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Showing 1 to 17 of 17 found. | Sort by date

1 Thymic factors and T cell maturation in vitro : A comparison of the effects of thymic epithelial cultures with thymic extracts and thymus dependent serum factors
article 1979    
Author: Kruisbeek, A.M.
Keywords: Animal · Antigens · Cell Differentiation · Cells, Cultured · Comparative Study · Concanavalin A · Cortisone · Epithelium · Human · Lymphocyte Culture Test, Mixed · Mice · Mice, Nude · Phytohemagglutinins · T-Lymphocytes · Thymic Factor, Circulating · Thymus Extracts · Thymus Gland · Thymus Hormones
[Abstract]

2 The SCID-hu mouse as a tool in immunotoxicological risk assessment: Effects of 2-acetyl-4(5)-tetrahydroxybutyl-imidazole (THI) and di-n-butyltin dichloride (DBTC) on the human thymus in SCID-hu mice
article 1995    
Author: Heer, C. de · Schuurman, H.J. · Houben, G.F. · Pieters, R.H.H. · Penninks, A.H. · Loveren, H. van
Keywords: Nutrition · Caramel colour III · Immunotoxicology · Organotins · Risk assessment · SCID-hu · Thymus · 2 acetyl 4 (1,2,3,4 tetrahydroxybutyl)imidazole · Dibutyltin dichloride · Food additive · Imidazole derivative · Animal experiment · Animal model · Animal tissue · Controlled study · Female · Histopathology · Immunotoxicity · Mouse · Nonhuman · Priority journal · Risk assessment · Thymus · Ammonia · Animal · Female · Food Coloring Agents · Human · Imidazoles · Immunosuppressive Agents · Mice · Mice, SCID · Organotin Compounds · Risk Assessment · Specific Pathogen-Free Organisms · Support, Non-U.S. Gov't · Teratogens · Thymus Gland · Animalia · Rodentia
[Abstract]

3 Potentially increased sensitivity of pregnant and lactating female rats to immunotoxic agents
article 2012    
Author: Menke, A. · Wolterbeek, A. · Snel, C. · Bruijntjes, J. · Groot, D.D. · Oostrum, L.V. · Waalkens, I. · Kuper, C.F.
Keywords: Biology · DOTC · immunotoxicity · lactation · pregnancy · sensitive periods · thymus · Healthy for Life · Healthy Living · Life Triskelion · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences TNO Bedrijven
[Abstract]

4 Lymphoid Tissue and Pathological Influences of Toxicants
bookPart 2014    
Author: Schaudien, D. · Harleman, H. · Bouallala, F. · Kuper, C. F.
Keywords: Toxicology · BALT · Bone marrow · Enhanced histopathology · Follicles · Germinal centers · Immune depletion · Immune stimulation · Lymph nodes · Lymphatics · MALT · NALT · Peyer's patches · Spleen · Tertiary lymphoid tissues · Thymus
[Abstract]

5 Thymus dependent immune competence; effects of ageing, tumour bearing and thymic humoral function
dissertation 1978    
Author: Kruisbeek, A.M.
Keywords: Biology · Bone marrow cells · Carbon 14 · ERDA/560122 · Foreign technology · Immunity · Irradiation · Labelled compounds · Life span · Lymphocytes · Macrophages · Mice · Neoplasms · Radiosensitivity · Rats · Spleen cells · Thymidine · Thymocytes · Thymus · Uptake
[PDF]

6 Histopathologic approaches to detect changes indicative of immunotoxicity
article 2000    
Author: Kuper, C.F. · Harleman, J.H. · Richter-Reichelm, H.B. · Vos, J.G.
Keywords: Immunomodulation · Immunosuppression · Lymph node · Lymphoid organs · Morphology · Mucosa-associated lymphoid tissue (MALT) · Spleen · Thymus · Animal tissue · Cell structure · Histopathology · Immunomodulation · Immunotoxicity · Lymph node · Lymphoid organ · Lymphoid tissue · Nonhuman · Priority journal · Review · Spleen · Thymus · Animals · Female · Immune System · Immunosuppressive Agents · Immunotoxins · Lymphoid Tissue · Male · Rats · Animalia · Rodentia
[Abstract]

7 Age-related changes in immune reactivity: The influence of intrinsic defects and of a changed composition of the CD4+ T cell compartment
article 1992    
Author: Nijhuis, E.W.P. · Nagelkerken, L.
Keywords: Biology · CD4+ T cell subsets · CD45 isoforms · Interleukin-4 · Cd4 antigen · Cd45 antigen · Immunoreactivity · Immunoregulation · Memory cell · T lymphocyte · T lymphocyte activation · T lymphocyte subpopulation · Thymus · Aging · Animal · Antigens, CD45 · CD4-Positive T-Lymphocytes · Human · Immunocompetence · Immunologic Memory · Interleukin-2 · Leukocyte Count · Mice · Thymus Gland
[Abstract]

8 Most probable origin of coeliac disease is low immune globulin A in the intestine caused by malfunction of Peyer's patches
article 2006    
Author: Mulder, S.J. · Mulder-Bos, G.C.
Keywords: Nutrition · gluten · immunoglobulin A · article · bone marrow · celiac disease · disease course · disease predisposition · human · immunocompetent cell · immunoglobulin production · Peyer patch · priority journal · secondary immune response · thymus · wheat · Celiac Disease · Gluten · Humans · IgA Deficiency · Infant · Intestines · Peyer's Patches · Triticum aestivum
[Abstract]

9 Extended histopathology in immunotoxicity testing: Interlaboratory validation studies
article 2004    
Author: Germolec, D.R. · Nyska, A. · Kashon, M. · Kuper, C.F. · Portier, C. · Kommineni, C. · Johnson, K.A. · Luster, M.I.
Keywords: Biology · Physiological Sciences · Histopathology · Immunology · Immunopathology · Lymph node · Pathology · Risk assessment · Spleen · Thymus · chemical agent · analysis of variance · animal cell · animal tissue · article · cellular distribution · concentration response · controlled study · disease severity · error · experience · factorial analysis · female · germinal center · health program · histopathology · immunopathology · immunotoxicity · intermethod comparison · laboratory test · lymph node · lymphatic system disease · lymphoid tissue · medical education · medical expert · mouse · nonhuman · observer variation · organogenesis · pathologist · quantitative analysis · reproducibility · screening test · sensitivity analysis · spleen cell · thymus · tissue injury · tissue structure · toxicity testing · validation process · Allergy and Immunology · Animals · Computational Biology · Data Interpretation, Statistical · Dose-Response Relationship, Drug · Histology · Immune System · Laboratories · Models, Statistical · Reproducibility of Results · Terminology · Toxicology
[Abstract]

10 General aspects of immunotoxicology including validation issues
article 2006    
Author: Frieke Kuper, C.
Keywords: Biology · Toxicology and Applied Pharmacology · Immunopathology · Organ sampling · Validation · allergy · article · autoimmune disease · histology · histopathology · human · immunotoxicity · immunotoxicology · lymphoid cell · lymphoid organ · lymphoid tissue · sensitivity and specificity · thymus · toxicology · validation study · Animals · Immune System · Immunosuppressive Agents · Lymphoid Tissue · Reproducibility of Results · Toxicity Tests · Xenobiotics
[Abstract]

11 The thymus atrophy inducing organotin compound DBTC stimulates TCRalfabeta-CD3 signalling in immature rat thymocytes
article 1995    
Author: Pieters, R.H.H. · Punt, P. · Bol, M. · Dijken, J.M. van · Seinen, W. · Penninks, A.H.
Keywords: Biology · Animal · Azides · Calcium · Cells, Cultured · Comparative Study · Cytochalasin B · Kinetics · Male · Organotin Compounds · Rats · Rats, Wistar · Receptor-CD3 Complex, Antigen, T-Cell · Receptors, Antigen, T-Cell, alpha-beta · Signal Transduction · Sodium Azide · Support, Non-U.S. Gov't · T-Lymphocytes · Teratogens · Thymus Gland · Animalia
[Abstract]

12 Monoclonal antibodies against the human mannose receptor as a specific marker in flow cytometry and immunohistochemistry for macrophages
article 1997    
Author: Noorman, F. · Braat, E.A.M. · Barrett-Bergshoeff, M.M. · Barbé, E. · Leeuwen, A. van · Lindeman, J. · Rijken, D.C.
Keywords: Biology · Human monocytes · KP1 · Lymph node · Biochemical marker · Dexamethasone · Lipopolysaccharide · Mannose receptor · Monoclonal antibody · Bone marrow · Cell culture · Flow cytometry · Gene expression · Immunohistochemistry · Lymph node · Skin · Technique · Thymus · Antibodies, Monoclonal · Biological Markers · Blotting, Western · Cell Differentiation · Dexamethasone · Flow Cytometry · Glucocorticoids · Humans · Immunohistochemistry · Lectins, C-Type · Lipopolysaccharides · Lymphocytes · Macrophage Activation · Macrophages · Mannose-Binding Lectins · Monocytes · Receptors, Cell Surface
[Abstract]

13 The accuracy of extended histopathology to detect immunotoxic chemicals
article 2004    
Author: Germolec, D.R. · Kashon, M. · Nyska, A. · Kuper, C.F. · Portier, C. · Kommineni, C. · Johnson, K.A. · Luster, M.I.
Keywords: Biology · Toxicology and Applied Pharmacology · B6C3F1 mice · Extended histopathology · Immunotoxicity · Safety Assessment · Screening tests · 2',3' dideoxyadenosine · 2,3,7,8 tetrachlorodibenzo para dioxin · 2,4 diaminotoluene · 4 nitrotoluene · aldicarb · chemical agent · didanosine · drug vehicle · gallium arsenide · immunosuppressive agent · oxymetholone · ribavirin · thalidomide · accuracy · analytical error · animal experiment · animal model · animal tissue · article · body weight · chemical analysis · controlled study · correlation analysis · disease severity · female · health program · histopathology · immune system · immunological procedures · immunotoxicity · incidence · intermethod comparison · leukocyte count · lymph node · lymphoid tissue · mouse · nonhuman · organ weight · pathologist · plaque forming cell · prediction · scoring system · sensitivity analysis · spleen · thymus · toxicity testing · toxicology · Animals · Body Weight · Dose-Response Relationship, Drug · Endpoint Determination · False Positive Reactions · Hemolytic Plaque Technique · Immune System · Immunity, Cellular · Lymph Nodes · Lymphocyte Count · Mice · Mice, Inbred Strains · Organ Size · Organ Specificity · Predictive Value of Tests · Reproducibility of Results · Spleen · Thymus Gland · Toxicity Tests · Vehicles
[Abstract]

14 Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure
article 2005    
Author: Heijne, W.H.M. · Jonker, D. · Stierum, R.H. · Ommen, B. van · Groten, J.P.
Keywords: Toxicology Biology · Toxicology and Applied Pharmacology · Benzene · cDNA microarrays · Gene expression · Hepatotoxicity · Metabolomics · Toxicogenomics · Transcriptomics · benzene · bromobenzene · paracetamol · animal experiment · animal tissue · biotransformation · blood toxicity · cholesterol metabolism · conference paper · DNA microarray · gene expression · genetic analysis · genetic toxicology · glutathione metabolism · liver necrosis · liver weight · male · nonhuman · nuclear magnetic resonance spectroscopy · nucleotide sequence · priority journal · rat · rat strain · unindexed sequence · Animals · Benzene · Blood Cell Count · Cholesterol · Fatty Acids · Gene Expression Profiling · Gene Expression Regulation · Hemoglobins · Liver · Male · Mutagens · Oligonucleotide Array Sequence Analysis · Organ Size · Rats · Rats, Inbred F344 · Spleen · Thymus Gland · Time Factors · Urinalysis · Martes pennanti
[Abstract]

15 The evaluation of the immunomodulating properties of ERA-63 a pharmaceutical with estrogenic activity
article 2008    
Author: Janssen, G.B. · Penninks, A.H. · Knippels, L.M.J. · Zijverden, M. van · Spanhaak, S.
Keywords: Chemistry · Ethinyl estradiol · Host resistance · Immunotoxicity · Listeria monocytogenes · PFC · Plaque-forming cell assay · T cell-dependent antibody response · bilirubin · era 63 · ethinylestradiol · gamma glutamyltransferase · immunomodulating agent · unclassified drug · animal experiment · antibody response · article · bilirubin blood level · body weight · controlled study · drug dose comparison · drug megadose · drug screening · estrogen activity · female · gamma glutamyl transferase blood level · immunomodulation · Listeria monocytogenes · low drug dose · male · nonhuman · priority journal · qualitative analysis · rat · testis weight · thymus · Animals · Antibody Formation · Body Weight · Estrogens · Ethinyl Estradiol · Female · Hemolytic Plaque Technique · Immunologic Factors · Listeria Infections · Male · Organ Size · Rats · Rats, Sprague-Dawley · Risk Assessment · T-Lymphocytes · Listeria monocytogenes · Rattus
[Abstract]

16 Developmental immunotoxicity of methylmercury: The relative sensitivity of developmental and immune parameters
article 2010    
Author: Tonk, E.C.M. · Groot, D.M.G. de · Penninks, A.H. · Waalkens - Berendsen, I.D.H. · Wolterbeek, A.P.M. · Slob, W. · Piersma, A.H. · Loveren, H. van
Keywords: Toxicology · Biomedical Research · Benchmark dose · Developmental immunotoxicity · Developmental toxicity · Dose-response modeling · Methylmercury · Perinatal exposure · Rat · gamma interferon · interleukin 10 · interleukin 13 · interleukin 2 · interleukin 4 · interleukin 6 · keyhole limpet hemocyanin · methylmercury · T lymphocyte antibody · adherent cell · animal tissue · antibody response · article · basophil · body weight · CD3+ T lymphocyte · CD4 CD8 ratio · CD8+ T lymphocyte · clinical evaluation · controlled study · cytokine production · delayed hypersensitivity · developmental screening · diagnostic value · environmental exposure · epididymis · erythrocyte · female · gestational age · immunological parameters · immunotoxicity · kidney mass · leukocyte count · litter size · liver weight · lymphocyte proliferation · natural killer cell · newborn mortality · nonhuman · rat · reticulocyte count · sensitivity and specificity · spleen cell · spleen weight · stillbirth · testis weight · thrombocyte count · thymus · weight reduction
[Abstract]

17 The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat
article 2008    
Author: Kuper, C.F. · Stierum, R.H. · Boorsma, A. · Schijf, M.A. · Prinsen, M. · Bruijntjes, J.P. · Bloksma, N. · Arts, J.H.E.
Keywords: Health · Dinitrochlorobenzene · LLNA · MCP-1 · MIP1-beta · Respiratory allergy · Skin allergy · 1 chloro 2,4 dinitrobenzene · CD4 antigen · immunoglobulin G · macrophage inflammatory protein 1beta · monocyte chemotactic protein 1 · monocyte chemotactic protein 3 · thymus and activation regulated chemokine · animal experiment · animal model · animal tissue · article · controlled study · female · lung function · lung lavage · lung parenchyma · male · microarray analysis · nonhuman · Norway · nucleotide sequence · priority journal · rat · respiratory tract allergy · skin allergy · skin irritation · skin sensitization · Th2 cell · upregulation · Administration, Cutaneous · Allergens · Animals · Dermatitis, Allergic Contact · Dinitrochlorobenzene · Female · Immunoglobulin E · Immunoglobulin G · Inhalation Exposure · Irritants · Local Lymph Node Assay · Lung · Lymph Nodes · Male · Rats · Rats, Inbred BN · Rats, Wistar · Respiratory Function Tests · Respiratory Hypersensitivity · Th2 Cells · Animalia · Rattus · Rattus norvegicus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 17 of 17 found. | Sort by date