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1 Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3
article 2003    
Author: Laan, W.H. van der · Quax, P.H.A. · Seemayer, C.A. · Huisman, L.G.M. · Pieterman, E.J. · Grimbergen, J.M. · Verheijen, J.H. · Breedveld, F.C. · Gay, R.E. · Gay, S. · Huizinga, T.W.J. · Pap, T.
Keywords: Adenoviridae · Animals · Arthritis, Rheumatoid · Cartilage, Articular · Cell Division · Fibroblasts · Gene Expression · Gene Therapy · Genetic Vectors · Humans · Matrix Metalloproteinases · Mice · Mice, SCID · Synovial Membrane · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Transduction, Genetic · Adenoviridae · Animalia
[Abstract]

2 A novel urokinase receptor-targeted inhibitor for plasmin and matrix metalloproteinases suppresses vein graft disease
article 2010    
Author: Eefting, D. · Seghers, L. · Grimbergen, J.M. · Vries, M.R. de · Boer, H.C. de · Lardenoye, J.W.H.P. · Jukema, J.W. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Health · Biomedical Research · Gene therapy · Matrix metalloproteinases · Plasmin(ogen) · Vascular surgery · Vein graft disease · apolipoprotein E3 · aprotinin · hybrid protein · matrix metalloproteinase · matrix metalloproteinase inhibitor · plasmin · plasmin inhibitor · plasminogen activator · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 1 amino terminal fragment of urokinase type plasminogen activator bovine pancreas trypsin inhibitor · unclassified drug · urokinase receptor · animal cell · animal experiment · animal model · animal tissue · article · carotid artery · cell surface · controlled study · electroporation · expression vector · female · gene overexpression · gene targeting · genetic transfection · human · human tissue · hypercholesterolemia · in vivo culture · intima · male · mouse · nonhuman · nonviral gene delivery system · priority journal · vein graft disease
[Abstract]

3 Temporal changes in collagen composition and metabolism during rodent palatogenesis
article 2000    
Author: Mansell, J.P. · Kerrigan, J. · McGill, J. · Bailey, J. · TeKoppele, J. · Sandy, J.R.
Keywords: Biomedical Research · Collagen · Cross-linking · Matrix metalloproteinase · MMP · Palate · TIMP · gelatinase A · pyridinium derivative · pyridinoline · stromelysin · tissue inhibitor of metalloproteinase · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 2 · animal experiment · animal tissue · article · calcification · collagen metabolism · collagen synthesis · controlled study · cross linking · embryo · embryo development · enzyme activity · extracellular matrix · fetus · mouse · nonhuman · ossification · palate · priority journal · Animal · Calcification, Physiologic · Collagen · Cross-Linking Reagents · Embryo and Fetal Development · Female · Gelatinase A · Male · Palate · Rats · Rats, Wistar · Stromelysin 1 · Tissue Inhibitor-of Metalloproteinase-2 · Tissue-Inhibitor of Metalloproteinase-1 · Rodentia · Trixis
[Abstract]

4 MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis
article 2004    
Author: Tchetverikov, I. · Ronday, H.K. · El, B. van · Kiers, G.H. · Verzijl, N. · TeKoppele, J.M. · Huizinga, T.W.J. · Groot, J. de · Hanemaaijer, R.
Keywords: alpha 2 macroglobulin · biological marker · gelatinase A · gelatinase B · hydroxyproline · interstitial collagenase · matrix metalloproteinase · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · aged · circulation · clinical article · collagen degradation · concentration (parameters) · controlled study · correlation analysis · enzyme activity · enzyme assay · enzyme linked immunosorbent assay · female · high performance liquid chromatography · human · male · osteoarthritis · priority journal · rheumatoid arthritis · sampling · serum · statistical significance · synovial fluid · Adult · Aged · alpha-Macroglobulins · Arthritis, Rheumatoid · Case-Control Studies · Collagenases · Enzyme Precursors · Enzyme-Linked Immunosorbent Assay · Female · Humans · Hydroxyproline · Male · Matrix Metalloproteinase 8 · Matrix Metalloproteinase 9 · Matrix Metalloproteinases · Metalloendopeptidases · Middle Aged · Osteoarthritis, Knee · Statistics, Nonparametric · Synovial Fluid · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

5 Fluorogenic MMP activity assay for plasma including MMPs complexed to α2-macroglobulin
article 1999    
Author: Beekman, B. · Drijfhout, J.W. · Ronday, H.K. · TeKoppele, J.M.
Keywords: Health · Biomedical Research · Alpha 2 macroglobulin · Batimastat · Fluorescein · Matrix metalloproteinase · Arthritis · Cancer · Collagen degradation · Conference paper · Controlled study · Enzyme active site · Enzyme activity · Enzyme assay · Fluorescence analysis · Human · Molecular weight · Alpha-Macroglobulins · Collagen · Collagenases · Fluorescent Dyes · Humans · Kinetics · Matrix Metalloproteinase 13 · Metalloendopeptidases · Phenylalanine · Protease Inhibitors · Substrate Specificity · Thiophenes · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

6 Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer
article 2007    
Author: Kubben, F.J.G.M. · Sier, C.F.M. · Hawinkels, L.J.A.C. · Tschesche, H. · Duijn, W. van · Zuidwijk, K. · Reijden, J.J. van der · Hanemaaijer, R. · Griffioen, G. · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Biology · Biomedical Research · Activity assay · Cancer · Metalloproteinase · Prognosis · gelatinase B · lipocalin · matrix metalloproteinase inhibitor · tissue inhibitor of metalloproteinase 1 · adult · aged · article · autolysis · cancer survival · disease classification · enzyme activity · enzyme degradation · epithelium cell · female · human · human tissue · immunohistochemistry · major clinical study · male · multivariate analysis · priority journal · protein function · stomach cancer · tumor · univariate analysis · world health organization
[Abstract]

7 Urinary matrix metalloproteinases reflect renal damage in anti-neutrophil cytoplasm autoantibody-associated vasculitis
article 2007    
Author: Sanders, J.S.F. · Huitema, M.G. · Hanemaaijer, R. · Goor, H. van · Kallenberg, C.G.M. · Stegeman, C.A.
Keywords: Biology · ANCA-associated vasculitis · Crescentic glomerulonephritis · Immunohistochemistry · MMP-2 · MMP-9 · Plasma levels · TIMP-1 · Urinary levels · C reactive protein · Adult · Aged · Aged, 80 and over · Antibodies, Antineutrophil Cytoplasmic · C-Reactive Protein · Creatine · Enzyme-Linked Immunosorbent Assay · Female · Humans · Immunohistochemistry · Kidney Diseases · Kidney Glomerulus · Male · Matrix Metalloproteinases · Middle Aged · Proteinuria · Tissue Inhibitor of Metalloproteinase-1 · Vasculitis
[Abstract]

8 Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content
article 2009    
Author: Abdul-Hussien, H. · Hanemaaijer, R. · Verheijen, J.H. · Bockel, J.H. van · Geelkerken, R.H. · Lindeman, J.H.N.
Keywords: Biology · Biomedical Research · antihypertensive agent · antithrombocytic agent · cystatin C · cysteine proteinase · doxycycline · gelatinase B · hydroxymethylglutaryl coenzyme A reductase inhibitor · messenger RNA · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · abdominal aorta aneurysm · adult · aged · aorta wall · article · clinical article · clinical trial · controlled clinical trial · controlled study · dose response · drug effect · drug megadose · drug tolerability · enzyme activity · enzyme assay · female · gene expression · human · human tissue · immunohistochemistry · low drug dose · male · neutrophil · polymerase chain reaction · priority journal · protein degradation · quantitative analysis · randomized controlled trial · treatment duration · Western blotting · Aged · Aged, 80 and over · Aorta, Abdominal · Aortic Aneurysm, Abdominal · Cardiovascular Agents · Cystatin C · Cysteine Endopeptidases · Dose-Response Relationship, Drug · Doxycycline · Female · Gene Expression Regulation, Enzymologic · Humans · Male · Matrix Metalloproteinases · Middle Aged · Neutrophil Infiltration · Neutrophils · Prospective Studies · Protease Inhibitors · RNA, Messenger · Time Factors · Tissue Inhibitor of Metalloproteinase-1 · Treatment Outcome · Vascular Surgical Procedures
[Abstract]

9 Increased matrix metalloproteinase-8 and -9 activity in patients with infarct rupture after myocardial infarction
article 2009    
Author: Borne, S.W.M. van den · Cleutjens, J.P.M. · Hanemaaijer, R. · Creemers, E.E. · Smits, J.F.M. · Daemen, M.J.A.P. · Blankesteijn, W.M.
Keywords: Biology · Biomedical Research · Infarct rupture · Inflammation · Matrix metalloproteinases · MMP activity assay · MMP immunohistochemistry · Myocardial infarction · gelatinase A · gelatinase B · neutrophil collagenase · tissue inhibitor of metalloproteinase 1 · adult · aged · article · clinical article · controlled study · enzyme activity · female · heart · heart disease · heart infarction · human · human tissue · immunohistochemistry · infarct rupture · inflammatory cell · male · priority journal · zymography · Aged · Aged, 80 and over · Cell Count · Female · Heart Rupture, Post-Infarction · Humans · Immunohistochemistry · Male · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 8 · Matrix Metalloproteinase 9 · Middle Aged · Myocardial Infarction · Myocarditis
[Abstract]

10 Gene transfer of the urokinase-type plasminogen activator receptor-targeted matrix metalloproteinase inhibitor TIMP-1.ATF suppresses neointima formation more efficiently than tissue inhibitor of metalloproteinase-1
article 2002    
Author: Lamfers, M.L.M. · Grimbergen, J.M. · Aalders, M.C. · Havenga, M.J. · Vries, M.R. de · Huisman, L.G.M. · Hinsbergh, V.W.M. van · Quax, P.H.A.
Keywords: Biology · Adenovirus · Matrix metalloproteinases · Neointima formation · Plasmin(ogen) · Urokinase-type plasminogen activator · Adenovirus · Adenoviridae · Animals · Cell Division · Cell Membrane · Cell Movement · Cells, Cultured · CHO Cells · Collagenases · Cricetinae · Culture Media, Conditioned · Enzyme Activation · Flow Cytometry · Gene Transfer Techniques · Humans · Matrix Metalloproteinase 13 · Muscle, Smooth, Vascular · Protein Structure, Tertiary · Receptors, Cell Surface · Recombinant Fusion Proteins · RNA, Messenger · Saphenous Vein · Tissue Inhibitor of Metalloproteinase-1 · Tunica Intima · Urinary Plasminogen Activator
[Abstract]

11 Matrix metalloproteinases in premature coronary atherosclerosis: influence of inhibitors, inflammation, and genetic polymorphisms
article 2007    
Author: Nanni, S. · Melandri, G. · Hanemaaijer, R. · Cervi, V. · Tomasi, L. · Altimari, A. · Lent, N. van · Tricoci, P. · Bacchi, L. · Branzi, A.
Keywords: Health · Biomedical Research · biological marker · gelatinase A · gelatinase B · glucose · haptoglobin · matrix metalloproteinase · stromelysin · tissue inhibitor of metalloproteinase · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 2 · adult · article · controlled study · coronary artery atherosclerosis · correlation analysis · enzyme activity · enzyme blood level · exon · genetic polymorphism · glucose blood level · human · human tissue · inflammation · major clinical study · male · metabolic disorder · pathogenesis · priority journal · protein expression · protein localization
[Abstract]

12 Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix
article 2003    
Author: Collen, A. · Hanemaaijer, R. · Lupu, F. · Quax, P.H.A. · Lent, N. van · Grimbergen, J. · Peters, E. · Koolwijk, P. · Hinsbergh, V.W.M. van
Keywords: Biology · Biomedical Research · Adenoviridae · Aprotinin · Cells, Cultured · Collagen · Culture Media · Defective Viruses · Drug Synergism · Endothelial Growth Factors · Endothelium, Vascular · Fibrin · Fibroblast Growth Factor 2 · Genetic Vectors · Heart Diseases · Humans · Intercellular Signaling Peptides and Proteins · Lymphokines · Matrix Metalloproteinase 1 · Matrix Metalloproteinase 2 · Matrix Metalloproteinases, Membrane-Associated · Metalloendopeptidases · Neovascularization, Pathologic · Neovascularization, Physiologic · Phenylalanine · Protease Inhibitors · Thiophenes · Thrombosis · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Transduction, Genetic · Tumor Necrosis Factor-alpha · Vascular Endothelial Growth Factor A · Vascular Endothelial Growth Factors
[Abstract]

13 MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis
article 2005    
Author: Tchetverikov, I. · Lohmander, L.S. · Verzijl, N. · Huizinga, T.W.J. · TeKoppele, J.M. · Hanemaaijer, R. · Groot, J. de
Keywords: Biomedical Research · alpha 2 macroglobulin · interstitial collagenase · matrix metalloproteinase · prointerstitial collagenase · prostromelysin · stromelysin · tissue inhibitor of metalloproteinase 3 · unclassified drug · arthritis · controlled study · enzyme activation · enzyme activity · enzyme inhibition · human · immunoassay · joint injury · knee · major clinical study · osteoarthritis · priority journal · protein determination · pseudogout · quantitative analysis · synovial fluid level · Acute Disease · Adult · alpha-Macroglobulins · Arthritis · Chondrocalcinosis · Cross-Sectional Studies · Female · Humans · Knee Injuries · Male · Matrix Metalloproteinases · Middle Aged · Osteoarthritis, Knee · Synovial Fluid · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

14 Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with α2 macroglobulin in serum of rheumatoid arthritis patients
article 2008    
Author: Tchetverikov, I. · Kraan, M.C. · El, B. van · Hanemaaijer, R. · Groot, J. de · Huizinga, T.W.J.
Keywords: Biology · Biomedical Research · alpha 2 macroglobulin · C reactive protein · leflunomide · matrix metalloproteinase · methotrexate · teriflunomide · tissue inhibitor of metalloproteinase 1 · analysis · blood sampling · clinical study · complex formation · controlled study · disease activity · drug activity · drug dose increase · drug effect · drug efficacy · drug exposure · loading drug dose · major clinical study · priority journal · protein blood level · quantitative analysis · rheumatoid arthritis · serum · systemic circulation · Aged · alpha-Macroglobulins · Antirheumatic Agents · Arthritis, Rheumatoid · Biological Markers · C-Reactive Protein · Down-Regulation · Enzyme Inhibitors · Female · Humans · Isoxazoles · Male · Matrix Metalloproteinases · Methotrexate · Middle Aged · Multiprotein Complexes · Phenylalanine · Statistics, Nonparametric · Thiophenes
[Abstract]

15 Sirolimus and paclitaxel provoke different vascular pathological responses after local delivery in a murine model for restenosis on underlying atherosclerotic arteries
article 2007    
Author: Pires, N.M.M. · Eefting, D. · Vries, M.R.de · Quax, P.H.A. · Jukema, J.W.
Keywords: Biology · Biomedical Research · collagen · Fas antigen · gelatinase B · messenger RNA · paclitaxel · protein Bax · protein bcl 2 · rapamycin · tissue inhibitor of metalloproteinase 1 · animal experiment · animal model · animal tissue · apoptosis · article · atherosclerosis · blood vessel reactivity · cell disruption · controlled study · dose response · drug eluting stent · drug megadose · femoral artery · histopathology · hypercholesterolemia · male · mouse · nonhuman · priority journal · protein expression · real time polymerase chain reaction · restenosis · upregulation · Actins · Animals · Apoptosis · Atherosclerosis · Cell Proliferation · Collagen · Drug Implants · Femoral Artery · Image Interpretation, Computer-Assisted · In Situ Nick-End Labeling · Male · Mice · Mice, Mutant Strains · Models, Animal · Muscle, Smooth, Vascular · Paclitaxel · Recurrence · Reverse Transcriptase Polymerase Chain Reaction · RNA, Messenger · Sirolimus · Stents · Tunica Intima
[Abstract]

16 Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer
article 2006    
Author: Kubben, F.J.G.M. · Sier, C.F.M. · Duijn, W. van · Griffioen, G. · Hanemaaijer, R. · Velde, C.J.H. van de · Krieken, J.H.J.M. van · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Health · Biomedical Research · Gelatinases · MMP-7 · MMP-8 · MMP-9 · TIMP · Tissue inhibitor of metalloproteinases · gelatinase A · gelatinase B · matrilysin · neutrophil collagenase · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 2 · bioassay · cancer classification · cancer patient · cancer staging · cancer survival · cancer tissue · comparative study · controlled study · correlation analysis · enzyme analysis · enzyme assay · enzyme linked immunosorbent assay · histopathology · human tissue · major clinical study · prognosis · protein variant · stomach cancer · stomach mucosa · tissue section · world health organization · Adult · Aged · Aged, 80 and over · Enzyme-Linked Immunosorbent Assay · Female · Humans · Male · Matrix Metalloproteinase 2 · Middle Aged · Predictive Value of Tests · Prognosis · Stomach Neoplasms · Survival Analysis
[PDF] [Abstract]

17 Involvement of Membrane-Type Matrix Metalloproteinases (MT-MMPs) in capillary tube formation by human endometrial microvascular endothelial Cells: Role of MT3-MMP
article 2004    
Author: Plaisier, M. · Kapiteijn, K. · Koolwijk, P. · Fijten, C. · Hanemaaijer, R. · Grimbergen, J.M. · Mulder-Stapel, A. · Quax, P.H.A. · Helmerhorst, F.M. · Hinsbergh, V.W.M. van
Keywords: Biology · Biomedical Research · Fibrin · Gelatinase A · Immunoglobulin G · Interstitial collagenase · Matrix metalloproteinase · Matrix metalloproteinase inhibitor · Membrane type 3 metalloproteinase · Membrane type 4 metalloproteinase · Messenger RNA · Unclassified drug · Urokinase · Adenovirus · Capillary · Cell culture · Controlled study · Endometrium cell · Endothelium cell · Enzyme inhibition · Enzyme regulation · Genetic transduction · Human cell · Immunohistochemistry · Prepuce · Protein expression · Vascular endothelium · Adenoviridae · Cells, Cultured · Collagen Type I · Endometrium · Endothelial Cells · Female · Humans · Matrix Metalloproteinase 16 · Matrix Metalloproteinases, Membrane-Associated · Metalloendopeptidases · Neovascularization, Physiologic · Plasmin · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Urinary Plasminogen Activator · Adenoviridae
[Abstract]

18 Active MMPs captured by alpha2Macroglobulin as a marker of disease activity in rheumatoid arthritis
article 2003    
Author: Tchetverikov, I. · Verzijl, N. · Huizinga, T.W.J. · TeKoppele, J.M. · Hanemaaijer, R. · Groot, J. de
Keywords: Biology · Biomedical Research · α2Macroglobulin · Matrix metalloproteases · Rheumatoid arthritis · alpha 2 macroglobulin · batimastat · collagenase 3 · matrix metalloproteinase · tissue inhibitor of metalloproteinase 1 · article · circulation · clinical article · complex formation · concentration (parameters) · controlled study · correlation analysis · disease activity · disease course · disease marker · enzyme linked immunosorbent assay · erythrocyte sedimentation rate · fast protein liquid chromatography · fluorescence analysis · human · molecular weight · priority journal · protein analysis · protein blood level · quantitative analysis · rheumatoid arthritis · Adult · alpha-Macroglobulins · Arthritis, Rheumatoid · Biological Markers · Case-Control Studies · Disease Progression · Enzyme-Linked Immunosorbent Assay · Female · Humans · Male · Matrix Metalloproteinases · Middle Aged · Probability · Prognosis · Reference Values · Sensitivity and Specificity · Severity of Illness Index
[PDF] [Abstract]

19 The association of 83 plasma proteins with CHD mortality, BMI, HDL-, and total-cholesterol in men: Applying multivariate statistics to identify proteins with prognostic value and biological relevance
article 2009    
Author: Geert Heidema, A. · Thissen, U. · Boer, J.M.A. · Bouwman, F.G. · Feskens, E.J.M. · Mariman, E.C.M.
Keywords: Biology Health Nutrition · Analytical research · BMI · CHD · HDL-cholesterol · Partial least squares · Proteomics · alpha 2 macroglobulin · apolipoprotein A1 · beta 2 microglobulin · C reactive protein · CD40 antigen · cholesterol · fibrinogen · growth hormone · high density lipoprotein cholesterol · immunoglobulin M · insulin · leptin · macrophage derived chemokine · macrophage inflammatory protein 1beta · matrix metalloproteinase · plasma protein · plasminogen activator inhibitor 1 · pregnancy associated plasma protein A · tissue inhibitor of metalloproteinase 1 · vascular cell adhesion molecule 1 · vasculotropin · adult · angiogenesis · article · blood clotting · body mass · cardiovascular disease · case control study · cholesterol blood level · cholesterol metabolism · clinical article · controlled study · disease association · enzyme activity · follow up · human · immune response · immunoassay · inflammation · ischemic heart disease · lipid metabolism · male · mortality · multivariate analysis · Netherlands · partial least squares regression · principal component analysis · priority journal · prognosis · protein analysis · proteomics · risk factor · statistical analysis · univariate analysis
[Abstract]

20 Do aberrant crypt foci have predictive value for the occurrence of colorectal tumours? Potential of gene expression profiling in tumours
article 2004    
Author: Wijnands, M.V.W. · Erk, M.J. van · Doornbos, R.P. · Krul, C.A.M. · Woutersen, R.A.
Keywords: Biology · Analytical research · AC, aberrant crypt · ACF, aberrant crypt focus · AIN, American Institute of Nutrition · ANOVA, analysis of variance · AOM, azoxymethane · BIT, benzyl isothiocyanate · CA2, carbonic anhydrase II · CDK4, cyclin-dependent kinase 4 · cDNA, complementary DNA · benzyl isothiocyanate · curcumin · rutoside · animal experiment · animal model · animal tissue · antineoplastic activity · article · carcinogenesis · colorectal tumor · controlled study · correlation analysis · crypt cell · dietary intake · disease marker · drug effect · gene expression profiling · intestine crypt · male · nonhuman · oncogene · prediction · protein expression · rat · scoring system · statistical significance · time series analysis · wheat bran · Animals · Anticarcinogenic Agents · Body Weight · Colorectal Neoplasms · Diet · DNA Primers · DNA, Complementary · Eating · Energy Metabolism · Gene Expression Profiling · Gene Expression Regulation, Neoplastic · Intestinal Mucosa · Male · Predictive Value of Tests · Rats · Rats, Inbred F344 · Reverse Transcriptase Polymerase Chain Reaction · RNA, Neoplasm · Survival Analysis · Tissue Inhibitor of Metalloproteinase-1 · Tumor Markers, Biological · Triticum aestivum
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 22 found. Next | Sort by date