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1 Fibrinogen and atherosclerosis : A study in transgenic mice
article 1997    
Author: Koopman, J. · Maas, A. · Rezaee, F. · Havekes, L. · Verheijen, J. · Gijbels, M. · Haverkate, F.
Keywords: Biology · Animal experiment · Atherogenesis · Atherosclerosis · Atherosclerotic plaque · Conference paper · Fibrinogen blood level · Mouse · Nonhuman · Priority journal · Transgenic mouse
[Abstract]

2 Comparison of the X-gal- and P-gal-based systems for screening of mutant λlacZ phages originating from the transgenic mouse strain 40.6
article 1996    
Author: Mientjes, E.J. · Steenwinkel, M.J.S.T. · Delft, J.H.M. van · Lohman, P.H.M. · Baan, R.A.
Keywords: Nutrition · λgt10lacZ phage · Muta Mouse · P-gal · Positive selection · Transgenic mouse, strain 40.6 · X-gal · benzo[a]pyrene · ethylnitrosourea · animal experiment · article · bacteriophage · brain · controlled study · female · genotoxicity · liver · mouse · mutagen testing · mutant · mutation rate · nonhuman · priority journal · screening test · transgenic mouse · Animals · Bacteriophage lambda · Benzo(a)pyrene · Brain · Ethylnitrosourea · Galactosides · Indoles · Liver · Mice · Mice, Transgenic · Mutagens · Mutation
[Abstract]

3 Effect of eugenol on the mutagenicity of benzo[a]pyrene and the formation of benzo[a]pyrene-DNA adducts in the X-lacZ-transgenic mouse.
article 1996    
Author: Rompelberg, C.J.M. · Steenwinkel, M.J.S.T. · Asten, J.G. van · Delft, J.H.M. van · Baan, R.A. · Verhagen, H.
Keywords: Toxicology · Antimutagenicity · Benzo[a]pyrene · DNA adduct · Eugenol · Transgenic mouse · benzo[a]pyrene · eugenol · animal experiment · article · controlled study · dna adduct · genotoxicity · male · mouse · mutagenicity · mutation rate · nonhuman · oral drug administration · priority journal · transgenic mouse · Animals · Antimutagenic Agents · Benzo(a)pyrene · Biotransformation · Body Weight · Diet · DNA Adducts · Eugenol · Glutathione Transferase · Lac Operon · Liver · Male · Mice · Mice, Transgenic · Mutagens · Phosphorus Radioisotopes · Animalia · Gale · Mus musculus
[Abstract]

4 Long- and medium-term carcinogenicity studies in animals and short-term genotoxicity tests.
article 1999    
Author: Feron, V.J. · Schwarz, M. · Hemminki, K. · Krewski, D.
Keywords: Toxicology · biological marker · mutagenic agent · animal · bioassay · carcinogen testing · human · methodology · mouse · review · species difference · time · transgenic mouse · Animals · Biological Assay · Biological Markers · Carcinogenicity Tests · Humans · Mice · Mice, Transgenic · Mutagens · Research Design · Species Specificity · Time Factors

5 Gene-mutation assays in lambda-lacZ transgenic mice : comparison of lacZ with endogenous genes in splenocytes and small intestinal epithelium
article 1998    
Author: Delft, J.H.M. van · Bergmans, A. · Dam, F.J. van · Tates, A.D. · Howard, L. · Winton, D.J. · Baan, R.A.
Keywords: Biology · λlacZ · Dlb-1 · hprt · Mutagenesis · Transgenic mouse · ethylnitrosourea · hypoxanthine phosphoribosyltransferase · mesylic acid ethyl ester · methylnitrosourea · mutagenic agent · animal cell · animal experiment · animal tissue · article · controlled study · gene · gene mutation · intestine epithelium · mouse · mutagenesis · mutagenicity · nonhuman · priority journal · small intestine mucosa · spleen cell · transgenic mouse · Alkylating Agents · Animals · Ethyl Methanesulfonate · Ethylnitrosourea · Genetic Markers · Hypoxanthine Phosphoribosyltransferase · Intestinal Mucosa · Intestine, Small · Lac Operon · Methylnitrosourea · Mice · Mice, Inbred C57BL · Mice, Transgenic · Mutagenicity Tests · Mutagens · Mutation · Spleen · Animalia · Mus musculus
[Abstract]

6 DNA adducts, mutant frequencies and mutation spectra in λlacZ transgenic mice treated with N-nitrosodimethylamine
article 1998    
Author: Souliotis, V.L. · Delft, J.H.M. van · Steenwinkel, M.-J.S.T. · Baan, R.A. · Kyrtopoulos, S.A.
Keywords: Nutrition · 6 o alkylguanine dna alkyltransferase · 6 o methylguanine · 7 methylguanine · Beta galactosidase · Dimethylnitrosamine · Dna · Animal experiment · Animal tissue · Carcinogenesis · Controlled study · Dna adduct · Liver · Male · Mouse · Mutation rate · Nonhuman · Priority journal · Spleen · Transgenic mouse · Animals · Carcinogens · Dimethylnitrosamine · DNA Adducts · Lac Operon · Male · Mice · Mice, Transgenic · Mutagens · Mutation · Sequence Deletion
[Abstract]

7 Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice
article 2007    
Author: Hoorn, J.W.A. van der · Kleemann, R. · Havekes, L.M. · Kooistra, T. · Princen, H.M.G. · Jukema, J.W.
Keywords: Biology · Biomedical Research · APOE*3Leiden mice · Atherosclerosis · Combination therapy · Olmesartan · Pravastatin · T lymphocyte · transgenic mouse · Angiotensin II Type 1 Receptor Blockers · Animals · Apolipoprotein E3 · Atherosclerosis · Blood Pressure · Collagen · Diet, Atherogenic · Drug Synergism · Female · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Imidazoles · Inflammation · Lipids · Macrophages · Mice · Mice, Transgenic · Monocytes · Muscle, Smooth, Vascular · Pravastatin · Recombinant Proteins · Serum Amyloid A Protein · T-Lymphocytes · Tetrazoles
[PDF] [Abstract]

8 Influence of nucleotide excision repair on N-hydroxy-2-acetylaminofluorene-induced mutagenesis studied in λlacZ-transgenic mice
article 1998    
Author: Frijhoff, A.F.W. · Krul, C.A.M. · Vries, A. de · Kelders, M.C.J.M. · Weeda, G. · Steeg, H. van · Baan, R.A.
Keywords: Nutrition · LacZ · Mutagenesis · N-hydroxy-2-acetylaminofluorene · Nucleotide excision repair · Transgenic mice · Fluorenylacetohydroxamic acid · Nucleotide · Animal experiment · Controlled study · Dna sequence · Excision repair · Female · Male · Mouse · Mutagenesis · Mutagenicity · Mutation rate · Nonhuman · Spontaneous mutation · Transgenic mouse · Animals · DNA Repair · DNA-Binding Proteins · Endonucleases · Hydroxyacetylaminofluorene · Lac Operon · Male · Mice · Mice, Transgenic · Mutagens · Proteins
[Abstract]

9 Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein C1
article 1996    
Author: Jong, M.C. · Dahlmans, V.E.H. · Gorp, P.J.J. van · Breuer, M.L. · Mol, M.J.T.M. · Zee, A. van der · Frants, R.R. · Hofker, M.H. · Havekes, L.M.
Keywords: Health · Transgenic mice · Triacylglycerol · Very low density lipoprotein · Animal experiment · Animal model · Atherosclerosis · Cholesterol blood level · Controlled study · Female · Lipolysis · Liver clearance · Liver metabolism · Male · Nonhuman · Protein transport · Transgenic mouse · Triacylglycerol blood level · Animals · Apolipoprotein C-I · Apolipoprotein E3 · Apolipoproteins C · Apolipoproteins E · Arteriosclerosis · Cholesterol · Cholesterol, Dietary · Gene Expression · Humans · Hyperlipoproteinemias · Lipolysis · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Triglycerides
[Abstract]

10 Induction of somatic mutations but not methylated DNA adducts in λlacZ transgenic mice by dichlorvos
article 1999    
Author: Pletsa, V. · Steenwinkel, M.-J.S.T. · Delft, J.H.M. van · Baan, R.A. · Kyrtopoulos, S.A.
Keywords: Nutrition · Dimethylsulphate · Methylating agents · N7-Methylguanine · O6-Methylguanine · Organosphosphate insecticides · 6 o methylguanine · 7 methylguanine · Dichlorvos · Dimethyl sulfate · Animal cell · Bone marrow cell · Controlled study · DNA adduct · DNA methylation · Genotoxicity · Liver cell · Mouse · Mutation rate · Nonhuman · Priority journal · Somatic mutation · Transgenic mouse · Animals · Dichlorvos · DNA Methylation · Guanine · Insecticides · Lac Operon · Mice · Mice, Transgenic · Mutation · Mus musculus
[Abstract]

11 Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsis.
article 2006    
Author: Berbée, J.F. · Hoogt, C.C. van der · Kleemann, R. · Schippers, E.F. · Kitchens, R.L. · Dissel, J.T. van · Bakker-Woudenberg, I.A. · Havekes, L.M. · Rensen, P.C.
Keywords: Biology · Drug effect · Gram negative bacterium · Immunology · Mortality · Mouse · Mouse mutant · Nucleotide sequence · Transgenic mouse · Animals · Antigen Presentation · Apolipoprotein C-I · Apolipoproteins C · Binding Sites · Conserved Sequence · Gram-Negative Bacteria · Humans · Immunity · Inflammation · Lipopolysaccharides · Macrophages · Mice · Mice, Knockout · Mice, Transgenic · Sepsis
[Abstract]

12 Effect of macrophage-derived mouse ApoE, human ApoE3-Leiden, and human ApoE2 (Arg158→Cys) on cholesterol levels and atherosclerosis in ApoE- deficient mice
article 2000    
Author: Eck, M. van · Herijgers, N. · Dijk, K.W. van · Havekes, L.M. · Hofker, M.H. · Groot, P.H.E. · Berkel, T.J.C. van
Keywords: Atherosclerosis · Hyperlipidemia · Low density lipoprotein · Animal model · Animal tissue · Cholesterol blood level · Cholesterol transport · Mouse · Nonhuman · Transgenic mouse · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Bone Marrow Transplantation · Cholesterol · Humans · Liver · Macrophages, Peritoneal · Mice · Mice, Knockout · Mice, Transgenic
[Abstract]

13 Reduced very-low-density lipoprotein fractional catabolic rate in apolipoprotein C1-deficient mice
article 1997    
Author: Jong, M.C. · Ree, J.H. van · Dahlmans, V.E.H. · Frants, R.R. · Hofker, M.H. · Havekes, L.M.
Keywords: Biology · very low density lipoprotein · animal experiment · catabolism · controlled study · human · hyperlipoproteinemia · lipolysis · metabolism · mouse · nonhuman · priority journal · protein degradation · protein metabolism · transgenic mouse · Animals · Apolipoprotein C-I · Apolipoproteins B · Apolipoproteins C · Cholesterol, Dietary · Female · Lipolysis · Lipoproteins, VLDL · Mice · Mice, Mutant Strains · Triglycerides · Ultracentrifugation · Animalia · Mus musculus
[Abstract]

14 Carcinogenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Prentice, D. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Health · Biomedical Research · animal testing alternative · carcinogenesis · carcinogenicity · cell communication · cell culture · cell transformation · gap junction · genotoxicity · heterozygosity · nonhuman · priority journal · review · risk assessment · standardization · transgenic mouse · validation process · Animal Testing Alternatives · Animals · Carcinogenicity Tests · Carcinogens · Cell Transformation, Neoplastic · Cells, Cultured · Consumer Product Safety · Cosmetics · European Union · Gap Junctions · Mice · Mice, Transgenic · Quantitative Structure-Activity Relationship · Rats · Animalia · Mus musculus

15 Salsalate activates brown adipose tissue in mice
article 2015    
Author: Dam, A.D. van · Nahon, K.J. · Kooijman, S. · Berg, S.M. van den · Kanhai, A.A. · Kikuchi, T. · Heemskerk, M.M. · Harmelen,V. van · Lombès, M. · Hoek,A.M. van den · Winther, M.P. de · Lutgens, E. · Guigas, B. · Rensen, P.C. · Boon, M.R.
Keywords: Biology · Salicylic acid derivative · Salsalate · Administration and dosage · Adverse effects · Brown adipose tissue · Drug administration · Drug effects · Fat intake · Metabolism · Mouse · Physiology · Transgenic mouse · Adipose Tissue, Brown · Animals · Dietary Fats · Drug Administration Schedule · Glucose · Lipid Metabolism · Male · Mice · Mice, Transgenic · Obesity · Salicylates · Weight Gain · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

16 Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance.
article 2010    
Author: Kleemann, R. · Erk, M. van · Verschuren, L. · Hoek, A.M. van den · Koek, M. · Wielinga, P.Y. · Jie, A. · Pellis, L. · Bobeldijk-Pastorova, I. · Kelder, T. · Toet, K. · Wopereis, S. · Cnubben, N. · Evelo, C. · Ommen, B. van · Kooistra, T.
Keywords: Biology · Biomedical Research · Apolipoprotein E3 · Fatty acid · Blood · DNA microarray · Genetics · Obesity · physiology · transgenic mouse · Western blotting · Adiposity · Animals · Apolipoprotein E3 · Blotting, Western · Fatty Acids, Nonesterified · Glucose Tolerance Test · Insulin Resistance · Male · Mice · Mice, Transgenic · Oligonucleotide Array Sequence Analysis · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

17 DNA adducts, mutant frequencies, and mutation spectra in various organs of λlacZ mice exposed to ethylating agents
article 1998    
Author: Mientjes, E.J. · Luiten-Schuite, A. · Wolf, E. van der · Borsboom, Y. · Bergmans, A. · Berends, F. · Lohman, P.H.M. · Baan, R.A. · Delft, J.H.M. van
Keywords: Nutrition · λlacZ transgenic mice · Ethyl DNA adducts · Muta(TM)Mouse · Mutagenesis · Mutation spectra · Alkylating agent · Diethylnitrosamine · Ethylnitrosourea · Guanine derivative · Mesylic acid ethyl ester · Animal experiment · Animal tissue · Bone marrow · Brain · Controlled study · Dna adduct · Female · Liver · Mouse · Mutagenesis · Mutation · Mutation rate · Nonhuman · Sequence analysis · Transgenic mouse · Animals · Bone Marrow · Brain · Diethylnitrosamine · DNA Adducts · Ethyl Methanesulfonate · Ethylnitrosourea · Female · Guanine · Lac Operon · Liver · Mice · Mice, Transgenic · Mutagens
[Abstract]

18 Quantitative assessment of aortic atherosclerosis in APOE*3 leiden transgenic mice and its relationship to serum cholesterol exposure
article 1996    
Author: Groot, P.H.E. · Vlijmen, B.J.M. van · Benson, G.M. · Hofker, M.H. · Schiffelers, R. · Vidgeon-Hart, M. · Havekes, L.M.
Keywords: Biology · animal model · apolipoprotein E · diet · familial dyslipoproteinemia · hyperlipidemia · apolipoprotein e · cholesterol · animal experiment · animal model · animal tissue · aorta atherosclerosis · aorta sinus · article · atherosclerosis · cholesterol blood level · cholesterol diet · controlled study · dyslipoproteinemia · feeding · female · hyperlipidemia · hypolipemia · lipid diet · male · mouse · nonhuman · priority journal · transgenic mouse · Animals · Aortic Diseases · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Cholesterol · Cholesterol, Dietary · Dietary Fats · Female · Hyperlipidemias · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Sinus of Valsalva
[Abstract]

19 Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL
article 2005    
Author: Berbée, J.F.P. · Hoogt, C.C. van der · Sundararaman, D. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Apolipoprotein C-I · Fatty acids · Lipid metabolism · Lipoprotein lipase · Triglycerides · Very low density lipoprotein · Lipoprotein receptor · Tritium · Very low density lipoprotein · Animal experiment · Animal model · Cholesterol blood level · Controlled study · Enzyme activity · Half life time · Hyperlipidemia · Hyperlipoproteinemia type 3 · Lipolysis · Mouse · Nonhuman · Pathophysiology · Protein expression · Transgenic mouse · Animals · Apolipoproteins · Apolipoproteins C · Apolipoproteins E · Humans · Hypertriglyceridemia · Lactoferrin · Lipoproteins, VLDL · Liver · Mice · Mice, Inbred C57BL · Mice, Transgenic · Phenotype · Time Factors
[PDF] [Abstract]

20 Phenotype characterisation using integrated gene transcript, protein and metabolite profiling
article 2004    
Author: Orešič, M. · Clish, C.B. · Davidov, E.J. · Verheij, E. · Vogels, J. · Havekes, L.M. · Neumann, E. · Adourian, A. · Naylor, S. · Greef, J. van der · Plasterer, T.
Keywords: Biology · Analytical research · Biomedical research · Apolipoprotein E3 · Protein · Animal experiment · Animal tissue · Atherosclerosis · Cohort analysis · Controlled study · Disease course · Electrospray · Genetic transcription · Information processing · Liquid chromatography · Male · Mass spectrometry · Metabolite · Metabolomics · Mouse · Nonhuman · Nucleotide sequence · Onset age · Pathophysiology · Proteomics · Transgenic mouse · Wild type · Algorithms · Animals · Cells, Cultured · Computer Simulation · Gene Expression Regulation · Liver · Mass Spectrometry · Mice · Models, Biological · Peptide Mapping · Phenotype · Proteome · Signal Transduction · Systems Integration · Transcription Factors · Mus musculus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 62 found. Next | Sort by date