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Efficacy of pretreatment and treatment against soman intoxication

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Author: Philippens, I.H.C.H.M. · Jongsma, M.J. · Vanwersch, R.A.
Type:article
Date:2006
Publisher: Springer
Place: Dordrecht
Institution: TNO Defensie en Veiligheid
Source:Dishovsky, C.Pivovarov, A.Benschop, H. P., Medical treatment of intoxications and decontamination of chemical agents in the area of terrorist attack. Proceedings of the NATO Advanced Research Workshop, Dnepropetrovsk, Ukraine, 25-28 January 2005, 113-121 (Chapter 13)
Identifier: 183423
doi: DOI:10.1007/1-4020-4170-5_13
ISBN: 1402041683 · 9781402041686
Keywords: Toxicology · Cavia · Cavia porcellus

Abstract

The efficacy against lethality and post-intoxication incapacitation after 2x LD50 soman of different subacute pretreatment scenarios of 12 days was tested with or without post-intoxication therapy in guinea pigs. These pretreatment regimes were 1) the currently used pyridostigmine (PYR, 0.04 mg/kg/hr), 2) the combination of physostigmine (PHY, 0.025 mg/kg/hr) with the muscarinic receptor antagonist scopolamine (SCO, 0.018 mg/kg/hr), and 3) the combination of PHY with the anti-Parkinson drug procyclidine (PC, 3 mg/kg, sc). The post-intoxication therapy consisted of HI-6 (21.4 mg/kg, im), atropine sulphate (AS, 0.085 mg/kg, im), and diazepam (DZP, 0.21 mg/kg, im). Behavioral and observational read-out systems were used to elucidate theseverity of soman induced incapacitation. © 2006 Springer.