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Protein metabolism in the rat cerebral cortex in vivo and in vitro as affected by the acquisition enhancing drug piracetam

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Author: Nickolson, V.J. · Wolthuis, O.L.
Type:article
Date:1976
Institution: Medisch Biologisch Laboratorium TNO
Source:Biochemical Pharmacology, 20, 25, 2237-2240
Identifier: 228017
doi: doi:10.1016/0006-2952(76)90003-4
Keywords: Biology · Piracetam · Protein · Radioisotope · Brain · Brain cortex · In vitro study · Intracerebroventricular drug administration · Intraperitoneal drug administration · Intravenous drug administration · Leucine h 3 · Pharmacokinetics · Rat · Theoretical study · Animal · Cerebral Cortex · In Vitro · Leucine · Male · Nerve Tissue Proteins · Piracetam · Pyrrolidinones · Rats · Stimulation, Chemical · Time Factors

Abstract

The effect of Piracetam on rat cerebral protein metabolism in vivo and in vitro was studied. It was found that the drug stimulates the uptake of labelled leucine by cerebral cortex slices, has no effect on the incorporation of leucine into cerebral protein, neither in slices nor in vivo, but inhibits the breakdown of newly formed protein in slices. Chemicals/CAS: piracetam, 7491-74-9; protein, 67254-75-5; Leucine, 61-90-5; Nerve Tissue Proteins; Piracetam, 7491-74-9; Pyrrolidinones