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1 Using chemical categories to fill data gaps in hazard assessment.
article 2009    
Author: Leeuwen, K. van · Schultz, T.W. · Henry, T. · Diderich, B. · Veith, G.D.
Keywords: Chemistry · Food and Chemical Risk Analysis · dangerous goods · methodology · quantitative structure activity relation · review · safety · Hazardous Substances · Quantitative Structure-Activity Relationship · Safety Management
[Abstract]

2 Read-across approaches - Misconceptions, promises and challenges ahead
article 2014    
Author: Patlewicz, G. · Ball, N. · Becker, R.A. · Booth, E.D. · Cronin, M.T.D. · Kroese, D. · Steup, D. · Ravenzwaay, B. van · Hartung, T.
Keywords: Biology · (Q)SARs · Adverse outcome pathways (AOP) · Analogue approach · Category approach · Scientific confidence framework · Chemical compound · Awareness · Data processing · Ecotoxicology · Human · Information processing · Nonhuman · Quantitative structure activity relation · Read across approach · Toxicity · Toxicology · Uncertainty · Validity · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

3 Chemical respiratory allergy: Opportunities for hazard identification and characterisation
article 2007    
Author: Kimber, I. · Agius, R. · Basketter, D.A. · Corsini, E. · Cullinan, P. · Dearman, R.J. · Gimenez-Arnau, E. · Greenwell, L. · Hartung, T. · Kuper, F. · Maestrelli, P. · Roggen, E. · Rovida, C. · Casati, S.
Keywords: Toxicology and Applied Pharmacology · cell assay · clinical feature · conference paper · nonhuman · occupational asthma · occupational exposure · pathogenesis · priority journal · quantitative structure activity relation · respiratory tract allergy · risk assessment · risk factor · sensitization · skin test · Animal Testing Alternatives · Animals · Hazardous Substances · Humans · Respiratory Hypersensitivity · Skin Tests · Structure-Activity Relationship

4 Genotoxicity and mutagenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Toxicology · Physiological sciences · Animal testing replacement · Animal testing alternatives · Chromosome aberration · Comet assay · DNA damage · DNA synthesis · Gene mutation · Genotoxicity · In vitro study · In vivo study · Micronucleus test · Mitotic recombination · Mutagenicity · Sister chromatid exchange · Toxicity testing · Toxicogenetics · Toxicokinetics · Toxicological parameters · Carcinogen testing · Cell culture · Chemistry · Legal aspects · Structure activity relation · Animalia · Consumer product safety · Cosmetics · European Union · Structure-Activity Relationship

5 Improving the applicability of (Q)SARs for percutaneous penetration in regulatory risk assessment.
article 2008    
Author: Bouwman, T. · Cronin, M.T. · Bessems, J.G. · Sandt, J.J. van de
Keywords: Health · xenobiotic agent · article · biological model · chemistry · drug effect · European Union · government regulation · human · legal aspect · physiology · prediction and forecasting · quantitative structure activity relation · risk assessment · skin absorption · European Union · Government Regulation · Humans · Models, Biological · Predictive Value of Tests · Quantitative Structure-Activity Relationship · Risk Assessment · Skin Absorption · Xenobiotics
[Abstract]

6 Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development
article 2006    
Author: Greef, J. van der · Adourian, A. · Muntendam, P. · McBurney, R.N.
Keywords: Biology · Analytical research · biological marker · drug metabolite · new drug · bioinformatics · body fluid · data base · decision making · drug determination · drug efficacy · drug marketing · drug research · drug safety · human · medical technology · metabolomics · multiple sclerosis · non insulin dependent diabetes mellitus · nonhuman · osteoarthritis · phenotype · postmarketing surveillance · proteomics · review · serology · structure activity relation
[Abstract]

7 Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships
article 2005    
Author: Netzeva, T.I. · Worth, A.P. · Aldenberg, T. · Benigni, R. · Cronin, M.T.D. · Gramatica, P. · Jaworska, J.S. · Kahn, S. · Klopman, G. · Marchant, C.A. · Myatt, G. · Nikolova-Jeliazkova, N. · Patlewicz, G.Y. · Perkins, R. · Roberts, D.W. · Schultz, T.W. · Stanton, D.T. · Sandt, J.J.M. van de · Tong, W. · Veith, G. · Yang, C.
Keywords: Biology · Food and Chemical Risk Analysis · chemical environment · chemical industry · conference paper · decision theory · geometry · mathematical analysis · priority journal · probability · quantitative structure activity relation · skin sensitization · statistical analysis · water contamination · Animal Testing Alternatives · Animals · Education · European Union · Health Planning Guidelines · Quantitative Structure-Activity Relationship · Reproducibility of Results · Toxicity Tests

8 The effect of ACTH analogues on motor behavior and visual evoked responses in rats
article 1976    
Author: Wolthuis, O.L. · Wied, D. de
Keywords: Biology · Amphetamine · Corticotropin · Corticotropin derivative · Gallamine triethiodide · Alertness · Brain cortex · Brain depth electrode · Brain depth recording · Electroretinography · Evoked visual response · Motor activity · Rat · Structure activity relation · Subcutaneous drug administration · theoretical study · Animal · Corticotropin · Electroretinography · Evoked Potentials · Male · Motor Activity · Photic Stimulation · Rats · Time Factors
[Abstract]

9 Anticoagulant and calcium-binding properties of high molecular weight derivatives of human fibrinogen (plasmin fragments Y)
article 1982    
Author: Nieuwenhuizen, W. · Voskuilen, M. · Hermans, J.
Keywords: Biology · alanine · anticoagulant agent · calcium · fibrinogen · fructose bisphosphate · plasmin · tyrosine · blood and hemopoietic system · drug binding · drug mechanism · fragmentation · human · metal binding · pharmacology · structure activity relation · Binding Sites · Blood Coagulation · Calcium · Fibrin Fibrinogen Degradation Products · Fibrinogen · Human · Kinetics · Plasmin · Protein Binding · Support, Non-U.S. Gov't
[Abstract]

10 Platinum compounds with anti-tumour activity
article 1980    
Author: Plooy, A.C.M. · Lohman, P.H.M.
Keywords: Biology · Antineoplastic agent · Cisplatin · Platinum derivative · Radioisotope · Animal experiment · Cytotoxicity · DNA damage · DNA strand breakage · DNA synthesis · Drug toxicity · Endocrine system · Female genital system · Heredity · In vitro study · Intoxication · Mutagenesis · Mutagenicity · Ovary cell · Structure activity relation · Thymidine h 3 · Alkalies · Animal · Antineoplastic Agents · DNA · DNA Replication · Hamsters · In Vitro · Platinum · Structure-Activity Relationship · Support, Non-U.S. Gov't
[Abstract]

11 Toxicology of chemical mixtures: International perspective
article 1998    
Author: Feron, V.J. · Cassee, F.R. · Groten, J.P.
Keywords: Nutrition · Data analysis · Europe · Japan · Mixtures · Research programs · Risk assessment · Strategies · Study designs · Aldehyde · Heterocyclic amine · Mycotoxin · Pesticide · Petroleum derivative · Solvent · Toxic substance · Volatile organic compound · Airborne particle · Conference paper · Environmental exposure · Europe · Exhaust gas · Food contamination · Foundry · Fume · Health hazard · Human · Indoor air pollution · Japan · priority journal · quantitative structure activity relation · risk assessment · Animals · Drug Interactions · Humans · Toxicology · World Health · Xenobiotics
[Abstract]

12 A rule for designing safer nanomaterials: do not interfere with the cellular redox equilibrium
article 2015    
Author: Burello, E. · Worth, A.P.
Keywords: Nutrition · Biocompatibility · Computational nanotoxicology · Mechanistic toxicology · Risk assessment · Safe by design · Antioxidant · Cytochrome c · Nanomaterial · Reactive oxygen metabolite · Absorption · Biosafety · Electron transport · Hazard assessment · Leaching · Letter · Oxidation reduction potential · Oxidation reduction state · Oxidative stress · Solubility · Structure activity relation · Surface property · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences

13 Computer-modeling-based QSARs for analyzing experimental data on biotransformation and toxicity
article 2001    
Author: Soffers, A.E.M.F. · Boersma, M.G. · Vaes, W.H.J. · Vervoort, J. · Tyrakowska, B. · Hermens, J.L.M. · Rietjens, I.M.C.M.
Keywords: Biotransformation · Molecular orbital descriptors · Quantitative structure-activity relationships (QSARs) · Quantum mechanical computer calculations · Toxicity · Biotransformation · Chemical reaction · Chemical structure · Computer model · Conference paper · Experiment · Information processing · Quantitative structure activity relation · Toxicity · Animal Testing Alternatives · Animals · Biotransformation · Computer Simulation · Hazardous Substances · Humans · Models, Molecular · Molecular Structure · Quantitative Structure-Activity Relationship · Toxicology
[Abstract]

14 Development of a QSAR for worst case estimates of acute toxicity of chemically reactive compounds
article 2007    
Author: Freidig, A.P. · Dekkers, S. · Verwei, M. · Zvinavashe, E. · Bessems, J.G.M. · Sandt, J.J.M. van de
Keywords: Biology · Analytical research · Biomedical research · Acute rodent toxicity · In vitro-in vivo correlation · QSAR · chemical compound · acute toxicity · article · clinical research · hazard assessment · in vitro study · in vivo study · LD 50 · mouse · nonhuman · prediction · priority journal · quantitative structure activity relation · rat · reference database · validation study · Algorithms · Animals · Data Interpretation, Statistical · Endpoint Determination · European Union · Forecasting · Hazardous Substances · Humans · Legislation · Lethal Dose 50 · Quantitative Structure-Activity Relationship · Reproducibility of Results · Animalia · Rattus · Rodentia
[Abstract]

15 Lactic acid bacteria as antigen delivery vehicles for oral immunization purposes
article 1998    
Author: Pouwels, P.H. · Leer, R.J. · Shaw, M. · Heijne Den Bak-Glashouwer, M.J. · Tielen, F.D. · Smit, E. · Martinez, B. · Jore, J. · Conway, P.L.
Keywords: Nutrition · Adherence · Expression vector · Lactobacillus · Surface protein · Vaccine · Antigen · Bacterial protein · Membrane protein · Antigen presentation · Bacterial colonization · Bacterium adherence · Developing country · Drug delivery system · Epithelium cell · Expression vector · Immunization · Immunogenicity · Lactic acid bacterium · Lactobacillus · Protein structure · Review · Structure activity relation · Administration, Oral · Animals · Antigens · Bacterial Adhesion · Colony Count, Microbial · Drug Delivery Systems · Gene Expression Regulation, Bacterial · Genetic Engineering · Humans · Intestinal Mucosa · Lactobacillus · Lactococcus · Mice · Vaccines · Bacteria (microorganisms) · Lactobacillus · Posibacteria
[Abstract]

16 Cloning and characterization of the NADPH cytochrome P450 oxidoreductase gene from the filamentous fungus Aspergillus niger
article 1995    
Author: Brink, J.M. van den · Zeijl, C.M.J. van · Brons, J.F. · Hondel, C.A.M.J.J. van den · Gorcom, R.F.M. van
Keywords: Nutrition · Benzoic acid derivative · Reduced nicotinamide adenine dinucleotide phosphate ferrihemoprotein reductase · Amino acid sequence · Aspergillus niger · Gene isolation · Gene sequence · Genetic analysis · Hybridization · Molecular cloning · Nonhuman · Nucleotide sequence · Polymerase chain reaction · Priority journal · Sequence analysis · Structure activity relation · Amidohydrolases · Amino Acid Sequence · Aspergillus niger · Base Sequence · Benzoates · Benzoic Acid · Cloning, Molecular · Conserved Sequence · Enzyme Induction · Gene Dosage · Gene Expression Regulation, Fungal · Genes, Structural, Fungal · Molecular Sequence Data · NADPH-Ferrihemoprotein Reductase · Polymerase Chain Reaction · Restriction Mapping · Sequence Alignment · Sequence Analysis, DNA · Transformation, Genetic
[Abstract]

17 The ecotoxicity and the biodegradability of lactic acid, alkyl lactate esters and lactate salts
article 1998    
Author: Bowmer, C.T. · Hooftman, R.N. · Hanstveit, A.O. · Venderbosch, P.W.M. · Hoeven, N. van der
Keywords: Nutrition · Alkyl group · Cation · Environmental chemical · Ester · Inorganic salt · Lactic acid · Lactic acid derivative · Lactic acid ethyl ester · Metal derivative · Metal ion · Methyl group · Narcotic agent · Propane · Alga · Biodegradation · Controlled study · Crustacea · Daphnia · Ecotoxicity · Fish · Nonhuman · Standard · Structure activity relation · Toxicity testing · Algae, Green · Animals · Biodegradation, Environmental · Daphnia · Ecology · Ecosystem · Esters · Lactates · Lactic Acid · Structure-Activity Relationship · Zebrafish · algae · Crustacea · Danio rerio · Daphnia · Daphnia magna · Pimephales promelas · Selenastrum capricornutum
[Abstract]

18 Butyrate stimulates the secretion of apolipoprotein (apo) A-I and apo B100 by the human hepatoma cell line Hep G2. Induction of apo A-I mRNA with no change of apo B100 mRNA
article 1991    
Author: Kaptein, A. · Roodenburg, L. · Princen, H.M.G.
Keywords: Biology · apolipoprotein b100 · messenger rna · protein · association · cell line · degradation · dose time effect relation · hepatoma cell · human · human cell · lipoprotein secretion · priority journal · protein synthesis · structure activity relation · Albumins · Apolipoprotein A-I · Apolipoproteins A · Apolipoproteins B · Butyric Acids · Carcinoma, Hepatocellular · Electrophoresis, Polyacrylamide Gel · Enzyme-Linked Immunosorbent Assay · Fibrinogen · Human · Liver Neoplasms · Nucleic Acid Hybridization · RNA, Messenger · Support, Non-U.S. Gov't · Tumor Cells, Cultured
[Abstract]

19 Safety evaluation of natural flavour complexes
article 2004    
Author: Smith, R.L. · Adams, T.B. · Cohen, S.M. · Doull, J. · Feron, V.J. · Goodman, J.I. · Hall, R.L. · Marnett, L.J. · Portoghese, P.S. · Waddell, W.J. · Wagner, B.M.
Keywords: Toxicology Chemistry · Food and Chemical Risk Analysis · Mixtures · Natural flavour complexes · Safety evaluation · acetic acid · aliphatic compound · citral · flavoring agent · geraniol · hydrocarbon · limonene · linalool · myrcene · oil · sabinene · terpene derivative · terpin hydrate · biosafety · botany · cardamom · chemical composition · chemical modification · complex formation · conference paper · correlation analysis · data analysis · diet · experience · extract · food intake · food poisoning · intermethod comparison · phase separation · priority journal · purification · structure activity relation · structure analysis · system analysis · technique · toxicity · toxicity testing · toxicology · Animals · Biological Factors · Complex Mixtures · Elettaria · Flavoring Agents · Humans · Plant Oils
[Abstract]

20 Mutational analysis of pea lectin: Substitution of Asn125 for Asp in the monosaccharide-binding site eliminates mannose/glucose-binding activity
article 1992    
Author: Eijsden, R.R. van · Hoedemaeker, F.J. · Díaz, C.L. · Lugtenberg, B.J.J. · Sylvia Pater, B. de · Kijne, J.W.
Keywords: mutagenesis · pea lectin · sugar binding · mannose · oligodeoxyribonucleotide · pea lectin · phytohemagglutinin · amino acid sequence · binding site · chemistry · comparative study · Escherichia coli · genetics · legume · medicinal plant · metabolism · molecular genetics · nucleotide sequence · site directed mutagenesis · structure activity relation · Amino Acid Sequence · Asparagine · Aspartic Acid · Base Sequence · Binding Sites · Calcium · Comparative Study · DNA Mutational Analysis · Escherichia coli · Fabaceae · Glucose · Lectins · Manganese · Mannose · Molecular Sequence Data · Mutagenesis, Site-Directed · Oligodeoxyribonucleotides · Phytohemagglutinins · Plants, Medicinal · Sequence Alignment · Structure-Activity Relationship
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 34 found. Next | Sort by date