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1 Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male mice
article 2007    
Author: Korsheninnikova, E. · Voshol, P.J. · Baan, B. · Zon, G.C.M. van der · Havekes, L.M. · Romijn, J.A. · Maassen, J.A. · Ouwens, D.M.
Keywords: Biology · Biomedical Research · Hepatic glucose production · High-fat diet · Insulin resistance · Insulin signalling · Liver · glucose · insulin · insulin receptor · phosphatidylinositol 3 kinase · protein kinase B · animal · article · blood · C57BL mouse · drug effect · fat intake · gene expression regulation · glucose clamp technique · hyperinsulinism · liver · male · metabolism · mouse · signal transduction · 1-Phosphatidylinositol 3-Kinase · Animals · Dietary Fats · Gene Expression Regulation, Enzymologic · Glucose · Glucose Clamp Technique · Hyperinsulinism · Insulin · Liver · Male · Mice · Mice, Inbred C57BL · Proto-Oncogene Proteins c-akt · Receptor, Insulin · Signal Transduction · Mus
[Abstract]

2 Leptin deficiency per se dictates body composition and insulin action in ob/ob mice
article 2008    
Author: Hoek, A.M. van den · Teusink, B. · Voshol, P.J. · Havekes, L.M. · Romijn, J.A. · Pijl, H.
Keywords: Biology · Adiposity hormone · Brain · Insulin resistance · Metabolism · Type 2 diabetes mellitus · glucose · insulin · leptin · animal experiment · animal tissue · article · body composition · body weight · caloric restriction · controlled study · diet restriction · female · gluconeogenesis · glucose clamp technique · glucose metabolism · hormone deficiency · insulin resistance · insulin sensitivity · lean body weight · leptin deficiency · male · mouse · mouse strain · nonhuman · obesity · pathophysiology · priority journal · quantitative analysis · signal transduction · wild type · Animals · Blood Glucose · Body Composition · Body Weight · Fatty Acids, Nonesterified · Female · Food Deprivation · Glucose · Glucose Clamp Technique · Growth and Development · Insulin · Leptin · Male · Mice · Mice, Inbred C57BL · Mice, Obese · Mice, Transgenic · Obesity
[Abstract]

3 Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation
article 2008    
Author: Hoek, A.M. van den · Heijningen, C. van · Schröder - Elst, J.P. van der · Ouwens, D.M. · Havekes, L.M. · Romijn, J.A. · Kalsbeek, A. · Pijl, H.
Keywords: corticosterone · glucose · insulin · liothyronine · neuropeptide Y · testosterone · thyroxine · antidiabetic agent · animal experiment · animal model · animal tissue · article · controlled study · drug mechanism · glucose metabolism · hormone blood level · insulin resistance · liver · male · nonhuman · parasympathetic innervation · priority journal · rat · sympathetic innervation · adrenergic system · animal · drug effect · glucose blood level · glucose clamp technique · hyperinsulinism · innervation · intracerebroventricular drug administration · metabolism · pathophysiology · physiology · sympathectomy · vagotomy · Wistar rat · Animals · Blood Glucose · Glucose Clamp Technique · Hyperinsulinism · Hypoglycemic Agents · Injections, Intraventricular · Insulin · Insulin Resistance · Liver · Male · Neuropeptide Y · Parasympathectomy · Rats · Rats, Wistar · Sympathectomy · Sympathetic Nervous System
[Abstract]

4 Hyperlipidaemia is associated with increased insulin-mediated glucose metabolism, reduced fatty acid metabolism and normal blood pressure in transgenic mice overexpressing human apolipoprotein C1
article 2001    
Author: Koopmans, S.J. · Jong, M.C. · Que, I. · Dahlmans, V.E.H. · Pijl, H. · Radder, J.K. · Frölich, M. · Havekes, L.M.
Keywords: Biology · APOC1 · Hypertension · Insulin resistance · Insulin resistance syndrome · Lipoprotein · NEFA · Fatty acid · Palmitic acid · Triacylglycerol · Tritium · Very low density lipoprotein · Adipose tissue · Animal model · Animal tissue · Blood pressure · Cholesterol blood level · Clearance · Controlled study · Fatty acid metabolism · Gene overexpression · Glucose blood level · Glucose clamp technique · Glucose metabolism · Glycogen synthesis · Glycolysis · Heart rate · Hyperinsulinemia · Hyperlipidemia · Hypertension · In vivo study · Infusion · Insulin resistance · Lipid transport · Lipogenesis · Mean arterial pressure · Mouse · Nonhuman · Skeletal muscle · Transgenic mouse · Animals · Apolipoprotein C-I · Apolipoproteins C · Blood Glucose · Blood Pressure · Cholesterol · Fatty Acids, Nonesterified · Gene Expression · Glucose · Glucose Clamp Technique · Glycogen · Humans · Hyperlipidemias · Insulin · Lipid Metabolism · Liver · Mice · Mice, Transgenic · Muscle, Skeletal · Palmitic Acid · Triglycerides · Tritium
[Abstract]

5 Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice
article 2005    
Author: Heijboer, A.C. · Hoek, A.M. van den · Pijl, H. · Voshol, P.J. · Havekes, L.M. · Romijn, J.A. · Corssmit, E.P.M.
Keywords: Biology · Biomedical Research · Brain · Diabetes · Glut4 · Insulin resistance · Metabolism · Neuropeptides · Glucose transporter 4 · Hormone receptor stimulating agent · Insulin · Melanocortin 3 receptor · Melanocortin 4 receptor · Melanotan II · Messenger RNA · Placebo · Tritium · Unclassified drug · Water · Animal experiment · Animal tissue · Body weight · Brain lateral ventricle · Controlled study · Distillation · Drug effect · Food intake · Gluconeogenesis · Glucose blood level · Glucose clamp technique · Glucose metabolism · Hyperinsulinemia · Insulin sensitivity · Isotope labeling · Mouse · Mouse strain · Nonhuman · Skeletal muscle · Alpha-MSH · Animals · Blood Glucose · Corticosterone · Fatty Acids, Nonesterified · Glucose · Glucose Clamp Technique · Glucose Transporter Type 4 · Injections, Intraventricular · Insulin · Insulin Resistance · Kinetics · Liver · Male · Mice · Mice, Inbred C57BL · Monosaccharide Transport Proteins · Muscle Proteins · Peptides, Cyclic · Receptor, Melanocortin, Type 3 · Receptor, Melanocortin, Type 4 · RNA, Messenger
[Abstract]

6 Hepatic glucose production is more sensitive to insulin-mediated inhibition than hepatic VLDL-triglyceride production
article 2006    
Author: Boer, M.A.M. den · Voshol, P.J. · Kuipers, F. · Romijn, J.A. · Havekes, L.M.
Keywords: Biology · Biomedical Research · Euglycemic hyperinsulinemic clamp · Fatty acid · Very-low-density lipoprotein · Insulin · Adipose tissue · Animal experiment · Aanimal model · Controlled study · Drug effect · Drug inhibition · Fatty acid blood level · Gluconeogenesis · Glucose infusion · Glucose transport · Hyperinsulinemia · Insulin blood level · Insulin resistance · Insulin sensitivity · Lipolysis · Liver function · Mouse · Nonhuman · Animals · Blood Glucose · Dose-Response Relationship, Drug · Fatty Acids, Nonesterified · Glucose · Glucose Clamp Technique · Hypoglycemic Agents · Insulin · Kinetics · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Inbred C57BL · Triglycerides
[Abstract]

7 Effect of Moderate Alcohol Consumption on Adiponectin, Tumor Necrosis Factor-α, and Insulin Sensitivity
article 2004    
Author: Sierksma, A. · Patel, H. · Ouchi, N. · Kihara, S. · Funahashi, T. · Heine, R.J. · Grobbee, D.E. · Kluft, C. · Hendriks, H.F.J.
Keywords: Health · Physiological Sciences · Adiponectin · C peptide · Cholesterol · Cytokine · Fatty acid · Glucose · High density lipoprotein cholesterol · Insulin · Insulin receptor · Low density lipoprotein cholesterol · Tap water · Triacylglycerol · Tumor necrosis factor alpha · Adipose tissue · Adult · Alcohol consumption · Cholesterol blood level · Clinical trial · Controlled study · Crossover procedure · Diabetes mellitus · Diet restriction · Glucose blood level · Insulin sensitivity · Non insulin dependent diabetes mellitus · Normal human · Randomized controlled trial · Risk factor · Whiskey · Adiponectin · Aged · Alcohol Drinking · Body Mass Index · Body Weight · Cross-Over Studies · Glucose Clamp Technique · Humans · Hyperinsulinism · Insulin · Insulin Resistance · Intercellular Signaling Peptides and Proteins · Male · Middle Aged · Proteins · Regression Analysis · Tumor Necrosis Factor-alpha
[Abstract]

8 Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice
article 2006    
Author: Heijboer, A.C. · Hoek, A.M. van den · Parlevliet, E.T. · Havekes, L.M. · Romijn, J.A. · Pijl, H. · Corssmit, E.P.M.
Keywords: Biology · Biomedical Research · Animal models · GHRP-6 · Glucose metabolism · Gut hormone · Hyperinsulinaemic- euglycaemic clamp technique · Insulin resistance · Tracer methodology · Deoxyglucose · Desoctanoylghrelin · Ghrelin · Growth hormone secretagogue receptor · Growth hormone secretagogue receptor stimulating agent · Histidyl dextro tryptophylalanyltryptophyl dextro phenylalanyllysinamide · Peptide derivative · Unclassified drug · Adipose tissue · Adolescent · Body weight · Controlled study · Food intake · Glucogenesis · Glucose clamp technique · Glucose metabolism · Hormone action · Hyperinsulinemia · Insulin sensitivity · Isotope dilution assay · Liver metabolism · Mouse · Muscle metabolism · Nonhuman · Animals · Body Weight · Glucose · Hepatocytes · Insulin · Male · Mice · Mice, Inbred C57BL · Peptide Hormones
[Abstract]

9 Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice
article 2006    
Author: Boer, M.A.M. den · Voshol, P.J. · Schröder-van Der Elst, J.P. · Korsheninnikova, E. · Ouwens, D.M. · Kuipers, F. · Havekes, L.M. · Romijn, J.A.
Keywords: Biology · Biomedical Research · Amyloid A protein · fibrinogen · interleukin 10 · protein kinase B · Animal experiment · Calorimetry · Cholesterol blood level · Controlled study · Experimental model · Fatty liver · Feeding · Glucose blood level · Hlucose metabolism · High performance liquid chromatography · Hyperinsulinemia · Insulin sensitivity · Lipid diet · Lipid metabolism · Mouse · Nonhuman · Phosphorylation · Steatosis · Triacylglycerol blood level · Adipose Tissue · Animals · Blood Glucose · Chromatography, Thin Layer · Diet · Dietary Fats · Energy Metabolism · Fibrinogen · Genotype · Glucose · Glucose Clamp Technique · Insulin Resistance · Interleukin-10 · Lipid Metabolism · Lipids · Liver Diseases · Male · Mice · Mice, Inbred C57BL · Mice, Knockout · Phenotype · Serum Amyloid A Protein
[Abstract]

10 CNTO736, a novel glucagon-like peptide-1 receptor agonist, ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice
article 2009    
Author: Parlevliet, E.T. · Schröder-van der Elst, J.P. · Corssmit, E.P.M. · Picha, K. · O'Neil, K. · Stojanovic-Susulic, V. · Ort, T. · Havekes, L.M. · Romijn, J.A. · Pijl, H.
Keywords: Biology · Biomedical Research · CNTO 736 · exendin 4 · glucagon like peptide 1 derivative · glucagon like peptide 1 receptor · very low density lipoprotein · glucagon like peptide receptor · glucagon receptor · glucagon-like peptide receptor · hybrid protein · triacylglycerol · animal experiment · animal model · chronic drug administration · controlled study · gluconeogenesis · glucose blood level · glucose transport · hyperinsulinemia · lipid diet · lipoprotein metabolism · male · mouse · nonhuman · single drug dose · animal food · blood · C57BL mouse · Cytomegalovirus · Drug effect · Drug potentiation · Fat intake · Genetics · Intravenous drug administration · Metabolism · Molecular cloning · Animal Feed · Animals · Blood Glucose · Cloning, Molecular · Cytomegalovirus · Dietary Fats · Glucose · Glucose Clamp Technique · Hyperinsulinism · Infusions, Intravenous · Insulin · Insulin Resistance · Lipoproteins, VLDL · Liver · Mice · Mice, Inbred C57BL · Promoter Regions, Genetic · Receptors, Glucagon · Recombinant Fusion Proteins · Triglycerides
[Abstract]

11 The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the α2-adrenergic receptors in beta cells
article 2010    
Author: Leeuw van Weenen, J.E. de · Parlevliet, E.T. · Maechler, P. · Havekes, L.M. · Romijn, J.A. · Ouwens, D.M. · Pijl, H. · Guigas, B.
Keywords: Biology · Biomedical Research · α2-Adrenergic receptor · Bromocriptine · Dopamine receptor · INS-1E cells · Insulin secretion · Mice · alpha 2 adrenergic receptor · bromocriptine · cyclic AMP · domperidone · dopamine 2 receptor stimulating agent · G protein coupled receptor · glucose · insulin · placebo · yohimbine · analytic method · animal cell · animal experiment · article · cell line · cell membrane depolarization · cell membrane potential · controlled study · drug effect · glucose clamp technique · glucose tolerance test · hyperglycemia · in vitro study · in vivo study · inhibition kinetics · insulin release · male · mouse · nonhuman · pancreas islet beta cell · priority journal · Western blotting · Animals · Bromocriptine · Cell Line · Dopamine Agonists · Dose-Response Relationship, Drug · Glucose · Insulin · Insulin-Secreting Cells · Insulinoma · Male · Mice · Mice, Inbred C57BL · Rats · Receptors, Adrenergic, alpha · Receptors, Dopamine D2
[Abstract]

12 Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
article 2006    
Author: Korsheninnikova, E. · Zon, G.C.M. van der · Voshol, P.J. · Janssen, G.M. · Havekes, L.M. · Grefhorst, A. · Kuipers, F. · Reijngoud, D.-J. · Romijn, J.A. · Ouwens, D.M. · Maassen, J.A.
Keywords: Biology · Biomedical Research · Hepatic steatosis · High-fat feeding · Nutrient sensing · Enzyme inhibitor · Glucose · Hydroxymethylglutaryl coenzyme A reductase kinase · Mammalian target of rapamycin · Protein kinase B · Protein S6 · S6 kinase · Tetradecylglycidic acid · Unclassified drug · Animal experiment · Animal model · Animal tissue · Controlled study · Diabetic obesity · Diabetogenesis · Enzyme activation · Glucose clamp technique · Hyperinsulinemia · Insulin resistance · Lipid diet · Liver homogenate · Liver mitochondrion · Mitochondrial membrane · Nonhuman · Nutrient concentration · Nutrient content · Protein blood level · Protein induction · Protein phosphorylation · Protein synthesis · Protein targeting · Species comparison · 1-Phosphatidylinositol 3-Kinase · Animals · Blood Glucose · Dietary Fats · DNA, Mitochondrial · Electron Transport Complex IV · Fatty Acids · Fatty Liver · Insulin · Insulin Resistance · Leucine · Liver · Male · Mice · Mice, Inbred C57BL · Phosphorylation · Protein Kinases · Ribosomal Proteins
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 12 of 12 found. | Sort by date