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1 Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes
article 2009    
Author: Treijtel, N. · Eijkeren, J.C.H.v. · Nijmeijer, S. · Greef de - Sandt, I.C.J. van der · Freidig, A.P.
Keywords: Health · Biomedical Research · HIV-protease inhibitors · Metabolism · P-Glycoprotein · Rat hepatocytes · rat liver microsomes · Sandwich-culture · cyclosporin A · drug metabolite · glycoprotein P · ketoconazole · proteinase inhibitor · ritonavir · saquinavir · testosterone derivative · valspodar · verapamil · animal cell · article · cell culture · controlled study · drug clearance · drug excretion · drug metabolism · drug transport · Human immunodeficiency virus 1 · hydroxylation · intrahepatic bile duct · liver cell · liver metabolism · male · microsome · nonhuman · rat · sandwich culture · Animals · Biological Transport, Active · Cell Culture Techniques · Cell Survival · Cells, Cultured · Cyclosporine · Cyclosporins · Dose-Response Relationship, Drug · Hepatocytes · HIV Protease Inhibitors · Ketoconazole · Male · Metabolic Clearance Rate · Microsomes, Liver · Rats · Rats, Wistar · Ritonavir · Saquinavir · Human immunodeficiency virus 1 · Rattus
[Abstract]

2 Toxicogenomics directory of chemically exposed human hepatocytes
article 2014    
Author: Grinberg, M. · Stöber, R.M. · Edlund, K. · Rempel, E. · Godoy, P. · Reif, R. · Widera, A. · Madjar, K. · Schmidt-Heck, W. · Marchan, R. · Sachinidis, A. · Spitkovsky, D. · Hescheler, J. · Carmo, H. · Arbo, M.D. · Water, B. van de · Wink, S. · Vinken, M. · Rogiers, V. · Escher, S. · Hardy, B. · Mitic, D. · Myatt, G. · Waldmann, T. · Mardinoglu, A. · Damm, G. · Seehofer, D. · Nüssler, A. · Weiss, T.S. · Oberemm, A. · Lampen, A. · Schaap, M.M. · Luijten, M. · van Steeg, H. · Thasler, W.E. · Kleinjans, J.C.S. · Stierum, R.H. · Leist, M. · Rahnenführer, J. · Hengstler, J.G.
Keywords: Biology · Bioinformatics · Biomarker identification · Cirrhosis · Hepatocellular cancer · Hepatotoxicity · In vivo validation · SEURAT-1 · Steatosis · Toxicotranscriptomics · Unsupervised clustering · allyl alcohol · biological marker · chemical compound · cytochrome P450 1A1 · cytochrome P450 3A4 · galactosamine · isoniazid · ketoconazole · liver protein · paracetamol · propranolol · thyroid hormone · transcription factor · triazolam · valproic acid · binding site · cell stress · data base · down regulation · fatty liver · gene expression · gene ontology · human · liver cell · liver cell carcinoma · liver cirrhosis · liver disease · microarray analysis · mutation · nonalcoholic fatty liver · quantitative analysis · real time polymerase chain reaction · RNA extraction · toxicogenomics · transcriptomics · upregulation · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

3 In vitro models for the prediction of in vivo performance of oral dosage forms
article 2014    
Author: Kostewicz, E.S. · Abrahamsson, B. · Brewster, M. · Brouwers, J. · Butler, J. · Carlert, S. · Dickinson, P.A. · Dressman, J. · Holm, R. · Klein, S. · Mann, J. · McAllister, M. · Minekus, M. · Muenster, U. · Müllertz, A. · Verwei, M. · Vertzoni, M. · Weitschies, W. · Augustijns, P.
Keywords: Biology · Biorelevant · In vitro evaluation · In vivo biopharmaceutical performance · Innovative Medicines Initiative (IMI) · Oral Biopharmaceutical Tools (OrBiTo) · Oral drug formulations · Albendazole · Amprenavir · Bile acid · Celecoxib · Cinnarizine · Cyclodextrin · Danazol · Diclofenac · Dipyridamole · Excipient · Gelucire · Ketoconazole · Loviride · Montelukast · Octanol · Propranolol · Saquinavir · Controlled drug release · Drug absorption · Drug bioavailability · Drug development · Drug dosage form · Drug formulation · Drug penetration · Drug solubility · Gastrointestinal motility · Human · Hydrodynamics · In vitro study · In vivo study · Lipolysis · Nonhuman · Precipitation · Prediction · Priority journal · Quality control · Review · Simulation · Tablet disintegration · Food and Nutrition · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies · ELSS - Earth, Life and Social Sciences
[Abstract]

4 Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons
article 2000    
Author: Kappers, W.A. · Och, F.M.M. van · Groene, E.M. de · Horbach, G.J.
Keywords: Nutrition · Acetyltransferase · Amestest · AminoPAHs · Cytochrome P450 · HPRT · Mutagenicity · NIH/3T3 cells · NitroPAHs · Shuttle vector · V79 cells · Cytochrome P450 · Polycyclic aromatic hydrocarbon · Animal cell · Cell strain 3T3 · Controlled study · Enzyme activity · Gene locus · In vitro study · Mouse · Mutagenicity · Nonhuman · Priority journal · Reaction analysis · Reporter gene · Shuttle vector · 3T3 Cells · Animals · Cell Line · Cell Survival · Cytochrome P-450 Enzyme System · Dose-Response Relationship, Drug · Enzyme Inhibitors · Ethyl Methanesulfonate · Fluorenes · Humans · Hypoxanthine Phosphoribosyltransferase · Ketoconazole · Lac Operon · Mice · Microsomes, Liver · Mutagenicity Tests · Mutagens · Mutation · Polycyclic Hydrocarbons, Aromatic · Pyrenes · Rats · Recombinant Fusion Proteins · Salmonella typhimurium · Theophylline · Animalia · Cricetinae · Cricetulus griseus · Eukaryota · Salmonella typhimurium · Typhimurium
[Abstract]

5 The novel antifungal agent PLD-118 is neither metabolized by liver microsomes nor inhibits cytochrome P450 in vitro
article 2005    
Author: Parnham, M.J. · Bogaards, J.J.P. · Schrander, F. · Schut, M.W. · Orešković, K. · Mildner, B.
Keywords: Health Pharmacology · Physiological Sciences · Cytochrome P450 · Metabolism · PLD-118 · 2 amino 4 methylenecyclopentanecarboxylic acid · alpha naphthoflavone · amino acid · antifungal agent · bufuralol · chlorzoxazone · coumarin · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2B6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · cytochrome P450 3A · diclofenac · diethyldithiocarbamic acid · ethoxyresorufin · ketoconazole · mephenytoin · monoclonal antibody · monoclonal antibody 2B6 · quinidine · reduced nicotinamide adenine dinucleotide phosphate · resorufin · sulfaphenazole · testosterone · umbelliferone · unclassified drug · unindexed drug · analytic method · animal tissue · article · candidiasis · concentration response · controlled study · derivatization · dog · drug structure · enzyme assay · enzyme inhibition · enzyme stability · enzyme substrate · fluorescence analysis · high performance liquid chromatography · human · human tissue · in vitro study · liver homogenate · liver microsome metabolism · nonhuman · rat · structure analysis · Administration, Oral · Animals · Antifungal Agents · Chemistry, Pharmaceutical · Cycloleucine · Cytochrome P-450 Enzyme System · Dogs · Drug Evaluation, Preclinical · Humans · Microsomes, Liver · Rats · Ribosomal Proteins
[Abstract]

Search results also available in MS Excel format.

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