In the clothing industry a discussion is going on about how to react to changing demands and wishes on the different markets. On the basis of a still on-going research project in the Netherlands this article describes how these changes can be taken into account in the technical and organizational architecture of the sewing room. Special attention is paid to three new production systems, namely (1) the Toyota Sewing System, (2) the Quick Response System, and (3) the Multi Operations System. From case studies it seems that companies do not benefit directly from the mentioned production systems. The solution can rather be found in new ways of production, that is, by making changes in both the production and the work organization. The nature of production and work organization has to be considered first before committing the organization to a technical choice of equipment.