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Heterogeneity and prediction of hemodynamic responses to dobutamine in patients with septic shock

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Author: Jellema, W.T. · Groeneveld, A.B.J. · Wesseling, K.H. · Thijs, L.G. · Westerhof, N. · Lieshout, J.J. van
Type:article
Date:2006
Source:Critical Care Medicine, 9, 34, 2392-2398
Identifier: 239451
doi: doi:10.1097/01.CCM.0000233871.52553.CD
Keywords: Cardiac output · Catecholamines · Critical care · Sepsis · Septic shock · dobutamine · APACHE · chronotropism · clinical article · heart index · heart muscle oxygen consumption · heart stroke volume · hemodynamics · human · inotropism · intensive care unit · maximum permissible dose · mean arterial pressure · septic shock · systemic vascular resistance · venous oxygen tension · Adult · Aged · Aorta · Blood Pressure · Cardiac Output · Cardiotonic Agents · Diastole · Dobutamine · Dose-Response Relationship, Drug · Female · Heart Rate · Humans · Infusions, Intravenous · Intensive Care Units · Male · Middle Aged · Oxygen · Prospective Studies · Shock, Septic · Systole · Vascular Resistance · Ventricular Function, Left

Abstract

OBJECTIVE: To establish the heterogeneity of hemodynamic responses to dobutamine in patients with septic shock and to identify the predictive factors of these hemodynamic responses. DESIGN: Prospective study. SETTING AND PATIENTS: A total of 12 patients with septic shock in a tertiary medical intensive care unit. INTERVENTIONS: A 20-min dobutamine infusion at 5 μg·kg· min with subsequent increments to 8, 12.6, and 20 μg·kg·min, on two consecutive days. Responses were dichotomized into changes in heart rate (HR) or stroke volume index (SVI) of >10% and ≤10% at the maximal dobutamine infusion. MEASUREMENTS AND MAIN RESULTS: No differences were found in survival, Acute Physiology and Chronic Health Evaluation II score, maximal dobutamine doses, or pharmacokinetics of dobutamine between HR and SVI groups. In ΔHR > 10% vs. ΔHR ≤ 10%, baseline HR was lower, and baseline mixed venous oxygen tension and saturation were higher. During dobutamine infusion, mean arterial pressure decreased in ΔHR > 10%. Cardiac index and the systemic oxygen delivery index increased and the systemic vascular resistance index decreased at unchanged SVI. Pressure work index increased and the ratio of the diastolic to systolic aortic pressure time indices decreased but not to <0.6. In ΔHR ≤ 10%, systemic vascular resistance index and the ratio of the diastolic to systolic aortic pressure time indices decreased (but remained >0.6) without changes in SVI or cardiac index. Baseline hemodynamic and metabolic variables did not differ between SVI groups. In ΔSVI > 10%, cardiac index increased with dobutamine, but Pao2 and the systemic oxygen delivery index decreased. In ΔSVI ≤ 10%, HR and the systemic oxygen delivery index increased; mean arterial pressure, left ventricular stroke work index, systemic vascular resistance index, and the ratio of the diastolic to systolic aortic pressure time indices decreased. CONCLUSIONS: Patients with a positive chronotropic response to dobutamine had lower baseline HR values, and a chronotropic rather than inotropic response predicted an increase in cardiac index and systemic oxygen delivery index. Incremental dosages of dobutamine did not compromise indirectly measured myocardial oxygen balance. Copyright © 2006 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins. Chemicals / CAS: dobutamine, 34368-04-2, 52663-81-7; Cardiotonic Agents; Dobutamine, 34368-04-2; Oxygen, 7782-44-7Chemicals / CAS: dobutamine, 34368-04-2, 52663-81-7; Cardiotonic Agents; Dobutamine, 34368-04-2; Oxygen, 7782-44-7