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A category approach to predicting the developmental (neuro) toxicity of organotin compounds: The value of the zebrafish (Danio rerio) embryotoxicity test (ZET)

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Author: Beker van Woudenberg, A. · Wolterbeek, A. · Brake, L. te · Snel, C. · Menke, A. · Rubingh, C. · Groot, D. de · Kroese, D.
Type:article
Date:2013
Source:Reproductive Toxicology, 41, 35-44
Identifier: 478864
doi: doi:10.1016/j.reprotox.2013.06.067
Keywords: Health · Alternative model · Biological verification · Developmental (neuro) toxicity · Grouping · Organotins · Read across · Zebrafish embryotoxicity test (ZET) · Biomedical Innovation · Healthy Living · Life Triskelion BV · QS - Quality & Safety TARA - Toxicology and Risk Assessment · EELS - Earth, Environmental and Life Sciences

Abstract

Zebrafish embryos were exposed to different organotin compounds during very early development (<100. h post fertilization). Morphology, histopathology and swimming activity (in a motor activity test) were the endpoints analyzed. DBTC was, by far, the most embryotoxic compound at all time points and endpoints studied. In fact, we observed a clear concordance between the effects observed in our zebrafish embryo model, and those observed with these compounds in full rodent in vivo studies. All organotin compounds classified as developmental (neuro) toxicants in vivo, were correctly classified in the present assay. Together, our results support the ZET model as a valuable tool for providing biological verification for a grouping and a read-across approach to developmental (neuro) toxicity. © 2013 Elsevier Inc.