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Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study

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Author: Steevens, J. · Schouten, L.J. · Goldbohm, R.A. · Brandt, P.A. van den
Type:article
Date:2011
Source:International Journal of Cancer, 11, 129, 2681-2693
Identifier: 526412
doi: doi:10.1002/ijc.25928
Keywords: Health · Epidemiology · Esophageal cancer · Stomach cancer · Adult · Aged · Brassica · Cancer incidence · Cancer risk · Cardia carcinoma · Cigarette smoking · Citrus fruit · Cohort analysis · Controlled study · Esophageal adenocarcinoma · Esophageal squamous cell carcinoma · Feeding behavior · Follow up · Food intake · Fruit · Major clinical study · Netherlands · Proportional hazards model · Questionnaire · Risk factor · Risk reduction · Stomach adenocarcinoma · Adenocarcinoma · Aged · Carcinoma, Squamous Cell · Cardia · Cohort Studies · Esophageal Neoplasms · Female · Follow-Up Studies · Fruit · Humans · Male · Middle Aged · Prognosis · Prospective Studies · Risk Factors · Stomach Neoplasms · Survival Rate · Vegetables

Abstract

Prospective epidemiologic data on vegetables and fruits consumption and risk of subtypes of esophageal and gastric cancer are sparse. We studied the association between vegetables and fruits consumption and risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA) and gastric noncardia adenocarcinoma (GNCA) in the Netherlands Cohort Study. In 1986, 120,852 Dutch men and women aged 55-69 filled out a questionnaire on diet and other cancer risk factors. After 16.3 years of follow-up, 101 ESCC, 144 EAC, 156 GCA, 460 GNCA cases and 4,035 subcohort members were available for case-cohort analysis using Cox proportional hazards models. Multivariable adjusted incidence rate ratios (RRs) were generally below unity. Total vegetable consumption was nonsignificantly inversely associated with EAC and ESCC risk, but not with GCA and GNCA risk. Significant inverse associations were observed for raw vegetables and EAC risk [RR per 25 g/day: 0.81, 95% confidence interval (CI) 0.68-0.98], and Brassica vegetables and GCA risk (RR per 25 g/day: 0.72, 95% CI 0.54-0.95). Total fruit consumption was associated with a nonsignificantly decreased EAC risk. Citrus fruits were inversely associated with EAC and GCA risk (RRs for highest vs. lowest intake: 0.55, 95% CI 0.31-0.98 and 0.38, 95% CI 0.21-0.69, respectively). Specifically for current smokers, vegetables and possibly also fruits intake was inversely associated with ESCC and EAC risk. Consumption of (specific groups of) vegetables and fruits may protect against subtypes of esophageal and gastric cancer. Copyright © 2011 UICC.