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Low-grade inflammation, diet composition and health: Current research evidence and its translation

Author: Minihane, A.M. · Vinoy, S. · Russell, W.R. · Baka, A. · Roche, H.M. · Tuohy, K.M. · Teeling, J.L. · Blaak, E.E. · Fenech, M. · Vauzour, D. · McArdle, H.J. · Kremer, B.H.A. · Sterkman, L. · Vafeiadou, K. · Benedetti, M.M. · Williams, C.M. · Calder, P.C.
Source:British Journal of Nutrition, 7, 114, 999-1012
Identifier: 528810
doi: doi:10.1017/S0007114515002093
Keywords: Biology · Biomarkers · Chronic diseases · Health claims · Low-grade inflammation · Bacterium lipopolysaccharide · Biological marker · C reactive protein · Chemokine · Flavonoid · Interleukin 6 · Tumor necrosis factor alpha · Alzheimer disease · Atherosclerosis · Carbohydrate intake · Cardiovascular disease · Chronic disease · Chronic inflammation · Cytokine production · Degenerative disease · Diet · Endotoxemia · Fat intake · Human · Inflammation · Intestine flora · Maternal obesity · Mucosal immunity · Nervous system inflammation · Non insulin dependent diabetes mellitus · Nonalcoholic fatty liver · Nonhuman · Review · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences


The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's European Branch (ILSI Europe). It is co-authored by the speakers from a 2013 workshop led by the Obesity and Diabetes Task Force entitled 'Low-grade inflammation, a high-grade challenge: biomarkers and modulation by dietary strategies'. The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation-health/disease associations. The evidence relating diet composition and early-life nutrition to inflammatory status is reviewed. Human epidemiological and intervention data are thus far heavily reliant on the measurement of inflammatory markers in the circulation, and in particular cytokines in the fasting state, which are recognised as an insensitive and highly variable index of tissue inflammation. Potential novel kinetic and integrated approaches to capture inflammatory status in humans are discussed. Such approaches are likely to provide a more discriminating means of quantifying inflammation-health/disease associations, and the ability of diet to positively modulate inflammation and provide the much needed evidence to develop research portfolios that will inform new product development and associated health claims. Copyright © 2015 ILSI Europe. Chemicals/CAS: C reactive protein, 9007-41-4