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1 The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system
article 2013    
Author: Coomans, C.P. · Geerling, J.J. · Berg, S.A.A. van den · Diepen, H.C. van · Garcia-Tardõn, N. · Thomas, A. · Schröder-Van Der Elst, J.P. · Ouwens, D.M. · Pijl, H. · Rensen, P.C.N. · Havekes, L.M. · Guigas, B. · Romijn, J.A.
Keywords: Health · Brain · Insulin · KATP-channels · Tolbutamide · Type 2 diabetes mellitus · Healthy for Life · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10
article 1996    
Author: Kappers, W.A. · Groene, E.M. de · Kleij, L.A. · Witkamp, R.F. · Zweers-Zeilmaker, W.M. · Feron, V.J. · Horbach, G.J.
Keywords: Toxicology · CYP2C9 protein, human · cytochrome P450 · diclofenac · enzyme inhibitor · flurbiprofen · ketoprofen · mixed function oxidase · nonsteroid antiinflammatory agent · phenylbutazone · sulfaphenazole · tolbutamide · tolbutamide 4 hydroxylase · tolbutamide 4-hydroxylase · unspecific monooxygenase · animal · article · cell line · Cricetulus · drug interaction · gene expression · genetic transfection · genetics · hamster · human · hydroxylation · lung · metabolism · methylation · Animals · Anti-Inflammatory Agents, Non-Steroidal · Aryl Hydrocarbon Hydroxylases · Cell Line · Cricetinae · Cricetulus · Cytochrome P-450 Enzyme System · Diclofenac · Drug Interactions · Enzyme Inhibitors · Flurbiprofen · Gene Expression · Humans · Hydroxylation · Ketoprofen · Lung · Methylation · Mixed Function Oxygenases · Phenylbutazone · Sulfaphenazole · Tolbutamide · Transfection
[Abstract]

3 Modeling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich-cultured rat hepatocytes
article 2004    
Author: Treijtel, N. · Barendregt, A. · Freidig, A.P. · Blaauboer, B.J. · Eijkeren, J.C.H. van
Keywords: Biology · Physiological Sciences · 4 tolylsulfonylurea · carboxytolbutamide · hydroxytolbutamide · sulfonylurea derivative · tolbutamide · unclassified drug · addition reaction · animal cell · article · cell culture · controlled study · drug blood level · drug clearance · in vitro study · in vivo study · liquid chromatography · liver cell · mass spectrometry · mathematical model · nonhuman · priority journal · radiochemistry · rat · Animals · Cells, Cultured · Hepatocytes · Male · Metabolic Clearance Rate · Models, Biological · Rats · Rats, Wistar · Tolbutamide · Animalia
[Abstract]

4 Stimulatory effect of insulin on glucose uptake by muscle involves the central nervous system in insulin-sensitive mice
article 2011    
Author: Coomans, C.P. · Biermasz, N.R. · Geerling, J.J. · Guigas, B. · Rensen, P.C.N. · Havekes, L.M. · Romijn, J.A.
Keywords: Biology · adenosine triphosphate sensitive potassium channel · glucose · insulin · tolbutamide · adipose tissue · animal experiment · animal tissue · article · central nervous system · controlled study · diet · gluconeogenesis · glucose transport · heart · hyperinsulinemia · insulin resistance · insulin sensitivity · lateral brain ventricle · male · mouse · muscle · nonhuman · obesity · priority journal · signal transduction · stimulation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous System only in insulin-sensitive mice
article 2011    
Author: Coomans, C.P. · Geerling, J.J. · Guigas, B. · Hoek, A.M. van den · Parlevliet, E.T. · Ouwens, D.M. · Pijl, H. · Voshol, P.J. · Rensen, P.C.N. · Havekes, L.M. · Romijn, J.A.
Keywords: Health Biology · Brain · Brown adipose tissue · Insulin resistance · Lipid metabolism · Lipoprotein lipase · Triglycerides · adenosine triphosphate sensitive potassium channel · CD36 antigen · cyclic AMP · fatty acid · insulin · leptin · serum albumin · tolbutamide · triacylglycerol · animal experiment · animal model · animal tissue · brown adipose tissue · central nervous system · channel gating · controlled study · drug administration route · drug distribution · drug half life · drug targeting · fatty acid metabolism · fatty acid retention · hormone action · hyperinsulinemia · insulin action · insulin sensitivity · male · mouse · nonhuman · signal transduction · white adipose tissue · wild type · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

6 Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices
article 2000    
Author: Renwick, A.B. · Watts, P.S. · Edwards, R.J. · Barton, P.T. · Guyonnet, I. · Price, R.J. · Tredger, J.M. · Pelkonen, O. · Boobis, A.R. · Lake, B.G.
Keywords: Nutrition · Apoprotein · Cytochrome P450 · Cytochrome p450 2a6 · Cytochrome P450 2B6 · Cytochrome P450 2C19 · Cytochrome p450 2c8 · Cytochrome P450 2C9 · Cytochrome P450 3A4 · Cytochrome P450 3A5 · Debrisoquine 4 hydroxylase · Dimethylnitrosamine demethylase · Ethoxyresorufin · O Deethylase · Peptide antibody · Phenacetin o deethylase · Tolbutamide methylhydroxylase · Unclassified drug · Enzyme activity · Enzyme metabolism · Human tissue · Liver cell culture · Liver slice · Protein stability · School child · Xenobiotic metabolism · Adolescent · Adult · Aged · Child · Child, Preschool · Culture Media · Culture Techniques · Cytochrome P-450 Enzyme System · Enzyme Stability · Female · Humans · Immunoblotting · Isoenzymes · Liver · Male · Microsomes, Liver · Middle Aged
[Abstract]

7 The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays
article 2008    
Author: Vinken, M. · Doktorova, T. · Ellinger-Ziegelbauer, H. · Ahr, H.-J. · Lock, E. · Carmichael, P. · Roggen, E. · Delft, J. van · Kleinjans, J. · Castell, J. · Bort, R. · Donato, T. · Ryan, M. · Corvi, R. · Keun, H. · Ebbels, T. · Athersuch, T. · Sansone, S.-A. · Rocca-Serra, P. · Stierum, R. · Jennings, P. · Pfaller, W. · Gmuender, H. · Vanhaecke, T. · Rogiers, V.
Keywords: Biology · Physiological Sciences · carcinoGENOMICS · Chemical carcinogenesis · FP6 project · Genomics · Genotoxic carcinogen · Metabolomics · Metabonomics · Model compounds · Non-genotoxic carcinogen · REACH · Selection criteria · 1,3 butadiene · 2 nitrofluorene · 2,3,7,8 tetrachlorodibenzo para dioxin · aflatoxin B1 · alkanone · arsenate sodium · asbestos · benzo[a]pyrene · bromodichloromethane · cadmium derivative · chemical compound · chloroprene · chlorothalonil · dichromate sodium · dimethylnitrosamine · isobutyl nitrite · methapyrilene · monuron · nifedipine · ochratoxin · phenobarbital · phorbol 13 acetate 12 myristate · piperonyl butoxide · pirinixic acid · potassium bromate · s (1,2 dichlorovinyl)cysteine · streptozocin · tolbutamide · unindexed drug · vinyl chloride · carcinogenicity · genomics · human · in vitro study · medical information · medical research · model · nonhuman · priority journal · review · screening · Animal Testing Alternatives · Carcinogenicity Tests · European Union · Gene Expression Profiling · Genomics · Hazardous Substances · International Cooperation · Toxicogenetics · Animalia
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 7 of 7 found. | Sort by date