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Showing 1 to 15 of 15 found. | Sort by date

1 Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2
article 2008    
Author: Wortelboer, H.M. · Balvers, M.G.J. · Usta, M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Health · Physiological Sciences · Arsenic trioxide · Cisplatin · Glutathione · Mercury chloride · MRP1 · MRP2 · Adenosine triphosphatase · Calcein · Cisplatin · Glutathione · Multidrug resistance protein 1 · Multidrug resistance protein 2 · Animal cell · Cell viability · Complex formation · Controlled study · Enzyme activity · Kidney cell · Membrane vesicle · Molecular interaction · Nonhuman · Protein expression · Transport kinetics
[Abstract]

2 Interplay between MRP Inhibition and Metabolism of MRP Inhibitors: The Case of Curcumin
article 2003    
Author: Wortelboer, H.M. · Usta, M. · Velde, A.E. van der · Boersma, M.G. · Spenkelink, B. · Zanden, J.J. van · Rietjens, I.M.C.M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Biology · Physiological Sciences · curcumin · glutathione · glutathionylcurcumin · multidrug resistance protein 1 · multidrug resistance protein 2 · protein inhibitor · unclassified drug · animal cell · article · controlled study · drug effect · IC 50 · inhibition kinetics · insect cell · intracellular transport · membrane vesicle · metabolism · monolayer culture · nonhuman · protein expression · protein transport · Animals · ATP-Binding Cassette Transporters · Baculoviridae · Cell Line · Curcumin · Cyclosporine · Dinitrochlorobenzene · Dose-Response Relationship, Drug · Drug Resistance, Multiple · Ethacrynic Acid · Fluoresceins · Glutathione · Glutathione Transferase · Humans · P-Glycoprotein · P-Glycoproteins · Propionates · Quinolines · Recombinant Proteins · Spodoptera · Animalia · Apus apus · Insecta
[Abstract]

3 The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential
article 2007    
Author: Zanden, J.J. van · Woude, H. van der · Vaessen, J. · Usta, M. · Wortelboer, H.M. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biomedical Research · ABC transporters · Flavonoids · MRP1 · MRP2 · Phase II metabolism · Quercetin · ABC transporter · flavonoid · multidrug resistance protein 1 · multidrug resistance protein 2 · quercetin · animal cell · article · cancer cell culture · cancer chemotherapy · chemical structure · controlled study · enzyme activity · enzyme inhibition · glucuronidation · human · human cell · multidrug resistance · nonhuman · priority journal · rat · Animals · Cell Line, Tumor · Humans · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Quercetin · Rats
[Abstract]

4 Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin
article 2005    
Author: Zanden, J.J. van · Mul, A. de · Wortelboer, H.M. · Usta, M. · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Biology · Physiological Sciences · Flavonoids · MRP1 · MRP2 · Multidrug resistance · Myricetin · Vincristine · antineoplastic agent · flavonoid · multidrug resistance protein 1 · multidrug resistance protein 2 · myricetin · vincristine · animal cell · article · cell line · cell proliferation · chemotherapy · concentration (parameters) · controlled study · drug resistance · drug transport · genetic transfection · IC 50 · in vitro study · nonhuman · priority journal · Animals · Cell Line · Cell Proliferation · Dogs · Dose-Response Relationship, Drug · Drug Resistance, Neoplasm · Flavonoids · Humans · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Vincristine
[Abstract]

5 Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of α,β-unsaturated carbonyl compounds
article 2005    
Author: Wortelboer, H.M. · Usta, M. · Zanden, J.J. van · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Nutrition · Biomedical Research · α,β-Unsaturated carbonyl compounds · Inhibition · MRP1 · MRP2 · 2 hexenal · acrolein · caffeic acid phenethyl ester · calcein · carbonyl derivative · cinnamaldehyde · citral · crotonaldehyde · curcumin · cyclosporin A · demethoxycurcumin · didemethoxycurcumin · drug metabolite · glutathione · multidrug resistance protein 1 · multidrug resistance protein 2 · thiol derivative · unclassified drug · verlukast · animal cell · article · cell isolation · cell metabolism · conjugate · controlled study · dog · drug efficacy · drug metabolism · drug potency · drug protein binding · glutathione metabolism · kidney cell · membrane vesicle · modulation · molecular model · molecular stability · nonhuman · priority journal · protein expression · protein transport · Aldehydes · Animals · Biological Transport · Cell Line · Curcumin · Dogs · Fluoresceins · Humans · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Transfection
[Abstract]

6 GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid
article 1998    
Author: Iersel, M.L.P.S. van · Lipzig, M.M.H. van · Rietjens, I.M.C.M. · Vervoort, J. · Bladeren, P.J. van
Keywords: EA, ethacrynic acid · Ethacrynic acid · Glutathione S-transferase · Stereoselectivity · Etacrynic acid · Glutathione · Glutathione transferase · Multidrug resistance protein · Chemical reaction · Conjugate · Controlled study · Diastereoisomer · Drug conjugation · Enzyme mechanism · Glutathione metabolism · Human cell · Melanoma cell · Nuclear magnetic resonance spectroscopy · Stereochemistry · Amino Acid Substitution · Ethacrynic Acid · Glutathione · Glutathione Transferase · Humans · Isoenzymes · Melanoma · Point Mutation · Stereoisomerism · Substrate Specificity · Tumor Cells, Cultured
[PDF] [Abstract]

7 Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2
article 2005    
Author: Zanden, J.J. van · Wortelboer, H.M. · Bijlsma, S. · Punt, A. · Usta, M. · Bladeren, P.J.V. · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Nutrition Pharmacology · Analytical research · Calcein · Flavonoids · MRP1 · MRP2 · QSAR · 3 hydroxyflavone · 3' hydroxyflavone · 3',4' dihydroxyflavone · 3,3' dihydroxyflavone · 3,3',4' trihydroxyflavone · 4' hydroxyflavone · 5,7,3',4' tetramethoxyflavone · acacetin · apigenin · baicalein · catechin · chrysin · fisetin · flavone · flavonoid · galangin · kaempferide · kaempferol · luteolin · morin · multidrug resistance protein 1 · multidrug resistance protein 2 · myricetin · naringenin · protein inhibitor · quercetin · robinetin · taxifolin · unclassified drug · unindexed drug · valspodar · verlukast · animal cell · article · cell kinetics · cell transport · controlled study · drug effect · drug inhibition · drug potency · drug selectivity · genetic transfection · IC 50 · nonhuman · priority journal · protein analysis · quantitative structure activity relation · Animals · Cell Line · Dogs · Flavonoids · Fluoresceins · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Quantitative Structure-Activity Relationship
[Abstract]

8 Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells
article 2004    
Author: Zanden, J.J. van · Geraets, L. · Wortelboer, H.M. · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Biology Toxicology · Physiological Sciences · 1-chloro-2,4-dinitrobenzene · 50% inhibition concentration · CDNB · DNP-SG · Glutathione · Glutathione conjugate · Glutathione S-transferase · GS-X · GSH · GST · IC50 · MRP · Multidrug resistance associated protein · P-gp · S-(2,4-dinitrophenyl)glutathione · 3',4' dihydroxyflavone · carbon · catechin · catechol derivative · eriodictyol · flavanoid · flavone derivative · galanin · glutathione transferase · hydroxyl group · kaempferol · luteolin · morin · multidrug resistance protein 1 · multidrug resistance protein 2 · myricetin · quercetin · taxifolin · unclassified drug · animal cell · article · breast cancer · cell strain MCF 7 · chemical bond · controlled study · drug activity · drug potency · enzyme activity · enzyme inhibition · genetic transfection · human · human cell · IC 50 · lipophilicity · nonhuman · priority journal · structure activity relation · toxicokinetics · Biological Transport · Breast Neoplasms · Carrier Proteins · Drug Resistance, Multiple · Drug Resistance, Neoplasm · Flavonoids · Glutathione · Glutathione S-Transferase pi · Glutathione Transferase · Humans · Isoenzymes · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Structure-Activity Relationship · Tumor Cells, Cultured
[Abstract]

9 Bile duct proliferation associated with bile salt-induced hypercholeresis in Mdr2 P-glycoprotein-deficient mice
article 2005    
Author: Hulzebos, C.V. · Voshol, P.J. · Wolters, H. · Kruit, J.K. · Ottenhof, R. · Groen, A.K. · Stellaard, F. · Verkade, H.J. · Kuipers, F.
Keywords: Bile flow · Bile formation · Bile salt synthesis · Cholangiocyte · Cholate kinetics · Cholehepatic shunt · beta actin · bile salt · binding protein · carrier protein · chenodeoxycholic acid · cholic acid · deoxycholic acid · glycoprotein P · ileal bile salt binding protein · lithocholic acid · messenger RNA · multidrug resistance protein 2 · multidrug resistance protein 3 · muricholic acid · tauroursodeoxycholic acid · unclassified drug · animal experiment · animal model · animal tissue · bile acid synthesis · cell proliferation · controlled study · dilution · immunohistochemistry · in vivo study · intestine mucosa · intrahepatic bile duct · kinetics · liver parenchyma · male · mouse · nonhuman · nucleotide sequence · protein analysis · protein deficiency · protein expression · upregulation · Western blotting · wild type · Animals · Bile Acids and Salts · Bile Duct Diseases · Bile Ducts · Carrier Proteins · Cell Division · Cholates · Deuterium · Gallbladder · Intestines · Membrane Glycoproteins · Mice · Mice, Mutant Strains · Organic Anion Transporters, Sodium-Dependent · P-Glycoproteins · Phospholipids · RNA, Messenger · Symporters
[Abstract]

10 Monolayers of IEC-18 cells as an in vitro model for screening the passive transcellular and paracellular transport across the intestinal barrier: Comparison of active and passive transport with the human colon carcinoma Caco-2 cell line
article 2002    
Author: Versantvoort, C.H.M. · Ondrewater, R.C.A. · Duizer, E. · Sandt, J.J.M. van de · Gilde, A.J. · Groten, J.P.
Keywords: Caco-2 · Carrier-mediated transport · H+-di/tripeptide carrier · IEC-18 · Intestinal cell lines · MRP · P-Glycoprotein · acetylsalicylic acid · calcein · carrier protein · dinitrophenylglutathione · glucose derivative · glutathione derivative · glycoprotein P · glycylsarcosine · hydrocortisone · macrogol 4000 · mannitol · methylglucose · multidrug resistance protein · probenecid · propranolol · rhodamine 123 · salicylic acid · testosterone · unclassified drug · verapamil · vincristine · animal cell · article · cell membrane permeability · cell strain CACO 2 · cell transport · colon carcinoma · controlled study · drug transport · human · human cell · in vitro study · ion transport · model · nonhuman · priority journal · protein expression · rat · screening
[Abstract]

11 Myricetin stimulates the absorption of the pro-carcinogen PhIP
article 2006    
Author: Schutte, M.E. · Sandt, J.J.M. van de · Alink, G.M. · Groten, J.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · ABC transporter · Apparent permeability · Caco-2 · Myricetin · PhIP · 2 amino 1 methyl 6 phenylimidazo[4,5 b]pyridine · carcinogen · cyclosporin A · glycoprotein P inhibitor · multidrug resistance protein 2 · myricetin · valspodar · absorption · article · cell differentiation · cell strain CACO 2 · cell transport · concentration (parameters) · excretion · human · human cell · intestine epithelium cell · priority journal · stimulation · Absorption · ATP-Binding Cassette Transporters · Caco-2 Cells · Carcinogens · Flavonoids · Humans · Imidazoles · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Permeability
[Abstract]

12 Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines
article 1998    
Author: Welters, M.J.P. · Fichtinger-Schepman, A.M.J. · Baan, R.A. · Flens, M.J. · Scheper, R.J. · Braakhuis, B.J.M.
Keywords: Nutrition · Cisplatin · Glutathione · Glutathione S-transferase · Head and neck cancer · Multidrug resistance · Calcein · Glycoprotein p · Multidrug resistance protein · Cancer cell culture · Controlled study · Drug sensitivity · Drug transport · Head and neck cancer · Human cell · Immunocytochemistry · Membrane transport · Antineoplastic Agents · ATP-Binding Cassette Transporters · Drug Resistance, Multiple · Drug Resistance, Neoplasm · Enzyme Inducti · Glutathione Transferase · Head and Neck Neoplasms · Humans · Multidrug Resistance-Associated Proteins · Neoplasm Proteins · P-Glycoprotein · Vault Ribonucleoprotein Particles
[PDF] [Abstract]

13 An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers
article 2006    
Author: Schutte, M.E. · Freidig, A.P. · Sandt, J.J.M. van de · Alink, G.M. · Rietjens, I.M.C.M. · Groten, J.P.
Keywords: Biology · Biomedical Research · ABC transporter · Caco-2 · Flavonoid · Heterocyclic amine · In silico · 2 amino 1 methyl 6 phenylimidazo[4,5 b]pyridine · breast cancer resistance protein · chrysoeriol · elacridar · flavone · flavonoid · kaempferol · luteolin · morin · multidrug resistance protein · myricetin · naringenin · quercetin · robinetin · taxifolin · unclassified drug · verlukast · absorption · apical membrane · article · cell strain CACO 2 · computer model · controlled study · drug effect · human · human cell · Acridines · ATP-Binding Cassette Transporters · Biological Transport, Active · Caco-2 Cells · Carcinogens · Cell Membrane Permeability · Diffusion · Dose-Response Relationship, Drug · Flavanones · Flavonoids · Humans · Imidazoles · Intestinal Absorption · Intestinal Mucosa · Kinetics · Membrane Transport Proteins · Models, Biological · Multidrug Resistance-Associated Proteins · Neoplasm Proteins · P-Glycoprotein · Propionates · Quinolines · Reproducibility of Results · Tetrahydroisoquinolines
[Abstract]

14 Comparison of in vitro assays in selecting radiotracers for in vivo P-glycoprotein PET imaging
article 2017    
Author: Raaphorst, R.M. · Savolainen, H. · Cantore, M. · Steeg, E. van de · Waarde, A. van · Colabufo, N.A. · Elsinga, P.H. · Lammertsma, A.A. · Windhorst, A.D. · Luurtsema, G.
Keywords: Biology · Apical and basolateral membrane · Bidirectional transport · Blood-brain barrier · Calcein-AM · Tritium labeling · Calcein · Mc 224 f 18 · Mc 225 f 18 · Multidrug resistance protein · N fluoroethylverapamil f 18 · O fluoroethyl norverapamil f 18 · Radiopharmaceutical agent · Unclassified drug · Verapamil c 11 · Animal experiment · Animal tissue · Chemical analysis · Controlled study · Drug accumulation · Drug blood level · Drug brain level · Drug half life · Enzyme inhibition · Fluoroethylation · In vitro study · In vivo study · Isotope labeling · Male · Mouse · Nonhuman · Positron emission tomography · Predictive value · Protein function · Radioactivity · Rat · Synthesis · Transport assay · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

15 Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants
article 2018    
Author: Groen, B.D. van · Steeg, E. van de · Mooij, M.G. · Lipzig, M.M.H. van · Koning, B.A.E. de · Verdijk, R.M. · Wortelboer, H.M. · Gaedigk, R. · Bi, C. · Leeder, S. · Schaik, R.H.N. van · Rosmalen, J. van · Tibboel, D. · Vaes, W.H. · Wildt, S.N. de
Keywords: Biology · Liver · Ontogeny · Pediatrics · Proteomics · Transporters · Bile salt export pump · Breast cancer resistance protein · Glucose transporter 1 · Monocarboxylate transporter 1 · Multidrug resistance associated protein 1 · Multidrug resistance associated protein 2 · Multidrug resistance associated protein 3 · Multidrug resistance protein 1 · Organic anion transporter B · Organic cation transporter 1 · RNA · Sodium bile acid cotransporter · Solute carrier organic anion transporter 1A1 · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Cohort analysis · Controlled study · Female · Fetus · Fetus liver · Genetic variability · Genotype · Human · Human tissue · Infant · Liquid chromatography-mass spectrometry · Liver membrane · Major clinical study · Male · Membrane transport · MRNA expression level · Newborn · Pilot study · Prematurity · Protein expression · Protein expression level · Proteomics · RNA sequence · Single nucleotide polymorphism
[PDF] [Abstract]

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Showing 1 to 15 of 15 found. | Sort by date