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Macrophage migration inhibitory factor: critical role in obesity, insulin resistance, and associated comorbidities.

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Author: Kleemann, R. · Bucala, R.
Type:article
Date:2010
Institution: TNO Kwaliteit van Leven
Source:Mediators of inflammation, 2010, 610479
Identifier: 352044
Keywords: Biology · glucose · macrophage migration inhibition factor · animal · genetics · human · insulin resistance · metabolism · obesity · physiology · review · Animals · Glucose · Humans · Insulin Resistance · Macrophage Migration-Inhibitory Factors · Obesity

Abstract

Obesity is associated with insulin resistance, disturbed glucose homeostasis, low grade inflammation, and comorbidities such as type 2 diabetes and cardiovascular disease. The cytokine macrophage migration inhibitory factor (MIF) is an ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders. Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity. This is a comprehensive summary of our current knowledge on the role of MIF in obesity and obesity-associated comorbidities, based on human clinical data as well as animal models of disease.