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1 Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy
article 2019    
Author: Graepel, R. · Braak, B. ter · Escher, S.E. · Fisher, C. · Gardner, I. · Kamp, H. · Kroese, D. · Leist, M. · Moné, M.J. · Pastor, M. · Water, B. van de
Keywords: Hazard assessment · Mechanism-based testingin vitroin silico · Repeated dose toxicity (RDT) · Developmental and reproductive toxicity (DART)
[Abstract]

2 Human embryonic stem cell-derived test systems for developmental neurotoxicity: A transcriptomics approach
article 2013    
Author: Krug, A.K. · Kolde, R. · Gaspar, J.A. · Rempel, E. · Balmer, N.V. · Meganathan, K. · Vojnits, K. · Baquié, M. · Waldmann, T. · Ensenat-Waser, R. · Jagtap, S. · Evans, R.M. · Julien, S. · Peterson, H. · Zagoura, D. · Kadereit, S. · Gerhard, D. · Sotiriadou, I. · Heke, M. · Natarajan, K. · Henry, M. · Winkler, J. · Marchan, R. · Stoppini, L. · Bosgra, S. · Westerhout, J. · Verwei, M. · Vilo, J. · Kortenkamp, A. · Hescheler, J. · Hothorn, L. · Bremer, S. · Thriel, C. van · Krause, K.-H. · Hengstler, J.G. · Rahnenführer, J. · Leist, M. · Sachinidis, A.
Keywords: Biology · Alternative testing strategies · Methylmercury · Reproductive toxicity · Transcription factor · Valproic acid · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 Implementation challenges for designing Integrated In Vitro Testing Strategies (ITS) aiming at reducing and replacing animal experimentation
article 2012    
Author: Wever, B.de · Fuchs, H.W. · Gaca, M. · Krul, C.A.M. · Mikulowski, S. · Poth, A. · Roggen, E.L. · Vilà, M.R.
Keywords: Eye irritation · ITS · ITS design · IVTIP · Replacement · Reproductive toxicity · Testing strategies · Validation · Healthy for Life · Healthy Living · Healthy Living Life · RAPID - Risk Analysis for Products in Development · Themalijn
[Abstract]

4 Oral two-generation reproduction toxicity study with NM-200 synthetic amorphous silica in Wistar rats
article 2015    
Author: Wolterbeek, A. · Oosterwijk, T. · Schneider, S. · Landsiedel, R. · Groot, D. de · Ee, R. van · Wouters, M. · Sandt, H. van de
Keywords: Nutrition · Nanomaterials · Synthetic amorphoussilica · NM-200 · Reproductive toxicity · Rat · Food and Nutrition · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

5 Regulatory acceptance and use of the extended one generation reproductive toxicity study within Europe
article 2015    
Author: Schiffelers, M.J.W.A. · Blaauboer, B.J. · Bakker, W.E. · Hendriksen, C.F.M. · Krul, C.
Keywords: Barriers and drivers · EOGRTS · REACH · Regulatory acceptance and use · Reproductive toxicity testing · Animalia · Rattus · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

6 Developmental immunotoxicity of di-n-octyltin dichloride (DOTC) in an extended one-generation reproductive toxicity study
article 2011    
Author: Tonk, E.C.M. · Groot, D.M.G. de · Penninks, A.H. · Waalkens-Berendsen, I.D.H. · Wolterbeek, A.P.M. · Piersma, A.H. · Loveren, H. van
Keywords: Nutrition · Delayed-type hypersensitivity response (DTH) · Developmental immunotoxicity · Extended one-generation reproductive toxicity study (EOGRTS) · Organotin · Triskelion BV Life · TAP - Toxicology and Applied Pharmacology QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

7 The FEMA GRAS assessment of α,β-unsaturated aldehydes and related substances used as flavor ingredients
article 2008    
Author: Adams, T.B. · Gavin, C.L. · Taylor, S.V. · Waddell, W.J. · Cohen, S.M. · Feron, V.J. · Goodman, J. · Rietjens, I.M.C.M. · Marnett, L.J. · Portoghese, P.S. · Smith, R.L.
Keywords: Nutrition · α,β-Unsaturated aldehydes · FEMA GRAS · Flavor ingredients · Genotoxicity · 2 hexenal · aldehyde · flavoring agent · sorbic acid · carcinogenicity · chemical analysis · flavor · genotoxicity · hydrolysis · reproductive toxicity · review · safety · Aldehydes · Animals · Carcinogens · Flavoring Agents · Food Analysis · Humans · Mutagens · Reproduction · Animalia
[Abstract]

8 Two-generation reproduction study of erythritol in rats
article 1996    
Author: Waalkens-Berendsen, D.H. · Smits- Prooije, A.E. van · Wijnands, M.V.M. · Bär, A.
Keywords: erythritol · article · diarrhea · female · fertility · male · nonhuman · priority journal · rat · reproductive toxicity · Animals · Body Weight · Diet · Eating · Erythritol · Female · Fertility · Litter Size · Male · Pregnancy · Rats · Rats, Wistar · Reproduction · Sweetening Agents · Animalia
[Abstract]

9 The ChemScreen project to design a pragmatic alternative approachto predict reproductive toxicity of chemicals
article 2015    
Author: Van der Burg, B. · Wedebye, E.B. · Dietrich, D.R. · Jaworska, J. · Mangelsdorf, I. · Paune, E. · Schwarz, M. · Piersma, A.H. · Kroese, E.D.
Keywords: Toxicology Nutrition · In vitro · In silico · Integrated testing · Read accross · Reproductive toxicity · Endocrine disruptiona · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

10 Two-generation reproductive toxicity study of plant stanol esters in rats
article 1999    
Author: Whittaker, M.H. · Frankos, V.H. · Wolterbeek, A.P.M. · Waalkens-Berendsen, D.H.
Keywords: Nutrition · Fatty acid ester · Animal experiment · Article · Body weight · Body weight disorder · Calorie · Controlled study · Female · Food intake · Infant mortality · Lipid absorption · Litter size · Male · Nonhuman · Plant · Priority journal · Rat · Reproductive toxicity · Sex ratio · Sexual behavior · Animals · Body Weight · Dihydrotestosterone · Female · Male · Phytosterols · Rats · Rats, Wistar · Reproduction · Animalia · Brassica napus var. napus · Rattus norvegicus
[Abstract]

11 Exposure profiles of pesticides among greenhouse workers: Implications for epidemiological studies
article 2007    
Author: Tielemans, E. · Bretveld, R. · Schinkel, J. · Wendel van - Joode, B. de · Kromhout, H. · Gerritsen-Ebben, R. · Roeleveld, N. · Preller, L.
Keywords: Safety · Food and Chemical Risk Analysis · Exposure assessment · Pesticides · Variability · fungicide · herbicide · insecticide · pesticide · article · controlled study · greenhouse · human · human experiment · male · normal human · occupational exposure · occupational hazard · questionnaire · reproductive toxicity · scoring system · semen analysis · worker · workplace · Agriculture · Air Pollutants, Occupational · Algorithms · Environmental Monitoring · Epidemiologic Studies · Hand · Humans · Male · Netherlands · Occupational Exposure · Pesticides · Questionnaires · Skin
[Abstract]

12 Toxicokinetics and metabolism
article 2005    
Author: Coecke, S. · Blaauboer, B.J. · Elaut, G. · Freeman, S. · Freidig, A. · Gensmantel, N. · Hoet, P. · Kapoulas, V.M. · Ladstetter, B. · Langley, G. · Leahy, D. · Mannens, G. · Meneguz, A. · Monshouwer, M. · Nemery, B. · Pelkonen, O. · Pfaller, W. · Prieto, P. · Proctor, N. · Rogiers, V. · Rostami-Hodjegan, A. · Sabbioni, E. · Steiling, W. · Sandt, J.J.M. van de
Keywords: Toxicology · Food and Chemical Risk Analysis · cosmetic · acute toxicity · artificial membrane · bioavailability · biotransformation · carcinogenicity · cell line · cell strain CACO 2 · computer model · concentration response · electric resistance · eye irritation · genotoxicity · human · metabolism · nonhuman · phototoxicity · plasma protein binding · practice guideline · priority journal · reproductive toxicity · review · skin absorption · skin sensitization · species difference · toxicokinetics · validation process · Animals · Biotransformation · Consumer Product Safety · Cosmetics · Drug Administration Routes · European Union · Humans

13 Safety evaluation of synthetic β-carotene
article 1999    
Author: Woutersen, R.A. · Wolterbeek, A.P.M. · Appel, M.J. · Berg, H. van den · Goldbohm, R.A. · Feron, V.J.
Keywords: Toxicology · Absorption · Cancer prevention · Distribution · Lung cancer · Toxicity · beta carotene · cancer risk · carcinogenicity · chronic toxicity · drug absorption · drug distribution · drug safety · drug transport · genotoxicity · human · nonhuman · reproductive toxicity · review · toxicity testing · Absorption · Animals · Antioxidants · beta Carotene · Cell Transformation, Neoplastic · Chemoprevention · Drug Interactions · Humans · Intervention Studies · Lung Neoplasms · Mice · Rats · Rats, Sprague-Dawley · Skin Neoplasms · Smoking · Animalia
[Abstract]

14 Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study
article 2013    
Author: Tonk, E.C.M. · Groot, D.M.G. de · Wolterbeek, A.P.M. · Penninks, A.H. · Waalkens-Berendsen, I.D.H. · Piersma, A.H. · Loveren, H. van
Keywords: Biology · Benchmark dose approach · Developmental immunotoxicity · Ethanol · Extended one-generation reproductive toxicity study · Alcohol · Concanavalin A · Drinking water · Keyhole limpet hemocyanin · Lipopolysaccharide · Nitric oxide · Tumor necrosis factor alpha · Adaptive immunity · Adult animal · Animal experiment · Animal model · blood cell · Cell adhesion · Cell proliferation · Cell stimulation · Cell subpopulation · Chemical parameters · Controlled study · Cytokine production · Developmental parameters · Developmental toxicity · Female · Immune response · Immunization · Immunological parameters · Immunomodulation · Immunotoxicity · Innate immunity · Lactation · Male · Mating · Medical parameters · Perinatal period · Priority journal · Rat · Reproductive toxicity · Spleen cell · Toxicity testing · Wistar rat · Rattus norvegicus · Biomedical Innovation · Healthy Living · Life Triskelion BV · QS - Quality & Safety TARA - Toxicology and Risk Assessment RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences TNO Bedrijven
[Abstract]

15 Genetic and reproductive toxicity of butadiene and isoprene
article 2001    
Author: Anderson, D.
Keywords: Nutrition · Cytogenetic effects · Isoprene · Somatic and germ cells · 1,2 epoxy 3 butene · 1,3 butadiene · butadiene diepoxide · cytochrome P450 · hypoxanthine phosphoribosyltransferase · alkalinity · biological monitoring · carcinogenesis · CHO cell · chromosome aberration · comparative study · concentration response · conference paper · cytogenetics · Drosophila melanogaster · exposure · gene translocation · genotoxicity · lethal mutant · liver metabolism · mutagenicity · nonhuman · reproductive toxicity · Salmonella typhimurium · Testis · Animalia · Drosophila melanogaster · Melanogaster · Salmonella typhimurium · Typhimurium · Cytogenetic effects · Isoprene · Somatic and germ cells · 1,2 epoxy 3 butene · 1,3 butadiene · butadiene diepoxide · cytochrome P450 · hypoxanthine phosphoribosyltransferase · alkalinity · biological monitoring · carcinogenesis · CHO cell · chromosome aberration · comparative study · concentration response · conference paper · cytogenetics · Drosophila melanogaster · exposure · gene translocation · genotoxicity · lethal mutant · liver metabolism · mutagenicity · nonhuman · reproductive toxicity · Salmonella typhimurium · sister chromatid exchange · spermatozoon motility · tissue distribution · Animals · Butadienes · Female · Hemiterpenes · Humans · Male · Mice · Mutagenicity Tests · Mutagens · Occupational Exposure · Ovary · Pentanes · Pregnancy · Rats · Reproduction · Testis · Animalia · Drosophila melanogaster · Melanogaster · Salmonella typhimurium · Typhimurium
[Abstract]

16 REACH, non-testing approaches and the urgent need for a change in mind set
article 2009    
Author: Schaafsma, G. · Kroese, E.D. · Tielemans, E.L.J.P. · Sandt, J.J.M. van de · Leeuwen, C.J. van
Keywords: Chemistry · Food and Chemical Risk Analysis · Intelligent testing strategies · Mind set change · Non-testing · REACH · Uncertainty paradox · chemical agent · acute toxicity · animal testing alternative · article · chronic toxicity · cost · drug screening · environmental exposure · hazard assessment · health care policy · human · human tissue · in vivo study · priority journal · process optimization · public opinion · REACH program · reproductive toxicity · risk assessment · skin toxicity · toxicity testing · uncertainty · Animal Testing Alternatives · Animals · Databases, Factual · Environmental Exposure · Europe · Hazardous Substances · Humans · Registries · Risk Assessment · Toxicity Tests · Animalia
[Abstract]

17 Nonclinical testing of vaccines: Report from a workshop
article 2009    
Author: Laan, J.W. van der · Forster, R. · Ledwith, B. · Gruber, M. · Gould, S. · Segal, L. · Penninks, A.
Keywords: Health · Adjuvants · Developmental and reproductive toxicology · DNA vaccines · Nonclinical evaluation · Safety testing · Therapeutic vaccines · Vaccines · diphtheria pertussis tetanus vaccine · DNA vaccine · immunological adjuvant · immunomodulating agent · live vaccine · Meningococcus vaccine · pertussis vaccine · vaccine · Wart virus vaccine · conference paper · disease model · drug dose regimen · drug efficacy · drug research · drug safety · drug screening · drug tolerability · electroporation · human · immune response · immunogenicity · male fertility · nonhuman · pharmacodynamics · practice guideline · priority journal · reproductive toxicity · tattooing · toxicity testing · toxicology · vaccination · workshop
[Abstract]

18 Locust bean gum safety in neonates and young infants: An integrated review of the toxicological database and clinical evidence
article 2014    
Author: Meunier, L. · Garthoff, J.A. · Schaafsma, A. · Krul, L. · Schrijver, J. · Goudoever, J.B. van · Speijers, G. · Vandenplas, Y.
Keywords: Health · Carob bean gum · Gastro-oesophageal reflux · Infant formula · Infants · Locust bean gum · Regurgitation · Thickener · Food additive · Galactomannan · Locust beam gum · Polysaccharide · Unclassified drug · Acute toxicity · Artificial milk · Carcinogenicity · Chemical structure · Chronic toxicity · Dietary intake · Food composition · Food safety · Genotoxicity · Human · Hypersensitivity · In vitro study · In vivo study · Nonhuman · Nutritional assessment · Priority journal · Reproductive toxicity · Safety · Surface property · Teratogenicity · Thickness · Toxicity testing · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

19 Embryotoxicity and teratogenicity study with α-cyclodextrin in rabbits
article 2004    
Author: Waalkens-Berendsen, D.H. · Smits-Van Prooije, A.E. · Bär, A.
Keywords: Biology · Toxicology and Applied Pharmacology · Cyclodextrin · Dietary Fiber · Lactose · Reproductive toxicity · alpha cyclodextrin · animal experiment · animal model · animal tissue · article · artificial insemination · body weight · chemical teratogenesis · controlled study · corpus luteum · diarrhea · embryotoxicity · female · fetus weight · food intake · gestational age · male · nidation · nonhuman · placenta weight · priority journal · sex ratio · sexual behavior · species comparison · teratogenicity · uterus weight · weight reduction · Abnormalities, Drug-Induced · Administration, Oral · alpha-Cyclodextrins · Animals · Cyclodextrins · Embryonic and Fetal Development · Female · Male · Pregnancy · Prenatal Exposure Delayed Effects · Rabbits · Animalia · Oryctolagus cuniculus
[Abstract]

20 One-generation reproductive toxicity study of DHA-rich oil in rats
article 2007    
Author: Blum, R. · Kiy, T. · Waalkens-Berendsen, I. · Wong, A.W. · Roberts, A.
Keywords: Toxicology · Toxicology and Applied Pharmacology · ω-3 Polyunsaturated fatty acid · DHA · DHA-rich oil · Docosahexaenoic acid · Food ingredient · Reproductive and developmental toxicity · Safety · algal oil · docosahexaenoic acid · lipid · adipose tissue · animal experiment · animal model · animal tissue · article · body weight · controlled study · diet · fat intake · female · fertility · food intake · liver weight · male · mortality · nonhuman · priority journal · rat · reproductive toxicity · spleen weight · toxicity testing · Algae · Animals · Animals, Newborn · Birth Weight · Docosahexaenoic Acids · Dose-Response Relationship, Drug · Eating · Embryonic Development · Female · Fetal Development · Hematopoiesis, Extramedullary · Liver · Male · Oils · Organ Size · Pituitary Gland · Pregnancy · Rats · Rats, Wistar · Reproduction · Spleen · Subcutaneous Fat, Abdominal · Toxicity Tests · Weight Gain · algae · Animalia · Protista · Rattus · Ulkenia sp. · Zea mays
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 22 found. Next | Sort by date