, E. de · Louisse, J. · Verwei, M. · Blaauboer, B.J. · Sandt, J.J.M. van de · Woutersen, R.A. · Rietjens, I.M.C.M. · Piersma, A.H.
Keywords: Chemistry · Toxicology and Applied Pharmacology · Alternatives to animal testing · Developmental toxicology · Embryonic stem cells · Glycol ethers · butoxyacetic acid · ethoxyacetic acid · glycol ether alkoxy acid metabolite · methoxyacetic acid · phenoxyacetic acid · toxin · unclassified drug · animal cell · article · cell differentiation · chemical analysis · chemical structure · concentration response · controlled study · cytotoxicity test · developmental disorder · developmental toxicity · embryonic stem cell · embryonic stem cell test · embryotoxicity · heart muscle cell · in vivo study · mouse · nonhuman · sensitivity analysis · toxicokinetics · Animal Testing Alternatives · Animals · Biotransformation · Cell Differentiation · Cell Survival · Dose-Response Relationship, Drug · Embryonic Development · Embryonic Stem Cells · Glycols · Kinetics · Mice · Models, Statistical · Myocytes, Cardiac · Predictive Value of Tests · Reference Standards · Structure-Activity Relationship · Teratogens · Animalia
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 17 of 17 found. | Sort by date