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Showing 1 to 13 of 13 found. | Sort by date

1 The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene
article 2002    
Author: Hissink, E.M. · Bogaards, J.J.P. · Freidig, A.P. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Environment · PBPK · Radioactivity · Trichloroethylene
[Abstract]

2 Straling en radioactiviteit : Tsjernobyl 1986 : vragen en antwoorden op een rij gezet door TNO
book 1986    
Author: Bekkum, D.W. van · Barendsen, G.W. · Broerse, J.J.
Keywords: Science · Kernrampen · radiation · radioactivity · Historisch materiaal TNO · Medicine · Geneeskunde · pathology
[PDF]

3 Influence of the porosity on the <sup>222</sup>RN exhalation rate of concrete
article 2011    
Author: Jong, P. de · Dijk, W. van · Rooij, M. de
Keywords: Geosciences · <sup>222</sup>Rn · Diffusion · Exhalation rate · Indoor · Natural · Radioactivity · Mechatronics, Mechanics & Materials · MIP - Materials for Integrated Products · TS - Technical Sciences
[Abstract]

4 In vitro adduct formation of phosgene with albumin and hemoglobin in human blood
article 2000    
Author: Noort, D. · Hulst, A.G. · Fidder, A. · Gurp, R.A. van · Jong, L.P.A. de · Benschop, H.P.
Keywords: Toxicology · Albumins · Alpha globin · Amino acid sequence · Environmental exposure · Humans · Protein analysis · Protein binding · Protein blood level · Protein determination · Protein synthesis · Radioactivity · Chromatography, High Pressure Liquid · Environmental monitoring · Hemoglobins · Mass Spectrometry · Phosgene · Protein Binding · Hemoglobins · Phosgene, 75-44-5
[Abstract]

5 The ultimate radiochemical nightmare : upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule
article 2015    
Author: Uhm, J.I.M. van · Visser, G.W.M. · Schans, M.J. van der · Geldof, A.A. · Meuleman, E.J.H. · Nieuwenhuijzen, J.A.
Keywords: Botulinum neurotoxin A · Iodine-125 · Monoclonal antibody · PET research · Radio-iodination · Botulinum toxin A · Cetuximab · Cetuximab i 125 · Radiopharmaceutical agent · Unclassified drug · Biological activity · Controlled study · Drug purity · Gel permeation chromatography · High performance liquid chromatography · Human cell · Immunoreactivity · Iodination · Isotope labeling · Luminescence · Radioactivity · Radiochemistry · Reaction time · Thin layer chromatography · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[PDF] [Abstract]

6 Percutaneous absorption of mexoryl SX® in human volunteers: Comparison with in vitro data
article 2003    
Author: Benech-Kieffer, F. · Meuling, W.J.A. · Leclerc, C. · Roza, L. · Leclaire, J. · Nohynek, G.
Keywords: Nutrition Health · Physiological Sciences · Human skin · Mass balance · Mexoryl SX® · Percutaneous absorption · Sunscreen · carbon 14 · mexoryl sr · sulfonic acid derivative · sunscreen · terephthalylidene dicamphor sulfonic acid · unclassified drug · adult · article · blood sampling · correlation analysis · dermis · drug absorption · drug exposure · feces analysis · human · human experiment · human tissue · in vitro study · male · normal human · priority journal · radioactivity · single drug dose · skin absorption · skin surface · urinalysis · Administration, Topical · Adult · Bornanes · Camphor · Diffusion · Diffusion Chambers, Culture · Half-Life · Humans · Male · Mesylates · Skin Absorption · Sulfonic Acids · Sunscreening Agents
[Abstract]

7 Urinary acetylated metabolites and N-acetyltransferase-2 genotype in human subjects treated with a para-phenylenediamine-containing oxidative hair dye
article 2004    
Author: Nohynek, G.J. · Skare, J.A. · Meuling, W.J.A. · Hein, D.W. · Bie, A.T.H.J. de · Toutain, H.
Keywords: Health · Physiological Sciences · Arylamines · CAS No.: 106-50-3 · Hair dyes · Human volunteers · N-acetyltransferase 2 · Para-phenylenediamine · Skin metabolism · arylamine acetyltransferase · carbon 14 · glucuronic acid · hair dye · phenylenediamine · acetylation · adult · aerobic metabolism · article · genotype · human · male · metabolism · metabolite · molecular weight · normal human · radioactivity · urinalysis · urine level · Absorption · Acetylation · Administration, Topical · Adolescent · Adult · Arylamine N-Acetyltransferase · Carbon Radioisotopes · Genetic Predisposition to Disease · Genotype · Hair Dyes · Humans · Male · Phenylenediamines · Pilot Projects · Urinary Bladder Neoplasms · Mammalia
[Abstract]

8 Human systemic exposure to [14C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment
article 2015    
Author: Nohynek, G.J. · Skare, J.A. · Meuling, W.J.A. · Wehmeyer, K.R. · Bie, A.T.H.J. de · Vaes, W.H.J. · Dufour, E.K. · Fautz, R. · Steiling, W. · Bramante, M. · Toutain, H.
Keywords: Biology · Consumer exposure · Hair dyes · Margin of safety · Paraphenylenediamine · TK-based safety assessment · Toxicokinetics · Carbon phenylenediamine c 14 · Hair dye · Phenylenediamine · Unclassified drug · Absorption · Adult · Blood analysis · Chemical reaction kinetics · Controlled study · Female · High performance liquid chromatography · Human · Human experiment · Male · Mass spectrometry · Metabolism · Population exposure · Radioactivity · Risk assessment · Skin test · Urinalysis · Urinary excretion · Rattus · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology TARA - Toxicology and Risk Assessment · ELSS - Earth, Life and Social Sciences
[Abstract]

9 Human systemic exposure to a [14C]-para-phenylenediamine- containing oxidative hair dye and correlation with in vitro percutaneous absorption in human or pig skin
article 2004    
Author: Hueber-Becker, F. · Nohynek, G.J. · Meuling, W.J.A. · Benech-Kieffer, F. · Toutain, H.
Keywords: Biology · Physiological Sciences · Bioavailability · Hair dyes · Human · MOS, margin of safety · PAP, para-aminophenol · Para-phenylenediamine · Percutaneous absorption · Pig · PPD, para-phenylenediamine · SCCNFP, EU Scientific Committee of Cosmetic and Non-Food Products Intended for Consumers · Skin · hair dye · phenylenediamine · animal tissue · article · bioavailability · blood analysis · controlled study · feces analysis · hair level · health hazard · human · human tissue · metabolic clearance rate · nonhuman · normal human · radioactivity · risk assessment · skin absorption · tissue distribution · urinalysis · Adolescent · Adult · Animals · Clinical Trials · Diffusion · Ear, External · Feces · Hair · Hair Dyes · Humans · Male · Oxidation-Reduction · Phenylenediamines · Skin Absorption · Swine · Sus scrofa
[Abstract]

10 Biomonitoring of exposure to lewisite based on adducts to haemoglobin
article 2000    
Author: Fidder, A. · Noort, D. · Hulst, A.G. · Jong, L.P.A.de · Benschop, H.P.
Keywords: Toxicology · Adducts · Electrospray mass spectroscopy · Gas chromatography-mass spectroscopy · Haemoglobin · 2 chlorovinylarsonous acid · Arsenic acid derivative · Beta globin · Dimercaprol · Hemoglobin · Imidazole derivative · Lewisite · Unclassified drug · Animal experiment · Biological monitoring · Chemical warfare · Controlled study · Erythrocyte · Gas chromatography · Guinea pig · Health hazard · Human · Human cell · Male · Mass spectrometry · Nonhuman · Radioactivity · Urinalysis · Animals · Arsenicals · Binding Sites · Carbon Radioisotopes · Chelating Agents · Dimercaprol · Environmental Exposure · Erythrocytes · Gas Chromatography-Mass Spectrometry · Globins · Guinea Pigs · Hemoglobins · Humans · Imidazoles · Male · Protein Binding · Mass spectrometry · Electrospray ionization · 1-(heptafluorobutyryl)imidazole, 32477-35-3 · 2-chlorovinylarsonous acid · Arsenicals · Carbon radioisotopes · Chelating agents · Dimercaprol, 59-52-9 · Globins, 9004-22-2 · Hemoglobins · Imidazoles · Lewisite, 541-25-3
[Abstract]

11 Transdermal administration of radiolabelled [14C]rotigotine by a patch formulation: A mass balance trial
article 2007    
Author: Cawello, W. · Wolff, H.M. · Meuling, W.J.A. · Horstmann, R. · Braun, M.
Keywords: Biomedical Research · carbon 14 · dopamine receptor stimulating agent · rotigotine · silicone · adult · article · clinical trial · diarrhea · dizziness · drug absorption · drug clearance · drug delivery system · drug distribution · drug elimination · drug formulation · drug metabolism · drug penetration · drug release · drug structure · drug tolerability · fatigue · human · human experiment · isotope labeling · liquid chromatography · liquid scintillation counting · male · mass balance · normal human · phase 1 clinical trial · priority journal · radioactivity · single drug dose · tandem mass spectrometry · Administration, Cutaneous · Adolescent · Adult · Carbon Radioisotopes · Chromatography, Liquid · Dopamine Agonists · Humans · Male · Middle Aged · Tandem Mass Spectrometry · Tetrahydronaphthalenes · Thiophenes
[Abstract]

12 Comparison of in vitro assays in selecting radiotracers for in vivo P-glycoprotein PET imaging
article 2017    
Author: Raaphorst, R.M. · Savolainen, H. · Cantore, M. · Steeg, E. van de · Waarde, A. van · Colabufo, N.A. · Elsinga, P.H. · Lammertsma, A.A. · Windhorst, A.D. · Luurtsema, G.
Keywords: Biology · Apical and basolateral membrane · Bidirectional transport · Blood-brain barrier · Calcein-AM · Tritium labeling · Calcein · Mc 224 f 18 · Mc 225 f 18 · Multidrug resistance protein · N fluoroethylverapamil f 18 · O fluoroethyl norverapamil f 18 · Radiopharmaceutical agent · Unclassified drug · Verapamil c 11 · Animal experiment · Animal tissue · Chemical analysis · Controlled study · Drug accumulation · Drug blood level · Drug brain level · Drug half life · Enzyme inhibition · Fluoroethylation · In vitro study · In vivo study · Isotope labeling · Male · Mouse · Nonhuman · Positron emission tomography · Predictive value · Protein function · Radioactivity · Rat · Synthesis · Transport assay · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

13 Protein adduct formation by glucuronide metabolites of permethrin
article 2008    
Author: Noort, D. · Zuylen, A. van · Fidder, A. · Ommen, B. van · Hulst, A.G.
Keywords: Nutrition · 3 (2,2 dichlorovinyl) 2,2 dimethylcyclopropane 1 carboxylic acid · 3 phenoxybenzoic acid · Albumin · Amino acid · Benzoic acid derivative · Carboxylic acid derivative · Glucuronide · Lysine derivative · Peptide · Permethrin · Pronase · Article · Biological monitoring · Chemical structure · Complex formation · Covalent bond · Crug conjugation · Enzyme synthesis · Liquid chromatography · Metabolite · Protein adduct · Protein binding · Proton nuclear magnetic resonance · Radioactivity · Synthesis · Tandem mass spectrometry · Chromatography, High Pressure Liquid · Environmental Monitoring · Glucuronides · Humans · Insecticides · Lysine · Magnetic Resonance Spectroscopy · Microsomes, Liver · Permethrin · Pesticide Residues · Protein Binding · Serum Albumin · Spectrometry, Mass, Electrospray Ionization · Tandem Mass Spectrometry · Chemicals · 3 phenoxybenzoic acid, 3739-38-6 · Amino acid, 65072-01-7 · Permethrin, 51877-74-8, 52645-53-1 · Pronase, 9036-06-0 · Glucuronides · Insecticides · Lysine, 56-87-1 · Permethrin, 52645-53-1 · Pesticide residues · Serum albumin
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 13 of 13 found. | Sort by date