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1 Toxicokinetics of a urinary metabolite of tebuconazole following controlled oral and dermal administration in human volunteers
article 2019    
Author: Oerlemans, A. · Verscheijden, L.F.M. · Mol, J.G.J. · Vermeulen, R.C.H. · Westerhout, J. · Roeleveld, N. · Russel, F.G.M. · Scheepers, P.T.J.
Keywords: Human volunteer study · Tebuconazole · Urine · Biomarker · Toxicokinetics · PBTK
[PDF] [Abstract]

2 Toxicokinetics and binding of nerve agents in the presence of scavengers
article 2004    
Author: Schans, M.J. van der · Langenberg, J.P. · Benschop, H.P.
Keywords: Warfare · Nerve agents · Toxicokinetics · Bioscavenger · Butyrylcholinesterase · Fluoride reactivation
[Abstract]

3 Effect of pretreatment with human butyrylcholinesterase scavengers on the toxicokinetics and binding of nerve agents in guinea pigs
article 2004    
Author: Schans, M.J. van der · Pleijsier, K. · Wiel, H.J. van der · Boone, C.M. · Langenberg, J.P.
Keywords: Warfare · Nerve agents · Toxicokinetics · Bioscavenger · Butyrylcholinesterase · Fluoride reactivation
[Abstract]

4 Intravenous toxicokinetics of sulfur mustard and its DNA-adducts in the hairless guinea pig and marmoset
bookPart 2009    
Author: Langenberg, J.P. · Spruit, W.E.T. · Kuijpers, W.C. · Mars, R.H. · Helden, H.P.M. van · Schans, G.P. van der · Benschop, H.P.
Keywords: Toxicokinetics · Mustard agents · DNA - Deoxyribonucleic acids · Guinea pigs · Therapy · Skin (anatomy) · Respiration
[Abstract]

5 Evaluating in vitro-in vivo extrapolation of toxicokinetics
article 2018    
Author: Wambaugh, J.F. · Hughes, M.F. · Ring, C.L. · MacMillan, D.K. · Ford, J. · Fennell, T.R. · Black, S.R. · Snyder, R.W. · Sipes, N.S. · Wetmore, B.A. · Westerhout, J. · Setzer, R.W. · Pearce, R.G. · Simmons, J.E. · Thomas, R.S.
Keywords: Biology · Environmental chemicals · IVIVE · Toxicokinetics · Animal experiment · Animal tissue · Clearance · Drug bioavailability · Health hazard · In vitro study · In vivo study · Nonhuman · Plasma · Prediction · Rat · Steady state · Toxicokinetics · Uncertainty · Volume of distribution
[Abstract]

6 Toxicokinetics of sulfur mustard
bookPart 2016    
Author: Langenberg, J.P. · Schans, M.J. van der · Noort, D.
Keywords: Warfare · Warfare · Military chemical agents · Mustard agents · Toxicokinetics · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

7 Toxicokinetic triage for environmental chemicals
article 2015    
Author: Wambaugh, J.F. · Wetmore, B.A. · Pearce, R. · Strope, C. · Goldsmith, R. · Sluka, J.P. · Sedykh, A. · Tropsha, A. · Bosgra, S. · Shah, I. · Judson, R. · Thomas, R.S. · Setzer, R.W.
Keywords: Chemistry · Environmental chemicals · High throughput · IVIVE · Toxicokinetics · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

8 Physiologically based pharmacokinetic modeling of cyclohexane as a tool for integrating animal and human test data
article 2009    
Author: Hissink, A.M. · Kulig, B.M. · Kruse, J. · Freidig, A.P. · Verwei, M. · Muijser, H. · Lammers, J.H.C.M. · Mckee, R.H. · Owen, D.E. · Sweeney, L.M. · Salmon, F.
Keywords: Biology · Toxicology and Applied Pharmacology · Acute central nervous system effects · Cross-species extrapolations · Cyclohexane · Occupational exposure limits · Physiologically based pharmacokinetic models · Solvent neurotoxicity toxicokinetics
[Abstract]

9 Behavioural effects and kinetics in brain in response to inhalation of constant or fluctuating toluene concentrations in the rat
article 2005    
Author: Lammers, J.H.C.M. · Asperen, J. van · Groot, D. de · Rijcken, W.R.P.
Keywords: Health Biology · Toxicology and Applied Pharmacology · Motor activity · Peak exposure · Rat · Toluene · Toxicokinetics · Visual discrimination · toluene · animal experiment · animal model · blood level · brain level · concentration response · conference paper · controlled study · exposure · male · motor activity · neurotoxicity · nonhuman · priority journal · rat · toxicokinetics · visual discrimination
[Abstract]

10 Evaluation of an alternative in vitro test battery for detecting reproductive toxicants
article 2013    
Author: Piersma, A.H. · Bosgra, S. · Duursen, M.B.M. van · Hermsen, S.A.B. · Jonker, L.R.A. · Kroese, E.D. · Linden, S.C. van der · Man, H. · Roelofs, M.J.E. · Schulpen, S.H.W. · Schwarz, M. · Uibel, F. · Vugt-Lussenburg, B.M.A. van · Westerhout, J. · Wolterbeek, A.P.M. · Burg, B. van der
Keywords: Biology · Alternative assay · Aromatase · CALUX · Embryonic stem cell test · ReProGlo · Test battery · Toxicokinetics · Zebrafish embryotoxicity assay · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[Abstract]

11 Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs
article 2000    
Author: Spruit, W.E.T. · Langenberg, J.P. · Trap, H.C. · Wiel, H.J. van der · Helmich, R.B. · Helden, H.P.M. van · Benschop, H.P.
Keywords: Acetylcholinesterase inhibition · Guinea pig · Intravenous bolus · Nose-only exposure · Respiratory parameters · Stereoisomers · Toxicokinetics · Animal experiment · Animal model · Binding site · Chemical warfare · Controlled study · Drug absorption · Drug elimination · Enzyme inhibition · Gas chromatography · Guinea pig · Nonhuman · Nose mucosa · Stereoisomerism · Toxicokinetics · Acetylcholinesterase · Administration, Inhalation · Animals · Area Under Curve · Atropine · Chemical Warfare Agents · Guinea Pigs · Injections, Intravenous · Male · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Sarin, 107-44-8
[Abstract]

12 The application of in vitro data in the derivation of the acceptable daily intake of food additives
article 1999    
Author: Walton, K. · Walker, R. · Sandt, J.J.M. van de · Castell, J.V. · Knapp, A.G.A.A. · Kozianowski, G. · Roberfroid, M. · Schilter, B.
Keywords: Nutrition · Acceptable daily intake · Food additives · In vitro · Metabolism · Toxicodynamics and uncertainty factor · Toxicokinetics · 2 hydroxybiphenyl · Aluminum · Aspartame · Biphenyl · Brilliant blue · Butylcresol · Curcumin · Cyclamate sodium · Cyclohexylamine · Dodecyl gallate · Erythrosine · Ferrocyanide · Food additive · Gallic acid · Gallic acid propyl ester · Nitrate · Nitrite · Tartrazine · Tiabendazole · Dietary intake · Food safety · Human · Nonhuman · Review · Risk assessment · Species difference · Toxicity testing · Toxicokinetics · Animals · Food Additives · Humans · No-Observed-Adverse-Effect Level · Toxicity Tests · Animalia
[Abstract]

13 Interpreting in vitro developmental toxicity test battery results: The consideration of toxicokinetics
article 2015    
Author: Bosgra, S. · Westerhout, J.
Keywords: Toxicology · In vitro test battery · In vitro-in vivo extrapolation · Protein binding · TK modeling · Toxicokinetics · 2 ethylhexanoic acid · Ammonium derivative · Cyclosporin A · Diethylstilbestrol · Endosulfan · Gluphosinate ammonium · Hexanoic acid derivative · Methoxyacetic acid · Methylhexanoic acid · Methylmercuric chloride · Phthalic acid 2 ethylhexyl monoester · Retinoic acid · Unclassified drug · Valproic acid · Animal experiment · Clinical observation · Controlled study · Developmental toxicity · In vitro study · In vivo study · Mouse · Mouse defense test battery · Nonhuman · Predictive value · Protein binding · Quantitative analysis · Rat · Reproductive toxicity · Risk assessment · Simulation · Toxicokinetics · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

14 Model studies for evaluating the neurobehavioral effects of complex hydrocarbon solvents. III. PBPK modeling of white spirit constituents as a tool for integrating animal and human test data
article 2007    
Author: Hissink, A.M. · Krüse, J. · Kulig, B.M. · Verwei, M. · Muijser, H. · Salmon, F. · Leenheers, L.H. · Owen, D.E. · Lammers, J.H.C.M. · Freidig, A.P. · McKee, R.H.
Keywords: Biology · Toxicology and Applied Pharmacology · Central nervous system effects · Cross-species extrapolation · n-Decane · Occupational exposure limits · PBPK model · Toxicokinetics · Trimethyl benzene · White spirit · 1,2,4 trimethylbenzene · decane · hydrocarbon · organic solvent · stoddard solvent · unclassified drug · adult · animal experiment · article · behavior · blood analysis · brain · central nervous system · cognition · controlled study · exposure · human · human experiment · in vitro study · lung alveolus · male · nonhuman · partition coefficient · priority journal · rat · toxicokinetics · validation study · Adult · Alkanes · Aniline Compounds · Animals · Behavior, Animal · Body Weight · Brain · Dose-Response Relationship, Drug · Humans · Hydrocarbons · Male · Models, Animal · Models, Biological · Rats · Rats, Wistar · Solvents · Time Factors · Tissue Distribution · Animalia · Rattus
[Abstract]

15 Safety evaluation of chemical mixtures and combinations of chemical and non-chemical stressors
article 2004    
Author: Jonker, D. · Freidig, A.P. · Groten, J.P. · Hollander, A.E.M.de · Stierum, R.H. · Woutersen, R.A. · Feron, V.J.
Keywords: Chemistry Biology · Toxicology and Applied Pharmacology · Combination toxicology · Cumulative risk assessment · chemical agent · bioinformatics · cold stress · environmental exposure · genomics · health hazard · heat stress · human · immobilization stress · indoor air pollution · microorganism · noise · nonhuman · rat · review · risk assessment · safety · stress · toxicokinetics · toxicology · traffic · Dose-Response Relationship, Drug · Drug Interactions · Environmental Exposure · Humans · Models, Statistical · Risk Assessment · Safety · Sequence Analysis, Protein · Structure-Activity Relationship · Toxicology · Xenobiotics
[Abstract]

16 Neurobehavioural evaluation and kinetics of inhalation of constant or fluctuating toluene concentrations in human volunteers
article 2005    
Author: Lammers, J.H.C.M. · Meuling, W.J.A. · Muijser, H. · Freidig, A.P. · Bessems, J.G.M.
Keywords: Health · Toxicology and Applied Pharmacology · Human · Neurobehaviour · PBTK modelling · Peak exposure · Toluene · Toxicokinetics · ortho cresol · toluene · adolescent · article · attention · blood analysis · brain level · central nervous system function · controlled study · exposure · human · male · memory · mood · motor performance · neurologic examination · normal human · perception · priority journal · qualitative analysis · urinalysis · Animalia
[Abstract]

17 Toxicokinetics and metabolism
article 2005    
Author: Coecke, S. · Blaauboer, B.J. · Elaut, G. · Freeman, S. · Freidig, A. · Gensmantel, N. · Hoet, P. · Kapoulas, V.M. · Ladstetter, B. · Langley, G. · Leahy, D. · Mannens, G. · Meneguz, A. · Monshouwer, M. · Nemery, B. · Pelkonen, O. · Pfaller, W. · Prieto, P. · Proctor, N. · Rogiers, V. · Rostami-Hodjegan, A. · Sabbioni, E. · Steiling, W. · Sandt, J.J.M. van de
Keywords: Toxicology · Food and Chemical Risk Analysis · cosmetic · acute toxicity · artificial membrane · bioavailability · biotransformation · carcinogenicity · cell line · cell strain CACO 2 · computer model · concentration response · electric resistance · eye irritation · genotoxicity · human · metabolism · nonhuman · phototoxicity · plasma protein binding · practice guideline · priority journal · reproductive toxicity · review · skin absorption · skin sensitization · species difference · toxicokinetics · validation process · Animals · Biotransformation · Consumer Product Safety · Cosmetics · Drug Administration Routes · European Union · Humans

18 Genotoxicity and mutagenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Toxicology · Physiological sciences · Animal testing replacement · Animal testing alternatives · Chromosome aberration · Comet assay · DNA damage · DNA synthesis · Gene mutation · Genotoxicity · In vitro study · In vivo study · Micronucleus test · Mitotic recombination · Mutagenicity · Sister chromatid exchange · Toxicity testing · Toxicogenetics · Toxicokinetics · Toxicological parameters · Carcinogen testing · Cell culture · Chemistry · Legal aspects · Structure activity relation · Animalia · Consumer product safety · Cosmetics · European Union · Structure-Activity Relationship

19 Semi-continuous high speed gas analysis of generated vapors of chemical warfare agents
article 1999    
Author: Trap, H.C. · Langenberg, J.P.
Keywords: Automation · Data acquisition · Nerve agents · Sulfur mustard · Valve injection · Vapor analysis · Mustard gas · Nerve gas · Neurotoxin · Sarin · Soman · Analytic method · Animal experiment · Article · Autoanalysis · Chemical warfare · Chromatography · Gas analysis · Gas chromatography · Guinea pig · Neurotoxicity · Nonhuman · Toxicokinetics · Vapor · Mustard gas, 505-60-2 · Neurotoxin, 39386-17-9 · Sarin, 107-44-8 · Soman, 96-64-0
[Abstract]

20 Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs
article 1998    
Author: Benschop, H.P. · Trap, H.C. · Spruit, H.E.T. · Wiel, H.J. van der · Langenberg, J.P. · Jong, L.P.A. de
Keywords: Perception · Atropine · Carboxylesterase · Cholinesterase · Animal cell · Blood level · Enzyme inhibition · Exposure · Guinea pig · Inhalation · Male · Neurotoxicity · Nonhuman · Stereoisomerism · Toxicokinetics · Administration, Inhalation · Animals · Carboxylic ester hydrolases · Chemical warfare agents · Dose-response relationship · Drugs · Erythrocytes · Soman · Stereoisomerism · Time factors · Atropine, 51-55-8 · Carboxylesterase, EC 3.1.1.1 · Carboxylic ester hydrolases, EC 3.1.1.- · Soman, 96-64-0
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 37 found. Next | Sort by date