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Showing 1 to 18 of 18 found. | Sort by date

1 GLC-analysis and pharmacokinetics of the four stereoisomers of soman
article 1981    
Author: Benschop, H.P. · Berends, F. · Jong, L.P.A. de
Keywords: Biology · Organophosphorus compound · Soman · Animal · Gas chromatography · Kinetics · Metabolism · Rat · Stereoisomerism · Animal · Chromatography, Gas · Kinetics · Organophosphorus Compounds · Rats · Soman · Stereoisomerism · organophosphorus compound · G agents · Prophylaxis · Therapy · Blood · Skin (anatomy) · GC - Gas chromatography · Reaction kinetics · Stereochemistry · Degradation
[Abstract]

2 L-sorbose but not D-tagatose induces hemolysis of dog erythrocytes in vitro
article 1999    
Author: Bär, A. · Leeman, W.R.
Keywords: Nutrition · Hemoglobin · Sorbose · Tagatose · Animal cell · Controlled study · Dog · Erythrocyte · Glycolysis · Hemolysis · Nonhuman · Priority journal · Stereoisomerism · Animals · Dogs · Glucose · Hemoglobinometry · Hemolysis · Hexoses · Male · Sorbose · Sweetening Agents
[Abstract]

3 Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14
article 2000    
Author: Werf, M.J. van der · Boot, A.M.
Keywords: Nutrition · Carveol · Carvone · Dihydrocarveol · Monoterpene metabolism · Rhodococcus erythropolis · Bacterial enzyme · Carveol · Carvone · Dihydrocarveol · Hexanoic acid derivative · Isomerase · Nicotinamide adenine dinucleotide · Oxepane derivative · Oxidoreductase · Oxygenase · Unclassified drug · Bacterial metabolism · Controlled study · Enzyme activity · Nonhuman · Priority journal · Rhodococcus · Stereoisomerism · 2,6-Dichloroindophenol · Alcohol Oxidoreductases · Anaerobiosis · Biodegradation, Environmental · Cyclohexenes · Hydrolases · Isomerases · Monoterpenes · Rhodococcus · Stereoisomerism · Terpenes · Actinobacteria (class) · Bacteria (microorganisms) · Erythropolis · Rhodococcus erythropolis · Uncultured actinomycete
[Abstract]

4 Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs
article 1998    
Author: Benschop, H.P. · Trap, H.C. · Spruit, H.E.T. · Wiel, H.J. van der · Langenberg, J.P. · Jong, L.P.A. de
Keywords: Perception · Atropine · Carboxylesterase · Cholinesterase · Animal cell · Blood level · Enzyme inhibition · Exposure · Guinea pig · Inhalation · Male · Neurotoxicity · Nonhuman · Stereoisomerism · Toxicokinetics · Administration, Inhalation · Animals · Carboxylic ester hydrolases · Chemical warfare agents · Dose-response relationship · Drugs · Erythrocytes · Soman · Stereoisomerism · Time factors · Atropine, 51-55-8 · Carboxylesterase, EC 3.1.1.1 · Carboxylic ester hydrolases, EC 3.1.1.- · Soman, 96-64-0
[Abstract]

5 The bispyridinium-dioxime HLö-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman
article 1989    
Author: Jong, L.P.A.de · Verhagen, M.A.A. · Langenberg, J.P. · Hagedorn, I. · Löffler, M.
Keywords: Biology · Bis(pyridinium oxime) derivative · Enzyme inhibitor · Organophosphorus compound · Radioisotope · Enzyme reactivation · Fish · Human · Nonbiological model · Nonhuman · Normal human · Rat · Stereoisomerism · Acetylcholinesterase 9000-81-1 · Animal · Cholinesterase Reactivators · Eels · Human · In Vitro · Organophosphorus Compounds · Oximes · Phosphoric Acid Esters · Pyridines · Pyridinium Compounds · Stereoisomerism · Structure-Activity Relationship · Organophosphorus compounds · Oximes · Phosphoric acid esters · Pyridines · Pyridinium compounds · Soman, 96-64-0 · Tabun, 77-81-6
[Abstract]

6 Antimalarial activity of the bisquinoline trans-N1,N2-bis (7- chloroquinolin-4-yl)cyclohexane-1,2-diamine: Comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737
article 1997    
Author: Ridley, R.G. · Matile, H. · Jaquet, C. · Dorn, A. · Hofheinz, W. · Leupin, W. · Masciadri, R. · Theil, F.P. · Richter, W.F. · Girometta, M.A. · Guenzi, A. · Urwyler, H. · Gocke, E. · Potthast, J.M. · Csato, M. · Thomas, A. · Peters, W.
Keywords: Health · Plasmodium berghei · Subcutaneous drug administration · Animals · Antimalarials · Chloroquine · Cyclohexylamines · Dogs · Drug Resistance · Half-Life · Heme · Malaria, Vivax · Male · Mice · Plasmodium falciparum · Plasmodium vivax · Quinolines · Rats · Rats, Wistar · Stereoisomerism
[Abstract]

7 Synthesis of reduced collagen crosslinks
article 1999    
Author: Nieuwendijk, A.M.C.H. van den · Benningshof, J.C.J. · Wegmann, V. · Bank, R.A. · Koppele, J.M. te · Brussee, J. · Gen, A. van der
Keywords: Biology · Collagen · Alkylation · Chemical reaction · Chemical structure · Cross linking · Diastereoisomer · Hydrogenation · Protein synthesis · Reaction analysis · Alkylation · Collagen · Cross-Linking Reagents · Dipeptides · Humans · Magnetic Resonance Spectroscopy · Mass Spectrometry · Oxidation-Reduction · Stereoisomerism
[Abstract]

8 Transport of glutathione A conjugates by the multifrug resistance protein 1
article 1997    
Author: Evers, R. · Cnubben, N.H.P. · Wijnholds, J. · Deemter, L. van · Bladeren, P.J. van · Borst, P.
Keywords: GS-X pump · Multidrug resistance · Adenosine Triphosphate · Animals · Biological Transport · Cell Line · Cell Polarity · Cyclic AMP · Dogs · Erythrocytes · Ethacrynic Acid · Glutathione · Humans · Kidney · Methotrexate · Mice · Mice, Mutant Strains · Microsomes · P-Glycoprotein · Prostaglandins A, Synthetic · Stereoisomerism
[PDF] [Abstract]

9 Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers
article 1999    
Author: Ordentlich, A. · Barak, D. · Kronman, C. · Benschop, H.P. · Jong, L.P.A. de · Ariel, N. · Barak, R. · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Cholinesterase reactivator · Soman · Binding site · Chirality · Dealkylation · Enzyme activity · Enzyme analysis · Enzyme binding · Enzyme specificity · Enzyme structure · Enzyme substrate · Human cell · Protein expression · Stereochemistry · Stereoisomerism · Alkylation · Amino acid substitution · Binding sites · Cell line · Cholinesterase inhibitors · Humans · Hydrogen Bonding · Kidney · Macromolecular substances · Models, Molecular · Mutagenesis, Site-Directed · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Alanine, 56-41-7 · Phenylalanine, 63-91-2 · Phosphorus, 7723-14-0 · Soman, 96-64-0
[Abstract]

10 Xanthobacter sp. C20 contains a novel bioconversion pathway for limonene
article 2000    
Author: Werf, M.J. van der · Keijzer, P.M. · Schaft, P.H. van der
Keywords: Biology · Cytochrome P-450 · Limonene-8,9-epoxide · Oxidation · Stereospecificity · Terpene bioconversion · Bacteria · Biopolymers · Carbon · Cell culture · Enzyme inhibition · Reaction kinetics · Cyclohexane · Cytochrome · Limonene · Bioconversion · cytochrome P450 · limonene · limonene 8,9 epoxide · terpene · unclassified drug · article · bacterium identification · bacterium isolation · biotransformation · enantiomer · nonhuman · nuclear magnetic resonance spectroscopy · priority journal · reaction analysis · river · sediment · stereoisomerism · Xanthobacter · Cyclohexanes · Cyclohexenes · Cytochrome P-450 Enzyme System · Food Microbiology · Ginger · Industrial Microbiology · Menthol · Monoterpenes · Oxidation-Reduction · Plants, Medicinal · Stereoisomerism · Terpenes · Xanthobacter · Xanthobacter sp.
[PDF] [Abstract]

11 Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs
article 2000    
Author: Spruit, W.E.T. · Langenberg, J.P. · Trap, H.C. · Wiel, H.J. van der · Helmich, R.B. · Helden, H.P.M. van · Benschop, H.P.
Keywords: Acetylcholinesterase inhibition · Guinea pig · Intravenous bolus · Nose-only exposure · Respiratory parameters · Stereoisomers · Toxicokinetics · Animal experiment · Animal model · Binding site · Chemical warfare · Controlled study · Drug absorption · Drug elimination · Enzyme inhibition · Gas chromatography · Guinea pig · Nonhuman · Nose mucosa · Stereoisomerism · Toxicokinetics · Acetylcholinesterase · Administration, Inhalation · Animals · Area Under Curve · Atropine · Chemical Warfare Agents · Guinea Pigs · Injections, Intravenous · Male · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Sarin, 107-44-8
[Abstract]

12 Stereoselectivity at the B2-adrenoceptor on macrophages is a major determinant of the anti-inflammatory effects of B2-agonists
article 2000    
Author: Izeboud, C.A. · Vermeulen, R.M. · Zwart, A. · Vos, H.P. · Miert, A.S.J.P.A.M. van · Witkamp, R.F.
Keywords: β-Adrenoceptor · Stereoselectivity · 3 isopropylamino 1 (7 methyl 4 indanyloxy) 2 butanol · 4 (3 tert butylamino 2 hydroxypropoxy) 2 benzimidazolone · Aprotinin · Benzylsulfonyl fluoride · Beta 2 adrenergic receptor · Beta 2 adrenergic receptor blocking agent · Beta 2 adrenergic receptor stimulating agent · Carmoterol · cyclic AMP · Interleukin 10 · Lipopolysaccharide · Tumor necrosis factor alpha · Xamoterol · Beta adrenergic receptor stimulating agent · Nonsteroid antiinflammatory agent · Antiinflammatory activity · Stereochemistry · Cell culture · Cell membrane · Drug antagonism · Metabolism · Radioassay · Signal transduction · Stereoisomerism · Adrenergic beta-Agonists · Anti-Inflammatory Agents, Non-Steroidal · Cell Membrane · Cells, Cultured · Cyclic AMP · Humans · Interleukin-10 · Lipopolysaccharides · Macrophages · Radioligand Assay · Receptors, Adrenergic, beta-2 · Signal Transduction · Stereoisomerism · Tumor Necrosis Factor-alpha
[Abstract]

13 GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid
article 1998    
Author: Iersel, M.L.P.S. van · Lipzig, M.M.H. van · Rietjens, I.M.C.M. · Vervoort, J. · Bladeren, P.J. van
Keywords: EA, ethacrynic acid · Ethacrynic acid · Glutathione S-transferase · Stereoselectivity · Etacrynic acid · Glutathione · Glutathione transferase · Multidrug resistance protein · Chemical reaction · Conjugate · Controlled study · Diastereoisomer · Drug conjugation · Enzyme mechanism · Glutathione metabolism · Human cell · Melanoma cell · Nuclear magnetic resonance spectroscopy · Stereochemistry · Amino Acid Substitution · Ethacrynic Acid · Glutathione · Glutathione Transferase · Humans · Isoenzymes · Melanoma · Point Mutation · Stereoisomerism · Substrate Specificity · Tumor Cells, Cultured
[PDF] [Abstract]

14 The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: A longitudinal study
article 1994    
Author: Groen, K. · Breimer, D.D. · Jansen, E.J. · Bezooijen, C.F.A. van
Keywords: Health · 3 hydroxymethylphenazone · 4 hydroxyphenazone · Norphenazone · Phenazone · Adolescent · Aged · Body weight · Controlled study · Drug blood level · Drug clearance · Drug metabolism · Drug urine level · Enantiomer · Enzyme activity · Enzyme specificity · High performance liquid chromatography · Nonhuman · Survival rate · Aging · Animal · Antipyrine · Cytochrome P-450 Enzyme System · Enzyme Induction · Hexobarbital · Longitudinal Studies · Male · Metabolic Clearance Rate · Phenobarbital · Rats · Rats, Inbred BN · Stereoisomerism
[Abstract]

15 Intake of fatty acids in Western Europe with emphasis on trans fatty acids: The TRANSFAIR study
article 1999    
Author: Hulshof, K.F.A.M · Erp van - Baart, M.A. · Anttolainen, M. · Becker, W. · Church, S.M. · Couet, C. · Hermann-Kunz, E. · Kesteloot, H. · Leth, T. · Martins, I. · Moreiras, O. · Moschandreas, J. · Pizzoferrato, L. · Rimestad, A.H. · Thorgeirsdottir, H. · Amelsvoort, J.M.M. van · Aro, A. · Kafatos, A.G. · Lanzmann-Petithory, D. · Poppel, G. van
Keywords: Diet · Total fat · Trans and other fatty acids · Western European countries · fatty acid · monounsaturated fatty acid · polyunsaturated fatty acid · saturated fatty acid · adolescent · adult · aged · article · Belgium · caloric intake · child · fat intake · female · Finland · food analysis · food intake · France · Germany · Greece · human · human experiment · Iceland · infant · Italy · male · Netherlands · normal human · Norway · Portugal · Spain · Sweden · trans isomer · United Kingdom · Western Europe · Adult · Dietary Fats · Energy Intake · Europe · Fatty Acids · Female · Humans · Male · Stereoisomerism
[Abstract]

16 Purification and characterization of a Baeyer-Villiger mono-oxygenase from Rhodococcus erythropolis DCL14 involved in three different monocyclic monoterpene degradation pathways
article 2000    
Author: Werf, M.J. van der
Keywords: Nutrition · Carvone · Flavoprotein · Limonene · Menthol · Regioselectivity · Bacterial enzyme · Carvone · Cyclohexanone derivative · Heptanoic acid derivative · Limonene · Menthone · Terpene · Unspecific monooxygenase · Amino acid sequence · Amino terminal sequence · Biodegradation · Enzyme activity · Enzyme analysis · Enzyme purification · Enzyme specificity · Enzyme structure · Molecular weight · Nonhuman · Priority journal · Rhodococcus · Sequence homology · Stereochemistry · Aldehydes · Amino Acid Sequence · Biodegradation, Environmental · Catalysis · Cyclohexanones · Enzyme Induction · Enzyme Inhibitors · Flavin-Adenine Dinucleotide · Hydrogen-Ion Concentration · Menthol · Metals · Molecular Sequence Data · Molecular Weight · Oxygenases · Rhodococcus · Sequence Alignment · Sequence Homology, Amino Acid · Spectrum Analysis · Stereoisomerism · Substrate Specificity · Temperature · Terpenes
[Abstract]

17 Toxicokinetics of the nerve agent (±)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration
article 2003    
Author: Schans, M.J. van der · Lander, B.J. · Wiel, H. van der · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Chiral HPLC · Hairless guinea pigs · Intravenous · Marmosets · Percutaneous · Persistence · Stereospecificity · Toxicokinetics · Treatment · Carbamic acid · Oxime · Volatile agent · Anesthesia · Animal experiment · Animal model · Bioavailability · Blood level · Dose response · Enantiomer · Guinea pig · Intoxication · Marmoset · Nonhuman · Primate · Toxicokinetics · Administration, Topical · Anesthesia · Animals · Atropine · Callithrix · Chemical Warfare Agents · Chromatography, Gas · Chromatography, High Pressure Liquid · Electrochemistry · Injections, Intravenous · Kinetics · Lethal Dose 50 · Male · Muscarinic Antagonists · Organothiophosphorus Compounds · Stereoisomerism · Animalia · Cavia · Cavia porcellus · Primates · Sus scrofa · Acetylcholinesterase, 9000-81-1 · Carbamic acid, 463-77-4 · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester, 50782-69-9 · Sarin, 107-44-8 · Soman, 96-64-0 · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Muscarinic antagonists · Organothiophosphorus compounds · VX, 50782-69-9
[Abstract]

18 A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes for soman in multiple species
article 2006    
Author: Sweeney, R.E. · Langenberg, J.P. · Maxwell, D.M.
Keywords: Toxicology · Acetylcholinesterase · Carboxylesterase · Enzyme · Soman · Adipose tissue · Allometry · Animal experiment · Animal tissue · Arterial blood · Blood flow velocity · BLood level · Body weight · Breathing rate · Computer language · Computer simulation · Controlled study · Exposure · Guinea pig · In vitro study · Kidney perfusion · LD 50 · Liver perfusion · Lung perfusion · Male · Marmoset · Metabolism · Nonhuman · Partition coefficient · Priority journal · Provocation test · Rat · Regression analysis · Sensitivity analysis · Stereoisomerism · Tidal volume · Tissue level · Toxicokinetics · Venous blood · Administration, Inhalation · Animals · Callithrix · Chemical Warfare Agents · Cholinesterase Inhibitors · Computer Simulation · Guinea Pigs · Injections, Intravenous · Injections, Subcutaneous · Male · Models, Biological · Rats · Rats, Wistar · Animalia · Cavia porcellus · Marmosets · Acetylcholinesterase, 9000-81-1 · Carboxylesterase, 59536-71-9, 83380-83-0, 9016-18-6, 9028-01-7 · Soman, 96-64-0 · Chemical warfare agents · Cholinesterase inhibitors
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 18 of 18 found. | Sort by date