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Effects of long term feeding of raw soya bean flour on virus- induced pancreatic carcinogenesis in guinea fowl

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Author: Kirev, T. · Woutersen, R.A. · Kiril, A.
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:Cancer Letters, 2, 135, 195-202
Identifier: 234924
doi: doi:10.1016/S0304-3835(98)00296-1
Keywords: Nutrition · Guinea fowl · Pancreatic carcinogenesis · Raw soya bean flour · Bird · Carcinogenesis · Diet · Histology · Microscopy · Pancreas cancer · Priority journal · Retrovirus · Soybean · Virus infection · Animals · Animals, Newborn · Body Weight · Carcinogenicity Tests · Cocarcinogenesis · Female · Flour · Hyperplasia · Male · Pancreas · Pancreatic Ducts · Pancreatic Neoplasms · Poultry · Random Allocation · Retroviridae · Retroviridae Infections · Soybeans · Tumor Virus Infections


The effects of a diet enriched with 25% raw soya bean flour (RSF) on the pancreas and on the avian retrovirus Pts 56-induced pancreatic carcinogenesis in guinea fowl were studied. It has been shown that prolonged RSF feeding of new-hatched virus-infected and uninfected guinea fowl-poults induced enlargement of the pancreas, which was less pronounced when administration of the RSF supplemented diet started at the age of 75 days. Time-dependent multifocal inter- and intralobular hyperplasia of pleomorphic ducts lined by mucin-producing epithelium in the exocrine pancreas of virus-infected guinea fowls fed a RSF supplemented diet was regularly observed. Enlargement of virus-induced ductular neoplasms has been shown only after simultaneous RSF and virus administration. Copyright (C) 1999 Elsevier Science Ireland Ltd.