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1 Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes
article 2009    
Author: Treijtel, N. · Eijkeren, J.C.H.v. · Nijmeijer, S. · Greef de - Sandt, I.C.J. van der · Freidig, A.P.
Keywords: Health · Biomedical Research · HIV-protease inhibitors · Metabolism · P-Glycoprotein · Rat hepatocytes · rat liver microsomes · Sandwich-culture · cyclosporin A · drug metabolite · glycoprotein P · ketoconazole · proteinase inhibitor · ritonavir · saquinavir · testosterone derivative · valspodar · verapamil · animal cell · article · cell culture · controlled study · drug clearance · drug excretion · drug metabolism · drug transport · Human immunodeficiency virus 1 · hydroxylation · intrahepatic bile duct · liver cell · liver metabolism · male · microsome · nonhuman · rat · sandwich culture · Animals · Biological Transport, Active · Cell Culture Techniques · Cell Survival · Cells, Cultured · Cyclosporine · Cyclosporins · Dose-Response Relationship, Drug · Hepatocytes · HIV Protease Inhibitors · Ketoconazole · Male · Metabolic Clearance Rate · Microsomes, Liver · Rats · Rats, Wistar · Ritonavir · Saquinavir · Human immunodeficiency virus 1 · Rattus
[Abstract]

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