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1 Human systemic exposure to a [14C]-para-phenylenediamine- containing oxidative hair dye and correlation with in vitro percutaneous absorption in human or pig skin
article 2004    
Author: Hueber-Becker, F. · Nohynek, G.J. · Meuling, W.J.A. · Benech-Kieffer, F. · Toutain, H.
Keywords: Biology · Physiological Sciences · Bioavailability · Hair dyes · Human · MOS, margin of safety · PAP, para-aminophenol · Para-phenylenediamine · Percutaneous absorption · Pig · PPD, para-phenylenediamine · SCCNFP, EU Scientific Committee of Cosmetic and Non-Food Products Intended for Consumers · Skin · hair dye · phenylenediamine · animal tissue · article · bioavailability · blood analysis · controlled study · feces analysis · hair level · health hazard · human · human tissue · metabolic clearance rate · nonhuman · normal human · radioactivity · risk assessment · skin absorption · tissue distribution · urinalysis · Adolescent · Adult · Animals · Clinical Trials · Diffusion · Ear, External · Feces · Hair · Hair Dyes · Humans · Male · Oxidation-Reduction · Phenylenediamines · Skin Absorption · Swine · Sus scrofa
[Abstract]

2 Human systemic exposure to [14C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment
article 2015    
Author: Nohynek, G.J. · Skare, J.A. · Meuling, W.J.A. · Wehmeyer, K.R. · Bie, A.T.H.J. de · Vaes, W.H.J. · Dufour, E.K. · Fautz, R. · Steiling, W. · Bramante, M. · Toutain, H.
Keywords: Biology · Consumer exposure · Hair dyes · Margin of safety · Paraphenylenediamine · TK-based safety assessment · Toxicokinetics · Carbon phenylenediamine c 14 · Hair dye · Phenylenediamine · Unclassified drug · Absorption · Adult · Blood analysis · Chemical reaction kinetics · Controlled study · Female · High performance liquid chromatography · Human · Human experiment · Male · Mass spectrometry · Metabolism · Population exposure · Radioactivity · Risk assessment · Skin test · Urinalysis · Urinary excretion · Rattus · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology TARA - Toxicology and Risk Assessment · ELSS - Earth, Life and Social Sciences
[Abstract]

3 Urinary acetylated metabolites and N-acetyltransferase-2 genotype in human subjects treated with a para-phenylenediamine-containing oxidative hair dye
article 2004    
Author: Nohynek, G.J. · Skare, J.A. · Meuling, W.J.A. · Hein, D.W. · Bie, A.T.H.J. de · Toutain, H.
Keywords: Health · Physiological Sciences · Arylamines · CAS No.: 106-50-3 · Hair dyes · Human volunteers · N-acetyltransferase 2 · Para-phenylenediamine · Skin metabolism · arylamine acetyltransferase · carbon 14 · glucuronic acid · hair dye · phenylenediamine · acetylation · adult · aerobic metabolism · article · genotype · human · male · metabolism · metabolite · molecular weight · normal human · radioactivity · urinalysis · urine level · Absorption · Acetylation · Administration, Topical · Adolescent · Adult · Arylamine N-Acetyltransferase · Carbon Radioisotopes · Genetic Predisposition to Disease · Genotype · Hair Dyes · Humans · Male · Phenylenediamines · Pilot Projects · Urinary Bladder Neoplasms · Mammalia
[Abstract]

4 Occupational exposure of hairdressers to [14C]-para-phenylenediamine-containing oxidative hair dyes: A mass balance study
article 2007    
Author: Hueber-Becker, F. · Nohynek, G.J. · Dufour, E.K. · Meuling, W.J.A. · Bie, A.T.H.J.de · Toutain, H. · Bolt, H.M.
Keywords: Biomedical Research · Bladder cancer · CAS 106-50-3 · Hair dyes · Hairdresser · Occupational exposure · para-Phenylenediamine, PPD · Sensitisation · carbon 14 · hair dye · phenylenediamine · adult · ambient air · article · blood level · blood sampling · controlled study · equipment · female · glove · hair · hairdresser · hand washing · human · human experiment · male · normal human · occupational exposure · personal monitoring · protective clothing · urinalysis · urinary excretion · Adult · Beauty Culture · Carbon Radioisotopes · Environmental Monitoring · Female · Gloves, Protective · Hair Dyes · Handwashing · Humans · Male · Middle Aged · Occupational Exposure · Phenylenediamines
[Abstract]

5 International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity
article 2014    
Author: Teunis, M.A.T. · Spiekstra, S.W. · Smits, M. · Adriaens, E. · Eltze, T. · Galbiati, V. · Krul, C.A.M. · Landsiedel, R. · Pieters, R. · Reinders, J. · Roggen, E. · Corsini, E. · Gibbs, S.
Keywords: Health · Epidermal equivalent · In vitro · NOEL · Sensitizer potency · 1 chloro 2,4 dinitrobenzene · 2 mercaptobenzothiazole · allergen · benzocaine · cinnamaldehyde · citral · cobalt chloride · formaldehyde · interleukin 1alpha · isoeugenol · oxazolone · phenylenediamine · accuracy · assay · controlled study · cytotoxicity · epidermal equivalent sensitizer potency assay · reproducibility · skin sensitization · Biomedical Innovation · Healthy Living · Healthy Living · Themalijn
[Abstract]

6 Xenobiotic metabolism in human skin and 3D human skin reconstructs: A review
article 2007    
Author: Gibbs, S. · Sandt, J.J.M. van de · Merk, H.F. · Lockley, D.J. · Pendlington, R.U. · Pease, C.K.
Keywords: Biology · 3D skin reconstructs · Cytochrome P450 · IDO expression · In vitro skin absorption · Microarray · Peptidases · 1 chloro 2,4 dinitrobenzene · 2 nitro 1,4 phenylenediamine · 4 aminophenol · alcohol dehydrogenase · aldehyde dehydrogenase · alpha tocopherol · atrazine · azo reductase · carnitine · cinnamaldehyde · cinnamyl alcohol · clobetasol propionate · cytochrome P450 · esterase · hydrogen peroxide · messenger RNA · nicotinic acid ethyl ester · oxygenase · phenylenediamine · propoxur · propranolol · resorufin · retinoic acid · retinol palmitate · T 2 toxin · toxic substance · triclosan · triolein · unindexed drug · xenobiotic agent · biotransformation · chemical carcinogenesis · environmental exposure · enzyme assay · ex vivo study · human · immunohistochemistry · in vitro study · nonhuman · Northern blotting · occupational exposure · protein expression · protein function · review · skin absorption · skin allergy · skin cancer · skin carcinogenesis · skin inflammation · skin sensitization · skin toxicity · toxicokinetics · Western blotting · xenobiotic metabolism · Biotransformation · Humans · Models, Biological · Skin · Xenobiotics
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 6 of 6 found. | Sort by date