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1 The mutagenicity of isoniazid in salmonella and its effects on DNA repair and synthesis in human fibroblasts
article 1980    
Author: Wade, D.R. · Lohman, P.H.M.
Keywords: Biology · Hydrazine · Isoniazid · Manganese · Abstract report · Adverse drug reaction · Cell culture · Chemical mutagenesis · DNA repair · DNA synthesis · Fibroblast · Human · Human cell · In vitro study · Liver microsome · Mouse · Mutagenicity · Normal human · Pharmacokinetics · Rat · Salmonella · Salmonella typhimurium · Soft tissue
[Abstract]

2 Characterization of human cytochrome P450s involved in the bioactivation of tri-Ortho-Cresyl phosphate (ToCP)
article 2015    
Author: Reinen, J. · Nematollahi, L. · Fidder, A. · Vermeulen, N.P.E. · Noort, D. · Commandeur, J.N.M.
Keywords: Toxicology · Cytochrome P450 1A2 · Cytochrome P450 2C18 · Cytochrome P450 2D6 · Cytochrome P450 3A4 · Cytochrome P450 3A5 · Organophosphorus compound · Unclassified drug · Animal cell · Biotransformation · Cholinesterase inhibition · Controlled study · Enzyme inactivation · Humans · human cell · Hydrolysis · IC50 · In vitro study · Liver microsome · Liver microsome metabolism · Neurotoxicity · Nonhuman · Rats · Acetylcholinesterase, 9000-81-1 · Cholinesterase, 9001-08-5 · cytochrome P450, 9035-51-2 · Cytochrome P450 3A4, 329736-03-0 · Cytochrome P450 3A5, 336874-97-6 · Tri ortho cresyl phosphate, 78-30-8 · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

3 Identification of some important metabolites of boldenone in urine and feces of cattle by gas chromatography-mass spectrometry
article 1998    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, L. · Zande, D.J.M. van der · Gelan, J. · Raus, J.
Keywords: Nutrition · Anabolic agent · Androstenedione · Boldenone · Drug metabolite · Animal tissue · Cattle · Conference paper · Drug feces level · Drug metabolism · Drug urine level · Gas chromatography · Liver cell · Liver microsome · Mass spectrometry · Nonhuman · Animals · Cells, Cultured · Feces · Gas Chromatography-Mass Spectrometry · Liver · Male · Microsomes, Liver · Testosterone
[PDF] [Abstract]

4 In vitro liver models are important tools to monitor the abuse of anabolic steroids in cattle
article 1998    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, T. · Zande, D.J.M. van der · Gelan, J. · Raus, J.
Keywords: Nutrition · Anabolic agent · Biological marker · Boldenone · Clostebol · Estrane derivative · Ethylestrenol · Norethandrolone · Steroid · Animal tissue · Cattle · Conference paper · Controlled study · Drug abuse · Drug determination · Drug metabolism · Drug monitoring · Female · Liver · Liver cell culture · Liver metabolism · Liver microsome · Male · Model · Nonhuman · Steroid metabolism · Anabolic Agents · Animals · Biological Markers · Cattle · Cells, Cultured · Drug Residues · Estradiol · Ethylestrenol · Liver · Microsomes, Liver · Models, Biological · Norethandrolone · Predictive Value of Tests · Testosterone
[PDF] [Abstract]

5 Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol
article 1996    
Author: Bessems, J.G.M. · Koppele, J.M. te · Dijk, P.A. van · Stee, L.L.P. van · Commandeur, J.N.M. · Vermeulen, N.P.E.
Keywords: Toxicology · beta naphthoflavone · cytochrome p450 · glutathione · paracetamol · paracetamol derivative · phenobarbital · animal tissue · article · controlled study · drug oxidation · liver microsome · male · nonhuman · rat · Acetaminophen · Animals · Benzoquinones · beta-Naphthoflavone · Cytochrome P-450 Enzyme System · Gas Chromatography-Mass Spectrometry · Glutathione · Imines · Kinetics · Male · Microsomes, Liver · Oxidation-Reduction · Rats · Rats, Wistar · Spectrophotometry, Ultraviolet · Animalia · Armoracia rusticana
[Abstract]

6 Report of a workshop on bacterial in vitro mutagenicity test systems
article 1978    
Author: Mattern, I.E. · Greim, H.
Keywords: Biology · 2 Aminoanthracene · 2 Nitrofluorene · Aflatoxin · Aroclor 1254 · Benzo[a]pyrene · Clophen a50 · Cyclophosphamide · Diethylnitrosamine · Dimethylnitrosamine · Mesylic acid ethyl ester · Methylnitronitrosoguanidine · Mitomycin c · N (2 fluorenyl)acetamide · Nitrosomorpholine · Polychlorinated biphenyl · Unclassified drug · Vinylidene chloride · 4 Nitroquinoline · Abstract report · Animal experiment · Bacterium · Benzoflavone · Drug activation · Drug metabolism · Drug screening · Hamster · In vitro study · Liver microsome · Methodology · Mouse · Mutagen testing · Mutagenesis · Rat
[Abstract]

7 Inhibition of zaleplon metabolism by cimetidine in the human liver : in vitro studies with subcellular fractions and precision-cut liver slices
article 2002    
Author: Renwick, A.B. · Ball, S.E. · Tredger, J.M. · Price, R.J. · Walters, D.G. · Kao, J. · Scatina, J.A. · Lake, B.G.
Keywords: Nutrition · Aldehyde oxidase · Cimetidine · Cytochrome P450 3A · Reduced nicotinamide adenine dinucleotide phosphate · Zaleplon · Cell fractionation · Drug inhibition · Drug metabolism · Human · Human cell · Human tissue · In vitro study · Liver metabolism · Liver microsome · Liver slice · Acetamides · Cimetidine · Cytosol · Dose-Response Relationship, Drug · Drug Interactions · Enzyme Inhibitors · Humans · Hypnotics and Sedatives · Inhibitory Concentration 50 · Kinetics · Liver · Models, Chemical · Pyrimidines · Subcellular Fractions · Staphylococcus phage 3A
[Abstract]

8 Human cytochrome P450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1′-hydroxysafrole
article 2004    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Awad, H.M. · Boersma, M.G. · Brand, W. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Physiological Sciences · 1' hydroxysafrole · carcinogen · cytochrome P450 · cytochrome P450 2A6 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · safrole · unclassified drug · animal cell · article · enzyme activation · enzyme specificity · human · insect cell · microsome · nonhuman · reaction analysis · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Humans · Microsomes, Liver · Risk Assessment · Safrole · Statistics, Nonparametric · Substrate Specificity · Animalia · Insecta
[Abstract]

9 Differences in cytochrome P450-mediated biotransformation of 1,2- dichlorobenzene by rat and man: Implications for human risk assessment
article 1996    
Author: Hissink, A.M. · Oudshoorn, M.J. · Ommen, B. van · Haenen, G.R.M.M. · Bladeren, P.J. van
Keywords: 1,2 dichlorobenzene · ascorbic acid · cytochrome p450 · epoxide hydrolase · glutathione · glutathione transferase · isoniazid · phenobarbital · animal cell · animal experiment · article · biotransformation · conjugation · controlled study · covalent bond · human · human cell · hydrolysis · liver microsome metabolism · liver toxicity · male · nonhuman · rat · Animals · Biotransformation · Chlorobenzenes · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Humans · Insecticides · Isoenzymes · Male · Microsomes, Liver · Protein Binding · Rats · Rats, Inbred F344 · Rats, Sprague-Dawley · Rats, Wistar · Risk Assessment · Species Specificity · Spectrophotometry, Ultraviolet · Animalia · Rattus norvegicus
[Abstract]

10 The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes
article 1996    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Bladeren, P.J. van
Keywords: Cytochrome P-450 · Isoprene · Metabolism · cyclohexane oxide · cytochrome p450 · cytochrome p450 isoenzyme · epoxide hydrolase · isoprene · animal experiment · article · controlled study · enzyme activity · enzyme specificity · epoxidation · human · human tissue · liver microsome metabolism · mouse · nonhuman · rat · species difference · xenobiotic metabolism · Animals · Biotransformation · Butadienes · Cyclohexanes · Cyclohexenes · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Epoxide Hydrolases · Epoxy Compounds · Hemiterpenes · Humans · Hydrolysis · Mice · Microsomes, Liver · Oxidation-Reduction · Pentanes · Rats · Rats, Wistar · Species Specificity
[Abstract]

11 Subcellular differences in post-translational modification of barley 14-3-3 proteins
article 2000    
Author: Zeijl, M.J. van · Testerink, C. · Kijne, J.W. · Wang, M.
Keywords: 14-3-3 Protein · Cell compartment · Germination · Hordeum distichum · Post-translational modification · isoprotein · protein antibody · trypsin · vegetable protein · barley · carboxy terminal sequence · cell fractionation · cell nucleus · controlled study · cytosol · electrophoresis · germination · microsome · priority journal · protein degradation · protein expression · protein modification · protein processing · Western blotting · 14-3-3 Proteins · Antibodies · Blotting, Western · Electrophoresis, Polyacrylamide Gel · Hordeum · Plant Proteins · Protein Isoforms · Protein Processing, Post-Translational · Proteins · Seeds · Subcellular Fractions · Trypsin · Tyrosine 3-Monooxygenase · Hordeum · Hordeum vulgare subsp. vulgare · Staphylococcus phage 3A
[PDF] [Abstract]

12 Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling
article 1996    
Author: Hissink, E. · Ommen, B. van · Bogaards, J.J. · Bladeren, P.J. van
Keywords: Toxicology · 1,2 dichlorobenzene · 1,4 dichlorobenzene · alanine aminotransferase · ascorbic acid · cytochrome p450 isoenzyme · epoxide · glutathione · isoniazid · animal cell · animal experiment · animal model · biotransformation · conference paper · controlled study · detoxification · enzyme substrate · liver microsome · liver toxicity · male · mathematical model · nonhuman · priority journal · rat · toxicokinetics · Animals · Biotransformation · Carcinogens · Chlorobenzenes · Cytochrome P-450 Enzyme System · Epoxy Compounds · Humans · Liver · Male · Microsomes, Liver · Models, Biological · Rats · Rats, Wistar

13 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

14 Cholestrol content of the rat lens is lowered by administration of simvastatin, but not pravastatin
article 1993    
Author: Vries, A.C.J. de · Vermeer, M.A. · Bredman, J.J. · Bar, P.R. · Cohen, L.H.
Keywords: Pharmacology · 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors · hypocholesterolaemic drugs · antilipemic agent · drug derivative · hydroxymethylglutaryl coenzyme A reductase inhibitor · hypocholesterolemic agent · mevinolin · animal experiment · cholesterol metabolism · oral drug administration · biosynthesis · dose response · drug effect · enzymology · liver microsome · metabolism · organ culture · rat strain · time · Aging · Animal · Anticholesteremic Agents · Antilipemic Agents · Cholesterol · Dose-Response Relationship, Drug · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lens, Crystalline · Lovastatin · Microsomes, Liver · Organ Culture · Pravastatin · Rats · Rats, Wistar · Simvastatin · Time Factors
[Abstract]

15 Human cytochrome P450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes
article 2007    
Author: Jeurissen, S.M.F. · Punt, A. · Boersma, M.G. · Bogaards, J.J.P. · Fiamegos, Y.C. · Schilter, B. · Bladeren, P.J. van · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxyestragole · alkenylbenzene derivative · alpha naphthoflavone · benzene derivative · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2D6 · cytochrome P450 2E1 · estragole · methyleugenol · safrole · article · enzyme specificity · human · human cell · hydroxylation · liver microsome · phenotype · protein expression · Anisoles · Biotransformation · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Hydroxylation · Microsomes, Liver · Safrole · Substrate Specificity
[Abstract]

16 Human cytochrome P450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1′-hydroxymethyleugenol
article 2006    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Boersma, M.G. · Horst, J.P.F. ter · Awad, H.M. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxymethyleugenol · barbituric acid derivative · carcinogen · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · methyleugenol · unclassified drug · article · carcinogenicity · concentration (parameters) · enzyme activation · enzyme kinetics · enzyme specificity · enzyme substrate · human · hydroxylation · incubation time · insect cell · lifestyle · liver microsome · nonhuman · sensitivity analysis · smoking · Aryl Hydrocarbon Hydroxylases · Benzoflavones · Biotransformation · Carcinogens · Cell Line · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Kinetics · Microsomes, Liver · Mixed Function Oxygenases · Recombinant Proteins · Risk Assessment · Sulfaphenazole · Insecta
[Abstract]

17 Acetoxy drug : Protein transacetylase of buffalo liver - Characterization and mass spectrometry of the acetylated protein product
article 2004    
Author: Kohli, E. · Gaspari, M. · Raj, H.G. · Parmar, V.S. · Sharma, S.K. · Greef, J. van der · Kumari, R. · Gupta, G. · Seema · Khurana, P. · Tyagi, Y.K. · Watterson, A.C. · Olsen, C.E.
Keywords: Chemistry Biology · Analytical research · Acetoxy drug · MALDI-TOF · Protein acetylation · Protein mass spectrometry · Transacetylase · 7,8 diacetoxy 4 methylcoumarin · 7,8 dihydroxy 4 methylcoumarin · acyltransferase · coumarin derivative · liver enzyme · monoacetoxymonohydroxy 4 methylcoumarin · peptide derivative · trypsin · unclassified drug · acetylation · animal cell · article · buffalo · catalysis · enzyme analysis · enzyme purification · liver microsome · mass spectrometry · matrix assisted laser desorption ionization time of flight mass spectrometry · model · molecular weight · nonhuman · peptide mapping · polyacrylamide gel electrophoresis · priority journal · Acetylation · Acetyltransferases · Amino Acid Sequence · Animals · Buffaloes · Coumarins · Glutathione Transferase · Liver · Microsomes, Liver · Molecular Sequence Data · Peptides · Protein Structure, Tertiary · Proteins · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization · Bubalus
[Abstract]

18 Characterization of a foldase, protein disulfide isomerase A, in the protein secretory pathway of Aspergillus niger
article 2000    
Author: Ngiam, C. · Jeenes, D.J. · Punt, P.J. · Hondel, C.A.M.J.J. van den · Archer, D.B.
Keywords: Nutrition · Egg white · Glucan 1,4 alpha glucosidase · Lysozyme · Messenger RNA · Microsome enzyme · Protein disulfide isomerase · Ribonuclease · Aspergillus niger · Endoplasmic reticulum · Enzyme activity · Enzyme analysis · Gene overexpression · Immunoblotting · Nonhuman · Protein folding · Protein induction · Protein secretion · Renaturation · Saccharomyces cerevisiae · Actins · Aspergillus niger · Calcimycin · Dithiothreitol · Down-Regulation · Endoplasmic Reticulum · Fungal Proteins · Gene Expression Regulation, Fungal · Heat-Shock Proteins · HSP70 Heat-Shock Proteins · Microsomes · Protein Denaturation · Protein Disulfide-Isomerase · Protein Folding · Recombinant Proteins · Ribonuclease, Pancreatic · RNA, Messenger · Saccharomyces cerevisiae · Transcription, Genetic · Transformation, Genetic · Aspergillus niger · Eukaryota · Saccharomyces cerevisiae
[PDF] [Abstract]

19 Localization of synthesis of β1,6-glucan in Saccharomyces cerevisiae
article 1999    
Author: Montijn, R.C. · Vink, E. · Müller, W.H. · Verkleij, A.J. · Ende, H. van den · Henrissat, B. · Klis, F.M.
Keywords: Nutrition · Chitin · Glucan · Glucosyltransferase · Glycosidase · Beta 1,6 glucan · Beta glucan · Beta-1,6-glucan · Fungal protein · KRE6 protein, S cerevisiae · Membrane protein · Multienzyme complex · Saccharomyces cerevisiae protein · SKN1 protein, S cerevisiae · Transferase · Transglycosidase enzyme system · Amino acid sequence · Cell surface · Cell wall · Endoplasmic reticulum · Golgi complex · Membrane vesicle · Microsome · Nonhuman · Nucleotide sequence · Priority journal · Saccharomyces cerevisiae · Synthesis · Biosynthesis · Cell membrane · Metabolism · Molecular genetics · Protein conformation · Protein secondary structure · Saccharomyces cerevisiae · Saccharomyces cerevisiae · Amino Acid Sequence · beta-Glucans · Cell Membrane · Fungal Proteins · Glucans · Glycoside Hydrolases · Membrane Proteins · Molecular Sequence Data · Multienzyme Complexes · Protein Conformation · Protein Structure, Secondary · Saccharomyces cerevisiae · Saccharomyces cerevisiae Proteins · Transferases
[Abstract]

20 Persistent alterations in regional brain glial fibrillary acidic protein and synaptophysin levels following pre- and postnatal polychlorinated biphenyl exposure
article 1996    
Author: Morse, D.C. · Plug, A. · Wesseling, W. · Berg, K.J. van den · Brouwer, A.
Keywords: Toxicology · aroclor 1254 · calcineurin · ethoxyresorufin deethylase · glial fibrillary acidic protein · polychlorinated biphenyl · synaptophysin · animal experiment · animal tissue · article · brain · brain region · brain stem · brain weight · cerebellum · controlled study · corpus striatum · dose response · female · fetus · fetus weight · immunochemistry · liver microsome · male · neurotoxicity · newborn · nonhuman · olfactory tract · prefrontal cortex · pregnancy · rat · sex difference · Animals · Animals, Newborn · Antithyroid Agents · Aroclor 1254 · Aroclors · Biological Markers · Body Weight · Brain · Brain Stem · Ca(2+)-Calmodulin Dependent Protein Kinase · Cerebellum · Cytochrome P-450 CYP1A1 · Female · Glial Fibrillary Acidic Protein · Male · Organ Size · Pregnancy · Prenatal Exposure Delayed Effects · Rats · Rats, Wistar · Reproduction · Synaptophysin · Animalia
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 26 found. Next | Sort by date